Intervention Review

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Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation

  1. David Churchill1,*,
  2. Lelia Duley2,
  3. Jim G Thornton3,
  4. Leanne Jones4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 26 JUL 2013

Assessed as up-to-date: 10 JUL 2013

DOI: 10.1002/14651858.CD003106.pub2


How to Cite

Churchill D, Duley L, Thornton JG, Jones L. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD003106. DOI: 10.1002/14651858.CD003106.pub2.

Author Information

  1. 1

    The Royal Wolverhampton Hospitals NHS Trust, Department of Obstetrics and Gynaecology, Wolverhampton, West Midlands, UK

  2. 2

    Nottingham Health Science Partners, Nottingham Clinical Trials Unit, Nottingham, UK

  3. 3

    University of Nottingham, Department of Obstetrics and Gynaecology, Nottingham, Nottinghamshire, UK

  4. 4

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*David Churchill, Department of Obstetrics and Gynaecology, The Royal Wolverhampton Hospitals NHS Trust, New Cross Hospital, Wednesfield, Wolverhampton, West Midlands, WV10 0QP, UK. david.churchill1@nhs.net.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 26 JUL 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
GRIT 2003 {published data only}
  • GRIT Study Group. A randomised trial of timed delivery for the compromised preterm fetus: short term outcomes and bayesian interpretation. BJOG: an international journal of obstetrics and gynaecology 2003;110:27-32.
  • Hornbuckle J, Thornton JG, Vail A, GRIT SG. The Growth Restriction Intervention Trial (GRIT): interim progress report. Women's Health - into the new millennium. Proceedings of the 4th International Scientific Meeting of the Royal College of Obstetricians and Gynaecologists; 1999 October 3-6; Cape Town South Africa. RCOG, 1999:76.
  • Schneider KTM, Brocker J, Thornton J. A randomised intervention of timed delivery for the compromised preterm fetus [abstract] [Randomisierte Intervention zur Optimierung des Entbindungszeitpunktes bei kompromittierten IUGR-Feten (Euro-GRIT)]. Geburtshilfe und Frauenheilkunde 2000;60 Suppl 1:S72.
  • Thornton JG, Hornbuckle J, Vail A, Spiegelhalter DJ, Levene M, GRIT study group. Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial. Lancet 2004;364:513-20.
  • Walker DM, Marlow N, Upstone L, Gross H, Hornbuckle J, Vail A, et al. The Growth Restriction Intervention Trial: long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. American Journal of Obstetrics and Gynecology 2011;204(1):34.e1-9.
Mesbah 2003 {published data only}
  • Mesbah EMM. Severe preterm preeclampsia: aggressive or expectant management?. Medical Journal of Cairo University 2003;71(1):175-82.
Odendaal 1990 {published data only}
  • Odendaal HJ, Pattinson RC. Active or conservative treatment of severe preeclampsia - a randomized control trial. Proceedings of 37th Annual Meeting of the Society for Gynecologic Investigation; 1990 March 21-24; St Louis, USA. 1990:359.
  • Odendaal HJ, Pattinson RC, Bam R, Grove D, Kotze TJ. Aggressive or expectant management for patients with severe preeclampsia between 28-34 weeks' gestation: a randomized controlled trial. Obstetrics & Gynecology 1990;76:1070-5.
Sibai 1994 {published data only}
  • Sibai BM, Mercer BM, Schiff E, Friedman SA. Aggressive versus expectant management of severe preeclampsia at 28 to 32 weeks' gestation: a randomized controlled trial. American Journal of Obstetrics and Gynecology 1994;171:818-22.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Gruppo di Studio1998 {published data only}
  • Gruppo di Studio Ipertensione in Gravidanza. Nifedipine versus expectant management in mild to moderate hypertension in pregnancy. British Journal of Obstetrics and Gynaecology 1998;105:718-22.
Langenveld 2011 {published data only}
  • Langenveld J, Broekhuijsen K, van Baaren GJ, van Pampus MG, van Kaam AH, Groen H, et al. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia between 34 and 37 weeks' gestation (HYPITAT-II): A multicentre, open-label randomised controlled trial. BMC Pregnancy and Childbirth 2011;11:50.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Duvekot 2011 {published data only}
  • Duvekot JJ, Steegers EAP, Hop WCJ, Franx A, van der Post JAM, van Wassenaer A, et al. TOTEM study (temporise or terminate pregnancy in women with severe preeclampsia at 28-34 weeks): a study protocol. Pregnancy Hypertension 2011;1 Suppl 1:295.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Brown 2001
  • Brown MA, Lindheimer MD, de Swiet M, van Assche A, Moutquin J-M. The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy. Hypertension in Pregnancy 2001;20:ix-xiv.
Crowley 1996
Davey 1988
Derham 1989
Duley 1999a
  • Duley L, Henderson-Smart D. Reduced salt intake compared to normal dietary salt, or high intake, in pregnancy. Cochrane Database of Systematic Reviews 1999, Issue 3. [DOI: 10.1002/14651858.CD001687]
Duley 1999b
Duley 2005
Duley 2006
Duley 2007
Duley 2009
  • Duley L, Henderson-Smart DJ, Walker GJA. Interventions for treating pre-eclampsia and its consequences: generic protocol. Cochrane Database of Systematic Reviews 2009, Issue 2. [DOI: 10.1002/14651858.CD007756]
Duley 2010
Higgins 2005
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]. In: The Cochrane Library, Issue 3, 2005. Chichester, UK: John Wiley & Sons, Ltd.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hofmeyr 2010
Magee 2009
  • Magee LA, Yong PJ, Espinosa V, Cote AM, Chen I, von Dadelszen P. Expectant management of severe pre-eclampsia remote from term: a structured systematic review. Hypertension in Pregnancy 2009;28(3):312-47.
Makrides 2001
Morris 2012
  • Morris RK, Riley RD, Doug M, Deeks JJ, Kilby MD. Diagnostic accuracy of spot urinary protein and albumin to creatinine ratios for detection of significant proteinuria or adverse pregnancy outcome in patients with suspected pre-eclampsia: systematic review and meta-analysis. BMJ (Clinical research ed.) 2012;345:e4342. [PUBMED: 22777026]
RCOG 2003
  • Royal College of Obstetricians and Gynaecologists. Pre-eclampsia - study group consensus statement. http://www.rcog.org.uk/print/womens-health/clinical-guidance/pre-eclampsia-study-group-consensus-statement 2003.
RevMan 2000 [Computer program]
  • The Cochrane Collaboration. Review Manager (RevMan). Version 4.1 for Windows. Oxford, England: The Cochrane Collaboration, 2000.
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Sibai 1984
von Dadelszen 2011
  • von Dadelszen P, Payne B, Li J, Ansermino MJ, Broughton FP, Cote A, et al. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet 2011;377(9761):219-27.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Churchill 2002
  • Churchill D, Duley L 10.1002/14651858.CD003106. Interventionist versus expectant care for severe pre-eclampsia before term. Cochrane Database of Systematic Reviews 2002, Issue 3. [DOI: 10.1002/14651858.CD003106]
Duley 1995
  • Duley L. Aggressive vs expectant management of pre-eclampsia.. In: Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) . Pregnancy and Childbirth Module. In: The Cochrane Database of Systematic Reviews [database on disk and CDROM]. The Cochrane Collaboration; Issue 2, Oxford: Update Software; 1995.