Intervention Review

You have free access to this content

Drug treatment for faecal incontinence in adults

  1. Muhammad Imran Omar*,
  2. Cameron Edwin Alexander

Editorial Group: Cochrane Incontinence Group

Published Online: 11 JUN 2013

Assessed as up-to-date: 21 JUN 2012

DOI: 10.1002/14651858.CD002116.pub2


How to Cite

Omar MI, Alexander CE. Drug treatment for faecal incontinence in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD002116. DOI: 10.1002/14651858.CD002116.pub2.

Author Information

  1. University of Aberdeen, Academic Urology Unit, Aberdeen, Scotland, UK

*Muhammad Imran Omar, Academic Urology Unit, University of Aberdeen, Health Sciences Building (second floor), Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK. m.i.omar@abdn.ac.uk. drimran@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 11 JUN 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Carapeti 2000a # {published and unpublished data}
Carapeti 2000b # {published and unpublished data}
  • Carapeti EA, Kamm MA, Nicholls RJ, Phillips RKS. Randomized, controlled trial of topical phenylephrine for fecal incontinence in patients after ileoanal pouch construction. Diseases of the Colon and Rectum 2000;43(8):1059-63. [MEDLINE: 20404936]
Chassagne 2000 {published data only}
  • Chassagne P, Jego A, Gloc P, Capet C, Trivalle C, Doucet J, et al. Does treatment of constipation improve faecal incontinence in institutionalized elderly patients?. Age and Ageing 2000;29:159-64.
Cheetham 2001 # {published data only}
Cohen 2001 # {published data only}
  • Cohen LD, Levitt MD. A comparison of the effect of loperamide in oral or suppository form vs placebo in patients with ileo-anal pouches. Colorectal Disease 2001;3(2):95-9.
Fox 2005 # {published data only}
  • Fox M, Stutz B, Menne D, Fried M, Schwizer W, Thumshirn M. The effects of loperamide on continence problems and anorectal function in obese subjects taking orlistat. Digestive Diseases & Sciences 2005;50(9):1576-83.
Hallgren 1994 # {published data only}
  • Hallgren T, Fasth S, Delbro DS, Nordgren S, Oresland T, Hulten L. Loperamide improves anal sphincter function and continence after restorative proctocoloectomy. Digestive Diseases and Sciences 1994;39(12):2612-18. [MEDLINE: 95087506]
Harford 1980 # {published data only}
  • Harford WV, Krejs GJ, Santa Ana CA, Fordtran JS. Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhoea and faecal incontinence. Gastroenterology 1980;78(3):440-3. [MEDLINE: 80092619]
Kusunoki 1990 # {published data only}
  • Kusunoki M, Shoji Y, Ikeuchi H, Yamagata K, Yamamura T, Utsunomiya J. Usefulness of valproate sodium for the treatment of incontinence after ileoanal anastomosis. Surgery 1990;107(3):311-5. [MEDLINE: 90176598]
Lumi 2009 {published data only}
  • Lumi CM, La Rosa L, Coraglio MF, Munoz JP, Gualdrini UA, Masciangioli G. [Prospective, double-blind study of topical phenylephrine treatment for nocturnal fecal incontinence in patients after ileoanal pouch construction]. [Spanish]. Acta Gastroenterologica Latinoamericana 2009;39(3):179-83.
Palmer 1980 # {published data only}
  • Corbett CL, Palmer KR, Holdsworth CD. Effect of loperamide, codeine phosphate and diphenoxylate on urgency and incontinence in chronic diarrhoea (abstract). Gut 1980;21(Suppl 1-12):A924.
  • Palmer KR, Corbett CL, Holdsworth CD. Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhoea. Gastroenterology 1980;79(6):1272-5. [MEDLINE: 81067755]
Park 2007 {published data only}
  • Park JS, Kang SB, Kim DW, Namgung HW, Kim HL. The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer. International Journal of Colorectal Disease 2007;22(11):1319-24.
Pinedo 2012 {published data only}
Read 1982 # {published data only}
  • Read M, Read NW, Barber DC, Duthie HL. Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhoea with faecal incontinence and urgency. Digestive Diseases and Sciences 1982;27(9):807-14. [MEDLINE: 82261173]
Ryan 1974 {published data only}
  • Ryan D, Wilson A, Muir TS, Judge TG. The reduction of faecal incontinence by the use of 'Duphalac' in geriatric patients. Current Medical Research and Opinion 1974;2(6):329-33.
  • Wilson A, Ryan D, Muir TS. Geriatric faecal incontinence. A drug trial conducted by nurses. Nursing Mirror & Midwives Journal 1975;140(16):50-2.
Sun 1997 # {published data only}
  • Sun WM, Read NW, Verlinden M. Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence. Scandinavian Journal of Gastroenterology 1997;32(1):34-8. [MEDLINE: 97171546]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bliss 2001 {published data only}
Christensen 2006 {published data only}
  • Christensen P, Bazzocchi G, Coggrave M, Abel R, Hultling C, Krogh K, et al. A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients. Gastroenterology 2006;131(3):738-47.
  • Christensen P, Bazzocchi G, Coggrave M, Abel R, Hultling C, Krogh K, et al. Treatment of faecal incontinence and constipation in patients with spinal cord injury - a prospective, randomised, controlled, multicentre trial of transanal irrigation vs conservative bowel management (Abstract). Neurourology and Urodynamics 2007;25(6):594-5.
Drossman 2007 {published data only}
