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Beta2-agonists for exercise-induced asthma

  1. Matteo Bonini1,2,3,*,
  2. Corrado Di Mambro4,
  3. Moises A Calderon3,
  4. Enrico Compalati5,
  5. Holger Schünemann6,
  6. Stephen Durham3,
  7. Giorgio W Canonica5

Editorial Group: Cochrane Airways Group

Published Online: 2 OCT 2013

Assessed as up-to-date: 13 SEP 2013

DOI: 10.1002/14651858.CD003564.pub3


How to Cite

Bonini M, Di Mambro C, Calderon MA, Compalati E, Schünemann H, Durham S, Canonica GW. Beta2-agonists for exercise-induced asthma. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD003564. DOI: 10.1002/14651858.CD003564.pub3.

Author Information

  1. 1

    "Sapienza" University, Department of Public Health and Infectious Diseases, Rome, Italy

  2. 2

    Institute of Translational Pharmacology (IFT), CNR, Rome, Italy

  3. 3

    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, Section of Allergy and Clinical Immunology, London, UK

  4. 4

    Children's Hospital "Bambino Gesù", Department of Medical and Surgical Pediatric Cardiology - UOC Arrhythmology, Rome, Italy

  5. 5

    University of Genoa, Allergy and Respiratory Diseases Clinic, Department of Internal Medicine (DIMI), Genoa, Italy

  6. 6

    McMaster University, Departments of Clinical Epidemiology and Biostatistics and of Medicine, Hamilton, Ontario, Canada

