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Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia

  1. Mical Paul1,*,
  2. Yaakov Dickstein2,
  3. Agata Schlesinger3,
  4. Simona Grozinsky-Glasberg4,
  5. Karla Soares-Weiser5,
  6. Leonard Leibovici3

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 29 JUN 2013

Assessed as up-to-date: 7 JUN 2013

DOI: 10.1002/14651858.CD003038.pub2


How to Cite

Paul M, Dickstein Y, Schlesinger A, Grozinsky-Glasberg S, Soares-Weiser K, Leibovici L. Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD003038. DOI: 10.1002/14651858.CD003038.pub2.

Author Information

  1. 1

    Rambam Health Care Campus, Division of Infectious Diseases, Haifa, Israel

  2. 2

    Rambam Health Care Center, Medicine A and Unit of Infectious Diseases, Haifa, Israel

  3. 3

    Beilinson Hospital, Rabin Medical Center, Department of Medicine E, Petah Tikva, Israel

  4. 4

    Dept of Medicine, Hadassah-Hebrew University Medical Center, Neuroendocrine Tumors Unit, Endocrinology & Metabolism Service, Jerusalem, Israel

  5. 5

    Cochrane, Cochrane Editorial Unit, London, UK

*Mical Paul, Division of Infectious Diseases, Rambam Health Care Campus, Ha-aliya 8 St, Haifa, 33705, Israel. paulm@post.tau.ac.il. m_paul@rambam.health.gov.il.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 29 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Agaoglu 2001 {published and unpublished data}
  • Agaoglu L, Devecioglu O, Anak S, Karakas Z, Yalman N, Biner B, et al. Cost-effectiveness of cefepime + netilmicin or ceftazidime + amikacin or meropenem monotherapy in febrile neutropenic children with malignancy in Turkey. Journal of Chemotherapy 2001;13(3):281-7.
Ahmed 2007 {published and unpublished data}
  • Ahmed N, Borollosy N, Beshlawy A, Mahallawy H, Haddad A. Outpatient single dose ceftriaxone and amikacin vs. imipenem/cilastatin monotherapy in the empiric treatment of pediatric patients with high risk fever and neutropenia: a randomized, prospective clinical trial. Proceedings of Meeting of the American Society of Hematology; Abstract No. 887. 2003.
  • Ahmed N, Borollosy N, Beshlawy A, Mahallawy H, Haddad A. Outpatient single dose ceftriaxone and amikacin vs. imipenem/cilastatin monotherapy in the empiric treatment of pediatric patients with high risk fever aneutropenia: a randomized, prospective clinical trial. Proceedings of ASCO Meeting; Abstract No. 8520. 2004.
  • Ahmed N, Mahallawy HA, Ahmed IA, Nassif S, Beshlawy A, Haddad A. Early hospital discharge versus continued hospitalization in febrile pediatric cancer patients with prolonged neutropenia: a randomized, prospective study. Pediatric Blood Cancer 2007;49:786-92.
Akova 1999 {published and unpublished data}
  • Akova M, Akan H, Korten V, Biberoglu K, Hayran M, Unal S, et al. Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. Meropenem Study Group of Turkey. International Journal of Antimicrobial Agents 1999;13(1):15-9.
Alanis 1983 {published data only}
  • Alanis A, Rehm S, Weinstein AJ. Comparative efficacy and toxicity of moxalactam and the combination of nafcillin and tobramycin in febrile granulocytopenic patients. Cleveland Clinic Quarterly 1983;50(4):385-95.
Antmen 2001 {published data only}
  • Antmen B, Sasmaz I, Tanyeli A, Yaman A, Kocabas E, Bayram I, et al. Initial empiric antibiotic treatments in childhood febrile neutropenia: meropenem versus ceftazidime plus amikacin combination. Proceedings of the 11th European Congress of Clinical Microbiology and Infectious Diseases Apr 1-4; Istanbul, Turkey. 2001:Poster 1087. [MEDLINE: http://www.akm.ch/eccmid2001]
Au 1994 {published data only}
  • Au E, Tow A, Allen DM, Ang PT. Randomised study comparing imipenem/cilastatin to ceftriaxone plus gentamicin in cancer chemotherapy-induced neutropenic fever. Annals of the Academy of Medicine Singapore 1994;23(6):819-22.
Behre 1998 {published and unpublished data}
  • Behre G, Link H, Maschmeyer G, Meyer P, Paaz U, Wilhelm M, et al. Meropenem monotherapy versus combination therapy with ceftazidime and amikacin for empirical treatment of febrile neutropenic patients. Annals of Hematology 1998;76(2):73-80.
Bezwoda 1985 {published data only}
  • Bezwoda WR, Derman DP, Perkins S, Cassel R. Treatment of neutropenic infection: a randomized trial comparing latamoxef (moxalactam) with cephradine plus tobramycin. Journal of Antimicrobial Chemotherapy 1985;15(2):239-45.
Borbolla 2001 {published data only}
  • Borbolla JR, Lopez-Hernandez MA, Gonzalez-Avante M, DeDiego J, Trueba E, Alvarado ML, et al. Comparison of cefepime versus ceftriaxone-amikacin as empirical regimens for the treatment of febrile neutropenia in acute leukemia patients. Chemotherapy 2001;47(5):381-4.
Cometta 1996 {published data only}
  • Cometta A, Calandra T, Gaya H, Zinner SH, De Bock R, Del Favero A, et al (EORTC). Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. Antimicrobial Agents and Chemotherapy 1996;40(5):1108-15.
Conte 1996 {published data only}
