Ketogenic diet and other dietary treatments for epilepsy

  • Review
  • Intervention

Authors


Abstract

Background

The ketogenic diet, being high in fat and low in carbohydrates, has been suggested to reduce seizure frequency. It is currently used mainly for children who continue to have seizures despite treatment with antiepileptic drugs. Recently there has been interest in less restrictive ketogenic diets including the Atkins diet and the use of these diets has extended into adult practice.

Objectives

To review the evidence from randomised controlled trials regarding the effects of ketogenic and similar diets.

Search methods

We searched the Cochrane Epilepsy Group's Specialised Register (June 2011), the Cochrane Central Register of Controlled Trials (CENTRAL 2011, Issue 2 of 4), MEDLINE (1948 to May week 4, 2011) and EMBASE (1980 to March 2003). No language restrictions were imposed. We checked the reference lists of retrieved studies for additional reports of relevant studies.

Selection criteria

Studies of ketogenic diets and similar diets for people with epilepsy.

Data collection and analysis

Three review authors independently applied pre-defined criteria to extract data and also assessed study quality.

Main results

We identified four randomised controlled trials which generated five publications.

These included Kossoff 2007, Bergqvist 2005, Seo 2007, Neal 2008 and Neal 2009. All trials applied the intention-to-treat analysis with varied randomisation method. The four studies recruited a total of 289 children and adolescents and no adults. Meta-analysis could not be conducted due to heterogeneity of the studies. Seven prospective studies and four retrospective studies were also identified.

Authors' conclusions

Our review update included data from four new randomised studies of the ketogenic diet. Although none were blinded, some were of good quality. These studies suggest that in children, the ketogenic diet results in short to medium term benefits in seizure control, the effects of which are comparable to modern antiepileptic drugs. However, one study of long term outcome reports a high attrition rate for the diet. This would suggest that many children find the diet difficult to tolerate. The main reasons for drop-outs in the included studies included gastrointestinal side effects and dislike for the diet.

We found just three studies on the use of the diet in adults and none of these were randomised. There has been less research involving other diets. We found one randomised study of reasonable quality of the Atkins diet. This study showed similar benefits in seizure control with a less restrictive diet.

For those with medically intractable epilepsy or those in whom surgery is unsuitable, a ketogenic diet could improve seizure control, but tolerability is poor. One observational study suggested that the Atkins diet may have a similar effect on seizure control, but this requires more investigation.

Plain language summary

Ketogenic and other dietary treatments for epilepsy

Epilepsy is a disorder where recurrent seizures are caused by abnormal electrical discharges from the brain. Most seizures can be controlled by one or more anti-epileptic drugs but drug-resistant seizures may develop. The ketogenic diet was introduced prior to the introduction of these modern drugs and continues to be used, particularly for those who do not respond to drug treatment.

Several large observational studies investigated the effect of ketogenic diets in epilepsy and reported a beneficial effect. Recently, this view has been strengthened by the publication of four randomised controlled trials including one study which looked specifically at the Atkins diet, a related diet. It was not possible to meta-analyse data from these randomised trials due to heterogeneity. However, all studies showed 30-40% reduction in seizures compared to comparative controls.

Laički sažetak

Ketogena prehrana i drugi prehrambeni postupci za liječenje epilepsije

Epilepsija je poremećaj u kojem dolazi do opetovanih napadaja uzrokovanih nenormalnim električnim pražnjenjima u mozgu. Većinu napada moguće je kontrolirati jednim ili više anti-epileptičkih lijekova, no može doći do razvoja otpornosti na lijekove. Prehrana bogata mastima i proteinima, a siromašna ugljikohidratima (ketogena prehrana) koristila se u liječenju epilepsije prije uvođenja modernih lijekova, a nastavlja se koristiti i danas, naročito kod onih pacijenata kod kojih liječenje lijekovima ne daje rezultata.

U nekoliko velikih opservacijskih istraživanja, uočen je blagotvorni učinak ketogene prehrane kod epilepsije. Ovaj Cochrane sustavni pregled je pokazao da od nedavno ovo stajalište podupiru rezultati četiri randomizirana istraživanja, uključujući i ono koje se posebno bavilo učinkom slične, Atkinsonove dijete. Te četiri studije uključile su ukupno 298 djece i adolescenata. Zbog heterogenosti, meta-analiza ovih randomiziranih studija nije bila moguća. Ipak, sve studije su pokazale smanjenje epileptičkih napada za 30-40% u usporedbi s kontrolnom skupinom.

Bilješke prijevoda

Hrvatski Cochrane ogranak
Prevela: Viljemka Bučević Popović

Ancillary