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Treatment of Lennox-Gastaut syndrome

  1. Eleanor C Hancock1,*,
  2. J Helen Cross2

Editorial Group: Cochrane Epilepsy Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 15 JAN 2013

DOI: 10.1002/14651858.CD003277.pub3

How to Cite

Hancock EC, Cross JH. Treatment of Lennox-Gastaut syndrome. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD003277. DOI: 10.1002/14651858.CD003277.pub3.

Author Information

  1. 1

    University of Liverpool, c/o Cochrane Epilepsy Group, Liverpool, UK

  2. 2

    The Wolfson Centre, UCL Institute of Child Health, London, UK

*Eleanor C Hancock, c/o Cochrane Epilepsy Group, University of Liverpool, Room 2.28, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool, L9 7LJ, UK.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 FEB 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anonymous 1989 {published data only}
  • Anonymous. Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut syndrome. The Group for the Evaluation of Cinromide in the Lennox-Gastaut syndrome. Epilepsia 1989;30(4):422-9. [MEDLINE: 89325225]
Anonymous 1993 {published data only}
  • Anonymous. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). The Felbamate Study Group in Lennox Gastaut syndrome. New England Journal of Medicine 1993;328(1):29-33. [MEDLINE: 93096004]
Conry 2009 {published data only}
Conry 2010 {published data only}
  • Conry J, Ng Y, Drummond R, Stolle J, Sagar S. Efficacy and safety of clobazam in the treatment of seizures associated with Lennox Gastaut syndrome: results of a phase III trial (abstract no: 1.283). Proceedings of the 64th Annual Meeting of the American Epilepsy Society. December 3-7, 2010, San Antonio, TX. (accessed 28 April 2012).
Eriksson 1998 {published data only}
  • Eriksson AS, Nergardh A, Hoppu K. The efficacy of lamotrigine in children and adolescents with refractory generalised epilepsy: a randomised, double blind, crossover study. Epilepsia 1998;39(5):495-501.
Glauser 2008 {published and unpublished data}
Glauser 2009 {published data only}
  • Glauser T, Santana B V, Wang W, Narurkar M. Early and sustained response to rufinamide as adjunctive therapy for seizures associated with Lennox Gastaut syndrome. Epilepsia 2009;50 (suppl 11):261.
Inanaga 1989 {published data only}
Motte 1997 {published data only}
  • Motte J, Trevathan E, Arvidsson JF, Barrera MN, Mullens EL, Manasco P. Lamotrigine for generalised seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. New England Journal of Medicine 1997;337(25):1807-12. [MEDLINE: 98051155; : 1998002039]
Sachdeo 1999 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Jensen 1994 {published data only}
Vajda 1985 {published data only}
  • Vajda FJ, Bladin PF, Parsons BJ. Clinical experience with clobazam: a new 1,5 benzodiazepine in the treatment of refractory epilepsy. Clinical and Experimental Neurology 1985;21:177-82. [MEDLINE: 87188404]
Vassella 1978 {published data only}
  • Vassella F, Rudeberg A, Da Silva V, Pavlincova E. Double-blind study on the anticonvulsive effect of phenobarbital and valproate in the Lennox syndrome [Doppletblind-Untersuchung uber die antikonvulsive Wirkung von Phenobarbital und Valproat beim Lennox-Syndrom]. Schweizerische Medizinische Wochenschrift 1978;108(19):713-6. [MEDLINE: 78321217]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aicardi 1996
  • Aicardi J. Lennox-Gastaut syndrome. In: Wallace editor(s). Epilepsy in Children. First Edition. London: Chapman & Hall Medical, 1996:249-62.
Arzimanoglou 2009
  • Arzimanoglou A, French J, Blume WT, Cross J, Ernst JP, Feucht M, et al. Lennox Gastaut Syndrome: a consensus approach on diagnosis, assessment, management and trial methodology. Lancet Neurology 2009;8(1):82-93.
Beaumanoir 2005
  • Beaumanoir A, Blume W. The Lennox-Gastaut syndrome. In: Roger J, Bureau M, Dravet C, Tassinari C, Wolf P editor(s). Epileptic Syndromes in Infancy, Childhood and Adolescence. 4th Edition. London: John Libby Eurotext, 2005:125-48.
Berg 2011
European Union 2006
  • The European Parliament and the Council of the European Union. Regulation (EC) No 1901/2006 of the European Council and of the Council of 12th December 2006 on medicinal products for paediatric use and amending Regulation (EEC) No 1768/92, Directive 2001/20/EC, Directive 2001/83/EC and Regulation (EC) No 726/2004. 2006.
Lefebvre 2009
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009. Available from
Patwardhan 2000