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Vaccines for women to prevent neonatal tetanus

  1. Vittorio Demicheli1,*,
  2. Antonella Barale2,
  3. Alessandro Rivetti1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 31 JAN 2013

DOI: 10.1002/14651858.CD002959.pub3


How to Cite

Demicheli V, Barale A, Rivetti A. Vaccines for women to prevent neonatal tetanus. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD002959. DOI: 10.1002/14651858.CD002959.pub3.

Author Information

  1. 1

    Azienda Sanitaria Locale ASL AL, Servizio Regionale di Riferimento per l'Epidemiologia, SSEpi-SeREMI - Cochrane Vaccines Field, Alessandria, Piemonte, Italy

  2. 2

    ASL VC, Struttura di Epidemiologia, Vercelli, Piemonte, Italy

*Vittorio Demicheli, Servizio Regionale di Riferimento per l'Epidemiologia, SSEpi-SeREMI - Cochrane Vaccines Field, Azienda Sanitaria Locale ASL AL, Via Venezia 6, Alessandria, Piemonte, 15100, Italy. vdemicheli@aslal.it. vittoriodemicheli@gmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 31 MAY 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Black 1980 {published data only}
  • Black RE, Huber DH, Curlin GT. Reduction of neonatal tetanus by mass immunization of non-pregnant women: duration of protection provided by one or two doses of aluminium-adsorbed tetanus toxoid. Bulletin of the World Health Organization 1980;58(6):927-30.
Newell 1966 {published data only}
  • Newell KW, Duenas Lehmann A, LeBlanc DR, Garces Osorio N. The use of toxoid for the prevention of tetanus neonatorum: preliminary report of a double-blind controlled field trial. Bulletin of the World Health Organization 1964;30:439-44.
  • Newell KW, Duenas Lehmann A, LeBlanc DR, Garces Osorio N. The use of toxoid for the prevention of tetanus neonatorum. Final report of a double-blind controlled field trial. Bulletin of the World Health Organization 1966;35(6):863-71.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Abuwa 1997 {published data only}
  • Abuwa PN, Alikor EA, Gbaraba PV, Mung KS, Oruamabo RS. Epidemiology of neonatal tetanus in the Rivers State of Nigeria: a community based study. Journal of Epidemiology and Community Health. 1997;51(3):336.
Al-Safi 2011 {published data only}
  • Al-Safi ZA, Shavell VI, Gonik B. Vaccination in pregnancy. Womens Health (Lond Engl) 2011;7(1):109-19.
Anh 1999 {published data only}
  • Anh NQ, Hong HA, Nhon TN, Thinh ND, Van NT, Hendriks J. Tetanus antibodies measured by the toxin binding inhibition test (ToBI) in mothers and children in the Neonatal Tetanus Program in Vietnam. Developments in Biological Standardization 1999;101:247-53.
Axelsson 2002 {published data only}
  • Axelsson I. A Cochrane review on the umbilical cord care and prevention of infections. Antiseptic solutions are not necessary in developed countries but life-saving in developing countries [Cochrane-oversikt om att forebygga navelinfektioner. Antiseptisk losning ar onodig i i-lander men livraddande i u-lander.]. Lakartidningen 2002;99(14):1563-6.
Aylward 1996 {published data only}
  • Aylward RB, Mansour E, Oon el-S A, Tawfik SA, Makar S, Abu el Kheir A, et al. The role of surveillance in a 'high risk' approach to the elimination of neonatal tetanus in Egypt. International Journal of Epidemiology 1996;25(6):1286-91.
Baltazar 1994 {published data only}
  • Baltazar JC, Sarol JN Jr. Prenatal tetanus immunization and other practices associated with neonatal tetanus. Southeast Asian Journal of Tropical Medicine and Public Health 1994;25(1):132-8.
Basher 2010 {published data only}
  • Basher MS. Knowledge and practice about TT vaccination among undergraduate female medical students. Mymensingh Medical Journal 2010;19(4):520-3.
Berggren 1971 {published data only}
  • Berggren WL, Berggren GM. Changing incidence of fatal tetanus of the newborn. A retrospective study in a defined rural Haitian populations. American Journal of Tropical Medicine And Hygiene 1971;20(3):491-4.
Blencowe 2010 {published data only}
  • Blencowe H, Lawn J, Vandelaer J, Roper M, Cousens S. Tetanus toxoid immunization to reduce mortality from neonatal tetanus. International Journal of Epidemiology 2010;39(Suppl 1):i102-9.
Canning 2011 {published data only}
  • Canning D, Razzaque A, Driessen J, Walker DG, Streatfield PK, Yunus M. The effect of maternal tetanus immunization on children's schooling attainment in Matlab, Bangladesh: follow-up of a randomized trial. Social Science & Medicine 2011;72(9):1429-36.
