Intervention Review

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Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma

  1. Sebastian Weis1,*,
  2. Annegret Franke2,
  3. Joachim Mössner1,
  4. Janus C Jakobsen3,
  5. Konrad Schoppmeyer4

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 19 DEC 2013

Assessed as up-to-date: 19 SEP 2012

DOI: 10.1002/14651858.CD003046.pub3


How to Cite

Weis S, Franke A, Mössner J, Jakobsen JC, Schoppmeyer K. Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD003046. DOI: 10.1002/14651858.CD003046.pub3.

Author Information

  1. 1

    University of Leipzig, Division of Gastroenterology and Rheumatology Department of Internal Medicine, Neurology and Dermatology, Leipzig, Germany

  2. 2

    Universität Leipzig, Zentrum für Klinische Studien (ZKS) Leipzig, Leipzig, Germany

  3. 3

    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, The Cochrane Hepato-Biliary Group, Copenhagen, Sjælland, Denmark

  4. 4

    Euregio-Klinik GmbH, Internal Medicine, Nordhorn, Germany

*Sebastian Weis, Division of Gastroenterology and Rheumatology Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Liebigstrasse 20, Leipzig, 04103, Germany. sebastian.weis@medizin.uni-leipzig.de.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 19 DEC 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Brunello 2008 {published data only}
  • Brunello F, Veltri A, Carucci P, Pagano E, Ciccone G, Moretto P, et al. Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: a randomized controlled trial. Scandinavian Journal of Gastroenterology 2008;43:727-35.
Chen 2006 {published data only}
  • Chen MS, Li JQ, Zheng Y, Go RP, Liang HH, Zhang YQ, et al. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Annals of Surgery 2006;243(3):321-8.
Feng 2012 {published data only}
  • Feng K, Yan J, Li X, Ma K, Wang S, Bie P, et al. A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. Journal of Hepatology 2012;57(4):794-802.
Ferrari 2007 {published data only}
  • Ferrari FS, Mgliola A, Scorzelli A, Stella A, Vigni F, Drudi FM, et al. Treatment of small HCC through radiofrequency ablation and laser ablation. Comparison of techniques and long-term results. La Radiologia Medica 2007;112(3):377-93.
Giorgio 2011 {published data only}
  • Giorgio A, Di Sarno A, De Stefano G, Scognamiglio U, Farella N, Mariniello A, et al. Percutaneous radiofrequency ablation of hepatocellular carcinoma compared to percutaneous ethanol injection in treatment of cirrhotic patients: an Italian randomized controlled trial. Anticancer Research 2011;31(6):2291-5.
Huang 2010 {published data only}
  • Huang J, Yan L, Cheng Z, Wu H, Du L, Wang J, et al. A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria. Annals of Surgery 2010;252(6):903-12.
Lencioni 2003 {published data only}
  • Lencioni R, Allgaier HP, Cioni D, Olschewski M, Deibert P, Crocetti L, et al. Small hepatocellular carcinoma: randomized comparison of radio-frequency thermal ablation and percutaneous ethanol injection. Radiology 2003;228:235-40.
Lin 2004 (RFA vs. PEI) {published data only}
  • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YG. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4 or less than 4 cm. Gastroenterology 2004;127:1714-23.
Lin 2004 (RFA vs. PEI-hd) {published data only}
  • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YG. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4 or less than 4 cm. Gastroenterology 2004;127:1714-23.
Lin 2005 (RFA vs. PAI) {published data only}
  • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less. Gut 2005;54(8):1151-6.
Lin 2005 (RFA vs. PEI) {published data only}
  • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less. Gut 2005;54(8):1151-6.
Shibata 2002 {published data only}
  • Shibata T, Iimuro Y, Yamamoto Y, Maetani Y, Ametani F, Itoh K, et al. Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology 2002;223:331-7.
Shiina 2005 {published data only}
  • Shiina S, Teratani T, Obi S, Sato S, Tateishi R, Fujishima T, et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 2005;129(1):122-30.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Akamatsu 2004 {published data only}
