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Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children

  1. Seokyung Hahn1,*,
  2. Yaejean Kim2,
  3. Paul Garner3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 27 NOV 2001

DOI: 10.1002/14651858.CD002847

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Additional Information

How to Cite

Hahn S, Kim Y, Garner P. Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD002847. DOI: 10.1002/14651858.CD002847.

Author Information

  1. 1

    Seoul National University Hospital, Medical Research Collaborating Center, Seoul, Korea, South

  2. 2

    Fred Hutchinson Cancer Research Centre, Department of Infectious Diseases, Seattle, USA

  3. 3

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, Merseyside, UK

*Seokyung Hahn, Medical Research Collaborating Center, Seoul National University Hospital, 2nd Floor, 28 Yongon-dong Chongno-gu, Seoul, 110-744, Korea, South. hahns@snu.ac.kr.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bangladesh 1995a {published data only}
  • Saker SA, Majid N, Mahalanabis D. Alanine- and glucose-based hypo-osmolar oral rehydration solution in infants with persistent diarrhoea: a controlled trial. Acta Paediatrica 1995;84:775-80.
    Direct Link:
Bangladesh 1995b {published data only}
  • Mahalanabis D, Faruque ASG, Hoque SS, Faruque SM. Hypotonic oral rehydration solution in acute diarrhoea: a controlled clinical trial. Acta Paediatrica 1995;84:289-93.
    Direct Link:
Bangladesh 1996a {published data only}
CHOICE 2001 {published data only}
  • CHOICE study group. Multicenter randomized double blind clinical trial to evaluate the efficacy and safety of a reduced osmolarity oral rehydration solution in children with acute watery diarrhoea. Pediatrics 2001;107:613-8.
Colombia 2000 {published data only}
  • Bernal C, Velasquez C, Garcia G, Uribe G, Palacio C. Oral rehydration with a low-osmolarity solution in children dehydrated by diarrheric diseases. A controlled clinical study [Hidratacion oral con una solucion de baja osmolaridad en ninos deshidratados por enfermedades diarreicas: un estudio clinico controlado]. Saludarte 2000;1:6-23.
Egypt 1994 {published data only}
  • El-Mougi M, El-Akkad N, Hendawi A, Hassan M, Amer A, Fontaine O, Pierce N F. Is a low-osmolarity ORS solution more efficacious than standard WHO ORS solution?. Journal of Pediatric Gastroenterology and Nutrition 1994;19(1):83-6.
Egypt 1996b {published data only}
  • Santosham M, Fayad I, Zikiri MA, Hussein A, Amponsah A, Duggan C, et al. A double-blind clinical trial comparing World Health Organization oral rehydration solution with a reduced osmolarity solution containing equal amounts of sodium and glucose. Journal of Pediatrics 1996;128(1):45-51.
India 1984a {published data only}
  • Bhargava SK, Sachdev HP, Das Gupta B, Daral TS, Singh HP, Mohan M. Oral rehydration of neonates and young infants with dehydration diarrhea: compararison of low and standard sodium content in oral rehydration solutions. Journal of Pediatric Gastroenterology and Nutrition 1984;3(4):500-5. [MEDLINE: 85009156]
India 2000a {published data only}
  • Dutta P, Dutta S, Manna B, Chatterjee MK, De A, Bhattacharya SK. Hypo-osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double-blind, randomized, controlled clinical trial. Acta Paediatrica 2000;89:411-6.
India 2000b {published data only}
  • Alam S, Afzal K, Maheshwari M, Shukia I. Controlled trial of hypo-osmolar versus World Health Organization oral rehydration solution. Indian Pediatrics 2000;37:952-9.
Mexico 1990a {published data only}
  • Moreno-Sanchez H, Velasques-Jones L, Becerra FC, Faure A, Maulen I, Leon M de, et al. A comparative study on two oral rehydration solutions(ORS) containing 60 or 90 mmol/L of sodium and of different osmolalities [Estudio comparativo de dos soluciones de hidratacion oral conteniendo 60 o 90 mmol/L de sodio y con diferente osmolalidad]. Boletin Medico del Hospital Infantil de Mexico 1990;47(9):630-5.