  • Conte G, Flores C, Alfaro J, Araos D, Thompson L, Barahona O, et al. Single agent sulperazone vs. two agent ceftazidime-amikacin in high risk febrile neutropenic patients. Blood 1996;88(10):30b.
Corapcioglu 2005 {published data only}
  • Corapcioglu F, Sarper N. Cefepime versus ceftazidime + amikacin as empirical therapy for febrile neutropenia in children with cancer: a prospective randomized trial of the treatment efficacy and cost. Pediatric Hematologic Oncology 2005;22(1):59-70.
Cornelissen 1992 {published data only}
  • Cornelissen JJ, de Graeff A, Verdonck LF, Branger T, Rozenberg-Arska M, Verhoef J, et al. Imipenem versus gentamicin combined with either cefuroxime or cephalothin as initial therapy for febrile neutropenic patients. Antimicrobial Agents and Chemotherapy 1992;36(4):801-7.
Cornely 2001 {unpublished data only}
  • Cornely OA, Reichert D, Buchheidt D, Maschmeyer G, Wilhelm M, Chiel X (for the Paul-Erlich-Gesellschaft). Three-armed multicenter randomized study on the empiric treatment of neutropenic fever in a high risk patient population (PEG study III). Proceedings of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy;Abstract L-775. 2001.
  • Maschmeyer G. Cefepime in the empirical initial treatment of febrile neutropenic cancer patients [Cefepim in der empirischen Initial therapie bei febrilen neutropenischen Patienten mit mignen erkankungen]. Chemotherapie Journal 2004;13:174-180.
De la Camara 1997 {published and unpublished data}
  • De la Camara R, Figuera A, Sureda A, Hermida G, Verge G, Olalla I, et al. Meropenem versus ceftazidime plus amikacin in the treatment of febrile episodes in neutropenic patients: a randomized study. Haematologica 1997;82(6):668-75.
Del Favero 2001 {published data only}
  • Del Favero A, Menichetti F, Martino P, Bucaneve G, Micozzi A, Gentile G, et al. A multicenter, double-blind, placebo-controlled trial comparing piperacillin-tazobactam with and without amikacin as empiric therapy for febrile neutropenia. Clinical Infectious Diseases 2001;33(8):1295-301.
  • Del Favero A, Micozzi A, Bucaneve G, Martino P. Double-blind, randomised, clinical trial comparing monotherapy with piperacillin-tazobactam vs piperacillin-tazobactam plus amikacin as empiric therapy for febrile neutropenic cancer patients. Proceedings of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy; Abstract No. 1092. 1999.
  • Micozzi A, Bucaneve G, Menichetti F, Martino P, Del Favero A, G.I.M.E.M.A.Infection Program. Double blind, randomized, clinical trial comparing monotherapy with piperacillin-tazobactam versus piperacillin-tazobactam plus amikacin as empiric therapy for febrile neutropenic cancer patients.. Supportive Care in Cancer 2000;8 Suppl:160, Abstract 63.
De Pauw 1983 {published data only}
  • De Witte T. Antibiotic treatment in patients with haematological malignancies and bone marrow transplantation. Perspectives on Therapeutics in Northern Europe. Vol. 46, London: Glaxo, 26 September 1986:6-7.
  • de Pauw BE, Kauw F, Muytjens H, Williams KJ, Bothof T. Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients. Journal of Antimicrobial Chemotherapy 1983;12 Suppl A:93-9.
De Pauw 1994 {published and unpublished data}
  • De Pauw BE, Deresinski SC, Feld R, Lane Allman EF, Donnelly JP. Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer: a multicenter randomized trial. The Intercontinental Antimicrobial Study Group. Annals of Internal Medicine 1994;120(10):834-44.
  • De Pauw BE, Feld R, Deresinski S, Donnelly JP, Lane-Allman E. Multicentre, randomised, comparative study of ceftazidime vs piperacillin as empirical therapy for febrile granulocytic patients. Proceedings of the Sixth International Symposium of Infections in the Immunocompromised Host. Abstract No 116. 1990.
  • Dompeling EC, Donnelly JP, Deresinski SC, Feld R, Lane Allman EF, De Pauw BE. Early identification of neutropenic patients at risk of gram positive bacteraemia and the impact of empirical administration of vancomycin. European Journal of Cancer 1996;32a(8):1332-9.
Dincol 1998 {published and unpublished data}
  • Dincol D, Arican A, Aydin F, Samur M, Willke A, Akbulut H, et al. A comparison of imipenem monotherapy versus cefoperazone/sulbactam plus amikacin combination treatment in febrile neutropenic cancer patients. Cancer Journal 1998;11(2):89-93.
Doyen 1983 {published and unpublished data}
  • Doyen C, Tepantondele JM, Wauters G, Michaux JL. A randomized therapeutic trial for ceftazidime versus ceftazidime and amikacin in febrile granulopenic patients. Proceedings of the 13th International Congress of Chemotherapy. Vienna: Spitzy KH, 1983:26-29.
Duzova 2001 {published and unpublished data}
  • Duzova A, Kutluk T, Kanra G, Buyukpamukcu M, Akyuz C, Secmeer G, Ceyhan, M. Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors. The Turkish Journal of Pediatrics 2001;43(2):105-9.
El Haddad 1995 {published data only}
