Intervention Review

Methadone maintenance at different dosages for opioid dependence

  1. Fabrizio Faggiano1,*,
  2. Federica Vigna-Taglianti2,
  3. Elisabetta Versino3,
  4. Patrizia Lemma4

Editorial Group: Cochrane Drugs and Alcohol Group

Published Online: 21 JUL 2003

Assessed as up-to-date: 1 MAY 2003

DOI: 10.1002/14651858.CD002208


How to Cite

Faggiano F, Vigna-Taglianti F, Versino E, Lemma P. Methadone maintenance at different dosages for opioid dependence. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD002208. DOI: 10.1002/14651858.CD002208.

Author Information

  1. 1

    University of Piemonte Orientale A. Avogadro, Department of Medical Sciences, Novara, Italy

  2. 2

    ASL 5 - Grugliasco, Osservatorio Epidemiologico Dipendenze, Grugliasco, TO, Italy

  3. 3

    University of Torino, Department of Public Health, Turin, Italy

  4. 4

    University of Torino, Department of Public Health, Torino, Italy

*Fabrizio Faggiano, Department of Medical Sciences, University of Piemonte Orientale A. Avogadro, Via Santena 5 bis, Novara, 28100, Italy. fabrizio.faggiano@med.unipmn.it.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JUL 2003

SEARCH

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Nadia Fairbairn, Kanna Hayashi, Lianping Ti, Karyn Kaplan, Paisan Suwannawong, Evan Wood, Thomas Kerr, Compulsory drug detention and injection drug use cessation and relapse in Bangkok, Thailand, Drug and Alcohol Review, 2015, 34, 1
  2. 2
    Leslie Lappalainen, Seonaid Nolan, Sabina Dobrer, Cathy Puscas, Julio Montaner, Keith Ahamad, Huiru Dong, Thomas Kerr, Evan Wood, M.-J. Milloy, Dose–response relationship between methadone dose and adherence to antiretroviral therapy among HIV-positive people who use illicit opioids, Addiction, 2015, 110, 8
  3. 3
    Paxton Bach, M-J Milloy, Paul Nguyen, John Koehn, Silvia Guillemi, Thomas Kerr, Evan Wood, Gender differences in access to methadone maintenance therapy in a Canadian setting, Drug and Alcohol Review, 2015, 34, 5
  4. 4
    Thien C. Pham, Jeffrey Fudin, Robert B. Raffa, Is levorphanol a better option than methadone?, Pain Medicine, 2015, 16, 9
  5. 5
    Marina Davoli, Laura Amato, Nicolas Clark, Michael Farrell, Matthew Hickman, Suzanne Hill, Nicola Magrini, Vladimir Poznyak, Holger J. Schünemann, The role of Cochrane reviews in informing international guidelines: a case study of using the Grading of Recommendations, Assessment, Development and Evaluation system to develop World Health Organization guidelines for the psychosocially assisted pharmacological treatment of opioid dependence, Addiction, 2015, 110, 6
  6. 6
    Anil Batra, Karl F. Mann, Michael M. Berner, Arthur Günthner, Psychische Erkrankungen, 2015,

    CrossRef

  7. 7
    James Bell, Pharmacological maintenance treatments of opiate addiction, British Journal of Clinical Pharmacology, 2014, 77, 2
  8. 8
    Pier Paolo Pani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Marina Davoli, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Fabrizio Faggiano, Angelo Giovanni Icro Maremmani, Icro Maremmani, Psychopathological symptoms of patients with heroin addiction entering opioid agonist or therapeutic community treatment, Annals of General Psychiatry, 2014, 13, 1

    CrossRef

  9. 9
    Raul Perez-Montejano, Emily Finch, Kim Wolff, A National Survey Investigating Methadone Treatment for Pregnant Opioid Dependent Women in England and Wales, International Journal of Mental Health and Addiction, 2013, 11, 6, 693

    CrossRef

  10. 10
    Ashley P. Kennedy, Karran A. Phillips, David H. Epstein, David A. Reamer, John Schmittner, Kenzie L. Preston, A randomized investigation of methadone doses at or over 100mg/day, combined with contingency management, Drug and Alcohol Dependence, 2013, 130, 1-3, 77

