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Methadone at tapered doses for the management of opioid withdrawal

  1. Laura Amato1,*,
  2. Marina Davoli1,
  3. Silvia Minozzi1,
  4. Eliana Ferroni2,
  5. Robert Ali3,
  6. Marica Ferri4

Editorial Group: Cochrane Drugs and Alcohol Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 20 JUL 2012

DOI: 10.1002/14651858.CD003409.pub4


How to Cite

Amato L, Davoli M, Minozzi S, Ferroni E, Ali R, Ferri M. Methadone at tapered doses for the management of opioid withdrawal. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD003409. DOI: 10.1002/14651858.CD003409.pub4.

Author Information

  1. 1

    Lazio Regional Health Service, Department of Epidemiology, Rome, Italy

  2. 2

    Public Health Agency of Lazio Region, Infectious Diseases Unit, Rome, Italy

  3. 3

    University of Adelaide, Discipline of Pharmacology, Adelaide, SA, Australia

  4. 4

    European Monitoring Centre for Drugs and Drug Addiction, Interventions, Best Practice and Scientific Partners, Lisbon, Portugal

*Laura Amato, Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, 00198, Italy. l.amato@deplazio.it.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 FEB 2013

SEARCH

[Figure 1]
Figure 1. Flow chart of studies
[Figure 2]
Figure 2. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Tapered methadone versus any other treatment, outcome: 1.1 Completion of treatment.
[Figure 5]
Figure 5. Forest plot of comparison: 1 Tapered methadone versus any other treatment, outcome: 1.2 Number of participants abstinent at follow-up.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Tapered methadone versus any other treatment, Outcome 1 Completion of treatment.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Tapered methadone versus any other treatment, Outcome 2 Number of participants abstinent at follow-up.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Tapered methadone versus adrenergic agonists, Outcome 1 Completion of treatment.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Tapered methadone versus other opioid agonists, Outcome 1 Completion of treatment methadone versus any other opioid agonist.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Tapered methadone versus other opioid agonists, Outcome 2 Completion of treatment methadone versus buprenorphine.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Tapered methadone versus anxiolytic, Outcome 1 Completion of treatment.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Tapered methadone versus placebo, Outcome 1 Completion of treatment.