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Amantadine and rimantadine for influenza A in children and the elderly

  1. Márcia G Alves Galvão2,
  2. Marilene Augusta Rocha Crispino Santos2,
  3. Antonio JL Alves da Cunha1,*

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 18 JAN 2012

Assessed as up-to-date: 27 JUN 2011

DOI: 10.1002/14651858.CD002745.pub3


How to Cite

Alves Galvão MG, Rocha Crispino Santos MA, Alves da Cunha AJL. Amantadine and rimantadine for influenza A in children and the elderly. Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD002745. DOI: 10.1002/14651858.CD002745.pub3.

Author Information

  1. 1

    School of Medicine, Federal University of Rio de Janeiro, Department of Pediatrics, Rio de Janeiro, Rio de Janeiro, Brazil

  2. 2

    Municipal Secretariat of Health, Rio de Janeiro, RJ, Brazil

*Antonio JL Alves da Cunha, Department of Pediatrics, School of Medicine, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, Edificio do CCS - Bloco K - 2o. andar, Sala K49, Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. acunha@hucff.ufrj.br. antonioledo@yahoo.com.br.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 18 JAN 2012

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This is not the most recent version of the article. View current version (21 NOV 2014)

[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 AMT and RMT compared to control in the treatment of influenza A in children, Outcome 1 Fever day 3.
[Analysis 1.2]
Analysis 1.2. Comparison 1 AMT and RMT compared to control in the treatment of influenza A in children, Outcome 2 Cough day 7.
[Analysis 1.3]
Analysis 1.3. Comparison 1 AMT and RMT compared to control in the treatment of influenza A in children, Outcome 3 Malaise day 6.
[Analysis 1.4]
Analysis 1.4. Comparison 1 AMT and RMT compared to control in the treatment of influenza A in children, Outcome 4 Conjunctivitis day 5.
[Analysis 1.5]
Analysis 1.5. Comparison 1 AMT and RMT compared to control in the treatment of influenza A in children, Outcome 5 Eye symptoms day 5 (pain on movement and visual distortion).
[Analysis 2.1]
Analysis 2.1. Comparison 2 AMT and RMT compared to control in the prophylaxis of influenza A in children, Outcome 1 Infection.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 1 Diarrhoea.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 2 Exanthema.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 3 Malaise.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 4 Muscular, limb pain.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 5 Headache.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 6 Dyspnoea.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 7 Gastrointestinal symptoms.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 8 Dizziness.
[Analysis 3.9]
Analysis 3.9. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 9 Central nervous system symptoms.
[Analysis 3.10]
Analysis 3.10. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 10 Change in behaviour.
[Analysis 3.11]
Analysis 3.11. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 11 Stimulation/insomnia.
[Analysis 3.12]
Analysis 3.12. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 12 Cerebelar ataxia.
[Analysis 3.13]
Analysis 3.13. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 13 Hyperreactivity.
[Analysis 3.14]
Analysis 3.14. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 14 Tinnitus.
[Analysis 3.15]
Analysis 3.15. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 15 Nausea/vomiting.
[Analysis 3.16]
Analysis 3.16. Comparison 3 Adverse effects of AMT and RMT compared to control in children, Outcome 16 Arrythmia.
[Analysis 4.1]
Analysis 4.1. Comparison 4 AMT and RMT compared to control in the prophylaxis of influenza A in the elderly, Outcome 1 RMT (proved and clinical infection).
[Analysis 4.2]
Analysis 4.2. Comparison 4 AMT and RMT compared to control in the prophylaxis of influenza A in the elderly, Outcome 2 RMT 200.
[Analysis 4.3]
Analysis 4.3. Comparison 4 AMT and RMT compared to control in the prophylaxis of influenza A in the elderly, Outcome 3 RMT 100.
[Analysis 4.4]
Analysis 4.4. Comparison 4 AMT and RMT compared to control in the prophylaxis of influenza A in the elderly, Outcome 4 RMT Monto (100 + 200) and Patriarca.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 1 Headache.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 2 Stimulation/insomnia.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 3 Dizziness.
[Analysis 5.4]
Analysis 5.4. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 4 Anxiety.
[Analysis 5.5]
Analysis 5.5. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 5 Confusion.
[Analysis 5.6]
Analysis 5.6. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 6 Fatigue.
[Analysis 5.7]
Analysis 5.7. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 7 Nausea.
[Analysis 5.8]
Analysis 5.8. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 8 Depression.
[Analysis 5.9]
Analysis 5.9. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 9 Impaired concentration.
[Analysis 5.10]
Analysis 5.10. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 10 Loss of appetite.
[Analysis 5.11]
Analysis 5.11. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 11 Rash or allergic reaction.
[Analysis 5.12]
Analysis 5.12. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 12 Seizures or clonic twitching.
[Analysis 5.13]
Analysis 5.13. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 13 Dry mouth.
[Analysis 5.14]
Analysis 5.14. Comparison 5 Adverse effects of AMT and RMT compared to control in the elderly, Outcome 14 Vomiting.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Use of different doses of AMT and RMT for prophylaxis and treatment of influenza A in the elderly, Outcome 1 Clinical and laboratorial infection.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 1 Confusion.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 2 Depression.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 3 Impaired concentration.
[Analysis 7.4]
Analysis 7.4. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 4 Insomnia or sleeplessness.
[Analysis 7.5]
Analysis 7.5. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 5 Loss of appetite.
[Analysis 7.6]
Analysis 7.6. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 6 Rash or allergic reaction.
[Analysis 7.7]
Analysis 7.7. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 7 Seizure or clonic twitching.
[Analysis 7.8]
Analysis 7.8. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 8 Dry mouth.
[Analysis 7.9]
Analysis 7.9. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 9 Fatigue and drowsiness.
[Analysis 7.10]
Analysis 7.10. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 10 Headache.
[Analysis 7.11]
Analysis 7.11. Comparison 7 Adverse effects related to different doses of AMT and RMT in the elderly, Outcome 11 Body weakness or debility.
[Analysis 8.1]
Analysis 8.1. Comparison 8 AMT and RMT compared to other antivirals in the elderly, Outcome 1 RMT and zanamivir.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Additional comparison: RMT compared to control in the prophylaxis of influenza A in children and the elderly, Outcome 1 Infection.