    CrossRef

  11. 11
    James Bell, Commentary on Krupitsky et al.(2013): Refuge from the streets—parked on methadone, or seeking shelter of a depot?, Addiction, 2013, 108, 9
  12. 12
    Louisa Degenhardt, Stuart Gilmour, Fiona Shand, Raimondo Bruno, Gabrielle Campbell, Richard P. Mattick, Briony Larance, Wayne Hall, Estimating the proportion of prescription opioids that is consumed by people who inject drugs in Australia, Drug and Alcohol Review, 2013, 32, 5
  13. 13
    Nan Li, Jing Wang, Xue-lian Wang, Chong-wang Chang, Shun-nan Ge, Li Gao, He-ming Wu, Hai-kang Zhao, Ning Geng, Guo-dong Gao, Nucleus Accumbens Surgery for Addiction, World Neurosurgery, 2013, 80, 3-4, S28.e9

    CrossRef

  14. 14
    Angelo Giovanni Icro Maremmani, Luca Rovai, Silvia Bacciardi, Fabio Rugani, Matteo Pacini, Pier Paolo Pani, Liliana Dell' Osso, Hagop Akiskal, Icro Maremmani, The long-term outcomes of heroin dependent-treatment-resistant patients with bipolar 1 comorbidity after admission to enhanced methadone maintenance, Journal of Affective Disorders, 2013, 151, 2, 582

    CrossRef

  15. 15
    Bohdan Nosyk, Huiying Sun, Elizabeth Evans, David C. Marsh, M. Douglas Anglin, Yih-Ing Hser, Aslam H. Anis, Defining dosing pattern characteristics of successful tapers following methadone maintenance treatment: results from a population-based retrospective cohort study, Addiction, 2012, 107, 9
  16. 16
    Jaime Delgadillo, Depression and anxiety symptoms: measuring reliable change in alcohol and drug users, Advances in Dual Diagnosis, 2012, 5, 3, 102

    CrossRef

  17. 17
    John Strang, Thomas Babor, Jonathan Caulkins, Benedikt Fischer, David Foxcroft, Keith Humphreys, Drug policy and the public good: evidence for effective interventions, The Lancet, 2012, 379, 9810, 71

    CrossRef

  18. 18
    Brian J. Cleary, Maeve Eogan, Michael P. O'Connell, Tom Fahey, Paul J. Gallagher, Tom Clarke, Martin J. White, Christine McDermott, Anne O'Sullivan, Deirdre Carmody, Justin Gleeson, Deirdre J. Murphy, Methadone and perinatal outcomes: a prospective cohort study, Addiction, 2012, 107, 8
  19. 19
    Riza Sarasvita, Anne Tonkin, Budi Utomo, Robert Ali, Predictive factors for treatment retention in methadone programs in Indonesia, Journal of Substance Abuse Treatment, 2012, 42, 3, 239

    CrossRef

  20. 20
    Dagmar Hedrich, Paula Alves, Michael Farrell, Heino Stöver, Lars Møller, Soraya Mayet, The effectiveness of opioid maintenance treatment in prison settings: a systematic review, Addiction, 2012, 107, 3
  21. 21
    Paul Kurdyak, Tara Gomes, Zhan Yao, Muhammad M. Mamdani, Chelsea Hellings, Benedikt Fischer, Jürgen Rehm, Ahmed M. Bayoumi, David N. Juurlink, Use of other opioids during methadone therapy: a population-based study, Addiction, 2012, 107, 4
  22. 22
    Karl Mann, Michael M. Berner, Arthur Günthner, Psychische Erkrankungen, 2012,

    CrossRef

  23. 23
    Joseph J. Benich, Opioid Dependence, Primary Care: Clinics in Office Practice, 2011, 38, 1, 59

    CrossRef

  24. 24
    Melinda Campopiano, Methadone maintenance therapy in the United States: a case example of dual diagnosis, Advances in Dual Diagnosis, 2010, 3, 3, 11

    CrossRef

  25. 25
    Valerie A. Gruber, Kevin L. Delucchi, Anousheh Kielstein, Steven L. Batki, A randomized trial of 6-month methadone maintenance with standard or minimal counseling versus 21-day methadone detoxification, Drug and Alcohol Dependence, 2008, 94, 1-3, 199