  • El Haddad AMA. Comparison of cefoperazone-sulbactam versus piperacillin plus amikacin as empiric therapy in pediatric febrile neutropenic cancer patients. Current Therapeutic Research Clinical and Experimental 1995;56(10):1094-9.
Erjavec 1994 {published data only}
  • Erjavec Z, de Vries Hospers HG, van Kamp H, van der Waaij D, Halie MR, Daenen SM. Comparison of imipenem versus cefuroxime plus tobramycin as empirical therapy for febrile granulocytopenic patients and efficacy of vancomycin and aztreonam in case of failure. Scandinavian Journal of Infectious Diseases 1994;26(5):585-95.
Esteve 1997 {published data only}
  • Esteve J, Nomdedeu B, Mensa J, Guardia R, Marco F, Montserrat E. Piperacillin/tazobactam vs. piperacillin/tazobactam plus amikacin as empiric therapy for fever in neutropenic patients. Blood 1997;10(Suppl 1 (Pt 2)):229b. Abstract 3767.
Gaytan-Martinez 2002 {published data only}
  • Gaytan-Martinez JE, Mateos-Garcia E, Casanova LJ, Fuentes-Allen JL, Sanchez-Cortes E, Manjarrez-Tellez B, et al. Efficacy of empirical therapy with cefepime compared with ceftazidime plus amikacin in febrile neutropenic patients. Proceedings of the Annual Meeting of the American Society of Hematology. 2002:Abstract No. 3655.
Gibson 1989 {published data only}
  • Gibson J, Date L, Joshua DE, Young GA, Wilson A, Benn R, et al. A randomised trial of empirical antibiotic therapy in febrile neutropenic patients with hematological disorders: ceftazidime versus azlocillin plus amikacin. Australian and New Zealand Journal of Medicine 1989;19(5):417-25.
Gorschluter 2003 {published data only}
  • Glasmacher A, Hahn C, Molitor E, Fixson A, Mey U, Sauerbruch T, et al. A randomized comparison of piperacillin-tazobactam vs. ceftriaxone and gentamicin in 172 severely neutropenic patients with hematologic malignancies. Proceedings of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1999:Abstract 1090.
  • Gorschluter M, Hahn C, Fixson A, Mey U, Ziske C, Molitor E, et al. Piperacillin-tazobactam is more effective than ceftriaxone plus gentamicin in febrile neutropenic patients with hematological malignancies: a randomized comparison. Supportive Care in Cancer 2003;11(6):362-70.
Gribble 1983 {published data only}
  • Gribble MJ, Chow AW, Naiman SC, Smith JA, Bowie WR, Sacks SL, et al. Prospective randomized trial of piperacillin monotherapy versus carboxypenicillin-aminoglycoside combination regimens in the empirical treatment of serious bacterial infections. Antimicrobial Agents and Chemotherapy 1983;24(3):388-93.
Hansen 1986 {published data only}
Hense 2000 {published and unpublished data}
  • Hense J, Bertz H, Leifert J, Meusers P, Mertelsmann R, Brittinger G. Final results of a prospective randomized trial of bolus meropenem versus infusion meropenem versus ceftazidime/amikacin as empiric initial therapy for infections and fever of unknown origin in neutropenic patients with hematologic malignancies. Supportive Care in Cancer 2000;8:Suppl:160. Abstract 64.
  • Hense J, Uppenkamp M, Meusers P, Hofeler H, Brittinger G. Prospective randomized trial of bolus meropenem versus infusion meropenem versus ceftazidime/amikacin as empiric initial therapy for infections and fever of unknown origin in neutropenic patients with hematologic malignancies. Annals of Hematology 1998;77:Suppl 2:S199.
Hess 1998 {published data only}
  • Hess UBC, Rey K, Senn HJ. Monotherapy with piperacillin/tazobactam versus combination therapy with ceftazidime plus amikacin as an empiric therapy for fever in neutropenic cancer patients. Supportive Care in Cancer 1998;6:402-9.
Hung 2003 {published data only}
  • Hung KC, Chiu HH, Tseng YC, Wang JH, Lin HC, Tsai FJ, et al. Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empirical therapy for neutropenic fever in children with malignancy. Journal of Microbiology, Immunology, and Infection 2003;36(4):254-9.
Jacobs 1993 {published data only}
Jimeno 2006 {published and unpublished data}
  • Jimeno A, Arcediano A, Bazares S, Amador ML, Gonzalez-Cortijo L, Ciruelos E, et al. Randomized study of cefepime versus ceftazidime plus amikacin in patients with solid tumors treated with high dose chemotherapy (HDC) and peripheral blood stem cell support (PBSCS) with febrile neutropenia. Clinical Transplantation and Oncology 2006;8(12):889-95.
  • Jimeno A, Arcediano A, Gomez C, Bezares S, Castellano D, Paz-Ares L, et al. Randomized study of cefepime versus ceftazidime plus amikacin in febrile neutropenic patients with solid tumors treated with high dose chemotherapy (HDC) and peripheral blood stem cell support (PBSCS). Proceedings of the Annual Meeting of the American Society of Clinical Oncology; Abstract 3387. 2003.
Kiehl 2001 {published data only}
  • Kiehl MG, Bischoff M, Basara N, Guenzelmann S, Fauser AA. A prospective randomized trial comparing the efficacy and safety of piperacillin/tazobactam versus piperacillin/tazobactam plus netilmicin in the treatment of tebrile neutropenia in allogeneic stem cell recipients. Proceedings of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2001.
Kinsey 1990 {published data only}