Chai 2004 {published data only}
  • Chai F, Prevots DR, Wang X, Birmingham M, Zhang R, Chai F. Neonatal tetanus incidence in China, 1996-2001, and risk factors for neonatal tetanus, Guangxi Province, China. International Journal of Epidemiology 2004;33(3):551-7.
Chongsuvivatwong 93 {published data only}
de Walque 2008 {published data only}
  • de Walque D. Do unsafe tetanus toxoid injections play a significant role in the transmission of HIV/AIDS? Evidence from seven African countries. Sexually Transmitted Infections 2008;84(2):122-5.
Dhillon 1975 {published data only}
  • Dhillon H, Menon PS. Active immunization of women in pregnancy with two injections of adsorbed tetanus toxoid for prevention of tetanus neonatorum in Punjab, India. Indian Journal of Medical Research 1975;63(4):583-9.
Dietz 1996 {published data only}
  • Dietz V, Milstien JB, van Loon F, Cochi S, Bennett J. Performance and potency of tetanus toxoid: implications for eliminating neonatal tetanus. Bulletin of the World Health Organization 1996;74(6):619-28.
Gupta 1998 {published data only}
Halperin 2011 {published data only}
  • Halperin BA, Morris A, Mackinnon-Cameron D, Mutch J, Langley JM, McNeil SA, et al. Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum women. Clinical Infectious Diseases 2011;53(9):885-92.
Hardegree 1970 {published data only}
  • Hardegree MC, Barile MF, Pittman M, Schofield FD, Maclennan R, Kelly A. Immunization against neonatal tetanus in New Guinea. Bulletin of the World Health Organization 1970;43(3):439-51.
Hasnain 2007 {published data only}
  • Hasnain S, Sheikh NH. Causes of low tetanus toxoid vaccination coverage in pregnant women in Lahore district, Pakistan. Eastern Mediterranean Health Journal 2007;13(5):1142-52.
Heredia 1968 {published data only}
  • Heredia AF, Borkar MB, Rao SS. Active immunization in pregnancy with fluid tetanus toxoid. Indian Journal of Medical Sciences 1968;22(4):209-13.
Hlady 1992 {published data only}
  • Hlady WG, Bennett JV, Samadi AR, Begum J, Hafez A, Tarafdar AI, et al. Neonatal tetanus in rural Bangladesh: risk factors and toxoid efficacy. American Journal of Public Health 1992;82(10):1365-9.
Kielmann 1977 {published data only}
  • Kielmann AA, Vohra SR. Control of tetanus neonatorum in rural communities--immunization effects of high-dose calcium phosphate-absorbed tetanus toxoid. Indian Journal of Medical Research 1977;66(6):906-16.
Koenig 1998 {published data only}
  • Koenig MA, Roy NC, McElrath T, Shahidullah M, Wojtyniak B. Duration of protective immunity conferred by maternal tetanus toxoid immunization: further evidence from Matlab, Bangladesh. American Journal of Public Health 1998;88(6):903-7.
Lassi 2010 {published data only}
MacLennan 1965 {published data only}
  • MacLennan R, Schofield FD, Pittman M, Hardegree MC, Barile MF. Immunization against neonatal tetanus in New Guinea. Antitoxin response of pregnant women to adjuvant and plain toxoids. Bulletin of the World Health Organization 1965;32(5):683-97.
Mulholland 1996 {published data only}
  • Mulholland K, Suara RO, Siber G, Roberton D, Jaffar S, N'Jie J, et al. Maternal immunization with Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine in the Gambia. JAMA 1996;275(15):1182-8.
Nohynek 1999 {published data only}
  • Nohynek H, Gustafsson L, Capeding MR, Kayhty H, Olander RM, Pascualk L, et al. Effect of transplacentally acquired tetanus antibodies on the antibody responses to haemophilus influenzae type b-tetanus toxoid conjugate and tetanus toxoid vaccines in Filipino infants. Pediatric Infectious Disease Journal 1999;18(1):25-30.
Orozova-Bekkevold 2007 {published data only}
  • Orozova-Bekkevold I, Jensen H, Stensballe L, Olsen J. Maternal vaccination and preterm birth: using data mining as a screening tool. Pharmacy World and Science 2007;29(3):205-12.
Perry 1998 {published data only}
  • Perry H, Weierbach R, Hossain I, Islam R. Tetanus toxoid immunization coverage among women in zone 3 of Dhaka city: the challenge of reaching all women of reproductive age in urban Bangladesh. Bulletin of the World Health Organization 1998;76(5):449-57.
Rahman 1982 {published data only}