    CrossRef

  26. 26
    Peter Lawrinson, Robert Ali, Aumphornpun Buavirat, Sithisat Chiamwongpaet, Sergey Dvoryak, Boguslaw Habrat, Shi Jie, Ratna Mardiati, Azarakhsh Mokri, Jacek Moskalewicz, David Newcombe, Vladimir Poznyak, Emilis Subata, Ambrose Uchtenhagen, Diah S. Utami, Robyn Vial, Chengzheng Zhao, Key findings from the WHO collaborative study on substitution therapy for opioid dependence and HIV/AIDS, Addiction, 2008, 103, 9
  27. 27
    Thomas Clausen, Katinka Anchersen, Helge Waal, Mortality prior to, during and after opioid maintenance treatment (OMT): A national prospective cross-registry study, Drug and Alcohol Dependence, 2008, 94, 1-3, 151

    CrossRef

  28. 28
    Kenneth A. Harris, Julia H. Arnsten, Herman Joseph, Joe Hecht, Ira Marion, Patti Juliana, Marc N. Gourevitch, A 5-year evaluation of a methadone medical maintenance program, Journal of Substance Abuse Treatment, 2006, 31, 4, 433

    CrossRef

  29. 29
    Einat Peles, Shaul Schreiber, Miriam Adelson, Factors predicting retention in treatment: 10-year experience of a methadone maintenance treatment (MMT) clinic in Israel, Drug and Alcohol Dependence, 2006, 82, 3, 211

    CrossRef

  30. 30
    Andrea D. Furlan, Emma Irvin, Claire Bombardier, Limited search strategies were effective in finding relevant nonrandomized studies, Journal of Clinical Epidemiology, 2006, 59, 12, 1303

    CrossRef

  31. 31
    Harald Eder, Reinhold Jagsch, Dominik Kraigher, Andjela Primorac, Nina Ebner, Gabriele Fischer, Comparative study of the effectiveness of slow-release morphine and methadone for opioid maintenance therapy, Addiction, 2005, 100, 8
  32. 32
    Anna Maria Bargagli, Patrizia Schifano, Marina Davoli, Fabrizio Faggiano, Carlo A. Perucci, Determinants of methadone treatment assignment among heroin addicts on first admission to public treatment centres in Italy, Drug and Alcohol Dependence, 2005, 79, 2, 191

