Beta2-agonists for exercise-induced asthma
Editorial Group: Cochrane Airways Group
Published Online: 2 OCT 2013
Assessed as up-to-date: 13 SEP 2013
Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
How to Cite
Bonini M, Di Mambro C, Calderon MA, Compalati E, Schünemann H, Durham S, Canonica GW. Beta2-agonists for exercise-induced asthma. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD003564. DOI: 10.1002/14651858.CD003564.pub3.
- Publication Status: New
- Published Online: 2 OCT 2013
It is well known that physical exercise can trigger asthma symptoms and can induce bronchial obstruction in people without clinical asthma. International guidelines on asthma management recommend the use of beta
To assess the effects of inhaled short- and long-acting beta
Trials were identified by electronic searching of the Cochrane Airways Group Specialised Register of Trials and by handsearching of respiratory journals and meetings. Searches are current as of August 2013.
We included randomised, double-blind, placebo-controlled trials of any study design, published in full text, that assessed the effects of inhaled beta
Data collection and analysis
We used standard methodological procedures as expected by The Cochrane Collaboration.
We included 53 trials consisting of 1139 participants. Forty-eight studies used a cross-over design, and five were performed in accordance with a parallel-group design. Forty-five studies addressed the effect of a single beta
Among primary outcomes for short-term administration, data on maximum fall in forced expiratory volume in 1 second (FEV
Secondary outcomes on other pulmonary function parameters confirmed a more positive and protective effect of beta
Overall evaluation of the included long-term studies suggests a beta
Evidence of low to moderate quality shows that beta
Long-term regular administration of inhaled beta
Plain language summary
Asthma reliever inhalers (beta
2-agonists) used for exercise-induced asthma and exercise-induced bronchoconstriction
Physical exercise may trigger symptoms such as cough, chest tightness and shortness of breath in people with asthma that is not adequately treated (exercise-induced asthma). Sometimes people who do not have asthma still experience asthma-like symptoms during exercise; this is called exercise-induced bronchoconstriction. We looked at both types of people in this review. The treatments we were interested in are called beta
What evidence did we find?
We found 53 trials consisting of 1139 participants. Forty-eight studies used a cross-over design, which meant that each person in the trial received two or more treatments－one or more active treatments, the beta-agonist and a placebo in random order. The rest were parallel-group trials, meaning that people received either the active treatment or a placebo. Most of the studies addressed the effect of a giving a single beta
Studies in which people received a single administration of a beta-agonist showed that FEV
We found that included longer-term studies showed that beta
Quality of the evidence
Overall, we believe that the evidence was of low to moderate quality.
This review shows that beta
This review is current as of August 2013.