Amarnath 2006 {published data only}
  • Amarnath S, Griffith KA, Higgins E, Lawrence TS, Rubin J, Pan CC. Comparison of patients with hepatocellular carcinoma (HCC) treated with external beam radiotherapy (EBRT) or radiofrequency ablation (RFA). International Journal of Radiation Oncology, Biology, Physics 2006;66(3 Suppl):1071.
Buscarini 1996 {published data only}
  • Buscarini L, Di Stasi M, Buscarini E, Fornari F, Squassante L, Rossi S, et al. Clinical presentation, diagnostic work-up and therapeutic choices in two consecutive series of patients with hepatocellular carcinoma. Oncology 1996;53(3):204-9.
Chen 2005 {published data only}
  • Chen MS, Zhang YJ, Li JQ, Liang HH, Zhang YQ, Zheng Y. Randomized clinical trial of percutaneous radiofrequency ablation plus absolute ethanol injection compared with radiofrequency alone for small hepatocellular carcinoma. Chinese Journal of Oncology 2005;27(10):623-5.
Cheng 2008 {published data only}
  • Cheng BQ, Jia CQ, Liu CT, Fan W, Wang QL, Zhang ZL, et al. Chemoembolization combined with radiofrequency ablation for patients with hepatocellular carcinoma larger than 3 cm: a randomized controlled trial. Journal of the American Medical Association 2008;299(14):1669-77.
Cho 2010 {published data only}
Cuschieri 1999 {published data only}
Gan 2004 {published data only}
  • Gan YH, Yie SH, Ren ZG, Xia JL, Zhang BH, Wang YH, et al. Prospective randomized trial of RFA and chemotherapy for unresectable small hepatocellular carcinoma. Chinese Journal of Oncology 2004;26(8):496-8.
Giorgio 2011a {published data only}
  • Giorgio A, Farella N, Di Sarno A, Scognamiglio U, De Stefano G, De Rogatis A, et al. Western trial comparing percutaneous radiofrequency of both hepatocellular carcinoma and the portal venous tumor thrombus plus sorafenib with sorafenib alone. Journal of Hepatology 2011;54(Suppl 1):S542.
Goldberg 1998 {published data only}
  • Goldberg SN, Hahn PF, Tanabe KK, Mueller PR, Schima W, Athanasoulis CA, et al. Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis?. Journal of Vascular & Interventional Radiology 1998;9(1):101-11.
Gory 2012 {published data only}
  • Gory I, Fink M, Bell S, Gow P, Nicoll A, Knight V, et al. Radiofrequency ablation versus surgical resection for the treatment of early stage hepatocellular carcinoma (HCC) - a large multicentre study. Journal of Hepatology 2012;56(Suppl 2):S392-S393.
Jiao 1999 {published data only}
  • Jiao LR, Hansen PD, Havlik R, Mitry RR, Pignatelli M, Habib N. Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors. American Journal of Surgery 1999;177(4):303-6.
Khan 2007 {published data only}
  • Khan MR, Poon RTP, Ng KK, Chan ACC, Yuen J, Tung H, et al. Comparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinoma. Archives of Surgery 2007;142(12):1136-43.
Kobayashi 2007 {published data only}
  • Kobayashi M, Ikeda K, Kawamura Y, Hosaka T, Sezaki H, Yatsuji H, et al. Randomized controlled trial for the efficacy of hepatic arterial occlusion during radiofrequency ablation for small hepatocellular carcinoma-direct ablative effects and a long-term outcome. Liver International 2007;27(3):353-9.
Kurokohchi 2005 {published data only}
  • Kurokohchi K, Watanabe S, Masaki T, Hosomi N, Himoto T, Kimura Y, et al. Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma. World Journal of Gastroenterology 2005;11(10):1426-32.
Livraghi 1999 {published data only}
  • Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 1999;210(3):655-61.
Lü 2006 {published data only}
  • Lü MD, Kuang M, Liang LJ, Xie XY, Peng BG, Liu GJ, et al. Surgical resection versus percutaneous thermal ablation for early-stage hepatocellular carcinoma: a randomized clinical trial. National Medical Journal of China 2006;86(12):801-5.
Morimoto 2010 {published data only}
  • Morimoto M, Numata K, Kondou M, Nozaki A, Morita S, Tanaka K. Midterm outcomes in patients with intermediate-sized hepatocellular carcinoma a randomized controlled trial for determining the efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization. Cancer 2010;116(23):5452-60.
