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Intervention Review

Pharmacological interventions for non-ulcer dyspepsia

  1. Paul Moayyedi1,
  2. Soo Shelly2,
  3. Jonathan J Deeks3,
  4. Brendan Delaney4,
  5. Michael Innes5,
  6. David Forman6

Editorial Group: Cochrane Upper Gastrointestinal and Pancreatic Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 22 AUG 2006

DOI: 10.1002/14651858.CD001960.pub3

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Author Information

  1. 1

    McMaster University, Department of Medicine, Gastroenterology Division, Hamilton, Ontario, Canada

  2. 2

    The General Infirmary at Leeds, Gastroenterology Unit, Centre for Digestive Diseases, Leeds, UK

  3. 3

    University of Birmingham, Department of Public Health and Epidemiology, Birmingham, UK

  4. 4

    Primary Care and Clinical Sciences Building, Department of Primary Care and General Practice, Birmingham, West Midlands, UK

  5. 5

    The University of Birmingham, Department of Primary Care and General Practice, Birmingham, UK

  6. 6

    University of Leeds, Centre for Epidemiology and Biostatistics, Leeds, UK

Publication History

  1. Published Online: 21 JAN 2009

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary

Background

The commonest cause of upper gastrointestinal symptoms is non-ulcer dyspepsia (NUD) and yet the pathophysiology of this condition has been poorly characterised and the optimum treatment is uncertain. It is estimated that £450 million is spent on dyspepsia drugs in the UK each year.

Objectives

This review aims to determine the effectiveness of six classes of drugs (antacids, histamine H2 antagonists, proton pump inhibitors, prokinetics, mucosal protecting agents and antimuscarinics) in the improvement of either the individual or global dyspepsia symptom scores and also quality of life scores patients with non-ulcer dyspepsia.

Search strategy

We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2005), MEDLINE (1966 to January 2006), EMBASE (1988 to January 2006), CINAHL (1982 to January 2006), SIGLE, and reference lists of articles. We also contacted experts in the field and pharmaceutical companies. Trials were located through electronic searches of the Cochrane Controlled Trials Register (CCTR), MEDLINE, EMBASE, CINAHL and SIGLE, using appropriate subject headings and text words, searching bibliographies of retrieved articles, and through contacts with experts in the fields of dyspepsia and pharmaceutical companies.

Selection criteria

All randomised controlled trials (RCTs) comparing drugs of any of the six groups with each other or with placebo for non-ulcer dyspepsia (NUD).

Data collection and analysis

Two review authors independently assessed eligibility, trial quality and extracted data.

Main results

We included 73 trials: prokinetics (19 trials with dichotomous outcomes evaluating 3178 participants; relative risk reduction (RRR) 33%; 95% confidence intervals (CI) 18% to 45%), H2RAs (12 trials evaluating 2,183 participants; RRR 23%; 95% CI 8% to 35%) and PPIs (10 trials evaluating 3,347 participants; RRR 13%; 95% CI 4% to 20%) were significantly more effective than placebo. Bismuth salts (six trials evaluating 311 participants; RRR 40%; 95% CI -3 to 65%) were superior to placebo but this was of marginal statistical significance. Antacids (one trial evaluating 109 participants; RRR -2%; 95% CI -36% to 24%) and sucralfate (two trials evaluating 246 participants; RRR 29%; 95% CI -40% to 64%) were not statistically significantly superior to placebo. A funnel plot suggested that the prokinetic results could be due to publication bias or other small study effects.

Authors' conclusions

There is evidence that anti-secretory therapy may be effective in NUD. The trials evaluating prokinetic therapy are difficult to interpret as the meta-analysis result could have been due to publication bias. The effect of these drugs is likely to be small and many patients will need to take them on a long-term basis so economic analyses would be helpful and ideally the therapies assessed need to be inexpensive and well tolerated.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary

Anti-secretory drugs to relieve indigestion that is not caused by ulcers.

Dyspepsia (indigestion or heartburn) is due to ulcers (stomach or duodenal) and acid in the gullet (oesophagus) but in many people the cause is uncertain. People without a cause for dyspepsia have non-ulcer dyspepsia. There is no clear evidence on the best treatment for this. A variety of drugs are used to try and relieve dyspepsia. The main drugs used are either antacids, drugs to suppress stomach acids or drugs to promote stomach emptying. The review found one small trial of antacids that did not show any benefit. It found that drugs to promote stomach emptying may help but more research is needed. Drugs to suppress acid also helped. The quality of these trials was poor.

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