Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure

  • Protocol
  • Intervention

Authors

  • TN Young,

  • FJ Arens,

  • GE Kennedy,

  • JW Laurie,

  • GW Rutherford


Dr Taryn Young, Specialist Scientist, South African Cochrane Centre, Medical Research Council, PO Box 19070, Tygerberg, SOUTH AFRICA. taryn.young@mrc.ac.za.

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

1. To locate and describe available outcome studies evaluating the efficacy of PEP regimes (i.e. the prevention of seroconversion) and the efficacy of PEP post occupational exposure. To do this we shall look at PEP compared to placebo, one PEP regimen compared to another and the efficacy of immediately given PEP compared to delayed PEP. We shall also examine the frequency of side effects, issues of cost effectiveness and non-adherence.

2. To undertake a critical review of the quality of these studies, addressing factors determining internal and external validity, including study design, implementation and loss to follow up.

3. To conduct empirical synthesis, including meta-analysis if warranted, to address our questions about PEP and its uses.

4. To summarize the current protocols for PEP and the evidence associated with them.

5 Highlight future research, policy, and practice needs.