Intervention Review

You have free access to this content

Calcium antagonists as an add-on therapy for drug-resistant epilepsy

  1. Mohammad Hasan*,
  2. Jennifer Pulman,
  3. Anthony G Marson

Editorial Group: Cochrane Epilepsy Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 27 FEB 2013

DOI: 10.1002/14651858.CD002750.pub2


How to Cite

Hasan M, Pulman J, Marson AG. Calcium antagonists as an add-on therapy for drug-resistant epilepsy. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD002750. DOI: 10.1002/14651858.CD002750.pub2.

Author Information

  1. Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, UK

*Mohammad Hasan, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Fazakerley, Liverpool, L9 7AL, UK. dr.mohammadhasan@gmail.com. M.Hasan@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

SEARCH

[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Flunarizine versus placebo, Outcome 1 50% or greater reduction in seizure frequency.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Flunarizine versus placebo, Outcome 2 Treatment withdrawal.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Flunarizine versus placebo, Outcome 3 Adverse effects.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Nimodipine versus placebo, Outcome 1 50% or greater reduction in seizure frequency.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Nimodipine versus placebo, Outcome 2 Treatment withdrawal.