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Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence

  1. Richard P Mattick1,*,
  2. Courtney Breen1,
  3. Jo Kimber1,
  4. Marina Davoli2

Editorial Group: Cochrane Drugs and Alcohol Group

Published Online: 6 FEB 2014

Assessed as up-to-date: 3 DEC 2012

DOI: 10.1002/14651858.CD002207.pub4


How to Cite

Mattick RP, Breen C, Kimber J, Davoli M. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD002207. DOI: 10.1002/14651858.CD002207.pub4.

Author Information

  1. 1

    University of New South Wales, National Drug and Alcohol Research Centre, Sydney, New South Wales, Australia

  2. 2

    Lazio Regional Health Service, Department of Epidemiology, Rome, Italy

*Richard P Mattick, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, 2052, Australia. R.Mattick@unsw.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 6 FEB 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ahmadi 2002a {published data only}
Ahmadi 2003a {published data only}
Ahmadi 2003b {published data only}
Ahmadi 2004 {published data only}
  • Ahmadi J, Babaee-Beigi M, Alishahi M, Maany I, Hidari T. Twelve-month maintenance treatment of opium-dependent patients. Journal of Substance Abuse Treatment 2004;26(1):61-4.
Fischer 1999 {published and unpublished data}
Fudala 2003 {published and unpublished data}
  • Fudala PJ, Bridge TP, Herbert S, Williford WO, Chiang CN, Jones K, et al. Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. New England Journal of Medicine 2003;349(10):949-58.
Johnson 1992 {published and unpublished data}
  • Johnson R, Jaffe J, Fudala P. A controlled trial of buprenorphine treatment for opioid dependence. JAMA 1992;267(20):2750-5. [MEDLINE: 1992251936]
Johnson 1995a {published and unpublished data}
  • Johnson RE, Eissenberg T, Stitzer ML, Strain EC, Liebson IA, Bigelow GE. A placebo controlled trial of buprenorphine as a treatment for opioid dependence. Drug and Alcohol Dependence 1995;40(1):17-25.
Johnson 2000 {published and unpublished data}
  • Johnson RE, Chutuape MA, Strain, EC, Walsh SL, Stitzer ML, Begelow GE. A comparison of levomethadyl acetate, buprenorphine and methadone for opioid dependence. New England Journal of Medicine 2000;343(18):1290-7.
Kakko 2003 {published and unpublished data}
  • Kakko J, Svanborg KD, Kreek MJ, Heilig M. 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: A randomised, placebo-controlled trial. Lancet 2003;361(9358):662-8.
Kakko 2007 {published data only}
  • Kakko J, Grönbladh L, Svanborg KD, Von Wachenfeldt J, Rück C, Rawlings B, et al. A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomised controlled trial. American Journal of Psychiatry 2007;164(5):797-803.
Kamien 2008 {published data only}
  • Kamien JB, Branstetter SA, Amass L. Buprenorphine-naloxone versus methadone maitenance therapy: A randomised double-blind trial with opioid dependent patients. Heroin Addiction and Related Clinical Problems 2008;10(4):5-18.
Kosten 1993 {published data only}
Kristensen 2005 {published data only}
  • Kristensen Ø, Espegren O, Asland R, Jakobsen E, Lie Ø, Seiler S. Buprenorphine and methadone to opiate addicts--a randomized trial (English abstract only). Tidsskrift for den Norske Laegeforening 2005;125(2):148-51. [: PMID: 15665884]
Krook 2002 {published data only}
Ling 1996 {published and unpublished data}
  • Ling W, Wesson D, Charuvastra C, Klett J. A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence. Archives of General Psychiatry 1996;53(5):401-7. [MEDLINE: 1996212784]
Ling 1998 {published and unpublished data}
Ling 2010 {published data only}
Lintzeris 2004 {published data only}
Magura 2009 {published data only}
  • Magura S, Lee JD, Hershberger J, Joseph H, Marsch L, Shropshire C, et al. Buprenorphine and methadone maintenance in jail and post-release: A randomized clinical trial. Drug and Alcohol Dependence 2009;99(1-3):222-30.
Mattick 2003 {published data only}
Neri 2005 {published data only}
  • Neri S, Bruno CM, Pulvirenti D, Malaguarnera M, Italiano C, Mauceri B, et al. Randomised clinical trial to compare the effects of methadone and buprenorphine on the immune system in drug abusers. Psychopharmacology 2005;179(3):700-4.
Oliveto 1999 {published data only}
  • Oliveto AH, Feingold A, Schottenfeld R, Jatlow P, Kosten TR. Desipramine in opioid-dependent cocaine abusers maintained on methadone or buprenorphine. Archives of General Psychiatry 1999;56(9):812-20.
