Intervention Review

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Interventions for the treatment of twin-twin transfusion syndrome

  1. Devender Roberts1,*,
  2. James P Neilson2,
  3. Mark D Kilby3,
  4. Simon Gates4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 30 JAN 2014

Assessed as up-to-date: 5 JUL 2013

DOI: 10.1002/14651858.CD002073.pub3


How to Cite

Roberts D, Neilson JP, Kilby MD, Gates S. Interventions for the treatment of twin-twin transfusion syndrome. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD002073. DOI: 10.1002/14651858.CD002073.pub3.

Author Information

  1. 1

    Liverpool Women's NHS Foundation Trust, Obstetrics Directorate, Liverpool, Merseyside, UK

  2. 2

    The University of Liverpool, Department of Women's and Children's Health, Liverpool, UK

  3. 3

    College of Medical and Dental Sciences, Centre for Women's and Children's Health, Birmingham, UK

  4. 4

    Division of Health Sciences, Warwick Medical School, The University of Warwick, Warwick Clinical Trials Unit, Coventry, UK

*Devender Roberts, Obstetrics Directorate, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, Merseyside, L8 7SS, UK. devender.roberts@lwh.nhs.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 30 JAN 2014

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Eurofetus 2004 {published data only}
  • Ortqvist L, Bussieres L, Staraci S, Fermanian C, Ville Y. Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome (TTTS) in the Eurofoetus trial. American Journal of Obstetrics and Gynecology 2008;199(6 Suppl 1):S118.
  • Ortqvist L, Chevret S, Bussieres L, Staraci S, Huard F, Ville Y. Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome in the Eurofetus trial. American Journal of Obstetrics and Gynecology 2006;195(6 Suppl 1):S3.
  • Salomon LJ, Ortqvist L, Aegerter P, Bussieres L, Staracci S, Stirnemann JJ, et al. Long-term developmental follow-up of infants who participated in a randomized clinical trial of amniocentesis vs laser photocoagulation for the treatment of twin-to-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2010;203(5):444.e1-444.e7.
  • Senat MV, Deprest J, Boulvain M, Paupe A, Winer N, Ville Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. New England Journal of Medicine 2004;351(2):136-44.
  • Senat MV, Deprest J, Boulvain M, Ville Y. Fetoscopic laser surgery versus serial amniodrainage in the management of severe twin-to-twin transfusion syndrome at midgestation. American Journal of Obstetrics and Gynecology 2003;189(6):S56.
  • Ville Y. Treatment of TTTS. Journal of Maternal-Fetal & Neonatal Medicine 2009;22(Suppl 1):35.
  • Ville Y, Eurofetus Group. Treatment of twin-to-twin-transfusion syndrome. The end of a long-standing misunderstanding. Ultrasound in Obstetrics & Gynecology 2003;22(Suppl 1):64.
Moise 2005 {published and unpublished data}
  • Fisk N. Twin-twin transfusion syndrome: a multicentre randomised trial for the evaluation of septostomy versus serial amnioreduction for therapy. National Research Register 2000; Vol. Issue 1.
  • Moise KJ Jr, Dorman K, Lamvu G, Saade GR, Fisk NM, Dickinson JE, et al. A randomized trial of amnioreduction versus septostomy in the treatment of twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2005;193(3 Pt 1):701-7.
  • Saade G, Moise K, Dorman K, Fisk N, Dickinson JE, Wilson RD. A randomized trial of septostomy versus amnioreduction in the treatment of twin oligohydramnios polyhydramnios sequence (TOPS). American Journal of Obstetrics and Gynecology 2002;187(6 Pt 2):S54.
NIHCD 2007 {published and unpublished data}
  • Crombleholme T. Amnioreduction versus selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome. www.clinicaltrials.gov (accessed 12 April 2006).
  • Crombleholme T, Shera D, Porter F, Lee H, Chyu J, Silver RK, et al. NIH sponsored prospecive randomized clinical trial of amnioreduction vs selective fetoscopic laser photocoagulation for twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2006;195(6 Suppl 1):S21.
  • Crombleholme TM, Shera D, Lee H, D'Alton M, Porter F, Chyu J, et al. A prospective randomized multicenter trial of amnioreduction vs. selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2007;197(4):396.e1-396.e9.
  • Luks FI, Carr SR, O'Brien BM, Muratore CS. Power and interpretation of a randomized study on the treatment of severe twin-to-twin transfusion syndrome.[Comment]. American Journal of Obstetrics and Gynecology 2008;198(5):607; author reply 607-8.
  • Quintero RA, Chmait R. The Con trial. American Journal of Obstetrics and Gynecology 2009;200(3):e14-e15.
  • Silver R. Twin-twin transfusion trial. www.enh.org (accessed 14 June 2005).

