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Antipyretic measures for treating fever in malaria

  1. Martin M Meremikwu1,*,
  2. Karl Logan2,
  3. Paul Garner3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 24 APR 2000

Assessed as up-to-date: 15 JAN 2000

DOI: 10.1002/14651858.CD002151


How to Cite

Meremikwu MM, Logan K, Garner P. Antipyretic measures for treating fever in malaria. Cochrane Database of Systematic Reviews 2000, Issue 2. Art. No.: CD002151. DOI: 10.1002/14651858.CD002151.

Author Information

  1. 1

    University of Calabar Teaching Hospital, Department of Paediatrics, Calabar, Cross River State, Nigeria

  2. 2

    Royal Liverpool University Hospital, Liverpool, UK

  3. 3

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, Merseyside, UK

*Martin M Meremikwu, Department of Paediatrics, University of Calabar Teaching Hospital, PMB 1115, Calabar, Cross River State, Nigeria. mmeremiku@yahoo.co.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 24 APR 2000

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This is not the most recent version of the article. View current version (12 SEP 2012)

 

Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Fever control measures are commonly used in treating malaria. Some researchers have suggested that fever reduction may prolong malaria illness.

Objectives

We aim to assess whether antipyretic measures in malaria influences outcome, measured by length of illness, parasitaemia, and occurrence of convulsions.

Search methods

We searched the Cochrane Infectious Diseases Group Trial Register (December 2002), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 4, 2002), MEDLINE (1966 to December 2002); EMBASE (1980 to December 2002), LILACS (December 2002). We contacted researchers and organisations working in the field.

Selection criteria

Randomised or pseudo-randomised trials which compared antipyretic drugs with mechanical or no antipyretic measures in patients with slide-confirmed malaria.

Data collection and analysis

Inclusion criteria were independently applied by two reviewers. We extracted data from selected trials using a standard form. Mean difference with 95% confidence interval was calculated for continuous data.

Main results

Three randomised trials with pooled 128 adults and children with falciparum malaria; all unblinded; allocation concealment unclear in two. Inconsistent pattern of fever clearance between trials, but malaria cure rate reported to be similar between intervention and control in all trials. Mean parasite clearance time reported to be similar in one trial but longer in paracetamol group in two trials: sample size in one trial was too small to conclude anything (n=7), while the other trial was difficult to evaluate.

Authors' conclusions

There is insufficient data to confirm or refute an impact of antipyretic measures on parasitaemia or malarial illness.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Antipyretic measures for treating fever in malaria

Plain language summary pending.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

治療瘧疾之解熱措施

治療瘧疾時常會給與一些解熱措施,但有研究者認為,解熱措施可能會導致延長瘧疾疾病之時間。

目標

本次回顧主要評估解熱措施是否影響瘧疾的治療結果、計算罹病時間、是否引起寄生蟲血症以及是否發生抽搐。

搜尋策略

我們搜尋了Cochrane Infectious Diseases Group Trial Register (2002年12月), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 4, 2002), MEDLINE (1966 至 2002年12月); EMBASE (1980 至 2002年12月), LILACS (2002年12月)。我們並和本研究領域的研究者以及研究機構聯繫。

選擇標準

納入隨機或偽隨機臨床試驗,探討血液抹片確診為瘧疾之患者,比較是否使用解熱藥與使用物理性解熱法之差異。

資料收集與分析

由兩個獨立評審者依納入標準審查,由選定的臨床試驗中提取數據填入標準表格。以連續數據計算加權平均相差及95%信賴區間。

主要結論

總共有三個隨機試驗納入分析,有128個成年人和兒童惡性瘧疾患者加入研究,三個隨機試驗皆非盲測,兩個試驗不清楚是否以隱藏方式分配治療組別。三個試驗中退燒形式不一致,但瘧疾的治癒以及控制率相較於各試驗中之治療組和對照組皆相近,平均瘧原蟲廓清時間在其中一個臨床試驗相差不多,但另兩個使用樸熱息痛(Paracetamol)組所需時間較長,但其中一個試驗的樣本數太小(7例)以致無法達成結論,其他的試驗亦很難評估此議題。

作者結論

目前沒有足夠的數據來證實或否定解熱措施會影響寄生蟲血症或瘧疾的病程。

翻譯人

本摘要由三軍總醫院吳宜穎翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

本文並無總結