  • Rahman M, Chen LC, Chakraborty J, Yunus M, Chowdhury AI, Sarder AM, et al. Use of tetanus toxoid for the prevention of neonatal tetanus. 1. Reduction of neonatal mortality by immunization of non-pregnant and pregnant women in rural Bangladesh. Bulletin of the World Health Organization 1982;60(2):261-7.
Rahman 1982b {published data only}
  • Rahman M, Chen LC, Chakraborty J, Yunus M, Faruque AS, Chowdhury AI. Use of tetanus toxoid for the prevention of neonatal tetanus. 2. Immunization acceptance among pregnant women in rural Bangladesh. Bulletin of the World Health Organization 1982;60(2):269-77.
Relyveld 1991 {published data only}
Salama 2009 {published data only}
  • Salama MM, Hady OA, Ashour W, Mostafa A, El Alkamy S, El Sayed N, et al. A randomized controlled trial of oral administration of tetanus toxoid (TT) versus tetanus and reduced diphtheria (Td) in pregnant women. Journal of Clinical Immunology 2009;29(4):524-31.
Schofield 1961 {published data only}
  • Schofield FD, Tucker VM, Westbrook GR. Neonatal tetanus in New Guinea. Effect of active immunization in pregnancy. BMJ 1961;5255:785-9.
Silveira 1995 {published data only}
  • Silveira CM, Caceres VM, Dutra MG, Lopes-Camelo J, Castilla EE. Safety of tetanus toxoid in pregnant women: a hospital-based case-control study of congenital anomalies. Bulletin of the World Health Organization 1995;73(5):605-8.
Stanfield 1973 {published data only}
  • Stanfield JP, Gall D, Bracken PM. Single-dose antenatal tetanus immunisation. Lancet 1973;1(7797):215-9.
Suri 1964 {published data only}
  • Suri JC, Dhillon H, Grewal HS. Active immunization of women in pregnancy for prevention of neonatal tetanus. Bulletin of the World Health Organization 1964;31:349-57.
Tall 1991 {published data only}
  • Tall F, Prazuck T, Roisin A, Sanou J, Nacro B, Traore A, et al. Risk factors for neonatal tetanus in western Burkina Faso. Case-control study [Facteurs de risque du tetanos neonatal dans l'ouest du Burkina Faso. Etude cas temoin]. Bulletin de la Societe de Pathologie Exotique 1991;84(5 Pt 5):558-61.
Traverso 1991 {published data only}
  • Traverso HP, Kamil S, Rahim H, Samadi AR, Boring JR, Bennett JV. A reassessment of risk factors for neonatal tetanus. Bulletin of the World Health Organization 1991;69(5):573-9.
Yala 1980 {published data only}
  • Yala PF. Prevention of neonatal tetanus by active immunization of pregnant women in Brazzaville. Practical evalation and a comparison of single-dose and triple-dose vaccinations. Bulletin de la Societe de Pathologie Exotique et de ses Fil 1980;73(1):15-22.
Yusuf 1991 {published data only}
  • Yusuf B, Solter S, Bertsch D, Arnold RB. Impact of a tetanus toxoid immunization mass campaign on neonatal tetanus mortality in Aceh Province, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 1991;22(3):351-6.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alderson 2004
  • Alderson P, Green S, Higgins JPT, editors. Cochrane Reviewers' Handbook 4.2.2 [updated March 2004]. In: The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
Altman 2003
Black 2010
  • Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 2010;375(9730):1969-87.
Descombey 1924
  • Descombey P. L'anatoxine tetanique. Comptes rendus des séances de la Société de biologie et de ses filiales 1924;91:239-41.
Dietz 1996
  • Dietz V, Milstein JB, van Loon F, Cochi S, Bennet J. Performance and potency of tetatus toxoid: implications for eliminating neonatal tetanus. Bulletin of the World Health Organization 1996;74(6):619-28.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jefferson 1996
Jefferson 1998
Prevots 1998
  • Prevots DR. Neonatal tetanus. Bulletin of the World Health Organization 1998;76 Suppl 2:135-6. [PUBMED: 10063693]
RevMan 2003
  • The Cochrane Collaboration. Review Manager (RevMan). 4.2 for Windows. Oxford, England: The Cochrane Collaboration, 2003.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
WHO 1999
  • World Health Organization. Progress towards the global elimination of neonatal tetanus, 1990-1998. Weekly Epidemiological Record 1999;74(10):73-80.
WHO 2006
  • World Health Organization. Tetanus vaccine. WHO position paper. Weekly Epidemiological Record 2006;81(20):198-208.
WHO 2012
  • World Health Organization. Maternal and Neonatal Tetanus (MNT) elimination. http://www.who.int/immunization_monitoring/diseases/MNTE_initiative/en/index.html accessed on January 11th, 2012.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Demicheli 2001
Demicheli 2005