*Matteo Bonini, Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy. matte.bonini@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 2 OCT 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Anderson 2001 Salb Disk {published data only}
  • Anderson SD, Lambert S, Brannan JD, Wood RJ, Koskela H, Morton AR, et al. Laboratory protocol for exercise asthma to evaluate salbutamol given by two devices. Medicine & Science in Sports & Exercise 2001;33(6):893-900.
Anderson 2001 Salb MDI {published data only}
  • Anderson SD, Lambert S, Brannan JD, Wood RJ, Koskela H, Morton AR, et al. Laboratory protocol for exercise asthma to evaluate salbutamol given by two devices. Medicine & Science in Sports & Exercise 2001;33(6):893-900.
Blake 1999 Salb 180 {published data only}
  • Blake K, Pearlman DS, Scott C, Wang Y, Stahl E, Arledge T. Prevention of exercise-induced bronchospasm in pediatric asthma patients: a comparison of salmeterol powder with albuterol. Annals of Allergy, Asthma & Immunology 1999;82(2):205-11.
Blake 1999 Salm 25 {published data only}
  • Blake K, Pearlman DS, Scott C, Wang Y, Stahl E, Arledge T. Prevention of exercise-induced bronchospasm in pediatric asthma patients: a comparison of salmeterol powder with albuterol. Annals of Allergy, Asthma & Immunology 1999;82(2):205-11.
Blake 1999 Salm 50 {published data only}
  • Blake K, Pearlman DS, Scott C, Wang Y, Stahl E, Arledge T. Prevention of exercise-induced bronchospasm in pediatric asthma patients: a comparison of salmeterol powder with albuterol. Annals of Allergy, Asthma & Immunology 1999;82(2):205-11.
Boner 1994 Form 12 {published data only}
  • Boner AL, Spezia E, Piovesan P, Chiocca E, Maiocchi G. Inhaled formoterol in the prevention of exercise-induced bronchoconstriction in asthmatic children. American Journal of Respiratory and Critical Care Medicine 1994;149(4):935-9.
Boner 1994 Salb 200 {published data only}
  • Boner AL, Spezia E, Piovesan P, Chiocca E, Maiocchi G. Inhaled formoterol in the prevention of exercise-induced bronchoconstriction in asthmatic children. American Journal of Respiratory and Critical Care Medicine 1994;149(4):935-9.
Boulet 1989 Salb {published data only}
  • Boulet LP, Turcotte H, Tennina S. Comparative efficacy of salbutamol, ipratropium, and cromoglycate in the prevention of bronchospasm induced by exercise and hyperosmolar challenges. Journal of Allergy and Clinical Immunology 1989;83(5):882-7.
Bronski 1995 Salb MDI {published data only}
Bronski 1995 Salb Pwd {published data only}
Bronski 1999 Salm Disk {published data only}
  • Bronsky EA, Pearlman DS, Pobiner BF, Scott C, Wang Y, Stahl E. Prevention of exercise-induced bronchospasm in pediatric asthma patients: a comparison of two salmeterol powder delivery devices. Pediatrics 1999;104:501-6.
Bronski 1999 Salm Diskhal {published data only}
  • Bronsky EA, Pearlman DS, Pobiner BF, Scott C, Wang Y, Stahl E. Prevention of exercise-induced bronchospasm in pediatric asthma patients: a comparison of two salmeterol powder delivery devices. Pediatrics 1999;104:501-6.
Bronski 2002 Form 12 {published data only}
  • Bronsky EA, Yegen U, Yeh CM, Larsen LV, Della Cioppa G. Formoterol provides long-lasting protection against exercise-induced bronchospasm. Annals of Allergy, Asthma & Immunology 2002;89(4):407-12.
Bronski 2002 Form 24 {published data only}
  • Bronsky EA, Yegen U, Yeh CM, Larsen LV, Della Cioppa G. Formoterol provides long-lasting protection against exercise-induced bronchospasm. Annals of Allergy, Asthma & Immunology 2002;89(4):407-12.
Bronski 2002 Salb {published data only}
  • Bronsky EA, Yegen U, Yeh CM, Larsen LV, Della Cioppa G. Formoterol provides long-lasting protection against exercise-induced bronchospasm. Annals of Allergy, Asthma & Immunology 2002;89(4):407-12.
Carlsen 1995 Salm 25 {published data only}
  • Carlsen KH, Roksund O, Olsholt K, Njå F, Leegaard J, Bratten G. Overnight protection by inhaled salmeterol on exercise-induced asthma in children. European Respiratory Journal 1995;8(11):1852-5.
Carlsen 1995 Salm 50 {published data only}