  • Kinsey SE, Machin SJ, Goldstone AH. Ceftazidime monotherapy is as effective as ceftazidime combined with gentamicin in the treatment of febrile neutropenic patients. Journal of Hospital Infection 1990;15:49-53.
Kliasova 2001 {published data only}
  • Kliasova G, Savchenko V, Lubimova L, Mendeleeva L, Parovichnikova E, Tolkacheva T, et al. Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for febrile neutropenic bone marrow transplant patients. Proceedings of the 11th European Congress of Clinical Microbiology and Infectious Diseases. 2001. [MEDLINE: http://www.akm.ch/eccmid2001/]
Koehler 1990 {published data only}
  • Koehler M, Bubala H, Sonta-Jakimczyk D, Wieczorek M, Janik-Moszant A, Kuder K. [Assessment of the efficacy of treating infections in hematopoietic proliferative diseases: monotherapy with ceftazidime and tobramycin combined with amoxycillin/ampicillin]. Pol Tyg Lek 1990;45(21-22):417-20.
Kojima 1994 {published and unpublished data}
  • Kojima A, Shinkai T, Soejima Y, Okamoto H, Eguchi K, Sasaki Y, et al. A randomized prospective study of imipenem-cilastatin with or without amikacin as an empirical antibiotic treatment for febrile neutropenic patients. American Journal of Clinicial Oncology 1994;17(5):400-4.
Leyland 1992 {published data only}
  • Leyland MJ, Bayst K, Cohen J, Warren R, Newland AC, Bint AJ, et al. A comparative study of imipenem versus piperacillin plus gentamicin in the initial management of febrile neutropenic patients with haematological malignancies. Journal of Antimicrobial Chemotherapy 1992;30(6):843-54.
Lieschke 1990 {published and unpublished data}
  • Lieschke GJ, Bell D, Rawlinson W, Green M, Sheridan W, Morstyn G, et al. Imipenem/cilastatin versus tobramycin and piperacillin as initial empiric therapy for febrile episodes in neutropenic patients: interim analysis of a prospective randomized comparison. Australian and New Zealand Journal of Medicine 1990;3:Suppl 1:424.
Liu 1989 {published data only}
  • Liu CY, Wang FD. A comparative study of ceftriaxone plus amikacin, ceftazidime plus amikacin and imipenem/cilastatin in the empiric therapy of febrile granulocytopenic cancer patients. Chemotherapy 1989;35:Suppl 2:16-22.
Marie 1991 {published data only}
  • Marie JP, Pico J, Lapierre V, Maulard C, Pappo M, Chiche D, et al. Comparative trial of ceftazidime alone, ceftazidime + amikacin and ceftazidime + vancomycin as empiric therapy of febrile cancer patients with induced prolonged neutropenia [Traitement empirique des episodes febriles survenant chez les patients cancereux presentant une neutropenie prolongee: essai comparatif ceftazidime seule, ceftazidime+amikacine et ceftazidime+vancomycine]. Medicine et Maladies Infectieuses 1991;21:386-8.
  • Marie JP, Pico JL, Chiche D, Fitoussi F, Delmer A, Baume D, et al. [Antibiotic therapy protocol using ceftazidime 3g/day alone or in combination with vancomycin or amikacin. In febrile episodes in neutropenic patients]. [French] [Protocole d'antibiotherie utilisant la ceftazidime a la dose de 3g/jour seule ou en association avec la vancomycin ou l'amikacin]. Presse Medicale 1988;17(37):1968-70.
  • Marie JP, Vekhoff A, Pico JL, Guy H, Andremont A, Richet H. Neutropenic infections: a review of the French Febrile Aplasia Study Group trials in 608 febrile neutropenic patients. Journal of Antimicrobial Chemotherapy 1998;41(Suppl D):57-64.
  • Pico JL, Marie JP, Chiche D, Guiguet M, Andremont A, Lapierre V, et al. Should vancomycin be used empirically in febrile patients with prolonged and profound neutropenia? Results of a randomized trial. Eur J Med 1993;2(5):275-80.
Matsui 1991 {published and unpublished data}
  • Matsui K, Masuda N, Takada M, Kusunoki Y, Fukuoka M. A randomized trial comparing imipenem/cilastatine alone with latamoxef plus tobramycin in febrile neutropenic patients with lung cancer. Jpn J Clin Oncol 1991;21(6):428-34.
Miller 1993 {published data only}
  • Miller JA, Butler T, Beveridge RA, Kales AN, Binder RA, Smith LJ, et al. Efficacy and tolerability of imipenem-cilastatin versus ceftazidime plus tobramycin as empiric therapy of presumed bacterial infection in neutropenic cancer patients. Clinical Therapeutics 1993;15(3):486-99.
Morgan 1983 {published data only}
  • Morgan G, Duerden BI, Lilleyman JS. Ceftazidime as a single agent in the management of children with fever and neutropenia. Journal of Antimicrobial Chemotherapy 1983;12:Suppl A:347-51.
Norrby 1987 {published and unpublished data}
  • Norrby SR, Vandercam B, Louie T, Runde V, Norberg B, Anniko M, et al. Imipenem/cilastatin versus amikacin plus piperacillin in the treatment of infections in neutropenic patients: a prospective, randomized multiclinic study. Scandinavian Journal of Infectious Diseases Supplement 1987;52:65-78.
  • Vandercam B, Ezzeddine H, Agaliotis D, Gala JL, Gigi J, Wauters G, et al. Imipenem/cilastatin versus piperacillin plus amikacin as empiric therapy in the treatment of febrile episodes in neutropenic patients with haematologic malignancies. Acta Clinica Belgica 1989;44(2):99-109.
