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Formula milk versus maternal breast milk for feeding preterm or low birth weight infants

  1. Ginny Henderson1,*,
  2. Mary Y Anthony2,
  3. William McGuire3

Editorial Group: Cochrane Neonatal Group

Published Online: 17 OCT 2007

Assessed as up-to-date: 8 JUL 2007

DOI: 10.1002/14651858.CD002972.pub2


How to Cite

Henderson G, Anthony MY, McGuire W. Formula milk versus maternal breast milk for feeding preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD002972. DOI: 10.1002/14651858.CD002972.pub2.

Author Information

  1. 1

    Griffith University, School of Nursing and Midwifery, South Brisbane, Queensland, Australia

  2. 2

    John Radcliffe Hospital, Special Care Baby Unit, Headington, Oxford, UK

  3. 3

    Australian National University Medical School, Department of Paediatrics and Child Health, Canberra, ACT 2606, Australia

*Ginny Henderson, School of Nursing and Midwifery, Griffith University, Nathan Campus, 226 Grey St, PO Box 3370, South Brisbane, Queensland, 4104, Australia. G.Henderson@griffith.edu.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 17 OCT 2007

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Maternal breast milk may contain less nutrients than artificial formula milk but may confer important non-nutrient advantages for preterm or low birth weight infants.

Objectives

To determine the effect of feeding with formula milk compared with maternal breast milk on rate of growth and developmental outcomes in preterm or low birth weight infants.

Search methods

The standard search strategy of the Cochrane Neonatal Review Group was used. This included electronic searches of the Cochrane Central Register of Controlled Trials Register (CENTRAL, The Cochrane Library, Issue 3, 2007), MEDLINE (1966 - June 2007) and EMBASE (1980 - June 2007) and CINAHL (1982 to June 2007) (all accessed via OVID) and previous reviews including cross references.

Selection criteria

Randomised controlled trials comparing feeding with formula milk versus preterm human milk in preterm or low birth weight infants.

Data collection and analysis

The standard methods of the Cochrane Neonatal Review Group were used, with separate evaluation of trial quality and data extraction by two authors.

Main results

No eligible trials were identified.

Authors' conclusions

There are no data from randomised trials of formula milk versus maternal breast milk for feeding preterm or low birth weight infants. This may relate to a perceived difficulty of allocating an alternative feed to an infant whose mother wishes to feed with her own breast milk. Maternal breast milk remains the default choice of enteral nutrition because observational studies, and meta-analyses of trials comparing feeding with formula milk versus donor breast milk, suggest that feeding with breast milk has major non-nutrient advantages for preterm or low birth weight infants.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Formula milk versus maternal breast milk for feeding preterm or low birth weight infants

Formula milk may contain more nutrients than maternal breast milk but it lacks the antibodies and other substances present in breast milk that protect and develop the immature gut of preterm or low birth weight infants. No trials that compared feeding with formula milk rather than their own mother's breast milk were identified. However, since another Cochrane review has found that feeding with formula compared to donor breast milk increases the risk of serious gut problems in preterm or low birth weight infants, it is unlikely that a such a trial would be acceptable to mothers and caregivers.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

對早產兒或低出生體重嬰兒給予配方奶或母奶的比較

母奶可能較人工配方奶含有較少的營養,但可能對早產兒或低出生體重嬰兒有其他重要的非營養好處。

目標

評估早產兒或低出生體重嬰兒用配方奶或母奶餵食對生長速度和發展的效果。

搜尋策略

使用Cochrane Neonatal Review Group的標準搜尋策略,包括電子搜尋Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 3, 2007) 、MEDLINE (1966  June 2007) 、EMBASE (1980 June 2007) 、CINAHL (1982  June 2007) 、之前的回顧文獻包括交互參考資料。

選擇標準

隨機控制研究比較早產兒或低出生體重嬰兒餵食配方奶和早產兒母奶的差別。

資料收集與分析

由兩位評論者分別使用Cochrane Neonatal Review Group標準方法取得資料,並評估研究品質。

主要結論

沒有發現合格的試驗。

作者結論

沒有隨機試驗的資料比較配方奶或母奶餵食早產兒或低出生體重嬰兒。可能和指派想餵母奶的媽媽至實驗組實行上困難有關。母奶為腸道營養首選,因為根據觀察性的研究以及整合分析試驗比較餵食配方奶和捐贈母奶,顯示早產兒或低出生體重新生兒餵食母奶有除了營養外其他的好處。

翻譯人

本摘要由馬偕醫院張龍翻譯。

此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。

總結

配方奶可能較母奶含有更多的營養,但缺少了抗體和其他可以保護和促進早產兒和低出生體重嬰兒未成熟腸道生長的物質。沒有試驗比較過餵食配方奶或早產兒自己母親母奶的差別。然而,從另一個Cochrane回顧文章發現餵食配方奶比起捐贈母奶更會引起早產兒或低出生體重嬰兒嚴重的腸道疾病,如此往後類似的研究就更不被母親或照顧者所接受。