  • Carlsen KH, Roksund O, Olsholt K, Njå F, Leegaard J, Bratten G. Overnight protection by inhaled salmeterol on exercise-induced asthma in children. European Respiratory Journal 1995;8(11):1852-5.
Cavagni 1993 Salb Jet {published data only}
  • Cavagni G, Caffarelli C, Manni PL, Stapane I, Preti PAM, Cantini L. Salbutamol administered through a new spacer device to prevent exercise-induced asthma. Advanced Therapy 1993;10(5):207-16.
Cavagni 1993 Salb MDI {published data only}
  • Cavagni G, Caffarelli C, Manni PL, Stapane I, Preti PAM, Cantini L. Salbutamol administered through a new spacer device to prevent exercise-induced asthma. Advanced Therapy 1993;10(5):207-16.
Clarke 1990 Fen {published data only}
  • Clarke PS, Ratowsky DA. Effect of fenoterol hydrobromide and sodium cromoglycate individually and in combination on postexercise asthma. Annals of Allergy 1990;64:187-90.
Daugbjerg 1996 Form 12 {published data only}
Daugbjerg 1996 Salb {published data only}
Debelic 1988 Reproterol {published data only}
  • Debelic M, Hertel G, Konig J. Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus sodium cromoglycate, and placebo in exercise-induced asthma. Annals of Allergy 1988;61(1):25-9.
DeBenedictis 1996 Salm 25 {published data only}
  • de Benedictis FM, Tuteri G, Pazzelli P, Niccoli A, Mezzetti D, Vaccaro R. Salmeterol in exercise-induced bronchoconstriction in asthmatic children: comparison of two doses. European Respiratory Journal 1996;9(10):2099-103.
DeBenedictis 1996 Salm 50 {published data only}
  • De Benedictis FM, Tuteri G, Pazzelli P, Niccoli A, Mezzetti D, Vaccaro R. Salmeterol in exercise-induced bronchoconstriction in asthmatic children: comparison of two doses. European Respiratory Journal 1996;9(10):2099-103.
DeBenedictis 1998 Salb {published data only}
  • De Benedictis FM, Tuteri G, Pazzelli P, Solinas LF, Niccoli A, Parente C. Combination drug therapy for the prevention of exercise-induced bronchoconstriction in children. Annals of Allergy, Asthma & Immunology 1998;80(4):352-6.
Del Col 1993 Salb Jet {published data only}
  • Del Col G, Spezia E, Richelli C, Piovesan P, Cantini L, Boner AL. Assessment of a new space device (Jet) for use with inhaled beta2-agonists in children with exercise-induced asthma. Pediatric Allergy and Immunology 1993;7(2):119-26.
Del Col 1993 Salb MDI {published data only}
  • Del Col G, Spezia E, Richelli C, Piovesan P, Cantini L, Boner AL. Assessment of a new space device (Jet) for use with inhaled beta2-agonists in children with exercise-induced asthma. Pediatric Allergy and Immunology 1993;7(2):119-26.
Dinh Xuan 1989 Terb {published data only}
  • Dinh Xuan AT, Lebeau C, Roche R, Ferriere A, Chaussain M. Inhaled terbutaline administered via a spacer fully prevents exercise-induced asthma in young asthmatic subjects: a double-blind, randomized, placebo-controlled study. Journal of International Medical Research 1989;17(6):506-13.
Egglestone 1981 Terb 250 {published data only}
Ferrari 2000 Form 12 {published data only}
  • Ferrari M, Balestreri F, Baratieri S, Biasin C, Oldani V, Lo Cascio V. Evidence of the rapid protective effect of formoterol dry-powder inhalation against exercise-induced bronchospasm in athletes with asthma. Respiration 2000;67(5):510-3.
Garcia 2001 Form 12 {published data only}
  • Garcia R, Guerra P, Feo F, Galindo PA, Gómez E, Borja J, et al. Tachyphylaxis following regular use of formoterol in exercise-induced bronchospasm. Journal of Investigational Allergology and Clinical Immunology 2001;11(3):176-82.
Green 1992 Salm 50 {published data only}
Gronnerod 2000 Form 4.5 {published data only}
  • Gronnerod TA, von Berg A, Schwabe G, Soliman S. Formoterol via Turbuhaler gave better protection than terbutaline against repeated exercise challenge for up to 12 hours in children and adolescents. Respiratory Medicine 2000;94(7):661-7.
Gronnerod 2000 Form 9 {published data only}
  • Gronnerod TA, von Berg A, Schwabe G, Soliman S. Formoterol via Turbuhaler gave better protection than terbutaline against repeated exercise challenge for up to 12 hours in children and adolescents. Respiratory Medicine 2000;94(7):661-7.
