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Progestogen for preventing miscarriage

  1. David M Haas1,*,
  2. Patrick S Ramsey2

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 OCT 2013

Assessed as up-to-date: 3 SEP 2013

DOI: 10.1002/14651858.CD003511.pub3


How to Cite

Haas DM, Ramsey PS. Progestogen for preventing miscarriage. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD003511. DOI: 10.1002/14651858.CD003511.pub3.

Author Information

  1. 1

    Indiana University School of Medicine, Department of Obstetrics and Gynecology, Indianapolis, Indiana, USA

  2. 2

    Uniformed Services University of Health Sciences, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Bethesda, MD, USA

*David M Haas, Department of Obstetrics and Gynecology, Indiana University School of Medicine, 1001 West 10th Street, F-5, Indianapolis, Indiana, IN 46202, USA. dahaas@iupui.edu.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 31 OCT 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Berle 1980 {published data only}
Corrado 2002 {published data only}
  • Corrado F, Dugo C, Cannata M, Di Bartolo M, Scilipoti A, Stella N. A randomised trial of progesterone prophylaxis after midtrimester amniocentesis. European Journal of Obstetrics & Gynecology and Reproductive Biology 2002;100(2):196-8.
El-Zibdeh 2005 {published data only}
  • El Zibdeh M. Randomized clinical trial comparing the efficacy of dydrogesterone and human chorionic gonadotropin. Climacteric 2002;5(Suppl 1):136.
  • El Zibdeh M. Randomized study comparing the efficacy of reducing spontaneous abortion following treatment with progesterone and human chorionic gonadotropin (hCG). Fertility and Sterility 1998;70(3 Suppl 1):S77-S78.
  • El-Zibdeh MY. Dydrogesterone in the reduction of recurrent spontaneous abortion. Journal of Steroid Biochemistry & Molecular Biology 2005;97(5):431-4.
Gerhard 1987 {published data only}
  • Gerhard I, Gwinner B, Eggert-Kruse W, Runnebaum B. Double-blind controlled trial of progesterone substitution in threatened abortion. Biological Research in Pregnancy and Perinatology 1987;8:26-34.
Goldzieher 1964 {published data only}
Klopper 1965 {published data only}
Le Vine 1964 {published data only}
  • Le Vine L. Habitual abortion. A controlled clinical study of progestational therapy. Western Journal of Surgery 1964;72:30-6.
MacDonald 1972 {published data only}
  • MacDonald RR, Goulden R, Oakey RE. Cervical mucus, vaginal cytology and steroid excretion in recurrent abortion. Obstetrics & Gynecology 1972;40(3):394-402.
Moller 1965 {published data only}
  • Moller K, Fuchs F. Double blind controlled trial of 6-methyl-17-acetoxyprogesterone in threatened abortion. Journal of Obstetrics and Gynaecology of the British Commonwealth 1965;72:1042-4.
Nyboe Anderson 2002 {published data only}
  • Nyboe Anderson A, Popovic-Todorovic B, Schmidt K, Loft A, Lindhard A, Hojgaard A, et al. Progesterone supplement during early gestations after IVF or ICSI has no effect on the delivery rates: a randomized controlled trial. Human Reproduction 2002;17(2):357-61.
Reijnders 1988 {published data only}
Shearman 1963 {published data only}
  • Shearman R, Garrett W. Double-blind study of effect of 17-hydroxyprogesterone caproate on abortion rate. British Medical Journal 1963;1:292-5.
Swyer 1953 {published data only}
Tognoni 1980 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Brenner 1962 {published data only}
  • Brenner W, Hendricks C. Effect of medroxyprogesterone acetate upon the duration and characteristics of human gestation labour. American Journal of Obstetrics and Gynecology 1962;83(8):1094-8.
Check 1985 {published data only}
Check 1987a {published data only}
  • Check J, Chase J, Nowroozi K, Wu C, Adelson H. Progesterone therapy to decrease first-trimester spontaneous abortions in previous aborters. International Journal of Fertility 1987;32(3):192-9.
Check 1987b {published data only}
