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Antibiotics for treating scrub typhus

  1. Qin Liu2,
  2. Ratana Panpanich1,*

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 25 MAY 2010

DOI: 10.1002/14651858.CD002150

Database Title

Additional Information

How to Cite

Liu Q, Panpanich R. Antibiotics for treating scrub typhus. Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD002150. DOI: 10.1002/14651858.CD002150.

Author Information

  1. 1

    Faculty of Medicine, Community Medicine, Chiang Mai, North, Thailand

  2. 2

    School of Public Health, Chongqing Medical University, Effective Healthcare Research Programme Consortium China (Chongqing) RPC Programme, Chongqing, China

*Ratana Panpanich, Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Intawaroros, Chiang Mai, North, 50200, Thailand. rpanpani@mail.med.cmu.ac.th.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Brown 1978 {published data only}
  • Brown GW, Saunders JP, Singh SL, Haxsoll DL, Shirai A. Single dose doxycycline therapy for scrub typhus. Transactions of the Royal Society Tropical Medicine and Hygiene 1978;72(4):413-6.
Kim 2004 {published data only}
  • Kim YS, Yun HJ, Shim SK, Koo SH, Kim SY, Kim S. A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. Clinical Infectious Diseases 2004;39:1329-35.
Kim 2007 {published data only}
  • Kim DM, Yu KD, Lee JH, Kim HK, Lee SH. Controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus. Antimicrobial Agents and Chemotherapy 2007;51(6):2011-5.
Phimda 2007 {published data only}
  • Pimda K, Hoontrakul S, Suttinont C, Chareonwat S, Losuwanaluk K, Chueasuwanchai S, et al. Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub typhus. Antimicrobial Agents and Chemotherapy 2007;51(9):3259-63.
Sheehy 1973 {published data only}
Song 1995 {published data only}
  • Song JH, Lee C, Chang LW, Choi SW, Choi JE, Kim YS, et al. Short-course doxycycline treatment versus conventional tetracycline therapy for scrub typhus: A multiple randomized trial. Clinical Infectious Diseases 1995;21:506-10.
Watt 2000 {published data only}
  • Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D, Strickman D. Doxycycline and rifampicin for mild scrub typhus infections in northern Thailand: a randomised trial. Lancet 2000;356:1057-61.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Olson 1980 {published data only}
  • Olson JG, Bourgeois AL, Fang RCY, Coolbaugh JC, Dennes DT. Prevention of scrub typhus: prophylactic administration of doxycycline in a randomized double blind trial. Journal of Tropical Medicine and Hygiene 1980;29(5):989-97.
Twartz 1982 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
IRB043-31 {published data only}
  • IRB043-31. Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus. ClinicalTrials.gov (accessed June 23 2009).
ISRCTN47812566 {published data only}
  • ISRCTN47812566. Oral doxycycline versus oral azithromycin in the treatment of Scruband Murine Typhus in Laos. Wellcome Trust (accessed June 2009).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Berman 1973
Brown 1976
  • Brown GW, Robinson DM, Huxsoll DL. Scrub typhus: a common cause of illness in indigenous populations. Transactions of the Royal Society of Tropical Medicine and Hygiene 1976;70:516:444-8.
CDC 2007
  • Centers for Disease Control. Chapter 4. Rickettsial infections. Health Information for International Travel, 2005-2006. http://www2.ncid.cdc.gov/travel/yb/utils/ybGet.asp?section=dis&obj=rickettsial.htm. CDC, [Accessed on April 2007].
Chanyasanha 1998
  • Chanyasanha C, Kaeburong K, Chenchittikul M, Sujirarat D. Seroprevalence of scrub typhus infection in patients with pyrexia at some malaria clinics in three western provinces in Thailand. Asian Pacific Journal of Allergy and Immunology 1998;16(2-3):119-25.
Deller 1967
Higgins 2003
Jensenius 2006
Jüni 2001
Kumar 2004
  • Kumar K, Saxena VK, Thomas TG, Lal S. Outbreak investigation of scrub typhus in Himachal Pradesh (India). Journal of Communicable Disease 2004;36(4):277-83.
Lefebvre 2008
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook forSystematic Reviews of Interventions Version 5.0.0 (updated February 2008). Available from www.cochrane-handbook.org. The Cochrane Collaboration, 2008.
McDonald 1988
Review Manager 5
  • Copenhagen: The Nordic Cochrane Centre,The Cochrane Collaboration. Review Manager (RevMan). 5.0.3. Copenhagen: The Nordic Cochrane Centre,The Cochrane Collaboration, 2009.
Silpapojakul 1997
  • Silpapojakul K. Scrub typhus in the western Pacific Regian. Annals of the Academy of Medicine, Singapore 1997;26:794-800.
Sirisanthana 1989
  • Sirisanthana V, Poneprasert B. Scrub typhus in children at Chiang Mai University Hospital. Journal of Infectious Disease and Antimicrobial Agents 1989;6(1):22-7.
Smadel 1950
  • Smadel JE, Traub R, Frick LP, Dierck FH, Bailey CA. Chloramphenicol (chloromycetin) in the chemoprophylaxis of scrub typhus (Tsutsugamushi disease). American Journal of Hygiene 1950;51:216-28.
Strickman 1995
  • Strickman D, Sheer T, Salata K, Hershey J, Dasch G, Kelly D, et al. In vitro effectiveness of azithromycin against doxycycline resistant and susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus. Antimicrobial Agents and Chemotherapy 1995;39(11):2406-10.
Suntharasaj 1997
  • Suntharasaj T, Janjindamai W, Krisanapan S. Pregnancy with scrub typhus and vertical transmission: a case report. Journal of Obstetric and Gynaecology Research 1997;23(1):75-8.
Supparatpinyo 1990
  • Supparatpinyo K, Horsin P, Hirunsri P. Scrub typhus: Single oral doxycycline therapy in mild to moderately severe cases. Journal of Infectious Disease and Antimicrobial Agents 1990;7(3):135-37.
Suttinont 2006
  • Suttinont C, Losuwanaluk K, Niwattanyakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, et al. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Annual of Tropical Medicine and Parasitology 2006;100(4):363-70.
Varghese 2006
  • Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, Kavitha ML, et al. Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. Journal of Infection 2006;52(1):56-60.
Wang 1992
Watt 1994
Watt 1996
  • Watt G, Chouriyagune C, Ruangweerayud T, Watcharapichat P, Phulsuksombati D, Jongasakul K, et al. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Lancet 1996;348:86-9.
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