Gronnerod 2000 Terb 500 {published data only}
  • Gronnerod TA, von Berg A, Schwabe G, Soliman S. Formoterol via Turbuhaler gave better protection than terbutaline against repeated exercise challenge for up to 12 hours in children and adolescents. Respiratory Medicine 2000;94(7):661-7.
Hancox 2002 {published data only}
  • Hancox RJ, Subbarao P, Kamada D, Watson RM, Hargreave FE, Inman MD. Beta2-agonist tolerance and exercise-induced bronchospasm. American Journal of Respiratory and Critical Care Medicine 2002;165(8):1068-70.
Hawksworth 2002 Salb HFA {published data only}
  • Hawksworth RJ, Sykes AP, Faris M, Mant T, Lee TH. Albuterol HFA is as effective as albuterol CFC in preventing exercise-induced bronchoconstriction. Annals of Allergy, Asthma & Immunology 2002;88(5):473-7.
Hawksworth 2002 Salb MDI {published data only}
  • Hawksworth RJ, Sykes AP, Faris M, Mant T, Lee TH. Albuterol HFA is as effective as albuterol CFC in preventing exercise-induced bronchoconstriction. Annals of Allergy, Asthma & Immunology 2002;88(5):473-7.
Henricksen 1983 Terb {published data only}
  • Henriksen JM, Dahl R. Effects of inhaled budesonide alone and in combination with low-dose terbutaline in children with exercise-induced asthma. American Review of Respiratory Disease 1983;128(6):993-7.
Henricksen 1992 Salb {published data only}
  • Henriksen JM, Agertoft L, Pedersen S. Protective effect and duration of action of inhaled formoterol and salbutamol on exercise-induced asthma in children. Journal of Allergy and Clinical Immunology 1992;89(6):1176-82.
Henriksen 1992 Form 12 {published data only}
  • Henriksen JM, Agertoft L, Pedersen S. Protective effect and duration of action of inhaled formoterol and salbutamol on exercise-induced asthma in children. Journal of Allergy and Clinical Immunology 1992;89(6):1176-82.
Hills 1976 Salb {published data only}
Hills 1976 Salmefamol {published data only}
Inman 1996 {published data only}
Kemp 1994 Salb {published data only}
  • Kemp JP, Dockhorn RJ, Busse WW, Bleecker ER, Van As A. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. American Journal of Respiratory and Critical Care Medicine 94;150:1612-5.
Kemp 1994 Salm 42 {published data only}
  • Kemp JP, Dockhorn RJ, Busse WW, Bleecker ER, Van As A. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. American Journal of Respiratory and Critical Care Medicine 94;150:1612-5.
Konig 1981 Metaprot {published data only}
Konig 1984 Fen 0.4 {published data only}
Konig 1984 Fen 0.8 {published data only}
Larsson 1982 Fen {published data only}
McAlpine 1990 Form 12 {published data only}
McAlpine 1990 Salb {published data only}
McFadden 1986 Salb (I) {published data only}
  • McFadden ER Jr, Mills R. Prevention of exercise-induced bronchospasm with aerosolized albuterol. Current Therapeutic Research, Clinical and Experimental 1986;39(1):112-8.
McFadden 1986 Salb (II) {published data only}
  • McFadden ER, Mills R. Inhaled albuterol powder for the prevention of exercise-induced bronchospasm. Immunology and Allergy Practice 1986;8(6):199-203.
Morton 1989 Rimet {published data only}
Nelson 1998 {published data only}
Newnham 1993 Salb 200 {published data only}
  • Newnham DM, Ingram CG, Earnshaw J, Palmer JB, Dhillon DP. Salmeterol provides prolonged protection against exercise-induced bronchoconstriction in a majority of subjects with mild, stable asthma. Respiratory Medicine 1993;87(6):439-4.
Newnham 1993 Salm 50 {published data only}
  • Newnham DM, Ingram CG, Earnshaw J, Palmer JB, Dhillon DP. Salmeterol provides prolonged protection against exercise-induced bronchoconstriction in a majority of subjects with mild, stable asthma. Respiratory Medicine 1993;87(6):439-4.
Patel 1986 Salb 200 {published data only}
Patel 1986 Tulob 200 {published data only}
Patel 1986 Tulob 400 {published data only}
Patessio 1991 Form 24 {published data only}