  • Check J, Chase J, Wu C, Adelson H, Teichman M, Rankin A. The efficacy of progesterone in achieving successful pregnancy: prophylactic use during luteal phase in anovulatory women. International Journal of Fertility 1987;32(2):135-8.
Check 1995 {published data only}
  • Check JH, Tarquini P, Gandy P, Lauer C. A randomized study comparing the efficacy of reducing the spontaneous abortion rate following lymphocyte immunotherapy and progesterone treatment vs progesterone alone in primary habitual aborters. Gynecologic and Obstetric Investigation 1995;39:257-61.
Clifford 1996 {published data only}
Daya 1988 {published data only}
  • Daya S, Ward S, Burrows E. Progesterone profiles in luteal phase defect cycles and outcome of progesteron treatment in patients with recurrent spontaneous abortion. American Journal of Obstetrics and Gynecology 1988;158(2):225-32.
Fuchs 1966 {published data only}
  • Fuchs F, Olsen P. An attempted double-blind controlled trial of progesterone therapy in habitual abortion. Ugeskrift for Laeger 1966;128:1461-2.
Johnson 1975 {published data only}
  • Johnson J, Austin K, Jones G, Davis G, King T. Efficacy of 17 alpha-hydroxyprogesterone caproate on the prevention of premature labour. New England Journal of Medicine 1975;298(14):675-80.
Kyrou 2011 {published data only}
  • Kyrou D, Fatemi HM, Zepiridis L, Riva A, Papanikolaou EG, Tarlatzis BC, et al. Does cessation of progesterone supplementation during early pregnancy in patients treated with recFSH/GnRH antagonist affect ongoing pregnancy rates? A randomized controlled trial. Human Reproduction 2011;26(5):1020-4.
Norman 2006 {published data only}
  • Norman JE. Double blind randomised placebo controlled study of progesterone for the prevention of preterm birth in twins (STOPPIT). National Research Register. www.nrr.nhs.uk (accessed 6 July 2006).
Prietl 1992 {published data only}
  • Prietl G, Diedrich K, Van der Ven HH, Luckhaus J, Krebs D. The effect of 17alpha-hydroxyprogesterone caproate/oestradiol valerate on the development and outcome of early pregnancies following in vitro fertilization and embryo transfer: a prospective and randomized controlled trial. Human Reproduction 1992;7(1):1-5.
Rock 1985 {published data only}
  • Rock J, Colston Wentz A, Cole K, Kimball A, Zacur H, Early S, et al. Fetal malformations following progesterone therapy during pregnancy: a preliminary report. Fertility and Sterility 1985;44(1):17-9.
Shu 2002 {published data only}
  • Shu J, Miao P, Wang RJ. Clinical observation on effect of Chinese herbal medicine plus human chorionic gonadotropin and progesterone in treating anticardiolipin antibody-positive early recurrent spontaneous abortion. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi//Chinese Journal of Integrated Traditional and Western Medicine 2002;22(6):414-6.
Sidelnikova 1990 {published data only}
  • Sidelnikova VM, Demidova EM, Borisova IF, Dondukova TM, Absava GI, Korkhov VV. The use of acetomepegrenol in the therapy of threatened abortion. Akusherstvo i Ginekologiia 1990;66(9):37-40.
Smitz 1992 {published data only}
  • Smitz J, Devroey P, Faguer B, Bourgain C, Camus M, Van Steirteghem AC. Randomized prospective trial comparing supplementation of the luteal phase and of early pregnancy by natural progesterone given by intramuscular or vaginal administration. Revue Francaise de Gynecologie et d Obstetrique 1992;87:507-16.
Sondergaard 1985 {published data only}
  • Sondergaard F, Ottesen B, Detlefsen GU, Schierup L, Pederson SC, Lebech PE. Progesterone treatment of cases of threatened pre-term delivery in women with a low level of plasma progesterone. Contraception, Fertilite, Sexualite 1985;13(12):1227-31.
Turner 1966 {published data only}
  • Turner SJ, Mizock GB, Feldman GL. Prolonged gynecologic and endocrine manifestations subsequent to administration of medroxyprogesterone acetate during pregnancy. American Journal of Obstetrics and Gynecology 1966;95:222-7.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Coomarasamy 2012 {published data only}