Novakova 1990 {published data only}
  • Novakova I, Donnelly P, De Pauw B. Amikacin plus piperacillin versus ceftazidime as initial therapy in granulocytopenic patients with presumed bacteremia. Scandinavian Journal of Infectious Diseases 1990;22(6):705-11.
Novakova 1991 {published data only}
  • Novakova IR, Donnelly JP, de Pauw BE. Ceftazidime with or without amikacin for the empiric treatment of localized infections in febrile, granulocytopenic patients. Annals of Hematology 1991;63(4):195-200.
Ozyilkan 1999 {published and unpublished data}
  • Ozyilkan O, Yalcintas U, Baskan S. Imipenem-cilastatin versus sulbactam-cefoperazone plus amikacin in the initial treatment of febrile neutropenic cancer patients. The Korean Journal of Internal Medicine 1999;14(2):15-9.
Papachristodoulou 96 {published data only}
  • Papachristodoulou A, Vaslamatzis M, Xynogalos S, Papacharalambous A, Alexopoulos CG. Ceftazidime (CFZ) monotherapy as empirical initial treatment of febrile neutropenia cancer patients (Pts). Annals of Oncology 1996;7:Suppl 5:140. Abstract 676.
Pegram 1984 {published data only}
  • Pegram SP, Muss HB, McGall CE, Cooper RM, White DR, Richards F, et al. A comparative study of moxalactam vs. ticarcillin and tobramycin in febrile, neutropenic cancer patients. Proceedings of the Annual Meetings of the American Society of Clinical Oncology; Abstract No. 255. 1982.
  • Pegram SP, Muss HB, McGall CE, Cooper RM, White DR, Richards T, et al. A comparative study of moxalactam vs. ticarcillin and tobramycin in febrile, neutropenic cancer patients. Proceedings of the Annual Meetings of the American Society of Clinical Oncology; Abstract No. 391. 1984.
Pellegrin 1988 {published data only}
  • Pellegrin JL, Marit G, Fourche J, Broustet A, Texier MJ, Leng B, et al. Response to infection in patients with acute leukemia during remission induction treatment: ceftazidime versus cefotaxime + tobramycin [Etude prospective randomisee de la ceftazidime versus l'association cefotaxime-tobramycine, dans les leucemies aigues en aplasie therapeutique]. Presse Med 1988;17(37):1960-3.
Pereira 2009 {published data only (unpublished sought but not used)}
  • Pereira CAP, Petrilli AS, Carlesse FA, Luisi FAV, da Silva KVTB, Lee MLM. Cefepime monotherapy is as effective as ceftriaxone plus amikacin in pediatric patients with cancer and high-risk febrile neutropenia in a randomized comparison. Journal of Microbiology, Immunology and Infection 2009;42(2):141-7.
Perez 1995 {published data only}
  • Perez C, Sirham M, Labarca J, Grebe G, Lira P, Oliva J, et al. [Imipenem/cilastatin versus ceftazidime-amikacin in the treatment of febrile neutropenic patients] [Imipenem/cilastatina versus ceftazidima-amikacina para el tratmiento de pacientes neutropenicos febriles]. Revista Medica de Chile 1995;123(3):312-20.
Petrilli 2003 {published and unpublished data}
  • Petrilli AS, Cypriano M, Dantas LS, Lee LM, Vercillo Luisi MF, Torres B, et al. Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma.. Brazilian Journal of Infectious Diseases 2003;7(2):111-20.
Piccart 1984 {published data only}
  • Piccart M, Klastersky J, Meunier F, Lagast H, Van Laethem Y, Weerts D. Single-drug versus combination empirical therapy for gram-negative bacillary infections in febrile cancer patients with and without granulocytopenia. Antimicrobial Agents and Chemotherapy 1984;26(6):870-5.
Pickard 1983 {published and unpublished data}
  • Pickard W, Durack D, Gallis H. A randomized trial of empiric therapy with moxalactam versus tobramycin plus ticarcillin in febrile, neutropenic patients. Current Choices in Antibiotic Therapy for Febrile Episodes in Neutropenic Patients. 1983.
  • Pickard W, Durack D, Gallis H. A randomized trial of moxalactam versus tobramycin plus ticarcillin in 50 febrile neutropenic patients. Proceedings of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy; Abstract No. 66. 1982.
  • Pickard W, Gallis HA, Durack DT. A randomized trial of empiric therapy with moxalactam versus tobramycin plus ticarcillin in febrile neutropenic patients. Proceedings of the Second International Symposium in Infections in the Immunocompromised Host. 1982.
Piguet 1988 {published data only}
  • Piguet H, Pappo M. First-line treatment of febrile episodes in leukemia in adults: randomized, multicenter study of ceftazidime in single antibiotic therapy versus a cefotaxime-amikacin combination [Traitment de premiere intention des episodes febriles des leucemies de l'adulte. Etude randomisee, multicentrique de la ceftazidime en monoantibiotherapie versus l'association cefotaxime-amikacine]. Presse Med 1988;17(37):1954-9.
Rodjer 1987 {published data only}
  • Rodjer S, Alestig K, Bergmark J, Bergstrom T, Hultberg B, Jagenburg R, et al. Treatment of septicaemia in immunocompromised patients with ceftazidime or with tobramycin and cefuroxime, with special reference to renal effects. Journal of Antimicrobial Chemotherapy 1987;20(1):109-16.