Pani 2000 {published data only}
  • Pani PP, Maremmani I, Pirastu R, Tagliamonte A, Gessa GL. Buprenorphine: A controlled trial in the treatment of opioid dependence. Drug and Alcohol Dependence 2000;60(1):39-50.
Petitjean 2001 {published and unpublished data}
  • Petitjean S, Stohler R, Déglon JJ, Livoti S, Waldvogel D, Uehlinger C, et al. Double-blind randomised trial of buprenorphine and methadone in opiate dependence. Drug and Alcohol Dependence 2001;62(1):97-104.
Schottenfeld 1997 {published and unpublished data}
  • Schottenfeld RS, Pakes JR, Oliveto A, Ziedonis D, Kosten TR. Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse. Archives of General Psychiatry 1997;54(8):713-20. [MEDLINE: 1997429160]
Schottenfeld 2005 {published data only}
  • Schottenfeld RS, Chawarski MC, Pakes JR, Pantalon MV, Carroll KM, Kosten TR. Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence. American Journal of Psychiatry 2005;162(2):340-9.
Schottenfeld 2008 {published and unpublished data}
  • Schottenfeld RS, Chawarski MC, Mazlan M. Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371(9631):2192-200.
Soyka 2008a {published data only}
  • Soyka M, Zingg C, Koller G, Kuefner H. Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome:results form a randomised study. International Journal of Neuropsychopharmacology 2008;11(5):641-53.
Strain 1994a {published and unpublished data}
Strain 1994b {published and unpublished data}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Bickel 1988 {published data only}
  • Bickel WK, Stitzer ML, Bigelow GE, Liebson IA, Jasinski DR, Johnson RE. A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts. Clinical Pharmacology and Therapeutics 1988;43(1):72-8. [MEDLINE: 1988081296]
Bond 2004 {published data only}
  • Bond C, Matheson C, Lawrie T, Cameron I, Robinson A, McNamee P, et al. A randomised comparison of methadone against buprenorphine in the treatment of opioid dependency: a feasibility study. International Journal of Pharmacy Practice 2004;Supplement 2004:R52.
Bouchez 1998 {published data only}
  • Bouchez J, Beauverie P, Touzeau D. Substitution with buprenorphine in methadone- and morphine sulfate-dependent patients. Preliminary results. European Addiction Research 1998;4(Suppl 1):8-12.
Eder 1998 {published data only}
  • Eder H, Fischer G, Gombas W, Jagsch R, Stuehlinger G, Kasper S. Comparison of buprenorphine and methadone maintenance in opiate addicts. European Addiction Research 1998;4(Suppl 1):3-7.
Fischer 2006 {published data only}
Gerra 2004 {published data only}
  • Gerra G, Borella F, Zaimovic A, Moi G, Bussandri M, Bibici C, et al. Buprenorphine versus methadone for opioid dependence: Predictor variables for treatment outcome. Drug and Alcohol Dependence 2004;75(1):37-45.
Giacomuzzi 2003 {published data only}
Gryczynski 2013 {published data only}
  • Gryczynski J, Mitchell SG, Jaffe JH, Kelly SM, Myers CP, O'Grady KE, et al. Retention in methadone and buprenorphine treatment among African Americans. Journal of Substance Abuse Treatment 2013;45(3):287-92.
Harris 2005 {published data only}
  • Harris AH, Gospodarevskaya E, Ritter A. A randomised trial of the cost effectiveness of buprenorphine as an alternative to methadone maintenance treatment for heroin dependence. Pharmacoeconomics 2005;23(1):77-91.
Johnson 1995b {published data only}
  • Johnson RE, Eissenberg T, Stitzer ML, Strain EC, Liebson IA, Bigelow GE. Buprenorphine treatment of opioid dependence: Clinical trial of daily versus alternate-day dosing. Drug and Alcohol Dependence 1995;40(1):27-35.
Jones 2005a {published data only}
  • Jones HE, Johnson RE, Jasinski DR, Milio L. Randomised controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone. Drug and Alcohol Dependence 2005;78(1):33-8.
Jones 2005b {published data only}
  • Jones HE, Johnson RE, Jasinski DR, O'Grady KE, Chisholm CA, Choo RE, et al. Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: Effects on the neonatal abstinence syndrome. Drug and Alcohol Dependence 2005;79(1):1-10.
Jones 2010a {published data only}
  • Jones HE, O'Grady KE, Johnson RE, Velez M, Jansson LM. Infant neurobehaviour following prenatal exposure to methadone and buprenorphine: results from the neonatal intensive care unit network neurobehavioural scale. Substance Use and Misuse 2010;45(13):2244-57.
Jones 2010b {published data only}