  • Coomarasamy A. First trimester progesterone therapy in women with a history of unexplained recurrent miscarriages: a randomised double-blind placebo-controlled multi-centre trial (The PROMISE [PROgesterone in recurrent MIScarriagE] Trial). http://www.controlled-trials.com/ISRCTN92644181 (accessed 11.01.2012).
Raddatz 2006 {published data only}
  • Raddatz G. Habitual abortion study: oral dydrogesterone treatment during pregnancy in women with recurrent miscarriage. http://clinicaltrials.gov/ct2/show/NCT00193674 (accessed 21 March 2006).
Walch 2005 {published data only}
  • Walch K, Hefler L, Nagele F. Oral dydrogesterone treatment during the first trimester of pregnancy: the prevention of miscarriage study (PROMIS). A double-blind, prospectively randomized, placebo-controlled, parallel group trial. Journal of Maternal-Fetal & Neonatal Medicine 2005;18(4):265-9.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Alfirevic 2012
Atkin 1998
  • Atkin LC, Arcelus M, Fernandez A, Tolbert K. La Psicologia en el Ambito Perinatal. Mexico D.F: INPER, 1988.
Bamigboye 2003
  • Bamigboye AA, Morris J. Oestrogen supplementation, mainly diethylstilbestrol, for preventing miscarriages and other adverse pregnancy outcomes. Cochrane Database of Systematic Reviews 2003, Issue 3. [DOI: 10.1002/14651858.CD004353]
Briggs 2011
  • Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 9th Edition. Philadelphia: Lippincott Williams & Wilkins, 2011.
Burgoyne 1991
  • Burgoyne PS, Holland K, Stephens R. Incidence of numerical chromosome anomalies in human pregnancy estimation from induced and spontaneous abortion data. Human Reproduction 1991;6(4):555-65.
Coomarasamy 2011
  • Coomarasamy A, Truchanowicz EG, Rai R. Does first trimester progesterone prophylaxis increase the live birth rate in women with unexplained recurrent miscarriages?. BMJ 2011;342:d1914.
Coulam 1991
Deeks 2001
  • Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG editor(s). Systematic Reviews in Health Care: Meta-analysis in Context. London: BMJ Books, 2001.
Dyregrove 1987
Goldstein 1989
Grudzinskas 1995
  • Grudzinskas JG. Endocrinocolgical and metabolical assesssment of early pregnancy. In: Chamberlain G editor(s). Tumbull's Obstetrics. London: Pearson Professional Ltd, 1995.
Higgins 2005
  • Higgins JP, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 4.2.4 [updated March 2005]. In: The Cochrane Library, Issue 2, 2005. Chichester, UK: John Wiley & Sons, Ltd.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Howie 1995
  • Howie PG. Abortion and ectopic pregnancy. In: Whitfield CR editor(s). Dewhurst's Textbook of Obstetrics and Gynaecology for Postgraduates. Oxford: Blackwell Science Ltd, 1995.
Karamadian 1992
Keirse 1990
Lede 2005
McBride 1991
Morley 2013
Neilson 2006
Porter 2006
Regan 1989
RevMan 2003 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003.
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Royal 2001
  • Royal College of Obstetricians and Gynaecologists. The management of recurrent miscarriage. http://www.rcog.org.uk/guidelines/recurrent.html (accessed 2001).
Rumbold 2011
Simpson 1991
  • Simpson JL. Fetal wastage. In: Gabe SG, Simpson JL editor(s). Obstetrics. Normal and Problem Pregnancies. New York: Churchill Livingstone Inc, 1991.
Szabo 1996
  • Szabo I, Szilagyi A. Management of threatened abortion. Early Pregnancy 1996;2(4):233-40.
Vance 1991
  • Vance JC, Foster WJ, Najman JM, Embelton, Thearle MJ, Hogden FM. Early parental responses to sudden infant death, stillbirth or neonatal death. Medical Journal of Australia 1991;155(5):292-7.
Woods 1987
  • Woods JR, Esposito JL. Pregnancy Loss: Medical Therapeutics and Practical Considerations. Baltimore: Williams and Wilkins, 1987.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Haas 2008
Oates-Whitehead 2003
  • Oates-Whitehead RM, Haas DM, Carrier JAK. Progestogen for preventing miscarriage. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD003511]