Rodriguez 1995 {published data only}
  • Rodriguez W, Gomez H, Silva ME, Vallejos C, Valdivia S, Casanova L, et al. Cefotaxime vs cephalotin-gentamicin in the first febrile episode of patients having solid tumors and short-term neutropenia. Acta Cancer 1995;25:61-8.
Rolston 1992 {published data only}
  • Rolston KV, Berkey P, Bodey GP, Anaissie EJ, Khardori NM, Joshi JH, et al. A comparison of imipenem to ceftazidime with or without amikacin as empiric therapy in febrile neutropenic patients. Archives of Internal Medicine 1992;152(2):283-91.
Schuchter 1988 {published data only}
  • Schuchter L, Kaelin W, Petty B, Wingard J, Altomonte V, Dick J, et al. Ceftazidime vs ticalcillin and gentamicin in febrile neutropenic bone marrow transplant patients: a prospective, randomized, double-blind trial. Blood 1988;Abstract 1534(Suppl 1):1:406a.
Smith 1990 {published and unpublished data}
Tamura 2002 {published and unpublished data}
Tamura 2004 {published and unpublished data}
  • Tamura K, Imajo K, Akiyama N, Suzuki K, Urabe A, Ohyashiki K, et al. Randomized trial of cefepime monotherapy or cefepime in combination with amikacin as empirical therapy for febrile neutropenia. Clinical Infectious Diseases 2004;39:S15-24.
Wade 1987 {published data only}
  • Bustamante CI. Initial empiric therapy for fever in neutropenia. Recent Results in Cancer Research 1993;132:45-56.
  • Wade JC. Antibiotic therapy for the febrile granulocytopenic cancer patient: combination therapy versus monotherapy. Reviews of Infectious Diseases 1989;11:Suppl 7:S1572-81.
  • Wade JC, Delin A, Finely R, Drusano G, Thompson B. Imipenem versus piperacillin plus amikacin, empiric therapy for febrile neutropenic patients: a double blind trial. Proceedings of the 27th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1987:Abstract No. 1251.
Wrzesien-Kus 2001 {published and unpublished data}
  • Wrzesien-Kus A, Jamroziak K, Wierzbowska A, Robak T. Cefepime in monotherapy or in combination with amikacine as the empirical treatment of febrile neutropenic patients. Acta Haematologica Polonica 2001;32(2):165-72.
Yamamura 1997 {published and unpublished data}
  • Ramphal R, Gucalp R, Rotstein C, Cimino M, Oblon D. Clinical experience with single agent and combination regimens in the management of infection in the febrile neutropenic patient. American Journal of Medicine 1996;100(6a):83s-9s.
  • Yamamura D, Gucalp R, Carlisle P, Cimino M, Roberts J, Rotstein C. Open randomized study of cefepime versus piperacillin-gentamicin for treatment of febrile neutropenic cancer patients. Antimicrobial Agents and Chemotherapy 1997;41(8):1704-8.
Yildirim 2008 {published data only (unpublished sought but not used)}
  • Yildirim I, Aytac S, Ceyhan M, Cetin M, Tuncer M, Cengiz AB, et al. Piperacillin/tazobactam plus amikacin versus carbapenem monotherapy as empirical treatment of febrile neutropenia in childhood hematological malignancies. Pediatric Hematology and Oncology 2008;25:291-9.
Zengin 2011 {published and unpublished data}
  • Zengin E, Sarper N, Kiliç S. Piperacillin/tazobactam monotherapy versus piperacillin/tazobactam plus amikacin as initial empirical therapy for febrile neutropenia in children with acute leukemia. Pediatric Hematology and Oncology 2011;28:311-20.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Berezin 2003 {published data only}
  • Berezin EN, Almeida FJ, Santos AG, Arnoni M, Safadi M, Peixoto F, et al. Asessment of cefepime monotherapy versus combined therapy with ceftriaxone and aminoglycoside in oncologic children and adolescents with febrile neutropenia. Proceedings of the 13th European Congress of Clinical Microbiology and Infectious Diseases. 2003:UK. Poster 836. [MEDLINE: http://www.akm.ch/eccmid2003/]
Bodey 1976 {published data only}
  • Bodey GP, Feld R, Burgess MA. Beta-lactam antibiotics alone or in combination with gentamicin for therapy of gram-negative bacillary infections in neutropenic patients. American Journal of Medicine 1976;271(2):179-86.
Bru 1986 {published data only}
  • Bru JP, Michallet M, Legrand C, Swierz P, Stahl JP, Leautet JB, et al. A prospective randomized study comparing the efficacy of timentin alone or in combination with amikacin in the treatment of febrile neutropenic patients. Journal of Antimicrobial Chemotherapy 1986;17:Suppl C:203-9.
Cetto 1983 {published data only}
  • Cetto GL, Todeschini G, Caramaschi G, Vinante F, Benini F, Perona G. Empiric therapy of infections in hematologic malignancies: a prospective, randomized trial. Tumori 1983;69:155-60.
D'Antonio 1992 {published data only}
  • D'Antonio D, Fioritoni G, Iacone A, Dell'Isola M, Natale D, D'Arcangelo L, et al. Randomized comparison of ceftriaxone versus ceftriaxone plus amikacin for the empirical treatment of infections in patients with altered host defense: microbiological and clinical evaluation. Chemotherapy 1992;38(6):420-7.
Drusano 1985 {published data only}
