Intervention Review

Topical nasal steroids for intermittent and persistent allergic rhinitis in children

  1. Jamal J Al Sayyad1,*,
  2. Zbys Fedorowicz2,
  3. Dunia Alhashimi3,
  4. Ahmed Jamal4

Editorial Group: Cochrane Ear, Nose and Throat Disorders Group

Published Online: 24 JAN 2007

Assessed as up-to-date: 31 OCT 2006

DOI: 10.1002/14651858.CD003163.pub4


How to Cite

Al Sayyad JJ, Fedorowicz Z, Alhashimi D, Jamal A. Topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD003163. DOI: 10.1002/14651858.CD003163.pub4.

Author Information

  1. 1

    Ministry of Health, Bahrain, Medical Review Office, Manama, Bahrain

  2. 2

    Ministry of Health, Bahrain, UKCC (Bahrain Branch), Awali, Bahrain

  3. 3

    Salmaniya Medical Complex, Paediatrics, Manama, Bahrain

  4. 4

    Salmaniya Medical Complex, ENT, Manama, Bahrain

*Jamal J Al Sayyad, Medical Review Office, Ministry of Health, Bahrain, PO Box 12, Manama, Bahrain. JSayyad@health.gov.bh.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 24 JAN 2007

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary

Background

Allergic rhinitis is a very common chronic illness affecting 10% to 40% of children worldwide. There has been a significant increase in prevalence among children over the last two decades and this increase has been accompanied by a parallel increase in comorbid illnesses such as asthma.

Objectives

To evaluate the therapeutic effectiveness and adverse event profiles of topical nasal steroids for intermittent and persistent allergic rhinitis in children.

Search methods

We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2005), MEDLINE (1950 onwards) and EMBASE (1974 onwards) on 5th September 2005. CINAHL, mRCT(a meta-database of controlled trials), NRR (the National Research Register), LILACS, MedCarib, KOREAMED, IndMed, Samed, Panteleimon, Zetoc, ISI Proceedings, the GlaxoSmithKline Clinical Trials Database and the websites of AstraZeneca, Schering Plough and Aventis were also searched.

Selection criteria

Randomised controlled trials comparing topical nasal steroid preparations against each other or placebo, prescribed for allergic rhinitis in children.

Data collection and analysis

Two authors independently assessed trial quality and extracted data from the included trials. The limited and variable quality of reported data precluded any pooling of results and only a descriptive summary is presented.

Main results

Three trials involving a total of 79 participants were included. All three trials, which compared topical nasal steroids against placebo for perennial rhinitis, provided some, albeit limited data, relevant to our primary outcomes; but in two of the trials the data analysis was flawed and in the third trial it was incomprehensible. None of the trials provided data relevant to our secondary outcomes. There were no adverse events reported from any of the interventions.

Authors' conclusions

The three included trials provided some weak and unreliable evidence for the effectiveness of Beconase® and flunisolide used topically intranasally for the treatment of intermittent and persistent allergic rhinitis in children. The reduction of severity in symptoms as assessed by the trialists could not be confirmed with the data provided and decisions on the use of these medications should, until such time as more robust evidence is available, be guided by the physician's clinical experience and patients' individual circumstances and preferences.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary

Topical nasal steroids for intermittent and persistent allergic rhinitis in children

Allergic rhinitis is a very common chronic illness affecting 10% to 40% of children worldwide. There has been a significant increase in prevalence among children over the last two decades and this increase has been accompanied by a parallel increase in comorbid illnesses such as asthma. Symptoms include sneezing, itching, runny nose and nasal congestion. Allergic rhinitis may be defined as 'persistent' or 'intermittent'. These classifications loosely correspond to perennial (all year round) allergic rhinitis and seasonal allergic rhinitis ('hay fever'). There are a wide range of drug treatments available including topical and oral decongestants, topical and oral antihistamines, topical and systemic corticosteroids, leukotriene antagonists and a number of over the counter preparations. Topical steroids (nasal sprays) are often prescribed, and act directly on the nasal mucosa to reduce symptoms.

The authors of the review identified a large number of randomised controlled trials, however many were excluded due to the use of 'rescue' (additional) medication, which may have confounded the results.

The three included trials provided some weak and unreliable evidence for the effectiveness of Beconase® and flunisolide used topically in the nose for the treatment of intermittent and persistent allergic rhinitis in children. The review authors concluded that until more research is available, decisions on the use of topical steroids should be guided by the physician's clinical experience and patients' individual circumstances and preferences.