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Iodised salt for preventing iodine deficiency disorders

  1. Taixiang Wu1,*,
  2. Guan Jian Liu1,
  3. Ping Li2,
  4. Christine Clar3

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 30 AUG 2004

DOI: 10.1002/14651858.CD003204

Database Title

Additional Information

How to Cite

Wu T, Liu GJ, Li P, Clar C. Iodised salt for preventing iodine deficiency disorders. Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD003204. DOI: 10.1002/14651858.CD003204.

Author Information

  1. 1

    West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese EBM Centre, Chengdu, Sichuan, China

  2. 2

    CDC of Sichuan Provence, CHINA, Prevention and treatment of endemic disease institute, Chengdu, China

  3. 3

    Cochrane Metabolic and Endocrine Disorders Group, Researcher in Systematic Reviews , Berlin, Germany

*Taixiang Wu, Chinese Cochrane Centre, Chinese EBM Centre, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China. txwutx@hotmail.com. txwutx@public.cd.sc.cn.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Foo 1996 {published data only}
  • Foo LC, Zainab T, Nafikudin M, Letchuman GR. Salt: an ineffective vehicle for iodine delivery to young children in rural Sarawak. Annales d'Endocrinologie (Paris) 1996;57:470-5.
Hintze 1988 {published data only}
  • Hintze G, Emrich D, Richter K, Thal H, Wasielewski T, Köbberling J. Effect of voluntary intake of iodineated salt on prevalence of goitre in children. Acta endocrinologica (Copenh) 1988;117:333-8.
l'Ons 2000 {published data only}
  • l'Ons A, Jooste PL, Weight MJ, Huskisson J. A field clinical trial of the short-term effects of iodised salt on the iodine sattus of rural primary school children. South African Medical Journal 2000;90:30-6.
Romano 1991 {published data only}
  • Romano R, Jannini EA, Pepe M, Grimaldi A, Olivieri M, Spennati P, et al. The effects of iodoprophylaxis on thyroid size during pregnancy. American Journal of Obstetrics and Gynecology 1991;164:482-5.
Sooch 1965 {published data only}
  • Sooch SS, Ramalingaswami V. Preliminary report of an experiment in the Kangra Valley for the prevention of Himalayan endemic goitre with iodised salt. Bulletin of the World Health Organisation 1965;32:299-315.
Zhao 1999 {published data only}
  • Zhao JK, Xu FJ, Zhang QL, Shang L, Xu AX, Gao Y, et al. Randomized clinical trial comparing different iodine interventions in school children. Public health Nutrition 1999;2(2):173-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Carella 2002 {published data only}
  • Carella C, Mazziotti G, Rotondi M, Del Buono A, Zito G, Sorvillo F, et al. Iodized salt improves the effectiveness of L-thyroxine therapy after surgery for nontoxic goitre: a prospective and randomized study. Clinical Endocrinology 2002;57(4):507-13.
    Direct Link:
Hess 2002 {published data only}
  • Hess SY, Zimmermann MB, Adou P, Torresani T, Hurrell RF. Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Cote d'Ivoire. American Journal of Clinical Nutrition 2002;75(4):743-8.
Kimball 1937 {published data only}
  • Kimball OP. Prevention of goitre in Michigan and Ohio. Journal of the American Medical Association 1937;108:860-7.
Marine 1917/20 {published data only}
  • Marine D, Kimball OP. Prevention of simple goitre in man. Archives of Internal Medicine 1920;25:661-72.
  • Marine D, Kimball OP. The prevention of simple goitre in man. Journal of Laboratory and Clinical Medicine 1917;3:40-6.
Saowakhontha 1994 {published data only}
  • Saowakhontha S, Sanchaisuriya P, Pongpaew P, Tungtrongchitr R, Supawan V, Intarakhao C, et al. Compliance of population groups of iodine fortification in an endemic area of goitre in Northeast Thailand. Journal of the Medical Association of Thailand 1994;77:449-54.
Scrimshaw 1953 {published data only}
  • Scrimshaw NS, Cabezas A, Castillo F, et al. Results of the administration of potassium iodate, potassium iodide and placebo on endemic goitre and iodine bound to protein in groups of school children [Resultados de la administracion de yodato de potasio, yoduro de potasio y placebos sobre el bocio endemico y sobre los niveles de yodo ligado a la proteina entre grupos de escolares]. Boletín de la Oficina Sanitaria Panamericana 1953;35 Suppl 1:13-20.
