Intervention Review

Interventions for treating depression after stroke

  1. Maree L Hackett1,*,
  2. Craig S Anderson1,
  3. Allan House2,
  4. Jun Xia3

Editorial Group: Cochrane Stroke Group

Published Online: 8 OCT 2008

Assessed as up-to-date: 25 MAY 2008

DOI: 10.1002/14651858.CD003437.pub3

How to Cite

Hackett ML, Anderson CS, House A, Xia J. Interventions for treating depression after stroke. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD003437. DOI: 10.1002/14651858.CD003437.pub3.

Author Information

  1. 1

    The George Institute for International Health, Department of Neurological and Mental Health, Sydney, NSW, Australia

  2. 2

    University of Leeds, Leeds Institute of Health Sciences, Leeds, UK

  3. 3

    Bridge House, Cochrane Schizophrenia Group, Leeds, UK

*Maree L Hackett, Department of Neurological and Mental Health, The George Institute for International Health, PO Box M201, Missenden Road, Sydney, NSW, 2050, Australia.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 8 OCT 2008




  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要


Depression is an important consequence of stroke that impacts on recovery yet is often not detected or inadequately treated. This is an update of a Cochrane review first published in 2004.


To determine whether pharmaceutical, psychological, or electroconvulsive treatment (ECT) of depression in patients with stroke can improve outcome.

Search methods

We searched the trials registers of the Cochrane Stroke Group (last searched October 2007) and the Cochrane Depression Anxiety and Neurosis Group (last searched February 2008). In addition, we searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2008), MEDLINE (1966 to May 2006), EMBASE (1980 to May 2006), CINAHL (1982 to May 2006), PsycINFO (1967 to May 2006) and other databases. We also searched reference lists, clinical trials registers, conference proceedings and dissertation abstracts, and contacted authors, researchers and pharmaceutical companies.

Selection criteria

Randomised controlled trials comparing pharmaceutical agents with placebo, or various forms of psychotherapy or ECT with standard care (or attention control), in patients with stroke, with the intention of treating depression.

Data collection and analysis

Two review authors selected trials for inclusion and assessed methodological quality; three review authors extracted, cross-checked and entered data. Primary analyses were the prevalence of diagnosable depressive disorder at the end of treatment. Secondary outcomes included depression scores on standard scales, physical function, death, recurrent stroke and adverse effects.

Main results

Sixteen trials (17 interventions), with 1655 participants, were included in the review. Data were available for 13 pharmaceutical agents, and four trials of psychotherapy. There were no trials of ECT. The analyses were complicated by the lack of standardised diagnostic and outcome criteria, and differing analytic methods. There was some evidence of benefit of pharmacotherapy in terms of a complete remission of depression and a reduction (improvement) in scores on depression rating scales, but there was also evidence of an associated increase in adverse events. There was no evidence of benefit of psychotherapy.

Authors' conclusions

A small but significant effect of pharmacotherapy (not psychotherapy) on treating depression and reducing depressive symptoms was found, as was a significant increase in adverse events. More research is required before recommendations can be made about the routine use of such treatments.


Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Interventions for treating depression after stroke

Antidepressant drugs may be useful in treating depression after stroke, but also cause side effects. Depression is common after stroke and may be treated with antidepressant medication or psychological therapy. This review of 16 trials, including 1655 participants, found that antidepressant drugs may produce recovery or improve depression symptoms. However they also increase side effects. These drugs should be used with caution in people with persistent depressive symptoms after stroke, as little is known about the risks, especially of seizures, falls, and delirium. We found no evidence for the benefit of psychotherapy. Future research should include a broader group of stroke patients.



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要







我們搜查了the trials registers of the Cochrane Stroke Group (搜尋至2007年10月)以及 the Cochrane Depression Anxiety and Neurosis Group (搜尋至2008年2月)。此外,我們搜尋了Cochrane Central Register of Controlled Trials (The Cochrane Library,2008年第1期)、 MEDLINE (1966年至2006年5月)、EMBASE (1980年至2006年5月)CINAHL (1982年至2006年5月)、PsycINFO (1967年至2006年5月)以及其他資料庫。我們還搜尋參考文獻、臨床試驗資料庫、研討會摘要手冊及論文摘要,並聯絡作者、研究者與藥廠。


比較不同種類的藥劑與安慰劑,或各種心理治療或ETC加上標準照護(或注意力控制)的隨機對照試驗(randomised controlled trials)於中風病人且具有明確治療憂鬱症的意向者。









此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。