Morimoto 2011 {published data only}
  • Morimoto M, Numata K, Kondo M, Nozaki A, Moriya S, Takizawa K, et al. Long-term outcome in patients with intermediate-sized hepatocellular carcinoma: a randomized controlled trial to determine the efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization. Hepatology 2011;54(Suppl S1):1366A.
Ohmoto 2009 {published data only}
Opocher 2010 {published data only}
  • Opocher E, Barabino M, Costa M, Zuin M, Carnevali P, Santambrogio R. The impact of radiofrequency ablation and liver resection on patients with cirrhosis and early and very early hepatocellular carcinoma. HPB 2010;12(Suppl S1):69.
Peng 2012 {published data only}
  • Peng ZW, Zhang YJ, Liang HH, Lin XJ, Guo RP, Chen M. Recurrent hepatocellular carcinoma treated with sequential transcatheter arterial chemoembolization and RF ablation versus RF ablation alone: a prospective randomized trial. Radiology 2012;262(2):689-700.
Santambrogio 2012 {published data only}
  • Santambrogio R, Kluger M, Costa M, Belli A, Laurent A, Zuin M, et al. Hepatic resection versus laparoscopic radiofrequency ablation for "very early" hepatocellular carcinoma. Digestive and Liver Disease 2012;44(Suppl 1):S9-S10.
Sreenivasan 2010 {published data only}
  • Sreenivasan K, Roy S, Subramaniam M. Comparison of radiofrequency ablation versus resection for the treatment of hepatocellular carcinoma. HPB 2010;12(Suppl S1):164.
Ueno 2009 {published data only}
  • Ueno S, Sakoda M, Kubo F, Hiwatashi K, Tateno T, Baba Y, et al. Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria. Journal of Hepato-Biliary-Pancreatic Surgery 2009;16:359-66.
Zhang 2005 {published data only}
  • Zhang FJ, Wu PH, Zhao M, Gu YK, Zhang L, Tan ZB. Evaluation of combined percutaneous radio-frequency ablation and percutaneous ethanol injection after transcatheter arterial chemoembolization for hepatocellular carcinoma. Zhonghua Zhong Liu Za Zhi 2005;27(4):248-50.
Zhang 2007 {published data only}
  • Zhang YJ, Liang HH, Chen MS, Guo RP, Li JQ, Zheng Y, et al. Hepatocellular carcinoma treated with radiofrequency ablation with or without ethanol injection: a prospective randomized trial. Radiology 2007;244(2):599-607.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Di Costanzo 2011 {published data only}
  • Di Costanzo GG, Tortora R, D'Adamo G, Galeota Lanza A, Carannante N, Lampasi F, et al. Radiofrequency ablation versus laser ablation for the treatment of small hepatocellular carcinoma: a randomized controlled trial. Journal of Hepatology 2011;54(Suppl 1):S254-S255.
Kuansheng 2011 {published data only}
  • Kuansheng M, Feng K, Yan J, Wang S, Bie P. A randomized controlled study of radiofrequency ablation and surgical resection for early-stage hepatocellular carcinomas less than 4 cm in diameter. Hepatology 2011;54(S1):418A.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
NCT00814242 {published data only}
  • NCT00814242. Hepatectomy versus radiofrequency ablation for hepatocellular carcinoma adjacent to major blood vessels. clinicaltrials.gov/ct2/show/NCT00814242 (accessed 16 December 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Abu-Hilal 2008
  • Abu-Hilal M, Primrose JN, Casaril A, McPhail MJ, Pearce NW, Nicoli N. Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma. Journal of Gastrointestinal Surgery 2008;12(9):1521-6.
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Bosch 2004
Bouza 2009
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Brok 2008
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Rossi 1998
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Galandi 2001
  • Galandi D, Antes G. Radiofrequency thermal ablation versus other interventions for hepatocellular carcinoma [Protocol]. The Cochrane Library (Update Software, Oxford) 2001, Issue 2.
Galandi 2002
  • Galandi D, Antes G. Radiofrequency thermal ablation versus other interventions for hepatocellular carcinoma [Review]. The Cochrane Library (Update Software, Oxford) 2002, Issue 3.
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