  • Jones HE, Kaltenbach K, Heil SH, Stine SM, Coyle MG, Arria AM, et al. Neonatal abstinence syndrome after methadone and buprenorphine exposure. New England Journal of Medicine 2010;363(24):2320-2331.
Kosten 2004 {published data only}
Lott 2006 {published data only}
  • Lott DC, Strain EC, Brooner RK, BIgelow GE, Johnson RE. HIV risk behaviors during pharmacologic treatment for opioid dependence: A comparison of levomethadyl acetate [corrected], buprenorphine, and methadone. Journal of Substance Abuse Treatment 2006;31(2):187-94.
Lucas 2010 {published data only}
  • Lucas GM, Chaudry A, Hsu J, Woodson T, Lau B, Olsen Y, et al. Clinic-based treatment of opioid-dependent HIV-Infected patients versus referral to an opioid treatment program. A randomized trial. Annals of Internal Medicine 2010;152(11):704-11.
Marsch 2005 {published data only}
  • Marsch LA, Bickel WK, Badger GJ, Jacobs EA. Buprenorphine treatment for opioid dependence: relative efficacy of daily, twice and thrice weekly dosing. Drug and Alcohol Dependence 2005;77(2):195-204.
McKeganey 2013 {published data only}
  • McKeganey N, Russell C, Cockayne L. Medically assisted recovery from opiate dependence within the context of the UK drug strategy: methadone and Suboxone (buprenorphine-naloxone) patients compared. Journal of Substance Abuse Treatment 2013;44(1):97-102.
Meader 2010 {published data only}
  • Meader N. A comparison of methadone, buprenorphine and alpha2 adrenergic agonists for opioid detoxification: A mixed treatment comparison meta analysis. Drug and Alcohol Dependence 2010;108(1-2):110-4.
Montoya 2004 {published data only}
  • Montoya ID, Gorelick DA, Preston KL, Schroeder JR, Umbricht A, Cheskin LJ, et al. Randomized trial of buprenorphine for treatment of current opiate and cocaine dependence. Clinical Pharmacology and Therapeutics 2004;75(1):34-48.
Neumann 2013 {published data only}
  • Neumann AM, Blondell RD, Jaanimägi MS, Giambrone AK, Homish GG, Lozano JR, et al. A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction. Journal of Addictive Diseases 2013;32(1):68-78.
O'Connor 1998 {published data only}
  • O'Connor PG, Oliveto AH, Shi JM, Triffleman EG, Carroll KM, Kosten TR, et al. A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic. American Journal of Medicine 1998;105(2):100-5.
Oliveto 1994 {published data only}
  • Oliveto A, Kosten T, Schottenfeld R, Ziedonis D, Falcioni J. Cocaine use in buprenorphine vs methadone maintained patients. American Journal on Addictions 1994;3(1):43-8.
Pinto 2008 {published data only}
  • Pinto H, Rumball D, Maskrey V, Holland R. A pilot study for a randomized controlled and patient preference trial of buprenorphine versus methadone maintenance treatment in the management of opiate dependent patients. Journal of Substance Use 2008;13(2):73-82.
Resnick 1992 {published data only}
  • Resnick RB, Galanter M, Pycha C, Cohen A, Grandison P, Flood N. Buprenorphine: An alternative to methadone for heroin dependence treatment.. Psychopharmacology Bulletin 1992;28(1):109-13.
Sacerdote 2008 {published data only}
  • Sacerdote P, Franchi S, Gerra G, Leccese V, Panerai AE, Somaini L. Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function. Brain, Behavior, and Immunity 2008;22(4):606-13.
Schottenfeld 1998 {published data only}
Sigmon 2004 {published data only}
Soyka 2008b {published data only}
  • Soyka M, Lieb M, Kagerer S, Zingg C, Koller G, Lehnert P, et al. Cognitive functioning during methadone and buprenorphine treatment: Results of a randomized clinical trial. Journal of Clinical Psychopharmacology 2008;28(6):699-703.
Stine 1994 {published data only}
Strain 1996 {published data only}
  • Strain EC, Stitzer ML, Liebson IA, Bigelow GE. Buprenorphine versus methadone in the treatment of opioid dependence: self reports, urinalysis, and addiction severity index. Journal of Clinical Psychopharmacology 1996;16(1):58-67. [MEDLINE: 1996431336]
Uehlinger 1998 {published and unpublished data}
Warden 2012 {published data only}
  • Warden D, Subramaniam GA, Carmody T, Woody GE, Minhajuddin A, Poole SA, et al. Predictors of attrition with buprenorphine/naloxone treatment in opioid dependent youth. Addictive Behaviors 2012;37(9):1046-53.
Weiss 2011 {published data only}
  • Weiss RD, Sharpe Potter JS, Fiellin DA, Byrne M, Connery HS, Dickinson W, et al. Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: A 2-phase randomized controlled trial. Archives of General Psychiatry 2011;68(12):1238-46.