Simescu 2002 {published data only}
  • Simescu M, Varciu M, Nicolaescu E, Gnat D, Podoba J, Mihaescu M, et al. Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania.. Hormone Research 2002;58(2):78-82.
van den Briel 2000 {published data only}
  • van den Briel T, West C, Bleichrodt N, et al. Improved iodine status is associated with improved mental performance of school children in Benin. American Journal of Clinical Nutrition 2000;72:1179-85.
Yang 1997 {published data only}
  • Yang FY, Tang BD, Niu CL, Yao XZ, Z H, Chen YZ, et al. A study for endemic goiter control with combined iodine and selenium supplementation. Chinese Journal of Endemic Diseases 1997;16(4):214-8.
Zhao 2002 {published data only}
  • Zhao J, Zhang Q, Shang L, Chen Z, Hu X. Effects of three different iodine interventions on the speed of normalization of enlarged thyroid gland due to iodine deficiency. (Zhong Hua Liu Xin Bing Xue Za Zhi) Chinese Journal of Epidemiology 2002;23(4):254-7.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Beaufrere 2000
  • Beaufrere B, Bresson JL, Briend A, Ghisolfi J, Goulet O, Navarro J, et al. Iodine nutrition in the infant. Committee on Nutrition of the French Society of Pediatrics. Archives of Pediatrics 2000;7(1):66-74.
Bourdoux 1996
Chen 1984
  • Chen BZ, Shi ZF, Li XT, Lu CZ, Hou MT, Yang SH, et al. A survey of endemic goitre and endemic cretinism in Heba village of Guizhou province. Chinese Journal of Endemic Diseases 1984;3(2):97-102.
CONSORT 2001
Corvilain 1998
Delange 1999
Delange 2001
Delong 1994
Dunn 1998b
Dunn 2004
  • Dunn JT. Iodine deficiency disorders. UpToDate, www.uptodate.com accessed at 10 Sept. 2004.
FAO/WHO/IAEA 1996
  • FAO/WHO/IAEA Expert Consultation. Trace Elements in Human Nutrition and Health. 1996.
Fong 1981
  • Fong RJ, Jiang XM, Su MY. Relationship of endemic goitre epidemic characteristics and geological structure characteristics in Xinjiang Province. Chinese Journal of Preventive Medicine 1981;15(2):65-8.
Galofre 1994
  • Galofre JC, Fernandez-Calvet L, Rios M, Garcia-Mayor RV. Increased incidene of thyrotoxicosis after iodine supplementation in an iodine sufficient area. Jounal of Endocrinological Investigation 1994;17(1):23-7.
Jadad 1996
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds JM, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
Kahaly 1997
  • Kahaly G, Dienes HP, Beyer J, Hommel G. Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goitre. Journal of Clinical Endocrinology and Metabolism 1997;82(12):4049-53.
Köhrle 1999
Larsen 1981
Li 1997
  • Li SM, Wang RY, Lu B, Rao FG, Gao LD, Zhang YH, et al. Dynamic studies of iodised salt and iodised oil on iodine metabolism of pregnant women in IDD areas. Chinese Journal of Endemic Diseases 1997;16(4):229-33.
Lin 1995
  • Lin FF, Zhao HX, Sha NY, Yi LXT, Jiang JY, Yang CZ, et al. A study for fetus development during pregnancy in areas of iodine deficiency. Chinese Journal of Endemic Diseases 1995;14(2):91-3.
Mahomed 2001
  • Mahomed K, Gulmezoglu AM. Maternal iodine supplements in areas of deficiency (Cochrane review). Cochrane Database of Systematic Reviews 2001, Issue 2.
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association 1995;273:408-12.
Stanbury 1998
Todd 1995
WHO 1993
  • WHO/Unicef/ICCIDD. Indicators for assessment of iodine deficiency disorders and the control programme report of a Joint WHO/Unicef/ICCIDD Consultation. 1993:14-23.
WHO 2001
  • WHO/ICCIDD/UNICEF. Assessment of iodine deficiency disorders and monitoring their elimination.. 2nd Edition. Geneva: WHO, 2001.
Yang 1997
  • Yang FY, Tang BD, Niu CL, Yao XZ, Zhao H, Chen YZ, et al. A study for endemic goiter control with combined iodine and selenium supplementation. Chinese Journal of Endemic Diseases 1997;16(4):214-8.
Zimmermann 2000
  • Zimmermann M, Adou P, Torresani T, et al. Persistence of goitre despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire. American Journal of Clinical Nutrition 2000;71:88-93.
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