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Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients

  1. Marianne D van de Wetering1,*,
  2. Job BM van Woensel2,
  3. Theresa A Lawrie3

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 25 NOV 2013

Assessed as up-to-date: 28 JUN 2013

DOI: 10.1002/14651858.CD003295.pub3


How to Cite

van de Wetering MD, van Woensel JBM, Lawrie TA. Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD003295. DOI: 10.1002/14651858.CD003295.pub3.

Author Information

  1. 1

    Emma Children's Hospital/Academic Medical Center, Department of Paediatric Oncology, Amsterdam, Netherlands

  2. 2

    Emma Children's Hospital / Academic Medical Centre, Pediatrics, Amsterdam, Netherlands

  3. 3

    Royal United Hospital, Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group, Bath, UK

*Marianne D van de Wetering, Department of Paediatric Oncology, Emma Children's Hospital/Academic Medical Center, PO Box 22660, Amsterdam, 1100 DD, Netherlands. m.d.vandewetering@amc.uva.nl.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 25 NOV 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Barriga 1997 {published data only}
  • Barriga FJ, Varas M, Potin M, Sapunar F, Rojo H, Martinez A, et al. Efficacy of a vancomycin solution to prevent bacteraemia associated with an indwelling central venous catheter in neutropenic and non-neutropenic cancer patients. Medical and Pediatric Oncology 1997;28:196-200.
Daghistani 1996 {published data only}
Di Carlo 2011 {published data only}
  • Carlo I, Toro A, Pulvirenti E, Palermo F, Scibilia G, Cordio S. Could antibiotic prophylaxis be not necessary to implant totally implantable venous access devices? Randomized prospective study. Surgical Oncology 2011;20:20-5.
Handrup 2013 {published data only}
  • Handrup MM, Fuursted K, Funch P, Moller JK, Schroder H. Biofilm formation in long-term central venous catheters in children with cancer: A randomized controlled open-labelled trial of taurolidine versus heparin. APMIS 2012;120:794-801.
  • Handrup MM, Moller JK, Schroder H. Central venous catheters and catheter locks in children with cancer: A prospective randomized trial of taurolidine versus heparin. Pediatric Blood and Cancer. 2011; Vol. Conference: 43rd Congress of the International Society of Paediatric Oncology, SIOP 2011, Auckland, New Zealand, 28 to 30 October.
  • Handrup MM, Møller JK, Schrøder H. Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin. Pediatric Blood Cancer 2013;60(8):1292-8.
Henrickson 2000 {published data only}
  • Henrickson KJ, Axtell RA, Hoover SM, Kuhn SM, Pritchett J, Kehl SC, et al. Prevention of central venous catheter related infections and thrombotic events in immuno compromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: a randomized multicenter double blind trial. Journal of Clinical Oncology 2000;18(6):1269-78.
Lim 1993 {published data only}
  • Lim SH, Smith MP, Machin SJ, Goldstone AH. A prospective randomized study of prophylactic teicoplanin to prevent early Hickman catheter related sepsis in patients receiving intensive chemotherapy for haematological malignancies. European Journal of Haematology 1993;Suppl 54:10-3.
Ljungman 1997 {published data only}
  • Ljungman P, Hagglund H, Bjorkstrand B, Lonnqvist B, Ringden O. Peroperative teicoplanin for prevention of gram-positive infections in neutropenic patients with indwelling central venous catheters: a randomized controlled study. Support Care Cancer 1997;5:485-8.
Rackoff 1995 {published data only}
  • Rackoff WR, Weiman M, Jakobowski D, Hirschl R, Stallings V, Bilodeau, et al. A randomized controlled trial of the efficacy of a heparin and vancomycin flush solution in preventing central venous catheter infections in children. Journal of Paediatrics 1995;127(1):147-51.
Ranson 1990 {published data only}
  • Ranson MR, Oppenheim BA, Jackson A, Kamthan AG, Scarffe JH. Double blind placebo controlled study of vancomycin prophylaxis for central venous catheter insertion in cancer patients. The Journal of Hospital Infection 1990;15:95-102.
Schwartz 1990 {published data only}
  • Schwartz C, Henrickson K, Roghmann K, Powell K. Prevention of bacteraemia attributed to luminal colonization of tunnelled central venous catheters with vancomycin susceptible organisms. Journal of Clinical Oncology 1990;8(9):1591-7.
Vassilomaniakis 1995 {published data only}
  • Vassilomaniakis M, Platniotis G, Koumakis G. Central venous catheter related infections after bone marrow transplantation in patients with malignancies: a prospective study with short course vancomycin prophylaxis. Bone Marrow Transplantation 1995;15:77-80.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Abdelkefi 2005 {published data only}
