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Stimulant laxatives for constipation and soiling in children

  • Review
  • Intervention

Authors


John K MacDonald, Robarts Clinical Trials, Robarts Research Institute, P.O. Box 5015, 100 Perth Drive, London, Ontario, N6A 5K8, Canada. jmacdon1@uwo.ca . jmacdonald@robarts.ca.

Abstract

Background

Constipation is extremely common in childhood and may lead to overflow soiling/encopresis. Standard treatment of the more severe case is to empty the bowels of impacted faeces by the use of oral or rectal laxatives and then maintain regular bowel movements by the continuation of osmotic and stimulant laxatives.

Objectives

The objective of the review was to determine the effect of stimulant laxative treatment in children with chronic constipation who may also suffer from soiling / encopresis.

Search methods

The Cochrane database of randomised controlled trials was searched. Additional citations were sought by hand searching of paediatric journals and from contact with known professionals in the field.

Selection criteria

All identified randomised controlled trials (RCTs) which compare the administering of stimulant laxatives to children with either placebo or alternative treatment.

Data collection and analysis

No trials were found that met the selection criteria.

Main results

No trials were found that adequately met the selection criteria.

Authors' conclusions

The need exists to establish a secure footing for treatment decisions and adequately sized trials are required to provide comparative data on commonly used drugs.

摘要

背景

刺激性瀉藥對於兒童便秘和滲便的治療

便秘在童年時期極其常見並且可能導致溢出性的滲便/大便失禁。對於較嚴重個案的標準治療是使用口服或者直腸給予瀉藥使塞滿糞便的腸子清空,然後持續使用滲透性和刺激性瀉藥保持腸子規律的蠕動。

目標

本篇回顧的目標是要確定刺激性瀉藥治療對遭受滲便/大便失禁的慢性便秘孩子的效果。

搜尋策略

我們搜尋Cochrane資料庫中的隨機對照試驗。並以人工方式搜尋兒科期刊以及與該領域權威聯繫來取得文獻,另外的引證藉由手工搜尋兒科學的雜誌和與這個領域的知名專業人士聯繫。

選擇標準

我們選擇出比較給予孩童刺激性瀉藥和安慰劑或者其它的治療的所有隨機對照試驗(RCTs)。

資料收集與分析

沒有試驗符合這個選擇標準。

主要結論

沒有試驗適當地符合這個選擇標準。

作者結論

須要建立一個治療決定的安全基準,並且須要有足夠樣本大小的試驗提供常見用藥的比較性數據。

翻譯人

本摘要由臺中榮民總醫院王建得翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

對於治療童年便秘刺激性瀉藥的使用和效力的證據不足。和治療童年便秘的刺激物瀉藥的效力。便秘是一個常見的童年時期問題,傳統上用醫學和行為方法的結合來治療。沒有足夠的證據引導刺激性瀉藥的使用。更多的研究是須要的。

Plain language summary

Stimulant laxatives for constipation and soiling in children

Constipation is a common childhood disorder traditionally treated with a combination of medical and behavioural approaches. There is insufficient evidence on the use and effectiveness of stimulant laxatives for the treatment of childhood constipation. More research is required.

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