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High first dose quinine regimen for treating severe malaria

  1. Afolabi FE Lesi1,*,
  2. Martin M Meremikwu2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 18 FEB 2009

DOI: 10.1002/14651858.CD003341.pub2

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How to Cite

Lesi AFE, Meremikwu MM. High first dose quinine regimen for treating severe malaria. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD003341. DOI: 10.1002/14651858.CD003341.pub2.

Author Information

  1. 1

    College of Medicine of the University of Lagos, Department of Paediatrics and Child Health, Lagos, Nigeria

  2. 2

    University of Calabar Teaching Hospital, Department of Paediatrics, Calabar, Cross River State, Nigeria

*Afolabi FE Lesi, Department of Paediatrics and Child Health, College of Medicine of the University of Lagos, Lagos, PMB 12003, Nigeria. afolabilesi@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 JUL 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Assimadi 2002 {published data only}
  • Assimadi JK, Gbadoe AD, Agbodjan-Djossou O, Ayewada K, Goeh-Akue E, Kusiaku K, et al. Intravenous quinine treatment of cerebral malaria in African children: comparison of a loading dose regimen without loading dose [Traitment du paludisme cérébral de l'enfant africain par les sels de quinine: comparaison d'un schéma avec dose charge à un schéma classique sans dose charge]. Archives de Pediatrie 2002;9(6):587-94.
Fargier 1991 {published data only}
  • Fargier JJ, Louis FJ, Cot M, Maubert B, Hounsinou C, Louis JP, et al. Reducing of coma by quinine loading dose in falciparum cerebral malaria. Lancet 1991;338(8771):896-7.
  • Louis FJ, Fargier JJ, Maubert B, Louis JP, Hounsinou C, Le Bras J, et al. Severe malaria attacks in adults in Cameroon: comparison of 2 therapeutic protocols using quinine via parenteral route [Access palustre grave de l'adulte au Cameroun: comparaison de deux protocoles therapeutiques utilisant la quinine par voie parenterale]. Annales de La Societe Belge de Medecine Tropicale 1992;72(3):179-88.
Pasvol 1991 {published data only}
  • Pasvol G, Newton CRJC, Winstanley PA, Watkins WM, Peshu NM, Were JBO, et al. Quinine treatment of severe falciparum malaria in African children: A randomized comparison of three regimens. American Journal of Tropical Medicine and Hygiene 1991;45(6):702-13.
Tombe 1992 {published data only}
  • Tombe M, Bhatt KM, Obel AOK. Quinine loading dose in severe falciparum malaria at Kenya National Hospital, Kenya. East African Medical Journal 1992;69(12):670-4.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Davis 1988 {published data only}
  • Davis TM, White NJ, Looareesuwan S, Silamut K, Warrell DA. Quinine pharmacokinetics in cerebral malaria: predicted plasma concentrations after rapid intravenous loading using a two-compartment model. Transactions of the Royal Society of Tropical Medicine and Hygiene 1988;82(4):542-7.
Davis 1990 {published data only}
  • Davis TME, Supanaranond W, Pukrittayakamee S, Karbwang J, Molunto P, Mekthon S, et al. A safe and effective consecutive-infusion regimen for rapid quinine loading in severe falciparum malaria. Journal of Infectious Diseases 1990;161(6):1305-8.
Mehta 1994 {published data only}
  • Mehta SR, Lazar AI, Kasthuri AS. Experience on loading dose--quinine therapy in cerebral malaria. Journal of Association of Physicians in India 1994;42(5):376-8.
van der Torn 1998 {published data only}
  • van der Torn M, Thuma PE, Mabeza GF, Biemba G, Moyo VM, McLaren CE, et al. Loading dose of quinine in African children with cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(3):325-31.
White 1983 {published data only}
  • White NJ, Looareesuwan S, Warrell DA, Warrell MJ, Chanthavanich P, Bunnag D, et al. Quinine loading dose in cerebral malaria. American Journal of Tropical Medicine and Hygiene 1983;32(1):1-5.
Winstanley 1994 {published data only}
  • Winstanley PA, Mberu EK, Watkin WM, Murphy SA, Lowe B, Marsh K. Towards optimal regimens of parenteral quinine of young African children with cerebral malaria: unbound quinine concentrations following a single loading dose regimen. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(5):577-80.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Alderson 2004
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Allen 1996
Bjorkman 1990
Chongsuphajaisiddhi 1981
  • Chongsuphajaisiddhi T, Sabcharoen A, Attanath P. In vivo and in vitro sensitivity of falciparum malaria to quinine in Thai children. Annals of Tropical Paediatrics 1981;1(1):21-6.
Dorland 2000
  • Dorland WAN. Cinchonism. Dorland's illustrated medical dictionary. 29th Edition. Philadelphia: W.B. Saunders Co, 2000:354.
Hall 1977
Jacqz-Aigrain 1994
  • Jacqz-Aigrain E, Bennasr S, Desplanques L, Peralma A, Beaufils F. Severe poisoning risk linked to intravenous administration of quinine. Archives de Pediatrie 1994;1(1):14-9.
Jaffar 1997
  • Jaffar S, Hensbroek MB, Palmer A, Schneider G, Greenwood B. Predictors of fatal outcome following childhood cerebral malaria. American Journal of Tropical Medicine and Hygiene 1997;57(1):20-4.
Jüni 2001
Kawo 1991
  • Kawo NG, Msengi AE, Swai AB, Orskov H, Alberti KG, McLarty DG. The metabolic effects of quinine in children with severe and complicated Plasmodium falciparum malaria in Dar es Salaam. Transactions of the Royal Society of Tropical Medicine and Hygiene 1991;85(6):711-3.
Nuwaha 2001
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White 1982
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