  • Abdelkefi A, Torjman L, Ladeb S, Othman T B, Achour W, Lakhal A, et al. Randomized trial of prevention of catheter-related bloodstream infection by continuous infusion of low-dose unfractionated heparin in patients with hematologic and oncologic disease. Journal of Clinical Oncology 2005;23:7864-70.
Akyuz 2012 {published data only}
  • Akyuz C Kupeli S Yagci-Kupeli B Buyukpamukcu M. Prophylactic taurolidine use in central venous catheters of pediatric cancer patients: A prospective randomized study from single center. Pediatric Blood and Cancer. 2010; Vol. 42nd Congress of the International Society of Pediatric Oncology, SIOP 2010, Boston, MA United States, 21 to 24 October.
  • Akyuz C, Kupeli S, Yagci-Kupeli B, Buyukpamukcu M. Prophylactic taurolidine use in port catheters of pediatric cancer patients: a prospective randomised controlled study from single center. European Journal of Clinical and Medical Oncology submitted 2012 (authors' manuscript).
Al Sibai 1987 {published data only}
Carratala 1999 {published data only}
  • Carratala J, Niubo J, Fernandez-Sevilla A, Juve E, Castellsague X, Berlanga J, et al. Randomized, double-blind trial of an antibiotic-lock technique for prevention of Gram-positive central venous catheter-related infection in neutropenic patients with cancer. Antimicrobial Agents and Chemotherapy 1999;43(9):2200-4.
Chambers 2005 {published data only}
  • Chambers ST, Sanders J, Patton WN, Ganly P, Birch M, Crump JA, et al. Reduction of exit-site infections of tunnelled intravascular catheters among neutropenic patients by sustained-release chlorhexidine dressings: results from a prospective randomized controlled trial. The Journal of Hospital Infection 2005;61:53-61.
Chatzinikolaou 2003a {published data only}
  • Chatzinikolaou I, Zipf T, Hanna H, Umphrey J, Roberts W, Sheretz R, et al. Minocycline-ethylenediamine-tetraacetate lock solution for the prevention of implantable port infections in children with cancer. Clinical Infectious Diseases 2003;36:116-9.
Chatzinikolaou 2003b {published data only}
  • Chatzinilolaou I, Finkel K, Hanna H, Boktour M, Foringer J, Ho T, et al. Antibiotic coated hemodialysis catheters for the prevention of vascular catheter-related infections: a prospective randomized study. American Journal of Medicine 2003;115:352-7.
Dawson 2000 {published data only}
  • Dawson S, Fitzgerald P, Langer JC, Walton M, Winthrop A, Lau G, et al. A preoperative protocol for the prevention of infection in children with tunnelled right atrial catheters. Oncology Repertorium 2000;7:1239-42.
Dumichen 2012 {published data only}
  • Dumichen MJ, Seeger K, Lode HN, Kuhl JS, Ebell W, Degenhardt P, et al. Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. The Journal of Hospital Infection 2012;80:304-9.
Ferreira Chacon 2011 {published data only}
  • Ferreira Chacon JM, Hato de Almeida E, de Lourdes Simoes R, Lazzarin C Ozorio V, Alves BC, Mello de Andrea ML, et al. Randomized study of minocycline and edetic acid as a locking solution for central line (port-a-cath) in children with cancer. Chemotherapy 2011;57:285-91.
Fourcade 2001 {published data only}
  • Fourcade J, Mallaval FO, Raffenot D, Mercier D, Maret J, Morel B. Value of an antibiotic lock for the prevention of bacteraemia recurrence from central catheters in chronic hemodialysis. Nephrologie 2001;22(8):457-8.
Garland 2005 {published data only}
  • Garland JS, Alex CP, Henrickson KJ, McAuliffe TL, Maki DG. A vancomycin-heparin lock solution for the prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective randomized trial. Pediatrics 2005;116:198-205.
Hanna 2004 {published data only}
  • Hanna H, Benjamin R, Chatzinikolaou I, Alakech B, Richardson D, Mansfield P, et al. Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial. Journal of Clinical Oncology 2004;22(15):3163-71.
Hitz 2012 {published data only}
  • Hitz F, Klingbiel D, Omlin A, Riniker S, Zerz A, Cerny T. Athrombogenic coating of long-term venous catheter for cancer patients: A prospective, randomised, double-blind trial. Annals of Hematology 2012;91:613-20.
Jaeger 2005 {published data only}
  • Jaeger K, Zenz S, Juttner B, Ruschulte H, Kuse E, Heine J, et al. Reduction of catheter-related infections in neutropenic patients: A prospective controlled randomized trial using a chlorhexidine and silver sulfadiazine-impregnated central venous catheter. Annals of Hematology 2005;84:258-62.
Ocete 1998 {published data only}
  • Ocete E, Ruiz-Extremera A, Goicoechea A, Lozano E, Robles C, Rey ML, et al. Low dosage prophylactic vancomycin in central venous catheters for neonates. Early Human Development 1998;Suppl 53:S181-6.