  • Patessio A, Podda A, Carone M, Trombetta N, Donner CF. Protective effect and duration of action of formoterol aerosol on exercise-induced asthma. European Respiratory Journal 1991;4(3):296-300.
Patessio 1991 Salb 200 {published data only}
  • Patessio A, Podda A, Carone M, Trombetta N, Donner CF. Protective effect and duration of action of formoterol aerosol on exercise-induced asthma. European Respiratory Journal 1991;4(3):296-300.
Pearlman 2006 Form 12 {published data only}
  • Pearlman D, Milgrom H, Till D, Ziehmer B. Effect of formoterol fumarate treatment on exercise-induced bronchoconstriction in children. Annals of Allergy, Asthma & Immunology 2006;97(3):382-8.
Pearlman 2006 Form 24 {published data only}
  • Pearlman D, Milgrom H, Till D, Ziehmer B. Effect of formoterol fumarate treatment on exercise-induced bronchoconstriction in children. Annals of Allergy, Asthma & Immunology 2006;97(3):382-8.
Pearlman 2006 Salb 180 {published data only}
  • Pearlman D, Milgrom H, Till D, Ziehmer B. Effect of formoterol fumarate treatment on exercise-induced bronchoconstriction in children. Annals of Allergy, Asthma & Immunology 2006;97(3):382-8.
Pearlman 2007 Salb 90 {published data only}
Philip 2007 Salm 50 {published data only}
  • Philip G, Pearlman DS, Villarán C, Legrand C, Loeys T, Langdon RB, et al. Single-dose montelukast or salmeterol as protection against exercise-induced bronchoconstriction. Chest 2007;132(3):875-83.
Ramage 1994 {published data only}
  • Ramage L, Lipworth BJ, Ingram CG, Cree IA, Dhillon DP. Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol. Respiratory Medicine 1994;88(5):363-8.
Richter 2002 Form 12 {published data only}
  • Richter K, Janicki S, Jorres RA, Magnussen H. Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline. European Respiratory Journal 2002;19(5):865-71.
Richter 2002 Salm 50 {published data only}
  • Richter K, Janicki S, Jorres RA, Magnussen H. Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline. European Respiratory Journal 2002;19(5):865-71.
Richter 2002 Terb 500 {published data only}
  • Richter K, Janicki S, Jorres RA, Magnussen H. Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline. European Respiratory Journal 2002;19(5):865-71.
Shapiro 2002 Form 12 {published data only}
  • Shapiro GG, Kemp JP, DeJong R, Chapko M, Bierman CW, Altman LC, et al. Effects of albuterol and procaterol on exercise-induced asthma. Annals of Allergy 1990;65(4):273-6.
Shapiro 2002 Form 24 {published data only}
  • Shapiro GG, Kemp JP, DeJong R, Chapko M, Bierman CW, Altman LC, et al. Effects of albuterol and procaterol on exercise-induced asthma. Annals of Allergy 1990;65(4):273-6.
Shapiro 2002 Salb 180 {published data only}
  • Shapiro GG, Kemp JP, DeJong R, Chapko M, Bierman CW, Altman LC, et al. Effects of albuterol and procaterol on exercise-induced asthma. Annals of Allergy 1990;65(4):273-6.
Simons 1997 {published data only}
  • Simons FE, Gerstner TV, Cheang MS. Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment. Pediatrics 1997;99(5):655-9.
Stelmach 2008 {published data only}
  • Stelmach I, Grzelewski T, Majak P, Jerzynska J, Stelmach W, Kuna P. Effect of different antiasthmatic treatments on exercise-induced bronchoconstriction in children with asthma. Journal of Allergy and Clinical Immunology 2008;121(2):383-9.
Storms 2004 {published data only}
  • Storms W, Chervinsky P, Ghannam AF, Bird S, Hustad CM, Edelman JM, et al. A comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge. Respiratory Medicine 2004;98(11):1051-62.
Sturani 1983 Fen 400 {published data only}
  • Sturani C, Schiavina M, Tosi I, Gunella G. Comparison of inhaled fenoterol and salbutamol in the prevention of exercise-induced asthma. European Journal of Respiratory Diseases 1983;128(Suppl):526-8.
Sturani 1983 Salb 200 {published data only}
  • Sturani C, Schiavina M, Tosi I, Gunella G. Comparison of inhaled fenoterol and salbutamol in the prevention of exercise-induced asthma. European Journal of Respiratory Diseases 1983;128:526-8.
VanHaitsma 2010 Salb {published data only}
