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Nitric oxide donors for treating preterm labour

  1. Kirsten Duckitt1,*,
  2. Steve Thornton2,
  3. Oliver P O'Donovan3,
  4. Therese Dowswell4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 8 MAY 2014

Assessed as up-to-date: 1 DEC 2013

DOI: 10.1002/14651858.CD002860.pub2


How to Cite

Duckitt K, Thornton S, O'Donovan OP, Dowswell T. Nitric oxide donors for treating preterm labour. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD002860. DOI: 10.1002/14651858.CD002860.pub2.

Author Information

  1. 1

    Campbell River and District General Hospital, Campbell River, British Columbia, Canada

  2. 2

    University of Exeter Medical School and Peninsula College of Medicine and Dentistry, Exeter, UK

  3. 3

    South Devon Healthcare Trust, Department of Obstetrics and Gynaecology, Torquay, Devon, UK

  4. 4

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*Kirsten Duckitt, Campbell River and District General Hospital, 375 - 2nd Avenue, Campbell River, British Columbia, V9W 3V1, Canada. kduckitt@doctors.org.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 MAY 2014

SEARCH

[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 1 Prolongation of pregnancy greater than 48 hours.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 2 Birth prior to 37 completed weeks.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 3 Birth prior to 34 completed weeks.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 4 Birth prior to 28 completed weeks.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 5 Caesarean section.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 6 Any adverse drug reactions.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 7 Headache.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 8 Dizziness.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 9 Flushing.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 10 Hypotension.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 11 Completion of course of maternal steroids.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 12 Death unrelated to congenital abnormalities.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 13 Intraventricular haemorrhage.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 14 Respiratory distress syndrome.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 15 Chronic lung disease.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 16 Birthweight (grams).
[Analysis 1.17]
Analysis 1.17. Comparison 1 Nitric oxide donors versus placebo or no treatment, Outcome 17 (Non-prespecified) Composite outcome: serious infant morbidity or mortality.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 1 Prolongation of pregnancy greater than 24 hours.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 2 Prolongation of pregnancy greater than 48 hours.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 3 Prolongation of pregnancy greater than 7 days.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 4 Prolongation of pregnancy greater than 14 days.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 5 Birth prior to 37 completed weeks.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 6 Birth prior to 34 completed weeks.
[Analysis 2.7]
Analysis 2.7. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 7 Birth prior to 32 completed weeks.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 8 Caesarean section.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 9 Adverse effects.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 10 Headache.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 11 Dizziness.
[Analysis 2.12]
Analysis 2.12. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 12 Palpitations.
[Analysis 2.13]
Analysis 2.13. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 13 Shortness of breath.
[Analysis 2.14]
Analysis 2.14. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 14 Nausea.
[Analysis 2.15]
Analysis 2.15. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 15 Tachycardia.
[Analysis 2.16]
Analysis 2.16. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 16 Chest pain/tightness.
[Analysis 2.17]
Analysis 2.17. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 17 Adverse effects leading to treatment cessations.
[Analysis 2.18]
Analysis 2.18. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 18 Maternal pulmonary oedema.
[Analysis 2.19]
Analysis 2.19. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 19 Death unrelated to congenital abnormalities.
[Analysis 2.20]
Analysis 2.20. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 20 Use of mechanical ventilation.
[Analysis 2.21]
Analysis 2.21. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 21 Chronic lung disease.
[Analysis 2.22]
Analysis 2.22. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 22 Admission of infant to neonatal intensive care unit.
[Analysis 2.23]
Analysis 2.23. Comparison 2 Nitric oxide donors versus any betamimetic, Outcome 23 Birthweight.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Nitric oxide donors versus magnesium sulphate, Outcome 1 Headache.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Nitric oxide donors versus magnesium sulphate, Outcome 2 Dizziness.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Nitric oxide donors versus magnesium sulphate, Outcome 3 Flushing.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Nitric oxide donors versus magnesium sulphate, Outcome 4 Palpitations.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Nitric oxide donors versus magnesium sulphate, Outcome 5 Hypotension.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 1 Prolongation of pregnancy greater than 48 hours.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 2 Headache.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 3 Flushing.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 4 Hypotension.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 5 Nausea.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Nitric oxide donors versus any calcium channel blocker, Outcome 6 Tachycardia.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 1 Prolongation of pregnancy greater than 48 hours.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 2 Caesarean section.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 3 Headache.
[Analysis 5.4]
Analysis 5.4. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 4 Flushing.
[Analysis 5.5]
Analysis 5.5. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 5 Nausea.
[Analysis 5.6]
Analysis 5.6. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 6 Tachycardia.
[Analysis 5.7]
Analysis 5.7. Comparison 5 Nitric oxide donors versus combination of tocolytics, Outcome 7 Chest pain/tightness.