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Corticosteroids for managing tuberculous meningitis

  1. Kameshwar Prasad*,
  2. Mamta B Singh

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 13 NOV 2007

DOI: 10.1002/14651858.CD002244.pub3

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Additional Information

How to Cite

Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD002244. DOI: 10.1002/14651858.CD002244.pub3.

Author Information

  1. All India Institute of Medical Sciences, Department of Neurology, New Delhi, India

*Kameshwar Prasad, Department of Neurology, All India Institute of Medical Sciences, Ansarinagar, New Delhi, 110029, India. drkameshwarprasad@yahoo.co.in.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Chotmongkol 1996 {published data only}
  • Chotmongkol V, Jitpimolmard S, Thavornpitak Y. Corticosteroid in tuberculous meningitis. Journal of the Medical Association of Thailand 1996;79(2):83-90.
Girgis 1991 {published data only}
Kumarvelu 1994 {published and unpublished data}
Lardizabal 1998 {unpublished data only}
  • Lardizabal DV, Roxas AA. Dexamethasone as adjunctive therapy in adult patients with probable TB meningitis stage II and stage III: An open randomised controlled trial. Philippines Journal of Neurology 1998;4:4-10.
O'Toole 1969 {published data only}
  • O'Toole RD, Thornton GF, Mukherjee MK, Nath RL. Dexamethasone in tuberculous meningitis. Relationship of cerebrospinal fluid effects to therapeutic efficacy. Annals of Internal Medicine 1969;70(1):39-47.
Schoeman 1997 {published data only}
  • Schoeman JF, Van Zyl LE, Laubscher JA, Donald PR. Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis. Pediatrics 1997;99(2):226-31.
Thwaites 2004 {published data only}
  • Simmons CP, Thwaites GE, Quyen NT, Chau TT, Mai PP, Dung NT, et al. The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses. Journal of Immunology 2005;175(1):579-90.
  • Thwaites GE, Nguyen DB, Nguyen HD, Hoang TQ, Do TT, Nguyen TC, et al. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. New England Journal of Medicine 2004;351(17):1741-51.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Donald 2004 {published data only}
Escobar 1975 {published data only}
Freiman 1970 {published data only}
  • Frieman I, Geefhuysen J. Evaluation of IT therapy with streptomycin and hydrocortisone in tuberculous meningitis. Journal of Pediatrics 1970;87(6):895-901.
Girgis 1983 {published data only}
  • Girgis NI, Farid Z, Hanna LS, Yassin MW, Wallace CK. The use of dexamethasone in preventing ocular complications in tuberculous meningitis. Transactions of the Royal Society of Tropical Medicine and Hygiene 1983;77(5):658-9.
Hockaday 1966 {published data only}
  • Hockaday JM, Smith HM. Corticosteroids as an adjuvant to the chemotherapy of tuberculous meningitis. Tubercle 1966;47(1):75-91.
Kalita 2001 {published data only}
Kapur 1969 {published data only}
  • Kapur S. Evaluation of treatment of tuberculous meningitis since the use of steroids as an adjuvant. Indian Pediatrics 1969;6:166-71.
Karak 1998 {published data only}
  • Karak B, Garg RK. Corticosteroids in tuberculous meningitis. Indian Pediatrics 1998;35:193-4.
Lepper 1963 {published data only}
  • Lepper MH, Spies HW. The present status of the treatment of tuberculosis of the central nervous system. Annals of the New York Academy of Sciences 1963;106:106-8.
    Direct Link:
Marras 2005 {published data only}
  • Marras TK. Dexamethasone for tuberculous meningitis. New England Journal of Medicine 2005;352(6):628-30.
Quagliarello 2004 {published data only}
Seligman 2005 {published data only}
Vagenakis 2005 {published data only}
  • Vagenakis AG, Kyriazopoulou V. Dexamethasone for tuberculous meningitis. New England Journal of Medicine 2005;352(6):628-30.
Voljavec 1960 {published data only}
  • Volijavec BF, Corpe RF. The influence of corticosteroid hormones in the treatment of tuberculous meningitis in Negroes. American Review of Respiratory Disease 1960;81:539-45.
Wasz-Hockert 1963 {published data only}
  • Wosz-Hockert O, Donner M. Modern treatment and late prognosis of tuberculous meningitis. Acta Paediatr Scand 1963;51 Suppl 141:93-102.
    Direct Link:
Weiss 1965 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Prasad 2006 {unpublished data only}
  • Prasad K. A randomized controlled trial to study the effectiveness of dexamethasone as an adjunct to standard antituberculous treatment in patients with clinically presumed tuberculous meningitis: 10-year follow-up study.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Alarcon 1990
Berenguer 1992
  • Berenguer J, Moreno S, Laguna F, Vicente T, Adrados M, Ortega A, et al. Tuberculous meningitis in patients infected with the human immunodeficiency virus. New England Journal of Medicine 1992;326(10):668-72.
Berger 1994
Feldman 1958
Geiman 1992
Higgins 2006
  • Higgins J, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]; Appendix 5b. www.cochrane.org/resources/handbook/hbook.htm (accessed 1 January 2007).
Holdiness 1990
Jacobs 1990
  • Jacobs RF, Sunakorn P. Tuberculous meningitis in children: an evaluation of chemotherapeutic regimens. American Review of Respiratory Disease 1990;141 Suppl:A337.
Jacobs 1992
Jüni 2001
MRC 1948
  • Medical Research Council Report. Streptomycin treatment of tuberculous meningitis. Lancet 1948;1:582-96.
Parsons 1988
  • Parsons M. Tuberculous meningitis: A handbook for clinicians. A handbook for clinicians. Oxford: Oxford University Press, 1988:32-62.
Prasad 1997
  • Prasad K, Menon GR. Tuberculous meningitis: The present status and a viewpoint. Journal of Association of Phyiscians of India 1997;45:722-9.
Ramchandran 1986
  • RRamachandran P, Duraipandian M, Nagarajan M, Prabhakar R, Ramakrishnan CV, Tripathy SP. Three chemothaerapy studies of tuberculous meningitis in children. Tubercle 1986;67(1):17-29.
Review Manager 5
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Rieder 1990
Shafer 1991
Tandon 1988
  • Tandon PN, Bhatia R, Bhargava S. Tuberculous meningitis. Handbook of clinical neurology. Vol. 52, Elsevier Science Publishers, 1988:195-226.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Prasad 2000
  • Prasad K, Volmink J, Menon GR. Steroids for treating tuberculous meningitis. Cochrane Database of Systematic Reviews 2000, Issue 3. [DOI: ]
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