  • VanHaitsma TA,  Mickleborough T, Stager JM, Koceja DM,  Lindley MR, Chapman R. Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes. International Journal of Sports Medicine 2010;31(4):231-6.
Vasquez 1984 Salb 400 {published data only}
  • Vazquez C, Fidalgo I, Virto MC, Labayru MT, Casas C. Efficacy of disodium chromoglycate, salbutamol and ipratroprium bromide on inhibition of exercise induced bronchospasm. Anales Espanoles de Pediatria 1984;20(8):756-62.
Walker 1986 Bitolterol {published data only}
Wolley 1990 Terb 500 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Aebischer 1984 {published data only}
  • Aebischer JC, Benoit RC, Scherrer M. Pirbuterol and salbutamol aerosol for exercise-induced bronchoconstriction. Journal Suisse de Medecine 1984;114(46):1660-4.
Agostini 1983 I {published data only}
  • Agostini M, Barlocco G, Mastella G. Protective effect of fenoterol spray, ipratropium bromide plus fenoterol spray, and oral clenbuterol, on exercise-induced asthma in children. Double blind controlled and randomized clinical trial. European Journal of Respiratory Diseases 1983;128(2):529-32.
Agostini 1983 II {published data only}
  • Agostini M, Barlocco G, Mastella G. Protection against exercise induced asthma in children. Double blind controlled clinical trial with fenoterol spray, fenoterol plus ipratropium and oral clenbuterol. Rivista Italiana di Pediatria 1983;9(4):347-52.
Allegra 1976 {published data only}
  • Allegra J, Field J, Trautlein J, Gillin M, Zelis R. The pharmacologic effect of aerosolized terbutaline sulfate in exercise-induced bronchospasm. Journal of Clinical Pharmacology 1976;16(8-9):444-7.
Anderson 1975 {published data only}
Anderson 1976 {published data only}
  • Anderson SD, Seale JP, Rozea P, Bandler L, Theobald G, Lindsay D. Inhaled and oral salbutamol in exercise-induced asthma. American Review of Respiratory Disease 1976;114(3):493-500.
Anderson 1991 {published data only}
Aranda 1992 {published data only}
  • Aranda PC, Merello AM, Power A, Reus M, Astudillo P. Prevention of exercise induced asthma by bronchodilator drug aerosol. Revista Chilena de Pediatria 1992;63(4):202-5.
Bakran 1980 {published data only}
  • Bakran I, Vrhovac B, Plavsić F. Aminophylline vs. salbutamol in exercise-induced asthma. International Journal of Clinical Pharmacology, Therapy and Toxicology 1980;18(10):442-6.
Battistini 1980 {published data only}
  • Battistini A, Grzincich GL, Gorni A, Baroni AL. Asthma and bronchodilator drugs. Evaluation of a newly developed beta2-agonist: clenbuterol. Rivista Italiana di Pediatria 1980;6(3):313-9.
Baur 1979 {published data only}
Berkowitz 1986 {published data only}
  • Berkowitz R, Schwartz E, Bukstein D, Grunstein M, Chai H. Albuterol protects against exercise-induced asthma longer than metaproterenol sulfate. Pediatrics 1986;77(2):173-8.
Boner 1984 {published data only}
  • Boner AL, Zamo CR, Marchiori MM, Biancotto R, Antolini I, Vallone G. Comparison of nebulized ipratropium, salbutamol and cromoglicate solutions, cromoglicate inhaled powder, theophylline elixir and placebo in exercise induced asthma of the children. Giornale Italiano delle Malattie del Torace 1984;38(6):395-9.
Boner 1987 {published data only}
  • Boner AL, De Stefano G, Niero E, Vallone G, Gaburro D. Salbutamol and ipratropium bromide solution in the treatment of bronchospasm in asthmatic children. Annals of Allergy 1987;58(1):54-8.
Boner 1988 {published data only}
Bratteby 1986 {published data only}
  • Bratteby LE, Foucard T, Lönnerholm G. Combined treatment with ipratropium bromide and beta-2-adrenoceptor agonists in childhood asthma. European Journal of Respiratory Diseases 1986;68(4):239-47.
Bundgaard 1980 {published data only}
Bundgaard 1983 I {published data only}
  • Bundgaard AF. Pretreatment of exercise-induced asthma with beta-2 agonists inhaled from RV to TLC or at TLC. A preliminary report. European Journal of Respiratory Diseases 1983;128(2):518-20.
Bundgaard 1983 II {published data only}
