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Artichoke leaf extract for treating hypercholesterolaemia

  1. Barbara Wider1,*,
  2. Max H Pittler2,
  3. Joanna Thompson-Coon3,
  4. Edzard Ernst4

Editorial Group: Cochrane Heart Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 16 AUG 2012

DOI: 10.1002/14651858.CD003335.pub3


How to Cite

Wider B, Pittler MH, Thompson-Coon J, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD003335. DOI: 10.1002/14651858.CD003335.pub3.

Author Information

  1. 1

    University of Exeter Medical School, Institute of Health Services Research, Exeter, UK

  2. 2

    Hospital for Cancer Research, Plau am See, Germany

  3. 3

    University of Exeter, Peninsula CLAHRC, University of Exeter Medical School, Exeter, Exeter, UK

  4. 4

    Peninsula Medical School, Complementary Medicine, Exeter, Devon, UK

*Barbara Wider, Institute of Health Services Research, University of Exeter Medical School, Veysey Building, Salmon Pool Lane, Exeter, EX2 4SG, UK. b.wider@exeter.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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This is not the most recent version of the article. View current version (19 MAY 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bundy 2008 {published data only}
  • Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HC. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial. Phytomedicine 2008;15:668-75.
Englisch 2000 {published data only}
  • Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V. Efficacy of artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittel-Forschung 2000;50:260-5.
Petrowicz 1997 {published data only}
  • Petrowicz O, Gebhardt R, Donner M, Schwandt M, Kraft K. Effects of artichoke leaf extract (ALE) on lipoprotein metabolism in vitro and in vivo. Atherosclerosis 1997;129:147.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Anon 2007 {published data only}
  • High-dose extract from the leaves of artichoke increases choleresis and lowers the cholesterol level [Hochdosierter artischockenblatterextrakt steigert cholerese und senkt cholesterinspiegel]. Schweizerische Zeitschrift fur GanzheitsMedizin 2007;19:295-8.
Anon 2008 {published data only}
  • Artichoke leaf extract in the treatment of hyperlipoproteinemia [Artischockenblatterextrakt bei hyperlipoproteinamie]. Schweizerische Zeitschrift fuer GanzheitsMedizin 2008;20:73-4.
Dog 2003 {published data only}
Dorn 1995 {published data only}
  • Dorn M. Improvement in raised lipid levels with artichoke juice (Cynara scolymus L). British Journal of Phytotherapy 1995/1996;4:21-6.
Goetz 2007 {published data only}
  • Goetz P, Le Jeune R. Artichoke, Cynara scolymus. Phytotherapie 2007;5:219-22.
Hausler 2003 {published data only}
  • Hausler M, Ganzera M, Stuppner H, Abel G, Popp M. Artichoke preparations [Artischocken-praparate]. Deutsche Apotheker Zeitung 2003;143:64-73.
Joy 2007 {published data only}
Kirchoff 1994 {published data only}
  • Kirchhoff R, Beckers CH, Kirchhoff GM, Trinczek-Gaertner H, Petrowicz O, Reimann H-J. Increase in choleresis by means of artichoke extract. Phytomedicine 1994;1:107-15.
Kraft 2002 {published data only}
  • Kraft K. Artichoke leaf extract and pectin may lower serum cholesterol. Focus on Alternative and Complementary Therapies 2002;7:350-1.
Kupke 1991 {published data only}
  • Kupke D, Sanden von H, Trinczek-Gaertner, Lewin J, Bluemel, Reimann H-J. An evaluation of the choleretic activity of a plant-based cholagogue [Pruefung der choleretischen Aktivitaet eines pfanzlichen Cholagogums]. Zeitschrift fur Allgemeinmedizin 1991;67:1046-58.
Lupattelli 2004 {published data only}
Meletis 2003 {published data only}
  • Meletis CD. Cardiovascular disease: phytochemical and nutritional prevention and treatment. Alternative and Complementary Therapies 2003;9:158-62.
Montini 1975 {published data only}
  • Montini M, Levoni P, Ongaro A, Pagani G. Controlled application of cynarin in the treatment of hyperlipemic syndrome. Observations in 60 cases [Kontrollierte Anwendung von Cynarin in der Behandlung hyperlipaemischer Syndrome]. Arzneimittel-Forschung 1975;25:1311-4.
Nazni 2006 {published data only}
  • Nazni P, Poongodi VT, Alagianambi P, Amirthaveni M. Hypoglycemic and hypolipidemic effect of Cynara scolymus among selected type 2 diabetic individuals. Pakistan Journal of Nutrition 2006;5:147-51.
Pittler 2001 {published data only}
  • Pittler MH. Encouraging findings for artichoke extract in the treatment of hyperlipoproteinaemia. Focus on Alternative and Complementary Therapies 2001;6:13-4.
Rondanelli 2011 {published data only}
  • Rondanelli M, Giacosa A, Orsini F, Opizzi A, Villani S. Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from phaseolus vulgaris and Cynara scolymus. Phytotherapy Research 2011;25:1275-82.
Schmiedel 2002 {published data only}
  • Schmiedel V. Cholesterol-lowering effects of artichoke and dietary fibre [Senkung des Cholesterinspiegels durch Artischocke und Ballaststoffe]. Erfahrungsheilkunde 2002;51:405-14.
Springer 2003 {published data only}
  • Springer D. High-dose artichoke improves choleresis and lowers blood lipids [Hochdosierter Artischockenextrakt steigert Cholerese und senkt die Blutfette]. Gesundes Leben 2003;80:22-5.
Thompson 2003 {published data only}
  • Thompson Coon JS, Ernst E. Herbs for serum cholesterol reduction: a systematic view. Journal of Family Practice 2003;52:468-72.
Wolf 1996 {published data only}
  • Wolf E. Artichoke for lowering cholesterol level. Pharmazeutische Zeitung 1996;141:35-6.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Pittler 1998
Pittler 2002
  • Pittler MH, Thompson Coon J, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database of Systematic Reviews 2002, Issue 3. [DOI: 10.1002/14651858.CD003335]
Wider 2009