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Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients

  1. Frances Bunn1,*,
  2. Ian G Roberts2,
  3. Robert Tasker3,
  4. Daksha Trivedi1

Editorial Group: Cochrane Injuries Group

Published Online: 19 JUL 2004

Assessed as up-to-date: 14 OCT 2007

DOI: 10.1002/14651858.CD002045.pub2


How to Cite

Bunn F, Roberts IG, Tasker R, Trivedi D. Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD002045. DOI: 10.1002/14651858.CD002045.pub2.

Author Information

  1. 1

    University of Hertfordshire, Centre for Research in Primary and Community Care, Hatfield, Hertfordshire, UK

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    Department of Paediatrics, University of Cambridge School of Clinical Medicine, Cambridge, UK

*Frances Bunn, Centre for Research in Primary and Community Care, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, AL10 9PN, UK. f.bunn@herts.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 19 JUL 2004

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bortolani 1996 {published data only}
  • Bortolani A, Governa M, Barisoni D. Fluid replacement in burned patients. Acta Chirurgiae Plasticae 1996;38(4):132-6.
Caldwell 1979 {published data only}
Cooper 2004 {published data only}
  • Cooper J, Myles P, McDermott F, Murray L, Laidlaw J, Cooper G, et al. Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury. Journal of the American Medical Association 2004;291(11):1350-7.
Croft 1992 {published data only}
Cross 1989 {published data only}
Gunn 1989 {published data only}
  • Gunn ML, Hansbrough JF, Davis JW, Furst SR, Field TO. Prospective, randomized trial of hypertonic sodium lactate versus Ringer's solution for burn shock resuscitation. Journal of Trauma 1989;29(9):1261-7.
Jarvela 2002 {published data only}
  • Jarvela K, Kaukinen S. Hypertonic saline (7.5%) after coronary artery bypass grafting. European Journal of Anaesthesiology 2001;18(2):100-7.
  • Jarvela K, Kaukinen S. Hypertonic saline (7.5%) decreases perioperative weight gain following cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia 2002;16(1):43-6.
  • Jarvela K, Koskinen M, Kaukinen S, Koobi T. Effects of hypertonic saline (7.5%) on extracellular fluid volumes compared with normal saline (0.9%) and 6% hydroxyethly starch after aortocoronary bypass graft surgery. Journal of Cardiothoracic and Vascular Anesthesia 2001;15(2):210-15.
Jelenko 1978 {published data only}
  • Jelenko C, Wheeler ML, Calloway D, Divilio T, Bucklen KR, Holdredge TD. Shock and resuscitation II: volume repletion with minimal edema using the "HALFD" method. JACEP 1978;7(9):326-33.
McGough 1990 {published data only}
  • McGough EK, Kirby RR. Hypertonic saline for intraoperative fluid therapy. Critical Care Medicine 1990;18(4):5193.
Shackford 1983 {published data only}
  • Shackford SR, Sise MJ, Fridlund PH, Rowley WR, Peters RM, Virgilio RW, Brimm JE. Hypertonic sodium lactate versus lactated ringers solution for intravenous fluid therapy in operations on the abdominal aorta. Surgery 1983;94(1):41-51.
Shackford 1987 {published data only}
  • Shackford SR, Fortlage DA, Peters RM, Hollingsworth-Fridlund, Sise MJ. Serum osmolar and electrolyte changes associated with large infusions of hypertonic sodium lactate for intravascular volume expansion of patients undergoing aortic reconstruction. Surgery, Gynecology & Obstetrics 1987;164(2):127-136.
Simma 1998 {published data only}
  • Simma B, Burga R, Falk M, Sacher P, Fanconi S. A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated ringer's solution versus hypertonic saline. Critical Care Medicine 1998;26(7):1265-70.
  • Simma B, Burger R, Falk M, Sacher P, Torresani T, Fanconi S. The release of antidiuretic hormone is appropriate in response to hypovolemia and/or sodium administration in children with severe head injury: A trial of lactated ringer's solution versus hypertonic saline. Anesthesia and Analgesia 2001;92(3):641-5.
Vassar 1990 {published data only}
Vassar 1993a {published data only}
  • Vassar MJ, Perry CA, Holcroft JW. Prehospital resuscitation of hypotensive trauma patients with 7.5% NaCl versus 7.5% NaCl with added dextran: a controlled trial. The Journal of Trauma 1993;34(5):622-633.
Vassar 1993b {published data only}
  • Vassar MJ, Fischer RP, O'Brien PE, Bachulis BL, Chambers JA, Hoyt DB, Holcroft JW. A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. Arch Surg 1993;128:1003-1013.
Younes 1988a {published data only}
  • Younes RN, Aun F, Birolini D, Kawahara NT, Takeuti M, Casale L, Accioly C, Szajnbok I, Brito N. Initial treatment of hypovolemic patients with 7.5% solution of NaCl [O Tratamento inicial de pacientes hipovolemicos: Emprego da solucao hipertonica de NaCl a 7.5%]. Rev. Hosp. Clin. Fac. Med. S. Paulo 1988;43(3):138-141.
Younes 1988b {published data only}
  • Younes R, Bechara M, Langer B, Aun F, Birolini D, Kuznieck S, Guimaraes P. Hypertonic saline 7.5% in the prevention of hypotension in post abdominal aorta unclamping [Emprego da solucao hipertonica de NaCl a 7.5% na prevencao da hipotensao pos-desclampeamento da aorta abdominal]. Rev Ass Med Brasil 1988;34(5):150-154.
Younes 1992 {published data only}
  • Younes RN, Aun F, Accioly CQ, Casale LPL, Szajnbok I, Birolini. Hypertonic solutions in the treatment of hypovolemic shock: A prospective, randomized study in patients admitted to the emergency room. Surgery 1992;111(4):380-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Fisher 1992 {published data only}
Holcroft 1987 {published data only}
Shackford 1998 {published data only}
  • Shackford SR, Bourguignon PR, Wald SL, Rogers FB, Osler TM, Clark DE. Hypertonic saline resuscitation of patients with head injury: a prospective, randomized clinical trial. Journal of Trauma 1998;44(1):50-8.
Shao 2005 {published data only}
  • Shao Y, Zhang Y, Peng K, Quan Z. Effects of 7.5% hypertonic saline on fluid balance after radical surgery for gastrointestinal carcinoma. World J Gastroenterol 2005;11(11):1577-1581.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Berlin 1997
Jennett 1975
Khanna 2000
  • Khanna S, Davis D, Peterson B, Fisher B, Tung H, O'Quigley J, Deutsch R. Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Critical Care Medicine 2000;28(4):1144-51.
Krausz 1995
Perel 2007
Peterson 2000
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
Shenkin 1976
Walsh 1991