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Intervention Review

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Non-invasive ventilation for cystic fibrosis

  1. Fidelma Moran1,*,
  2. Judy M Bradley2,
  3. Amanda J Piper3

Editorial Group: Cochrane Cystic Fibrosis and Genetic Disorders Group

Published Online: 30 APR 2013

Assessed as up-to-date: 14 MAR 2013

DOI: 10.1002/14651858.CD002769.pub4


How to Cite

Moran F, Bradley JM, Piper AJ. Non-invasive ventilation for cystic fibrosis. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD002769. DOI: 10.1002/14651858.CD002769.pub4.

Author Information

  1. 1

    University of Ulster, Institute of Nursing and Health Research and School of Health Sciences, Newtownabbey, Northern Ireland, UK

  2. 2

    University of Ulster, Centre for Health and Rehabilitation Technologies (CHaRT), Institute of Nursing and Health Research, Newtownabbey, Northern Ireland, UK

  3. 3

    Royal Prince Alfred Hospital, Department of Respiratory and Sleep Medicine, Camperdown, NSW, Australia

*Fidelma Moran, Institute of Nursing and Health Research and School of Health Sciences, University of Ulster, Shore Road, Newtownabbey, Northern Ireland, BT37 0QB, UK. f.moran@ulster.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

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This is not the most recent version of the article. View current version (20 FEB 2017)

[Analysis 1.1]
Analysis 1.1. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 1 Lung function - chest physiotherapy including directed cough.
[Analysis 1.2]
Analysis 1.2. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 2 Lung function - chest physiotherapy including PEP.
[Analysis 1.3]
Analysis 1.3. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 3 Respiratory muscle strength (cmH20).
[Analysis 1.4]
Analysis 1.4. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 4 Airway resistance % predicted.
[Analysis 1.5]
Analysis 1.5. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 5 Oxygen saturation during airway clearance (%).
[Analysis 1.6]
Analysis 1.6. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 6 Oxygen saturation during airway clearance (change in SpO2 % during treatment).
[Analysis 1.7]
Analysis 1.7. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 7 Oxygen saturation after airway clearance (SpO2) - chest physiotherapy including directed cough.
[Analysis 1.8]
Analysis 1.8. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 8 Oxygen saturation after airway clearance (SpO2) - chest physiotherapy including PEP.
[Analysis 1.9]
Analysis 1.9. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 9 Sputum wet weight (g) - chest physiotherapy including directed cough.
[Analysis 1.10]
Analysis 1.10. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 10 Sputum wet weight (g)- chest physiotherapy including PEP.
[Analysis 1.11]
Analysis 1.11. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 11 Sputum dry weight (g) - chest physiotherapy including directed cough.
[Analysis 1.12]
Analysis 1.12. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 12 Sputum dry weight (g)- chest physiotherapy including PEP.
[Analysis 1.13]
Analysis 1.13. Comparison 1 NIV versus other methods of airway clearance (chest physiotherapy including directed cough or PEP), Outcome 13 Breathlessness.
[Analysis 2.1]
Analysis 2.1. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 1 CFQoL chest symptom score.
[Analysis 2.2]
Analysis 2.2. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 2 CFQoL transitional dyspnoea index.
[Analysis 2.3]
Analysis 2.3. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 3 Symptoms of Sleep Disordered Breathing.
[Analysis 2.4]
Analysis 2.4. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 4 Lung function during sleep.
[Analysis 2.5]
Analysis 2.5. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 5 Lung function while awake.
[Analysis 2.6]
Analysis 2.6. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 6 Respiratory rate (breaths/min).
[Analysis 2.7]
Analysis 2.7. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 7 Mean Respiratory Rate (breaths/min).
[Analysis 2.8]
Analysis 2.8. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 8 ABG: pH.
[Analysis 2.9]
Analysis 2.9. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 9 ABG: PaO2 (mmHg).
[Analysis 2.10]
Analysis 2.10. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 10 ABG: PaCO2 (mmHg).
[Analysis 2.11]
Analysis 2.11. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 11 ABG: HCO3 (mmol/L).
[Analysis 2.12]
Analysis 2.12. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 12 ABG: SaO2 (%).
[Analysis 2.13]
Analysis 2.13. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 13 Exercise performance (MSWT) (metres).
[Analysis 2.14]
Analysis 2.14. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 14 Total sleep time (min).
[Analysis 2.15]
Analysis 2.15. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 15 REM sleep architecture.
[Analysis 2.16]
Analysis 2.16. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 16 Sleep latency (min).
[Analysis 2.17]
Analysis 2.17. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 17 Nocturnal oxygen saturation (%).
[Analysis 2.18]
Analysis 2.18. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 18 Nocturnal oxygen saturation (%).
[Analysis 2.19]
Analysis 2.19. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 19 Nocturnal TcCO2 (mmHg.
[Analysis 2.20]
Analysis 2.20. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 20 Nocturnal TcCO2 (mmHg).
[Analysis 2.21]
Analysis 2.21. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 21 Nocturnal TcCO2 TST (mmHg).
[Analysis 2.22]
Analysis 2.22. Comparison 2 NIV in overnight ventilation compared to oxygen, Outcome 22 Hypopneas.
[Analysis 3.1]
Analysis 3.1. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 1 CF QoL chest symptom score.
[Analysis 3.2]
Analysis 3.2. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 2 CF QoL traditional dyspnoea index score.
[Analysis 3.3]
Analysis 3.3. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 3 Symptoms of sleep disordered breathing.
[Analysis 3.4]
Analysis 3.4. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 4 Lung function during sleep.
[Analysis 3.5]
Analysis 3.5. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 5 Lung function while awake.
[Analysis 3.6]
Analysis 3.6. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 6 Respiratory rate(breaths/min) during sleep.
[Analysis 3.7]
Analysis 3.7. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 7 Mean respiratory rate.
[Analysis 3.8]
Analysis 3.8. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 8 ABG: pH.
[Analysis 3.9]
Analysis 3.9. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 9 ABG: PaO2 (mmHg).
[Analysis 3.10]
Analysis 3.10. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 10 ABG: PaCO2 (mmHg).
[Analysis 3.11]
Analysis 3.11. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 11 ABG: HCO3 (mmol/L).
[Analysis 3.12]
Analysis 3.12. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 12 ABG: SaO2 (%).
[Analysis 3.13]
Analysis 3.13. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 13 Exercise performance (metres).
[Analysis 3.14]
Analysis 3.14. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 14 Total sleep time (min).
[Analysis 3.15]
Analysis 3.15. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 15 REM sleep architecture.
[Analysis 3.16]
Analysis 3.16. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 16 Sleep latency.
[Analysis 3.17]
Analysis 3.17. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 17 Nocturnal oxygen saturation (%).
[Analysis 3.18]
Analysis 3.18. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 18 Nocturnal oxygen saturation (%).
[Analysis 3.19]
Analysis 3.19. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 19 Nocturnal TcCO2 (mmHg).
[Analysis 3.20]
Analysis 3.20. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 20 Nocturnal TcCO2(mmHg).
[Analysis 3.21]
Analysis 3.21. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 21 Nocturnal TcCO2 TST (mmHg).
[Analysis 3.22]
Analysis 3.22. Comparison 3 NIV in overnight ventilation compared to room air, Outcome 22 Hypopneas.