  • Bundgaard AF, Buch D, Schmidt A, Bach-Mortensen N. Pretreatment of exercise-induced asthma in children using disodium cromoglycate and fenoterol inhalation powder. European Journal of Respiratory Diseases 1983;130:36-41.
Bundgaard 1983 III {published data only}
  • Bundgaard A, Schmidt A. Double-blind pretreatment of exercise-induced asthma with sequential inhalations of fenoterol from an aerosol and as a powder; second of two parts. European Journal of Respiratory Diseases 1983;130:67-72.
Bye 1980 {published data only}
  • Bye PT, Anderson SD, Daviskas E, Marty JJ, Sampson D. Plasma cyclic AMP levels in response to exercise and terbutaline sulphate aerosol in normal and asthmatic subjects. European Journal of Respiratory Diseases 1980;61(5):287-97.
Ceugniet 1997 {published data only}
  • Ceugniet F, Cauchefer F, Fragneaud C, Evano-Celli I. Prophylactic treatment of exercise-induced asthma in children: salmeterol or sodium cromoglycate single dose before exercise?. Annales De Pediatrie 1997;44(9):625-34.
Colice 1999 {published data only}
Coreno 2000 {published data only}
  • Coreno A, Skowronski M, Kotaru C, McFadden ER Jr. Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma. Journal of Allergy and Clinical Immunology 2000;106(3):500-6.
Corrias 1989 {published data only}
  • Corrias A, Pelosi U, Corona GB, Minelli R, Peri M, Corda R. Efficacy of broxaterol vs salbutamol in asthma induced by physical exercise in children. Pediatria Medica e Chirurgica 1989;11:161-3.
Dal Col 1995 {published data only}
  • Dal Col G, Martinati L, Mingoni S, Boner A, Cantini L. Salbutamol powder, administered via a multidose and a single-dose powder inhaler, in the prevention of exercise-induced asthma in children. Pediatric Asthma, Allergy and Immunology 1995;9(3):165-71.
Del Bono 1979 {published data only}
Di Gioacchino 1987 {published data only}
  • Di Gioacchino M, Mezzetti A, Mancini M, Guglielmi MD, Lo Medico E, Proietti Franceschilli G, et al. Study of the cardiovascular effects of clenbuterol in exercise-induced asthma. Respiration 1987;51(3):205-13.
Dockhorn 1997 {published data only}
  • Dockhorn RJ, Wagner DE, Burgess GL, Hafner KB, Letourneau K, Colice GL, et al. Proventil HFA provides protection from exercise-induced bronchoconstriction comparable to proventil and ventolin. Annals of Allergy 1997;79(1):85-8.
Edelman 2000 {published data only}
  • Edelman JL, Turpin JA, Bronsky EA, Grossman J, Kemp JP, Ghannam AF, et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group. Annals of Internal Medicine 2000;132(2):97-104.
Eggleston 1981 {published data only}
Ferrari 2002 {published data only}
  • Ferrari M, Segattini C, Zanon R, Bertaiola M, Balestreri F, Brotto E, et al. Comparison of the protective effect of formoterol and of salmeterol against exercise-induced bronchospasm when given immediately before a cycloergometric test. Respiration 2002;69(6):509-12.
Fogel 2010 {published data only}
  • Fogel BR, Rosario N, Aristizabal G, Loeys T, Noonan G, Gaile S, et al. Effect of montelukast or salmeterol added to inhaled fluticasone on exercise-induced bronchoconstriction in children. Annals of Allergy, Asthma & Immunology 2010;104:511-7.
Francis 1980 {published data only}
Freeman 1989 {published data only}
Gibson 1978 {published data only}
  • Gibson GJ, Greenacre JK, König P, Conolly ME, Pride NB. Use of exercise challenge to investigate possible tolerance to beta-adrenoceptor stimulation in asthma. British Journal of Diseases of the Chest 1978;72(3):199-206.
Gimeno 1985 {published data only}
  • Gimeno F, van Veenen R, Steenhuis EJ, Berg WC. Comparison of disodium cromoglycate, terbutaline and thiazinamium in the prevention of exercise-induced asthma and its relation to non-specific bronchial responsiveness. Respiration 1985;48(2):108-15.
GlaxoSmithKline 2006 I {unpublished data only}
  • GlaxoSmithKline. A study measuring asthma control in pediatric and adolescent subjects whose asthma is worsened by activity or exercise. clinicaltrials.gov.
GlaxoSmithKline 2006 II {unpublished data only}