    CrossRef

  33. 33
    M Minozzi, L Amato, PP Pani, S Vecchi, M Davoli, Anticonvulsants for cocaine dependence, The Cochrane Library,
  34. 34
    Silvia Minozzi, Laura Amato, Marina Davoli, Michael F Farrell, Anelise ARL Lima Reisser, Pier Paolo Pani, Mauricio Silva de Lima, Bernardo GO Soares, Simona Vecchi, Anticonvulsants for cocaine dependence, The Cochrane Library,
  35. 35
    Silvia Minozzi, Laura Amato, Marina Davoli, Michael F Farrell, Anelise ARL Lima Reisser, Pier Paolo Pani, Mauricio Silva de Lima, Bernardo GO Soares, Simona Vecchi, Anticonvulsants for cocaine dependence, The Cochrane Library,
  36. 36
    Maurício Silva de Lima, Michael Farrell, Anelise ARL Lima Reisser, Bernardo Soares, Antidepressants for cocaine dependence, The Cochrane Library,
  37. 37
    Mauricio Silva de Lima, Michael Farrell, Anelise ARL Lima Reisser, Bernardo Soares, Antidepressants for cocaine dependence, The Cochrane Library,
  38. 38
    Pier Paolo Pani, Emanuela Trogu, Simona Vecchi, Laura Amato, Antidepressants for cocaine dependence and problematic cocaine use, The Cochrane Library,
  39. 39
    L Amato, S Minozzi, PP Pani, M Davoli, Antipsychotic medications for cocaine dependence, The Cochrane Library,
  40. 40
    Laura Amato, Silvia Minozzi, Pier Paolo Pani, Marina Davoli, Antipsychotic medications for cocaine dependence, The Cochrane Library,
  41. 41
    Steve Lui, Chunbo Li, Jun Xia, Mishka Terplan, Auricular acupuncture for opiate dependence in substance misuse treatment programmes, The Cochrane Library,
  42. 42
    Richard P Mattick, Courtney Breen, Jo Kimber, Marina Davoli, Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence, The Cochrane Library,
  43. 43
    Pier Paolo Pani, Emanuela Trogu, Rosangela Vacca, Laura Amato, Simona Vecchi, Marina Davoli, Disulfiram for the treatment of cocaine dependence, The Cochrane Library,
  44. 44
    Pier Paolo Pani, Laura Amato, Marina Davoli, Simona Vecchi, Disulphiram for the treatment of cocaine dependence, The Cochrane Library,
  45. 45
    Laura Amato, Silvia Minozzi, Pier Paolo Pani, Renata Solimini, Simona Vecchi, Piergiorgio Zuccaro, Marina Davoli, Dopamine agonists for the treatment of cocaine dependence, The Cochrane Library,
  46. 46
    Silvia Minozzi, Laura Amato, Pier Paolo Pani, Renata Solimini, Simona Vecchi, Franco De Crescenzo, Piergiorgio Zuccaro, Marina Davoli, Dopamine agonists for the treatment of cocaine dependence, The Cochrane Library,
  47. 47
    Pier Paolo Pani, Emanuela Trogu, Icro Maremmani, Laura Amato, Silvia Minozzi, Simona Vecchi, Marina Davoli, ECG screening for preventing long QTc-related cardiac morbidity/mortality in methadone treated opioid addicts, The Cochrane Library,
  48. 48
    Lucy Platt, Jennifer Reed, Silvia Minozzi, Peter Vickerman, Holly Hagan, Clare French, Ashly Jordan, Louisa Degenhardt, Vivian Hope, Sharon Hutchinson, Lisa Maher, Norah Palmateer, Avril Taylor, Matthew Hickman, Effectiveness of needle/syringe programmes and opiate substitution therapy in preventing HCV transmission among people who inject drugs, The Cochrane Library,
  49. 49
    Amanda E Perry, Matthew Neilson, Marrissa Martyn-St James, Julie M Glanville, Rachael McCool, Steven Duffy, Christine Godfrey, Catherine Hewitt, Interventions for female drug-using offenders, The Cochrane Library,
  50. 50
    Amanda E Perry, Matthew Neilson, Marrissa Martyn-St James, Julie M Glanville, Rebecca Woodhouse, Catherine Hewitt, Interventions for female drug-using offenders, The Cochrane Library,
  51. 51
    Silvia Minozzi, Laura Amato, Simona Vecchi, Marina Davoli, Maintenance agonist treatments for opiate dependent pregnant women, The Cochrane Library,
  52. 52
    Silvia Minozzi, Laura Amato, Cristina Bellisario, Marica Ferri, Marina Davoli, Maintenance agonist treatments for opiate-dependent pregnant women, The Cochrane Library,
  53. 53
    Silvia Minozzi, Laura Amato, Cristina Bellisario, Marina Davoli, Maintenance treatments for opiate -dependent adolescents, The Cochrane Library,
  54. 54
    Silvia Minozzi, Laura Amato, Marina Davoli, Maintenance treatments for opiate dependent adolescent, The Cochrane Library,
  55. 55
    Silvia Minozzi, Laura Amato, Simona Vecchi, Maintenance treatments for opiate dependent adolescent, The Cochrane Library,
  56. 56
