Corticosteroids for hospitalised children with acute asthma

  • Review
  • Intervention




Systemic corticosteroids are used routinely in the management of children with severe acute asthma. There is a lack of consensus regarding the agent, dose and route of corticosteroid administration.


To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.

Search methods

All controlled trials were identified from the Cochrane Airways Review Group Register, hand searching of respiratory journals, reference lists and contacts with experts and pharmaceutical companies.

Selection criteria

Studies were included if they described a randomised controlled trial (RCT) involving children aged 1-18 years with severe acute asthma who received oral, inhaled, intravenous or intramuscular corticosteroids. Only studies in which patients required hospital admission were included.

Data collection and analysis

Two reviewers using a standard form extracted all data. All data, numeric calculations and graphic extrapolations were independently confirmed.

Main results

Seven trials were included with a total of 426 children studied (274 with oral prednisone vs. placebo, 106 with intravenous steroids vs placebo and 46 with nebulised budesonide vs prednisolone). A significant number of steroid treated children were discharged early after admission (>4 hours) with an OR of 7.00 (95% CI: 2.98 to 16.45) and NNT of 3 (95%CI: 2 to 8). The length of stay was shorter in the steroid groups with a WMD of -8.75 hours (95% CI: -19.23 to 1.74). There were no significant differences between groups in pulmonary function or oxygen saturation measurements. Children treated with steroids in hospital were less likely to relapse within one to three months with OR 0.19 (95%CI: 0.07 to 0.55) and NNT of 3 (95%CI: 2 to 7). The single small study that compared nebulised budesonide to oral prednisone failed to demonstrate equivalence or a difference between each therapy.

Authors' conclusions

Systemic corticosteroids produce some improvements for children admitted to hospital with acute asthma. The benefits may include earlier discharge and fewer relapses. Inhaled or nebulised corticosteroids cannot be recommended as equivalent to systemic steroids at this time. Further studies examining differing doses and routes of administration for corticosteroids will clarify the optimal therapy.








所有試驗都來自於Cochrane Airways Review Group Register、人工搜尋呼吸道期刊和參考資料表,另外並連絡專家及藥廠。


納入隨機對照試驗,其研究對象為1 – 18歲的嚴重急性氣喘兒童,並接受口服、吸入、靜脈注射或肌肉注射皮質類固醇。僅納入住院病患的研究。




納入七個試驗、共426位兒童(274位比較口服 prednisone和安慰劑,106 位比較靜脈注射類固醇和安慰劑,46位比較噴霧型budesonide 和 prednisolone)。類固醇治療組的兒童住院後出院較早(相差超過四個小時),危險對比值(OR)7.00 (95%信賴區間:2.98到16.45),益一需治數(NTT)為3(95%信賴區間:2到8)。類固醇治療組住院時間較短,加權平均差(WMD) 8.75小時(95%信賴區間:19.23到 1.74)。在肺功能或氧飽和度方面,各組間則沒有顯著差異。住院期間接受類固醇治療的兒童在一到三個月內復發率較低,危險對比值0.19 (95%信賴區間:0.07到0.55),益一需治數為3 (95%信賴區間:2到7)。只有一個小型研究比較噴霧型budesonide和口服prednisone的效果,但其結果無法確認兩組的優劣。




此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。



Plain language summary

Corticosteroids for hospitalised children with acute asthma

An acute asthma attack in a child often results in a trip to the hospital. In the emergency department steroid drugs are given which may improve the child's condition and allow them to be sent home after a few hours observation. However, some children require continued treatment in hospital. This review asked the question "do steroid drugs help children admitted to hospital with asthma?" We found that steroids given by mouth or through an intravenous tube help children recover from acute asthma. The benefits may include earlier discharge or a shorter stay in hospital. Children were less likely to come back to hospital in the one to three months following the admission. However, the evidence was not overwhelming due to the limited number of studies available and different medicines used. Further research needs to concentrate on the best medications to use and the best route of administration.