Panama 1982 {published data only}
  • Santosham M, Daum L Dillman RS, Rodriguez JL, Luque S, Russel R, et al. Oral rehydration therapy of infantile diarrhea: a controlled study of well-nourished children hospitalized in the United States and Panama. New England Journal of Medicine 1982;306(18):1070-6.
USA 1982 {published data only}
  • Santosham M, Daum L, Dillman RS, Rodriguez JL, Luque S, Russel R, et alA, Benenson AS, Sack RB. Oral rehydration therapy of infantile diarrhea: a controlled study of well-nourished children hospitalized in the United States and Panama. New England Journal of Medicine 1982;306(18):1070-6.
WHO 1995 {published data only}
  • International Study Group on Reduced-osmolarity ORS solutions. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. Lancet 1995;345:282-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Australia 1990 {published data only}
  • Cleghorn GJ, Shepherd RW, Patrick MK. Comparison of two oral rehydration solutions in children with gastroenteritis in Australia. Clinical Therapeutics 1990;12 Suppl A:81-5.
Australia 1993 {published data only}
  • Wall CR, Shepherd RW, Patric M, Chin S, Cleghorn G. Osmolality electrolyte and carbohydrate type and oral rehydration solutions: A controlled study to compare the efficacy of two commercially available solutions(osmolalities 240 mmol/L and 34 mmol/L). Journal of Diarrhoeal Diseases Research 1993;11(4):222-6.
Bangladesh 1978 {published data only}
  • Sack DA, Chowdhury AMAK, Eusof A, Ali MA, Merson MH, Islam S, et al. Oral hydration in rotavirus diarrhoea: a double blind comparison of sucrose with glucose electrolyte solution. Lancet 1978;2:280-3.
Bangladesh 1991 {published data only}
  • Akbar MS, Baker KM, Aziz MA, Khan WA, Salim AFM. A randomised, double-blind clinical trial of a maltodextrin containing oral rehydration solution in acute infantile diarrhoea. Journal of Diarrhoeal Diseases Research 1991;9(1):33-7.
Bangladesh 1996b {published data only}
Bangladesh 1999 {published data only}
  • Alam NH, Majumder RN, Fuchs GJ, CHOICE group. Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial. Lancet 1999;354:296-9.
Costa Rica 1987 {published data only}
  • Pizarro D, Castillo B, Posada G, Lizano C, Mata L. Efficacy comparison of oral rehydration solutions containing either 90 or 75 millimoles of sodium per liter. Pediatrics 1987;79(2):190-5.
Ecuador 1995 {published data only}
Egypt 1996a {published data only}
  • El-Mougi M, Hendawi A, Koura H, Hegazi E, Fontaine O, Pierce NF. Efficy of standard glucose-based and reduced osmolarity maltodextrin-based oral rehydration solution: effect of sugar malabsorption. Bulletin of the World Health Organization 1996;74(5):471-7.
Finland 1985 {published data only}
  • Isolauri E. Evaluation of an oral rehydration solution with Na 60 mmol/l in infants hospitalized for acute diarrhoea or treated as outpatients. Acta Paediatrica Scandinavica 1985;74:643-9.
    Direct Link:
Finland 1986 {published data only}
Finland 1993 {published data only}
  • Rautanen T, El-RAdhi S, Vesikari T. Clinical experience with a hypotonic oral rehydration solution in acute diarrhoea. Acta Paediatrica 1993;82:52-4.
    Direct Link:
Finland 1997 {published data only}
Finland 1998 {published data only}
  • Rautanen T, Isolauri E, Salo E, Vesikari T. Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG. Archives of Disease in Childhood 1998;79:157-60.
France 1990 {published data only}
  • Mallet E, Guillot M, Le Luyer B, Morin C, Pollet F, De Meynard C. Comparison of two oral rehydration solutions in eutrophic infants with moderate acute diarrhea: results of an interim analysis. Clinical Therapeutics 1990;12 Suppl A:104-12.
Guinea-Bissau 1999 {published data only}
  • Valentiner-Branth P, Steinsland H, Gjessing HK, Santos G, Bhan MK, Dias F, et al. Community-based randomized controlled trial of reduced osmolarity oral rehydration solution in acute childhood diarrhea. Pediatric Infectious Diseases Journal 1999;18:789-95.