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Soothill 2000 {published data only (unpublished sought but not used)}
  • Soothill PW. Twin to twin transfusion in dichorionic pregnancy. National Research Register 2000; Vol. Issue 1.
Sutcliffe 2000 {published data only (unpublished sought but not used)}
  • Sutcliffe AG. A comparative study of amniotic drainage and laser cryotherapy for twin-twin transfusion syndrome. National Research Register 2000; Vol. Issue 1.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Slaghekke 2008 {published data only}
  • Slaghekke F. Fetoscopic laser coagulation of the entire vascular equator for the treatment of twin-to-twin transfusion syndrome: the "Solomon study". http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1245 (accessed 7 January 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Arabin 1998
  • Arabin B, Laurini RN, van Eyck J, Nicolaides KH. Treatment of twin-twin transfusion syndrome by laser and digoxin. Biophysical and angiographic evaluation. Fetal Diagnosis and Therapy 1998;13(3):141-6.
Bajoria 1995
  • Bajoria R, Wigglesworth J, Fisk NM. Angioarchitecture of arterio-arterial anastomoses in vivo with the feto-fetal transfusion syndrome. American Journal of Obstetrics and Gynecology 1995;172:856-63.
Bower 1995
Brocklehurst 2000
Crombleholme 1996
De Lia 1985
  • De Lia JE, Emery MG, Sheafor SA, Jennison TA. Twin transfusion syndrome: successful in utero treatment with digoxin. International Journal of Gynecology & Obstetrics 1985;23(3):197-201.
De Lia 1990
  • De Lia JE, Cruikshank DP, Keye W. Fetoscopic neodynium: YAG laser occlusion of placental vessels in severe twin-twin transfusion syndrome. Obstetrics & Gynecology 1990;75:1046-53.
De Lia 1995
  • De Lia JE, Kuhlmann RS, Harstad TW, Cruikshank DP. Fetoscopic laser ablation of placental vessels in severe previable twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 1995;172:1202-8.
Denbow 1998
Deprest 1998
  • Deprest JA, Van Ballaer PP, Evrard VA, Peers KH, Spitz B, Steegers EA, et al. Experience with fetoscopic cord ligation. European Journal of Obstetrics & Gynecology and Reproductive Biology 1998;81(2):157-64.
Doll 2001
  • Doll R. The role of data monitoring committees. In: Duley L, Farrell B editor(s). Clinical Trials. London: BMJ Publishing Group, 2001:97-104.
Donner 1997
  • Donner C, Shahabi S, Thomas D, Noel JC, Kirkpatrick C, Rysselberghe MV, et al. Selective feticide by embolization in twin-twin transfusion syndrome. A report of two cases. Journal of Reproductive Medicine 1997;42(11):747-50.
Elliot 1991
  • Elliot JP, Urig MA, Clewell WH. Aggressive therapeutic amniocentesis for treatment of twin-twin transfusion syndrome. Obstetrics & Gynecology 1991;77:537-44.
Fusi 1990
Garry 1998
  • Garry D, Lysikiewicz A, Mays J, Canterino J, Tejani N. Intra-amniotic pressure reduction in twin-twin transfusion syndrome. Journal of Perinatology 1998;18(4):284-6.
Gates 2004
Gilbert 1991
  • Gilbert WM, Davis SE, Kaplan C, Pretorius D, Merritt TA, Benirschke K. Morbidity associated with prenatal disruption of the dividing membrane in twin gestations. Obstetrics & Gynecology 1991;78(4):623-30.
Grant 2004
Hecher 1999
  • Hecher K, Plath H, Bregenzer T, Hansmann M, Hackeloer BJ. Endoscopic surgery versus serial amniocenteses in the treatment of severe twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 1999;180(3):717-24.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jones 1993
Machin 1996
Mahony 1990
  • Mahony BS, Petty CN, Nyberg DA, Luthy DA, Hickok DE, Hirsch JH. The "stuck twin" phenomenon: ultrasonographic findings, pregnancy outcome, and management with serial amniocentesis. American Journal of Obstetrics and Gynecology 1990;163:1513-22.
Montan 1985
  • Montan S, Jorgensen C, Sjoberg N. Amniocentesis in the treatment of acute polyhydramnios in twin pregnancies. Acta Obstetricia et Gynecologica Scandinavica 1985;64:537-9.
Quintero 1996
  • Quintero RA, Romero R, Reich H, Goncalves L, Johnson MP, Carreno C, et al. In utero percutaneous umbilical cord ligation in the management of complicated monochorionic multiple gestations. Ultrasound in Obstetrics & Gynecology 1996;8(1):16-22.
Quintero 2003
  • Quintero RA, Dickinson JE, Morales WJ, Bornick PW, Bermudez C, Cincotta R, et al. Stage-based treatment of twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2003;188:1333-40.
Reisner 1993
  • Reisner DP, Mahony BS, Petty CN, Nyberg DA, Porter TF, Zingheim RN, et al. Stuck twin syndrome: outcome in thirty seven cases. American Journal of Obstetrics and Gynecology 1993;169:991-5.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Roman 1995
Saade 1998
  • Saade GR, Belfort MA, Berry DL, Bui TH, Montgomery LD, Johnson A, et al. Amniotic septostomy for the treatment of twin oligohydramnios-polyhydramnios sequence. Fetal Diagnosis and Therapy 1998;13(2):86-93.
Saunders 1991
  • Saunders NJ, Snijders RJM, Nicolaides KH. Therapeutic amniocentesis in twin-twin transfusion syndrome appearing in the second trimester of pregnancy. American Journal of Obstetrics and Gynecology 1991;166(3):820-4.
Schneider 1985
Steinberg 1990
Trespidi 1997
  • Trespidi L, Boschetto C, Caravelli E, Villa L, Kusterman A, Nicolini U. Serial amniocenteses in the management of twin-twin transfusion syndrome: when is it valuable?. Fetal Diagnosis and Therapy 1997;12:15-20.
Urig 1990
  • Urig MA, Clewell WH, Elliot JP. Twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 1990;163:1522-6.
Van Heteren 1998
  • Van Heteren CF, Nijhuis JG, Semmekrot BA, Mulders LG, van den Berg PP. Risk for surviving twin after fetal death of co-twin in twin-twin transfusion syndrome. Obstetrics & Gynecology 1998;92(2):215-9.
Ville 1995
Ville 1998

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Roberts 2001
  • Roberts D, Neilson JP, Weindling AM. Interventions for the treatment of twin-twin transfusion syndrome. Cochrane Database of Systematic Reviews 2001, Issue 1. [DOI: 10.1002/14651858.CD002073]
Roberts 2008a
Roberts 2008b