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Intervention Review

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Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants

  1. Nicola Austin1,*,
  2. Brian A Darlow2,
  3. William McGuire3

Editorial Group: Cochrane Neonatal Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 31 DEC 2012

DOI: 10.1002/14651858.CD003478.pub4


How to Cite

Austin N, Darlow BA, McGuire W. Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD003478. DOI: 10.1002/14651858.CD003478.pub4.

Author Information

  1. 1

    Christchurch Womens Hospital, NICU, Christchurch, New Zealand

  2. 2

    Christchurch School of Medicine, Department of Paediatrics, CHRISTCHURCH, New Zealand

  3. 3

    Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK

*Nicola Austin, NICU, Christchurch Womens Hospital, Christchurch, New Zealand. nicola.austin@cdhb.govt.nz.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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This is not the most recent version of the article. View current version (24 OCT 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Aydemir 2011a {published data only}
  • Aydemir C, Oguz SS, Dizdar EA, Akar M, Sarikabadayi YU, Saygan S, et al. Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(3):F164-8. [PUBMED: 20659937]
Aydemir 2011b {published data only}
  • Aydemir C, Oguz SS, Dizdar EA, Akar M, Sarikabadayi YU, Saygan S, et al. Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(3):F164-8. [PUBMED: 20659937]
Ozturk 2006 {published data only}
Sims 1988 {published data only}
Violaris 2010 {published data only}
  • Violaris K, Carbone T, Bateman D, Olawepo O, Doraiswamy B, LaCorte M. Comparison of fluconazole and nystatin oral suspensions for prophylaxis of systemic fungal infection in very low birthweight infants. American Journal of Perinatology 2010;27(1):73-8. [PUBMED: 19504425]
  • Violaris K, Doraiswamy B, Olawepo O, Gulrajani-LaCorte M. Fluconazole versus nystatin prophylaxis for fungal infection in very low birth weight (VLBW) infants. Pediatric Research. 1998; Vol. 44:254A.
Wainer 1992 {published data only}
  • Wainer S, Cooper PA, Funk E, Bental RY, Sandler DA, Patel J. Prophylactic miconazole oral gel for the prevention of neonatal fungal rectal colonization and systemic infection. Pediatric Infectious Disease Journal 1992;11(9):713-6.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Damjanovic 1993 {published data only}
  • Damjanovic V, Connolly CM, van Saene HK, Cooke RW, Corkill JE, van Belkum A, van Velzen D. Selective decontamination with nystatin for control of a candida outbreak in a neonatal intensive care unit. Journal of Hospital Infection 1993;24(4):245-59.
Harris 1960 {published data only}
  • Harris LJ. Further observations on a simple procedure to eliminate thrush from hospital nurseries. American Journal of Obstetrics and Gynecology 1960;80:30-1.
Herruzo-Cabrera 1994 {published data only}
  • Herruzo-Cabrera R, Garcia Gonzalez JI, Garcia-Magan P, del Rey-Calero J. Nosocomial infection in a neonatal intensive care unit and its prevention with selective intestinal decolonization. A multivariant evaluation of infection reduction. European Journal of Epidemiology 1994;10(5):573-80.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Yekta 2012 {published data only}
  • Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight Infants. Ongoing study February 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Austin 2012
Benjamin 2003
  • Benjamin DK Jr, Poole C, Steibach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics 2003;112(3 Pt 1):634-40.
Benjamin 2006
  • Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006;117(1):84-92.
Brecht 2009
  • Brecht, M, Clerihew, L, McGuire, W. Prevention and treatment of invasive fungal infection in very low birthweight infants. Archives of Disease in Childhood. Fetal & Neonatal Edition 2009;94(1):F65-9.
Brion 2007
Burwell 2006
  • Burwell LA, Kaufman D, Blakely J, Stoll BJ, Fridkin SK. Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. Pediatrics 2006;118(4):e1019-26.
Clerihew 2006
  • Clerihew L, Lamagni TL, Brocklehurst P, McGuire W. Invasive fungal infection in very low birthweight infants: national prospective surveillance study. Archives of Disease in Childhood. Fetal and Neonatal Edition 2006;91(3):F188-92.