Raad 1998 {published data only}
  • Raad II, Hachem RY, Abi-Said D, Rolston KV, Whimbey E, Buzaid AC, et al. A prospective crossover randomized trial of novobiocin and rifampin prophylaxis for the prevention of intravascular catheter infections in cancer patients treated with interleukin 2. Cancer 1998;82(2):403-11.
Raad 2005 {published data only}
  • Raad I, Darouiche R, Vazquez J, Lentnek A, Hachem R, Hanna H, et al. Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40:374-80.
Rubie 1995 {published data only}
  • Rubie H, Juricic M, Claeyssens S, Krimou A, Lemozy J, Izard P, et al. Morbidity using subcutaneous ports and efficacy of vancomycin flushing in cancer. Archives of Diseases in Childhood 1995;72:325-9.
Scaife 2010 {published data only}
  • Scaife CL, Gross ME, Mone MC, Hansen HJ, Litz CL, Nelson ET, et al. Antibiotic prophylaxis in the placement of totally implanted central venous access ports. The American Journal of Surgery 2010;200:719-23.
Schierholz 2010 {published data only}
  • Schierholz JM, Nagelschmidt K, Nagelschmidt M, Lefering R, Yucel N, Beuth J. Antimicrobial central venous catheters in oncology: Efficacy of a rifampicin-miconazole-releasing catheter. Anticancer Research 2010;30:1353-8.
Simon 2008 {published data only}
  • Simon A, Ammann RA, Wiszniewsky G, Bode U, Fleischhack G, Besuden MM. Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infectious Diseases 2008;8:102.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Abbas 2004
Bagnall-Reeb 2004
  • Bagnall-Reeb H. Evidence for the use of the antibiotic lock technique. Journal of Infusion Nursing 2004;27(2):118-22.
CPAC 1990
  • Hospital Infection Control Practices Advisory Committee. Recommendations for the prevention of nosocomial intravascular device related infections. American Journal of Infection Control 1990;24(4):277-93.
Darouiche 1999
Groeger 1993
  • Groeger JS, Lucas AB, Coit D, LaQuaglia M, Brown AE, Turnbull A, et al. A prospective, randomized evaluation of the effect of silver impregnated subcutaneous cuffs for preventing tunnelled chronic venous access catheter infections in cancer patients. Annals of Surgery 1993;91:3.
Hachem 2002
Ingram 1991
  • Ingram J, Weitzman S, Greenberg ML, Parkin P, Filler R. Complications of indwelling venous access lines in the pediatric hematology patient: a prospective comparison of external catheters and subcutaneous ports. American Journal of Pediatric Hematology and Oncology 1991;13:130-6.
Mermel 2001
O'Grady 2002
  • O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, et al. Guidelines for the prevention of intravascular catheter related infections. Pediatrics 2002;110:51-75.
Press 1984
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Salzman 1995
  • Salzman M, Rubin L. Intravenous catheter-related infections. Advances in Pediatric Infectious Diseases 1995;10:337-68.
Sarper 2006
  • Sarper N, Zengin E, Corapcioglu F, Tugay M. Totally implantable central venous access devices in children with hemato oncologic malignancies: Evaluation of complications and comparison of incidence of febrile episodes with similar patients without central venous access devices. Pediatric Hematology and Oncology 2006;23:459-70.
Schiffer 2013
  • Schiffer CA, Mangu PB, Wade JC, Camp-Sorrel D, Cope DG, El-Rayes BF, et al. Central venous catheter care for the patient with cancer: American Society of Clinical Oncology clinical practice guideline. Journal of Clinical Oncology 2013;31(10):1357-70.
Schinabeck 2003
  • Schinabeck MK, Ghannoum MA. Catheter related infections-diagnosis treatment and prevention. Clinical Microbiology Newsletter 2003;25(15):113-9.
Shaul 1998
  • Shaul DB, Scheer B, Rokhsar S, Jones VA, Chan LS, Boody BA, et al. Risk factors for early infection of central venous catheters in pediatric patients. Journal of the American College of Surgeons 1998;186(6):654-8.
Simon 2006
Snaterse 2010
  • Snaterse M, Ruger W, Scholte OP, Reimer WJM, Lucas C. Antibiotic-based catheter lock solutions for prevention of catheter-related bloodstream infection: a systematic review of randomised controlled trials. The Journal of Hospital Infection 2010;75:1-11.
van Tulder 1997
  • van Tulder MW, Assendelft WJ, Koes BW, Bouter LM. Method guidelines for systematic reviews in the Cochrane Collaboration Back review group for spinal disorders. Spine 1997;22:2323-30.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
van de Wetering 2005
  • van de Wetering MD, van Woensel JB, Kremer LC, Caron HN. Prophylactic antibiotics for preventing early Gram-positive central venous catheter infections in oncology patients, a Cochrane systematic review. Cancer Treatment Review 2005;3:186-96.
van de Wetering 2007