  • Drossman D, Morris CB, Hu Y, Toner BB, Diamant N, Whitehead WE, et al. Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment. American Journal of Gastroenterology 2007;102(7):1442-53.
    Direct Link:
Emblem 1989 {published data only}
Eogan 2007 {published data only}
Freedman 1959 {published data only}
  • Freedman N, Warshaw L, Engelhardt DM, Blumenthal IJ, Hankoff LD. The effect of various therapies upon fecal incontinence in chronic schizophrenic patients. Journal of Nervous & Mental Disease 1959;128(Jun):562-5.
Grijalva 2010 {published data only}
  • Grijalva I, Garcia-Perez A, Diaz J, Aguilar S, Mino D, Santiago-Rodriguez E, et al. High doses of 4-aminopyridine improve functionality in chronic complete spinal cord injury patients with MRI evidence of cord continuity. Archives of Medical Research 2010;41(7):567-75.
Harari 2004 {published data only}
Henriksson 1992 {published data only}
  • Henriksson R, Franzen L, Littbrand B. Effects of sucralfate on acute and late bowel discomfort following radiotherapy of pelvic cancer. Journal of Clinical Oncology 1992;10(6):969-75.
Heymen 2004 {published data only}
  • Heymen S, Scarlett Y, Whitehead WE. Education and medical management resolve fecal incontinence in 35%, but depression and greater symptom severity predict a poor response (Abstract). Gastroenterology 2004;126(4 (Suppl 2)):A480.
Heymen 2004a {published data only}
  • Heymen S, Scarlett Y, Whitehead WE. Anorectal physiology predicts response to conservative medical management of fecal incontinence (Abstract). Gastroenterology 2004;126(4 (Suppl 2)):A363.
Lauti 2008 {published data only}
Qvitzau 1988 {published data only}
Rosman 2008 {published data only}
  • Rosman AS, Chaparala G, Monga A, Spungen AM, Bauman WA, Korsten MA. Intramuscular neostigmine and glycopyrrolate safely accelerated bowel evacuation in patients with spinal cord injury and defecatory disorders. Digestive Diseases & Sciences 2008;53(10):2710-3.
Santos 1961 {published data only}
  • Santos L, Gross M. The clinical effect of norethandrolone on incontinent mental patients action induced by non-verbal communication. Clinical Notes 1962:223-6.
  • Santos L, Gross M. The clinical effect of norethandrolone on incontinent mental patients. Action induced by non-verbal communication. American Journal of Psychiatry 1961;118:223-6.
Schneiter 1972 {published data only}
  • Schneiter R. [Favorable surgical-clinical experiences with a new laxative acting on the large intestine]. [German]. Schweizerische Rundschau fur Medizin Praxis 1972;61(42):1311-2.
Shoji 1993 {published data only}
  • Shoji Y, Kusunoki M, Yanagi H, Sakanoue Y, Utsunomiya J. Effects of sodium valproate on various intestinal motor functions after ileal J pouch-anal anastomosis. Surgery 1993;113(5):560-3.
Tu 2008 {published data only}
  • Tu XH, Chen ZY. [Clinical efficacy of buzhong yiqi pill combined with imodium in treating post-operational diarrhea in patients of colonic cancer] [Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi/Chinese Journal of Integrated Traditional & Western Medicine/Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban 2008;28(8):738-41.
Van Assche 2012 {published data only}
Whitebird 2006 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Brown 2010
Da Silva 2003
Deutekom 2012
Fader 2009
  • Fader M, Cottenden AM, Getliffe K. Absorbent products for moderate-heavy urinary and/or faecal incontinence in women and men. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD007408]
Gattuso 1994
Herbst 1998
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Available from www.cochrane-handbook.org. The Cochrane Collaboration, 2011.
Lindsey 2004
Madoff 2009
  • Madoff RD, Laurberg S, Matzel KE, Mellgren AF, Mimura T, O’Connell PR, et al. Surgery for fecal incontinence. In: Abrams P, Cardozo L, Khoury S, Wein A editor(s). Incontinence: 4th International Consultation on Incontinence. Plymouth: Health Publications, 2008:1387-418.
Maeda 2013
Mowatt 2007
NICE 2007
  • National Institute for Health and Clinical Excellence, UK. Faecal Incontinence: the management of faecal incontinence in adults. NICE Clinical Guideline Reference Number CG49. http://www.nice.org.uk/CG49. June 2007 (accessed 10 March 2008).
Norton 2012
Perry 2002
Rao 2004
Rockwood 2000
Tuteja 2004
Vaizey 1997
Ware 1993
  • Ware JE, Snow KK, Kosinski M, Gaudek B. SF-36 Health Survey Manual and Interpretation Guide. Boston: New England Medical Centre, 1993.
Wheeler 2007
  • Wheeler TL 2nd, Richter HE. Delivery method, anal sphincter tears and fecal incontinence: new information on a persistent problem. Current Opinion in Obstetrics & Gynecology 2007;19(5):474-9.
Whitehead 2001
  • Whitehead WE, Wald A, Norton N. Treatment options for fecal incontinence: consensus conference report. Diseases of the Colon and Rectum 2001;44:131-44.
Whitehead 2009
  • Whitehead WE, Borrud L, Goode PS, Meikle S, Mueller ER, Tuteja A, et al. Pelvic Floor Disorders Network. Fecal incontinence in US adults: epidemiology and risk factors.. Gastroenterology 2009;137(2):512–7.
Zigmond 1983

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cheetham 2002
  • Cheetham M, Brazzelli M, Norton C, Glazener CMA. Drug treatment for faecal incontinence in adults. Cochrane Database of Systematic Reviews 2002, Issue 3. [DOI: 10.1002/14651858.CD002116]