India 1978 {published data only}
India 1984b {published data only}
  • Partra FC, Mahalanabis D, Jalan KN, Sen A, Banerjee P. In search of a super solution: controlled trial of glycin-glucose oral rehydration solution in infantile diarrhoea. Acta Paediatrica Scandanavica 1984;73:18-21.
    Direct Link:
Iran 1983 {published data only}
  • Saberi MS, Assaee M. Oral hydration of diarrhoeal dehydration : Comparison of high and low sodium concentration in rehydration solutions. Acta Paediatrica Scandanavica 1983;72:167-70.
    Direct Link:
Mexico 1988 {published data only}
  • Martinez-Pantaleon 0, Faure-Vilchis A, Gomez-Najera RI, Hernandez-Lopez M, Velasquez-Jones L. Comparative study of oral rehydration solutions containing either 90 or 60 millimoles of sodium per liter. [Estudio comparativo de dos soluciones de rehidratacion oral conteniendo 90 o 60 milimoles de sodio por litro]. Boletin Medico del Hospital Infantil de Mexico 1998;45(12):817-22. [MEDLINE: 89193920]
Mexico 1990b {published data only}
  • Velasquez-Jones L, Becerra F, Faure A, de Leon M, Moreno H, Maulen I, et al. Clinical experience in Mexico with a new oral rehydration solution with lower osmolality. Clinical Therapeutics 1990;12 Suppl A:95-103.
Myanmar 1991 {published data only}
  • Khin-Maunh-U, Myo-Khin, Nyunt-Nyunt-Wai, Mu-Mu-Khin, Mya-Thi, Thein-Thein-Myint. Comparison of glucose/elctrolyte and maltodextrin/glycine/glycyl-glycine/electrolye oral rehydration solution in acute diarrhea in children. Journal of Pediatric Gastroenterology and Nutrition 1992;13:397-401.
Russia 1997 {published data only}
  • Shornikova AV, Isolauri E, Burkanova L, Lukovnikova S, Vesikari R. A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhoea. Acta Paediatrica 1997;86:460-5.
    Direct Link:
Turkey 1985 {published data only}
  • Sokucu S, Marin L, Gunoz H, Aperia A, Neyzi O, Zetterstrom R. Oral rehydration therapy in infectious diarrhoea. Comparison of rehydration solutions with 60 and 90 mmol sodium per litre. Acta Paediatrica Scandinavica 1985;74:489-84.
Turkey 1986 {published data only}
  • Marin L, Gunoz H, Sokucu S, Saner G, Aperia A, Neyzi O, et al. Oral rehydration therapy in malnourished infants with infectious diarrhoea. Acta Paediatrica Scandinavica 1986;75:477-82.
    Direct Link:
USA 1972 {published data only}
  • Hirschhorn N, Cash RA, Woodward WE, Spivey GH. Oral fluid therapy of Apache children with acute infectious diarrhoea. Lancet 1972;7766:15-8.
USA 1986 {published data only}
  • Santosham M, Burns BA, Reid R, Letson W, Duncan B, Powlesland JA, et al. Glycine-based oral rehydration solutioin: reassessment of safety and efficacy. Jounal of Pediatrics 1986;109(5):795-801.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alam 1999
  • Alam NH, Majumder RN, Fuchs GJ, CHOICE study group. Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blinded clinical trial. Lancet 1999;354:296-9.
Almroth 1995
Egger 1997
Farthing 1988
Farugue 1996
Finberg 1973
Fontaine 2000
  • Fontaine O, Gore SM, Pierce NF. Rice-based oral rehydration solution for treating diarrhoea (Cochrane Review). Cochrane Database of Systematic Reviews 2000, Issue 3. [DOI: ]
Fordtran 1968
Grant 1983
  • Grant JP. The state of the world's children 1982-1983. UNICEF. New York: UNICEF, 1983.
Guarino 2001
Hunt 1992
Mahalanabis 1973
QUOROM Group 1999
  • Moher D, Cook DJ, Eastwood S, Okin I, Rennie D, Stroup DF, for the Quorum Group. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUORUM statement. Lancet 1999;354:1896-1900.
WHO 2001
  • World Health Organization. Expert consultation on oral rehydration salts (ORS) formulation. Child and Adolescent Health and Development 2001; Vol. WHO/FCH/CAH/01.22:[18 July 2001].

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Hahn 2001
  • Hahn S, Kim Y, Garner P. Reduced osmolarity oral rehydration salts solution for treating diarrhoea-associated dehydration in children: systematic review. British Medical Journal 2001;323:81-5.
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