  • Drusano GL, Joshi J, Forrest A, Ruxer R, Standiford H, Leslie J, et al. Pharmacokinetics of ceftazidime, alone or in combination with piperacillin or tobramycin, in the sera of cancer patients. Antimicrobial Agents and Chemotherapy 1985;27(4):605-7.
EORTC 1987 {published data only}
  • The EORTC International Antimicrobial Therapy Cooperative Group. Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. New England Journal of Medicine 1987;317(27):1692-8.
Fainstein 1983 {published data only}
  • Fainstein V, Bodey GP, Elting L, Bolivar R, Keating MJ, McCredie KB, et al. A randomized study of ceftazidime compared to ceftazidime and tobramycin for the treatment of infections in cancer patients. Journal of Antimicrobial Chemotherapy 1983;12:Suppl A:101-10.
Hauer 1990 {published data only}
Hazel 1998 {published data only}
  • Hazel DL, Phelan L, Kinsey SE, Picton S, Todd N, Hawkey PM, et al. Piperacillin-tazobactam plus tobramycin is safe and effective therapy in children with febrile neutropenic episodes who are colonised with Enterobacteriaceae expressing extended spectrum β-lactamases. Blood 1998;10:Suppl 1 (Pt 1):612a. Abstract 2526.
Hoepelman 1988 {published data only}
  • Hoepelman IM, Rozenberg-Arska M, Verhoef J. Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections: the efficacy, safety and effect on fecal flora. Chemotherapy 1988;34:Suppl 1:21-9.
  • Hoepelman IM, Rozenberg-Arska M, Verhoef J. Comparison of once daily ceftriaxone with gentamicin plus cefuroxime for treatment of serious bacterial infections. Lancet 1988;1(8598):1305-9.
Karthaus 1998 {published data only}
  • Karthaus M, Wolf H, Egerer G, Kampfe D, Suedhoff T, Ritter J, et al. Ceftriaxone in the treatment of solid tumour patients with febrile neutropenia. Onkologie 1998;21:212-6.
Moreno-Sanchez 1992 {published data only}
  • Moreno-Sanchez FGR, Lazaro RM, Tellez E, Torres E. Monotherapy in patients with neutropenic fever. Proceedings of the American Society for Clinical Oncology. 1992:Abstract No. 1364.
Moroni 1987 {published data only}
  • Moroni C, Viscoli C, Boni L, Garaventa A, Dini G, Haupt R, et al. A randomized study of the empirical antibiotic therapy of the infections in neutropenic patients, affected by neoplastic diseases in paediatric age and under a fever attack. Giornale di Malattie Infettive e Parassitarie (Journal of Infectious and Parasitic Dieases) 1987;39:1194-8.
Pegram 1989 {published data only}
  • Pegram PS, Phair JP, McMahan R, Murphy RL, Gordon LI, Washton H, et al. Prospective comparative trial of short course (four day) and continuous tobramycin in combination with cefoperazone or mezlocillin in febrile, granulocytopenic patients. Journal of Antimicrobial Chemotherapy 1989;24(4):591-604.
Petrilli 1991 {published data only}
  • Petrilli AS, Melarango R, Bianchi A, Kussano E, Barros KVT, Silva AAM. Fever and neutropenia in children: a new therapeutic proposal. Revista da Associação Médica Brasileira 1991;37(4):173-80.
Pizzo 1986 {published data only}
  • Pizzo PA, Hathorn JW, Hiemenz J, Browne M, Commers J, Cotton D, et al. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. New England Journal of Medicine 1986;315:552-8.
Reilly 1983 {published data only}
  • Reilly JT, Brada M, Bellingham AJ, Hart CA, Bennet C. Ceftazidime compared to tobramycin and ticarcillin in immunocompromised haematological patients. Journal of Antimicrobial Chemotherapy 1983;12:Suppl A:89-92.
Sampi 1987 {published data only}
  • Sampi K, Kumai R, Maseki N, Sakurai M, Kaneko Y, Hattori M. Cefmenoxime or piperacillin plus amikacin: a prospective randomized comparison of empiric antibiotic therapy of febrile granulocytopenic cancer patients. Gan to Kagaku Ryoho Cancer & Chemotherapy 1987;14:674-9.
Sanz 2005 {published data only}
  • Sanz MA, Bermudez A, Rovira M, Besalduch J, Pascual MJ, Nocea G, et al. Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE study.. Current Medical Research and Opinion 2005;21(5):645-55.
Sawae 1996 {published data only}
  • Sawae Y, Niho Y, Okamura T, Gondo H, Kozuru M, Uike N, et al. [Comparison between monotherapy with imipenem/cilastatin sodium (IPM/CS) and combinations of IPM/CS and other drugs for treating bacterial infections in patients with hematopoietic disorders]. [Japanese]. Jpn J Antibiot 1996;49(12):1049-61.
Wrzesien-Kus 2000 {published data only}
  • Wrzesien-Kus AL-ME, Robak T. Cefepime or ceftazidime in combination with amikacin as the empirical treatment of febrile neutropenic patients. Acta Haematologica Polonica 2000;31(1):79-85.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Li 1998 {published data only}
  • Li HC, Zhang M, Ye X. Evidence of treating febrile neutropenia with netilmicin-ceftazidime. Clinical Assembly 1998;13(23):1057-8.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Bilgir 2005 {published data only}
  • Bilgir O, Kadikoylu V, Bilgir F. The comparison of imipenem with piperacillin/tazobactam and amikacin combination in patients with hematological malignancies in the treatment of febrile neutropenia. Proceedings of the 10th Congress of the European Hematology Association. 2005:Abstract No. 1021.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Allan 1985