    S Minozzi, L Amato, S Vecchi, Maintenance treatments for opiate dependent pregnant women, The Cochrane Library,
  57. 57
    Soraya Mayet, Michael Farrell, Sivaguru G Mani, Opioid agonist maintenance for opioid dependent patients in prison, The Cochrane Library,
  58. 58
    Soraya Mayet, Michael Farrell, Sivaguru G Mani, Opioid agonist maintenance for opioid dependent patients in prison, The Cochrane Library,
  59. 59
    Suzanne Nielsen, Louisa Degenhardt, Briony Larance, Linda Gowing, Chyanne Kehler, Nicholas Lintzeris, Opioid agonist treatment for pharmaceutical opioid dependent people, The Cochrane Library,
  60. 60
    Silvia Minozzi, Laura Amato, Simona Vecchi, Marina Davoli, Ursula Kirchmayer, Annette Verster, Oral naltrexone maintenance treatment for opioid dependence, The Cochrane Library,
  61. 61
    Silvia Minozzi, Laura Amato, Simona Vecchi, Marina Davoli, Ursula Kirchmayer, Annette Verster, Oral naltrexone maintenance treatment for opioid dependence, The Cochrane Library,
  62. 62
    Silvia Minozzi, Laura Amato, Simona Vecchi, Marina Davoli, Ursula Kirchmayer, Annette Verster, Oral naltrexone maintenance treatment for opioid dependence, The Cochrane Library,
  63. 63
    Linda Gowing, Michael F Farrell, Reinhard Bornemann, Lynn E Sullivan, Robert Ali, Oral substitution treatment of injecting opioid users for prevention of HIV infection, The Cochrane Library,
  64. 64
    Amanda E Perry, Matthew Neilson, Marrissa Martyn-St James, Julie M Glanville, Rachael McCool, Steven Duffy, Christine Godfrey, Catherine Hewitt, Pharmacological interventions for drug-using offenders, The Cochrane Library,
  65. 65
    Amanda E Perry, Matthew Neilson, Marrissa Martyn-St James, Julie M Glanville, Rebecca Woodhouse, Christine Godfrey, Catherine Hewitt, Pharmacological interventions for drug-using offenders, The Cochrane Library,
  66. 66
    Afarin Rahimi-Movaghar, Masoumeh Amin-Esmaeili, Mitra Hefazi, Reza Yousefi-Nooraie, Pharmacological therapies for maintenance treatments of opium dependence, The Cochrane Library,
  67. 67
    Afarin Rahimi-Movaghar, Mitra Hefazi , Marina Davoli, Laura Amato, Masoomeh Amin-Esmaeili, Reza Yousefi-Nooraie, Pharmacological therapies for maintenance treatments of opium dependency, The Cochrane Library,
  68. 68
    Pier Paolo Pani, Rosangela Vacca, Emanuela Trogu, Laura Amato, Marina Davoli, Pharmacological treatment for depression during opioid agonist treatment for opioid dependence, The Cochrane Library,
  69. 69
    Pier Paolo Pani, Rosangela Vacca, Emanuela Trogu, Laura Amato, Marina Davoli, Pharmacological treatment for depression in opioid dependence, The Cochrane Library,
  70. 70
    L Amato, S Minozzi, M Davoli, S Vecchi, M Ferri, S Mayet, Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence, The Cochrane Library,
  71. 71
    Laura Amato, Silvia Minozzi, Marina Davoli, Simona Vecchi, Marica Ferri, Soraya Mayet, Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence, The Cochrane Library,
  72. 72
    Laura Amato, Silvia Minozzi, Marina Davoli, Simona Vecchi, Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence, The Cochrane Library,
  73. 73
    Soraya Mayet, Michael F Farrell, Marica Ferri, Laura Amato, Marina Davoli, Psychosocial treatment for opiate abuse and dependence, The Cochrane Library,
  74. 74
    Soraya Mayet, Michael Farrell, Marica Ferri, Laura Amato, Marina Davoli, Psychosocial treatment for opiate abuse and dependence, The Cochrane Library,
  75. 75
    Silvia Minozzi, Laura Amato, Simona Vecchi, Marina Davoli, Psychosocial treatments for opioid dependent adolescents, The Cochrane Library,
  76. 76
    Pier Paolo Pani, Emanuela Trogu, Icro Maremmani, Matteo Pacini, QTc interval screening for cardiac risk in methadone treatment of opioid dependence, The Cochrane Library,
  77. 77
    Marica Ferri, Silvia Minozzi, Laura Amato, Alessandra Bo, Marina Davoli, Slow-release oral morphine as maintenance therapy for opioid dependence, The Cochrane Library,
  78. 78
    Marica Ferri, Silvia Minozzi, Alessandra Bo, Laura Amato, Slow-release oral morphine as maintenance therapy for opioid dependence, The Cochrane Library,
  79. 79
    Lesley A Smith, Simon Gates, David Foxcroft, Therapeutic communities for substance related disorder, The Cochrane Library,
  80. 80
    LA Smith, S Gates, D Foxcroft, Therapeutic communities for substance related disorder, The Cochrane Library,