Clerihew 2008
Cotten 2006
  • Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr: National Institute for Child Health and Human Development Neonatal Research Network. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 2006;118(2):717-22.
Ernst 1983
  • Ernst JA, Williams JM, Glick MR, Lemons JA. Osmolality of substances used in the intensive care nursery. Pediatrics 1983;72(3):347-52. [PUBMED: 6889039]
Faix 1989
  • Faix RG, Kovarik SM, Shaw TR, Johnson RV. Mucocutaneous and invasive candidiasis among very low birth weight (<1,500 grams) infants in intensive care nurseries: a prospective study. Pediatrics 1989;83(1):101-7.
Frattarelli 2004
Friedman 2000
  • Friedman S, Richardson SE, Jacobs SE, O'Brien K. Systemic candida infection in extremely low birth weight infants: short term morbidity and long term neurodevelopmental outcome. Pediatric Infectious Disease Journal 2000;19(6):499-504.
Ganesan 2008
  • Ganesan K, Harigopal S, Neal T, Yoxall CW. Prophylactic oral nystatin for preterm babies under 33 weeks gestation decreases fungal colonisation and invasive fungaemia. Archives of Disease in Childhood Fetal & Neonatal Edition 2009;94(4):F275-8.
Horbar 2002
  • Horbar JD, Badger GJ, Carpenter JH, Fanaroff AA, Kilpatrick S, LaCorte M, et al. Members of the Vermont Oxford Network. Trends in mortality and morbidity for very low birth weight infants, 1991–1999. Pediatrics 2002;110(1 Pt 1):143-51.
Howell 2009
  • Howell AJ, Isaacs D, Halliday R. Oral nystatin prophylaxis and neonatal fungal infections. Archives of Disease in Childhood. Fetal & Neonatal Edition 2009;94(6):F429-33.
Huang 1998
  • Huang YC, Li CC, Lin TY, Lien RI, Chou YH, Wu JL, et al. Association of fungal colonization and invasive disease in very low birth weight infants. Pediatric Infectious Diseases Journal 1998;17(9):819-22.
Isaacs 2008
Kaguelidou 2012
  • Kaguelidou F, Pandolfini C, Manzoni P, Choonara I, Bonati M, Jacqz-Aigrain E. European survey on the use of prophylactic fluconazole in neonatal intensive care units. European Journal of Pediatrics 2012;171(3):439-45. [PUBMED: 21912893]
Karlowicz 2002
  • Karlowicz MG, Rowen JL, Barnes-Eley ML, Burke BL, Lawson ML, Bendel CM, et al. The role of birth weight and gestational age in distinguishing extremely low birth weight infants at high risk of developing candidemia from infants at low risk: a multicenter study. Pediatric Research 2002;51:301A.
Lee 1998
  • Lee BE, Cheung PY, Robinson JL, Evanochko C, Robertson CM. Comparative study of mortality and morbidity in premature infants (birth weight < 1,250g) with candidemia or candidal meningitis. Clinical Infectious Diseases 1998;27(3):559-65.
Makhoul 2002
  • Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics 2002;109(1):34-9.
Manzoni 2006
  • Manzoni P, Farina D, Leonessa M, d'Oulx EA, Galletto P, Mostert M, et al. Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization. Pediatrics 2006;118(6):2359-64.
O'Grady 2008
Pappu-Katikaneni 1990
  • Pappu-Katikaneni LD, Rao KP, Banister E. Gastrointestinal colonization with yeast species and Candida septicemia in very low birth weight infants. Mycoses 1990;33(1):20-3.
Radmacher 2012
RevMan 2011
  • The Nordic Cochrane Centre. The Cochrane Collabortion. Review Manager (Revman). 5.1. Copenhagan: The Nordic Cochrane Centre. The Cochrane Collabortion, 2011.
Rowen 1994
  • Rowen JL, Rench MA, Kozinetz CA, Adams JM, Baker CJ. Endotracheal colonization with candida enhances risk of systemic candidiasis in very low birth weight neonates. Journal of Pediatrics 1994;124(5 Pt 1):789-94.
Saiman 2000
  • Saiman L, Ludington BA, Pfaller M, Rangel-Frausto S, Wiblin RT, Dawson J, et al. Risk factors for candidemia in Neonatal Intensive Care Unit patients. The national epidemiology of mycosis survey study group. Pediatric Infectious Disease Journal 2000;19(4):319-24.
Stoll 2002
  • Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Austin 2004
  • Austin NC, Darlow B. Prophylactic oral antifungal agents to prevent systemic candida infection in preterm infants. Cochrane Database of Systematic Reviews 2004, Issue 1. [DOI: 10.1002/14651858.CD003478.pub2]
Austin 2009