  • Allan JD, Moellering RC Jr. Management of infections caused by gram negative bacilli: the role of antimicrobial combinations. Reviews of Infectious Diseases 1985;7:Suppl 4:S559-71.
Bliziotis 2005
  • Bliziotis IA, Samonis G, Vardakas KZ, Chrysanthopoulou S, Falagas ME. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials. Clinical Infectious Diseases 2005;41(2):149-58.
Bodey 1966
Bodey 1972
Chow 1991
  • Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Annals of Internal Medicine 1991;115(8):585-90.
Consensus 1990
  • Anonymous. From the Immunocompromised Host Society. The design, analysis, and reporting of clinical trials on the empirical antibiotic management of the neutropenic patient: report of a consensus panel. Journal of Infectious Diseases 1990;161(3):397-401.
Elphick 2001
Elting 1997
  • Elting LS, Rubenstein EB, Rolston KV, Bodey GP. Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials. Clinical Infectious Diseases 1997;25(2):247-59.
Freifeld 2011
  • Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2011;52(4):e56-93.
Giamarellou 1984
  • Giamarellou H, Zissis P, Tagari G, Bouzos J. In vitro synergistic activities of aminoglycosides and new beta lactams against multiresistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 1984;25(4):534-6.
Giamarellou 1986
  • Giamarellou H. Aminoglycosides plus beta lactams against gram negative organisms: evaluation of in vitro synergy and chemical interactions. American Journal of Medicine 1986;80:Suppl 6B:126-37.
Hann 1997
  • Hann I, Viscoli C, Paesmans M, Gaya H, Glauser M. A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC). British Journal of Haematology 1997;99(3):580-8.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hughes 1990
  • Hughes WT, Armstrong D, Bodey GP, Feld R, Mandell GL, Meyers JD, et al. From the Infectious Diseases Society of America: guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Journal of Infection 1990;161(3):381-96.
Hughes 1997
  • Hughes WT, Armstrong D, Bodey GP, Brown AE, Edwards JE, Feld R, et al. From the Infectious Diseases Society of America: 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Clinical Infectious Diseases 1997;25(3):551-73.
Klastersky 1976
Klastersky 1982
  • Klastersky J, Zinner SH. Synergistic combinations of antibiotics in gram negative bacillary infections. Review of Infectious Diseases 1982;4(2):294-301.
Klastersky 1986
  • Klastersky J, Glauser MP, Schimpff SC, Zinner SH, Gaya H. Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrobial Agents and Chemotherapy 1986;29(2):263-70.
Lin 2001
Marcus 2011
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Milatovic 1987
  • Milatovic D, Braveny I. Development of resistance during antibiotic therapy. European Journal of Clinical Microbiology and Infectious Diseases 1987;6(3):234-44.
Paul 2003
  • Paul M, Soares-Weiser K, Leibovici L. Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis. BMJ 2003;326:1111.
Paul 2004
  • Paul M, Benuri-Silbiger I, Soares-Weiser K, Leibovici L. Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials. BMJ 2004;328(7441):668.
Paul 2006
  • Paul M, Yahav D, Fraser A, Leibovici L. Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials. Antimicrobial Agents & Chemotherapy 2006;57(2):176-89.
Paul 2006a
Rossini 1994
  • Rossini F, Pioltelli P, Mingozzi S, Bregani R, Vigano F, Bolis S, et al. Amikacin and ceftazidime as empirical antibiotic therapy in severely neutropenic patients: analysis of prognostic factors. Supportive Care in Cancer 1994;2(4):259-65.
Schimpff 1971
  • Schimpff S, Satterlee W, Young VM, Serpick A. Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. New England Journal of Medicine 1971;284(19):1061-5.
Schimpff 1986
  • Schimpff SC. Empiric antibiotic therapy for granulocytopenic cancer patients. American Journal of Medicine 1986;80:Suppl 5C:13-20.
Schulz 1995
Talcott 1992
  • Talcott JA, Siegel RD, Finberg R, Goldman L. Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule. Journal of Clinical Oncology 1992;10(2):316-22.
Tam 2011
Vardakas 2013
  • Vardakas KZ, Tansarli GS, Bliziotis IA, Falagas ME. β-Lactam plus aminoglycoside or fluoroquinolone combination versus β-lactam monotherapy for Pseudomonas aeruginosa infections: a meta-analysis. International Journal of Antimicrobial Agents 2013;41(4):301-10.
Wade 1989
  • Wade JC. Antibiotic therapy for the febrile granulopenic cancer patient: combination therapy versus monotherapy. Review of Infectious Diseases 1989;11:Suppl 7:S1572-81.
Weistein 1985
  • Weistein L. Gram negative bacterial infections: a look at the past, a view of the present, and a glance at the future. Review of Infectious Diseases 1985;7:Suppl 4:S538-44.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Paul 2003a
  • Paul M, Soares-Weiser K, Leibovici L. Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis. BMJ 2003;326:1111.