Intervention Review

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Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants

  1. Nicola Austin1,*,
  2. Brian A Darlow2,
  3. William McGuire3

Editorial Group: Cochrane Neonatal Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 31 DEC 2012

DOI: 10.1002/14651858.CD003478.pub4

How to Cite

Austin N, Darlow BA, McGuire W. Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD003478. DOI: 10.1002/14651858.CD003478.pub4.

Author Information

  1. 1

    Christchurch Womens Hospital, NICU, Christchurch, New Zealand

  2. 2

    Christchurch School of Medicine, Department of Paediatrics, CHRISTCHURCH, New Zealand

  3. 3

    Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK

*Nicola Austin, NICU, Christchurch Womens Hospital, Christchurch, New Zealand. nicola.austin@cdhb.govt.nz.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Forest plot of comparison: 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, outcome: 1.1 Incidence of invasive fungal infection.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, outcome: 1.2 Mortality.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, outcome: 1.6 Length of stay in NICU (days).
[Figure 5]
Figure 5. Forest plot of comparison: 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, outcome: 2.1 Incidence of invasive fungal infection.
[Figure 6]
Figure 6. Forest plot of comparison: 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, outcome: 2.2 Mortality.
[Figure 7]
Figure 7. Forest plot of comparison: 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, outcome: 2.4 Necrotising enterocolitis.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 1 Incidence of invasive fungal infection.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 2 Mortality.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 3 Bronchopulmonary dysplasia.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 4 Necrotising enterocolitis.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 5 Retinopathy of prematurity.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Oral/topical non-absorbed antifungal prophylaxis vs placebo or nothing, Outcome 6 Length of stay in NICU (days).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 1 Incidence of invasive fungal infection.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 2 Mortality.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 3 Bronchopulmonary dysplasia.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 4 Necrotising enterocolitis.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 5 Retinopathy of prematurity.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Oral/topical non-absorbed prophylaxis vs. systemic antifungal prophylaxis, Outcome 6 Length of stay in NICU (days).