Intervention Review

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High first dose quinine regimen for treating severe malaria

  1. Afolabi FE Lesi1,*,
  2. Martin M Meremikwu2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 18 FEB 2009

DOI: 10.1002/14651858.CD003341.pub2

How to Cite

Lesi AFE, Meremikwu MM. High first dose quinine regimen for treating severe malaria. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD003341. DOI: 10.1002/14651858.CD003341.pub2.

Author Information

  1. 1

    College of Medicine of the University of Lagos, Department of Paediatrics and Child Health, Lagos, Nigeria

  2. 2

    University of Calabar Teaching Hospital, Department of Paediatrics, Calabar, Cross River State, Nigeria

*Afolabi FE Lesi, Department of Paediatrics and Child Health, College of Medicine of the University of Lagos, Lagos, PMB 12003, Nigeria. afolabilesi@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 JUL 2009

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[Analysis 1.1]
Analysis 1.1. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 1 Death.
[Analysis 1.2]
Analysis 1.2. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 2 Coma recovery time.
[Analysis 1.3]
Analysis 1.3. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 3 Convulsions.
[Analysis 1.4]
Analysis 1.4. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 4 Fever clearance time.
[Analysis 1.5]
Analysis 1.5. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 5 Parasite clearance time.
[Analysis 1.6]
Analysis 1.6. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 6 Number with asexual parasitaemia at 24 hours.
[Analysis 1.7]
Analysis 1.7. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 7 Number with asexual parasitaemia at 48 hours.
[Analysis 1.8]
Analysis 1.8. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 8 Neurological sequelae.
[Analysis 1.9]
Analysis 1.9. Comparison 1 High first (loading) dose compared with no loading dose, Outcome 9 Adverse events.