Woody 2008 {published data only}
  • Woody GE, Poole SA, Subramaniam G, Dugosh K, Bogenschutz M, Abbott P, et al. Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: A randomized trial. JAMA 2008;300(17):2003-11.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ahmadi 2002b {published data only}
Cropsey 2011 {published data only}
  • Cropsey KL, Lane PS, Hale GJ, Jackson DO, Clark CB, Ingersoll KS, et al. Results of a pilot randomized controlled trial of buprenorphine for opioid dependent women in the criminal justice system. Drug and Alcohol Dependence 2011;119(3):172-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Barnett 2001
Clark 2002
  • Clark NC, Lintzeris N, Gijsbers A, Whelan G, Dunlop A, Ritter A, Ling WW. LAAM maintenance vs methadone maintenance for heroin dependence. Cochrane Database of Systematic Reviews 2002, Issue 2. [DOI: 10.1002/14651858.CD002210]
Clausen 2008
  • Clausen T, Anchersen K, Waal H. Mortality prior to, during and after opioid maintenance treatment (OMT): A national prospective cross-registry study. Drug and Alcohol Dependence 2008;94(1-3):151-7.
Connock 2007
  • Connock M, Juarez-Garcia A, Jowett S, Frew E, Liu Z, Taylor RJ, et al. Methadone and buprenorphine for the management of opioid dependence; a systematic review and economic evaluation. Health Technology Assessment 2007;11(9):1-190.
Degenhardt 2009
  • Degenhardt L, Randall D, Hall W, Law M, Butler T, Burns L. Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: risk factors and lives saved. Drug and Alcohol Dependence 2009;105(1-2):9-15.
Degenhardt 2011
Degenhardt 2012
  • Degenhardt L, Hall W. Extent of illicit drug use and dependence, and their contribution to the global burden of disease. Lancet 2012;379(9810):55-70.
Dole 1965
  • Dole VP, Nyswander M. A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride. JAMA 1965;193:646-50.
Drummer 1992
  • Drummer OH, Opeskin K, Syrjanen M, Cordner SM. Methadone toxicity causing death in ten subjects starting on a methadone maintenance program.. American Journal of Forensic Medicine and Pathology 1992;13(4):346–50.
Faggiano 2003
  • Faggiano F, Vigna-Taglianti F, Versino E, Lemma P. Methadone maintenance at different dosages for opioid dependence. Cochrane Database of Systematic Reviews 2003, Issue 3. [DOI: 10.1002/14651858.CD002208]
Fudala 1990
  • Fudala PJ, Jaffe JH, Dax EM, Johnson RE. Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal. Clinical Pharmacology and Therapeutics 1990;47(4):525-34.
Gibson 2008
Higgins 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jasinski 1978
  • Jasinski D, Pevnick J, Griffith J. Human pharmacology and abuse potential of the analgesic buprenorphine. Archives of General Psychiatry 1978;35(4):501-6.
Lind 2005
  • Lind B, Chen S, Weatherburn D, Mattick R. The effectiveness of methadone maintenance treatment in controlling crime. An Australian aggregate-level analysis. Journal of Criminology 2005;45(2):201-11.
Ling 2003
Mathers 2008
  • Mathers BM, Degenhardt L, Phillips B, Wiessing L, Hickman M, Strathdee SA, et al. Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review. Lancet 2008;372(9651):1733-45.
Mattick 1998
  • Mattick RP, Oliphant D, Ward J, Hall W. The effectiveness of other opioid replacement therapies: LAAM, heroin, buprenorphine, naltrexone and injectable maintenance. Methadone maintenance and other opioid replacement therapies. Amsterdam: Harwood Academic Publishers, 1998:123-60. [DOI: 10.1002/14651858]
Mattick 2009
Minozzi 2013
Mitchell 2004
Nelson 2011
  • Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, et al. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet 2011;378(9791):571-83.
Perneger 1998
  • Perneger TV, Giner F, Del Rio M, Mino A. Randomised trial of heroin maintenance programme for addicts who fail in conventional drug treatments. BMJ 1998;317(7150):13-8.
Soyka 2011
  • Soyka M, Träder A, Klotsche J, Backmund M, Bühringer G, Rehm J, et al. Six-year mortality rates of patients in methadone and buprenorphine maintenance therapy: results form a nationally representative cohort study. Journal of Clinical Psychopharmacology 2011;31(5):678-80.
UNODC 2012
  • UNODC. World Drug Report 2012. www.unodc.org/unodc/en/data-and-analysis/WDR-2012.html (accessed 6 January 2014) 2012; Vol. Sales No E.12.XI.1.
West 2000
White 2007

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Mattick 2008