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Tricyclic drugs for depression in children and adolescents

  1. Philip Hazell1,*,
  2. Mohsen Mirzaie2

Editorial Group: Cochrane Common Mental Disorders Group

Published Online: 18 JUN 2013

Assessed as up-to-date: 12 APR 2013

DOI: 10.1002/14651858.CD002317.pub2


How to Cite

Hazell P, Mirzaie M. Tricyclic drugs for depression in children and adolescents. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD002317. DOI: 10.1002/14651858.CD002317.pub2.

Author Information

  1. 1

    Sydney Medical School, Discipline of Psychiatry, Concord West, New South Wales, Australia

  2. 2

    Sydney Local Health District, Rivendell Child, Adolescent and Family Mental Health Service, Sydney, New South Wales, Australia

*Philip Hazell, Discipline of Psychiatry, Sydney Medical School, G03 - Thomas Walker Hospital, Hospital Rd, Concord West, New South Wales, 2138, Australia. Philip.Hazell@sswahs.nsw.gov.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 18 JUN 2013

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Tricyclic antidepressant (TCA) drugs versus placebo, Outcome 1 Achieved response/remission according to predetermined criteria.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Tricyclic antidepressant (TCA) drugs versus placebo, Outcome 2 Change in depression checklist scores.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Tricyclic antidepressant (TCA) drugs versus placebo, Outcome 3 Adverse events.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Tricyclic antidepressant (TCA) drugs versus placebo, Outcome 4 Change in clinical global assessment scale scores.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Tricyclic antidepressant (TCA) drugs versus placebo, Outcome 5 Number of withdrawals.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Tricyclic antidepressant (TCA) drugs versus placebo: subgroup analysis, Outcome 1 Child: achieved response/remission according to predetermined criteria.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Tricyclic antidepressant (TCA) drugs versus placebo: subgroup analysis, Outcome 2 Child: change in depression checklist scores.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Tricyclic antidepressant (TCA) drugs versus placebo: subgroup analysis, Outcome 3 Adolescent: achieved remission/response according to predetermined criteria.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Tricyclic antidepressant (TCA) drugs versus placebo: subgroup analysis, Outcome 4 Adolescent: change in depression checklist scores.