Beta-blocker therapy for tremor in Parkinson's disease
Editorial Group: Cochrane Movement Disorders Group
Published Online: 20 JAN 2003
Assessed as up-to-date: 10 SEP 2002
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
How to Cite
Crosby NJ, Deane K, Clarke CE. Beta-blocker therapy for tremor in Parkinson's disease. Cochrane Database of Systematic Reviews 2003, Issue 1. Art. No.: CD003361. DOI: 10.1002/14651858.CD003361.
- Publication Status: Edited (no change to conclusions)
- Published Online: 20 JAN 2003
The tremor of Parkinson's disease can cause considerable disability for the individual concerned. Traditional antiparkinsonian therapies such as levodopa have only a minor effect on tremor. Beta-blockers are used to attenuate other forms of tremor such as Essential Tremor or the tremor associated with anxiety. It is thought that beta-blockers may be of use in controlling the tremor of Parkinson's disease.
To compare the efficacy and safety of adjuvant beta-blocker therapy against placebo for the treatment of tremor in patients with Parkinson's disease.
Electronic searches of MEDLINE, EMBASE, SCISEARCH, BIOSIS, GEROLIT, OLDMEDLINE, LILACS, MedCarib, PASCAL, JICST-EPLUS, RUSSMED, DISSERTATION ABSTRACTS, SIGLE, ISI-ISTP, Aslib Index to Theses, The Cochrane Controlled Trials Register, Clinicaltrials.gov, metaRegister of Controlled Trials, NIDRR, NRR and CENTRAL were conducted. Grey literature was hand searched and the reference lists of identified studies and reviews examined. The manufacturers of beta-blockers were contacted.
Randomised controlled trials of adjuvant beta-blocker therapy versus placebo in patients with a clinical diagnosis of idiopathic Parkinson's disease.
Data collection and analysis
Data was abstracted independently by two of the authors onto standardised forms and disagreements were resolved by discussion.
Four randomised controlled trials were found comparing beta-blocker therapy with placebo in patients with idiopathic Parkinson's disease. These were double-blind cross-over studies involving a total of 72 patients. Three studies did not present data from the first arm, instead presenting results as combined data from both treatment arms and both placebo arms. The risk of a carry-over effect into the second arm meant that these results were not analysed. The fourth study presented data from each arm. This was in the form of a mean total score for tremor for each group. Details of the baseline scores, the numbers of patients in each group and standard deviations were not provided, meaning that the magnitude and significance of any changes due to therapy could not be calculated. One study reported a substantial fall in heart rate in 14 of the 22 patients, with one patient withdrawing after his heart rate dropped to 56 beats per minute (baseline heart rate was not reported).
In view of this lack of evidence, it is impossible to determine whether beta-blocker therapy is effective and safe for the treatment of tremor in Parkinson's disease. The high frequency of bradycardia in one trial raises some concerns about the prescription of beta-blockers to normotensive elderly patients but the study was too small for the true degree of risk to be calculated.
Plain language summary
Beta-blockers may be able to help relive tremor for people with Parkinson's disease, but more research is needed on safety and effectiveness.
Tremor is one of the main symptoms of Parkinson's disease, and it can be embarrassing and limit daily activities. The drugs most commonly used for Parkinson's disease tend to be more effective in treating other symptoms of the disease (such as rigidity or slowness of movement). Beta-blocker drugs are used to relieve tremor from other conditions. However, the review found there is not enough evidence from trials to show whether beta-blockers are safe and effective for tremor in Parkinson's disease. The blood pressure lowering effect of beta-blockers may be a problem to people with Parkinson's disease and normal blood pressure.
我們搜尋了MEDLINE、EMBASE、SCISEARCH、BIOSIS、MedCarib、PASCAL、JICSTEPLUS、RUSSMED、DISSERTATION ABSTRACTS、SIGLE、ISIISTP、Aslib Index to Theses、The Cochrane Controlled Trials Register、Clinicaltrials.gov、Controlled Trials的metaRegister、NIDRR、NRR和CENTRAL等電子資料庫。手動搜尋Grey literature及檢視找到研究中的參看資料。並和beta收體阻斷劑的製造商連絡。
此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。