  • GlaxoSmithKline. A Stratified, Multicenter, Randomized, Double-Blind, Parallel Group, 4-Week Comparison of Fluticasone Propionate/Salmeterol DISKUS Combination Product 100/50 mcg BID versus Fluticasone Propionate DISKUS 100 mcg BID in Pediatric and in Adolescent Subjects With Activity-Induced Bronchospasm. GlaxoSmithKline Clinical Trial Register.
Godfrey 1975 {published data only}
  • Godfrey S, König P. Suppression of exercise-induced asthma by salbutamol, theophylline, atropine, cromolyn, and placebo in a group of asthmatic children. Pediatrics 1975;56(5 pt 2 suppl):930-4.
Godfrey 1976 {published data only}
Guerin 1992 {published data only}
  • Guerin JC, Brambilla C, Godard P, de Muizon H, Aubert B, Bons J. Prolonged effect against exercise-induced bronchospasm: salmeterol versus sodium cromoglycate. Revue des Maladies Respiratoires 1992;9(1):27-30.
Gunawardena 2005 {published data only}
  • Gunawardena K, Palmer P, Das S, Hewitt A. Using exercise-induced bronchoconstriction as a method to compare formoterol inhalers in children. Journal of Applied Therapeutic Research 2005;5(3):16-23.
Hermansen 2006 {published data only}
  • Hermansen MN, Nielsen KG, Buchvald F, Jespersen JJ, Bengtsson T, Bisgaard H. Acute relief of exercise-induced bronchoconstriction by inhaled formoterol in children with persistent asthma. Chest 2006;129(5):1203-9.
Higgs 1983 {published data only}
  • Higgs CM, Laszlo G. The duration of protection from exercise-induced asthma by inhaled salbutamol, and a comparison with inhaled reproterol. British Journal of Diseases of the Chest 1983;77(3):262-9.
Ienna 1997 {published data only}
  • Ienna TM, McKenzie DC. The asthmatic athlete: metabolic and ventilatory responses to exercise with and without pre-exercise medication. International Journal of Sports Medicine 1997;18(2):142-8.
Iikura 1988 {published data only}
  • Iikura Y, Inui H, Obata T, Nagakura T, Sugimoto H, Lee TH, et al. Drug effects on exercise-induced late asthmatic responses. New England and Regional Allergy Proceedings 1988;9(3):203-7.
Ioli 1986 {published data only}
  • Ioli F, Donner CF, Fracchia C, Manini G, Patessio A, Spada EL, et al. A new bronchodilating agent, procaterol, in preventing exercise-induced asthma. International Journal of Clinical Pharmacology Research 1986;6(5):389-96.
Johnson 1986 {published data only}
  • Johnson CE, Belfield PW, Davis S, Cooke NJ, Spencer A, Davies JA. Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol. Thorax 1986;41(4):290-4.
Koch 1972 {published data only}
  • Koch G. Terbutaline in bronchial asthma. Effect on lung volumes, ventilatory performance, pulmonary gas exchange and circulation at rest and during exercise. Scandinavian Journal of Respiratory Diseases 1972;53(4):187-95.
Kumar 1988 {published data only}
  • Kumar AS. Salmeterol in exercise induced asthma. Indian Pediatrics 1988;35(7):681-2.
Lopes Dos Santos 1991 {published data only}
Machado 2012 {published data only}
  • Machado D, Pereira G, Tavares B, Loureiro G, Segorbe-Luis A. Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics. European Annals of Allergy and Clinical Immunology 2012;44(1):12-7.
Macucci 2004 {published data only}
  • Macucci F, Guerrini L, Strambi M. Oral montelukast compared with inhaled salbutamol to prevent exercise-induced asthma in children. Minerva Pneumologica 2004;43(1):41-50.
Magnussen 1984 {published data only}
Makela 2012 {published data only}
  • Makela MJ, Malmberg LP, Csonka P, Klemola T, Kajosaari M, Pelkonen AS. Salmeterol and fluticasone in young children with multiple-trigger wheeze. Annals of Allergy, Asthma & Immunology 2012;109:65-70.
Martinsson 1985 {published data only}
Merck 2005 I {unpublished data only}
  • Merck. An investigational drug to prevent exercise-induced bronchospasm. clinicaltrials.gov.
Merck 2005 II {unpublished data only}
  • Merck. Two investigational drugs in the prevention of airway constriction brought on by exercise in asthmatic patients. clinicaltrials.gov.
Mickleborough 2007 {published data only}
  • Mickleborough TD, Lindley MR, Turner LA. Comparative effects of a high-intensity interval warm-up and salbutamol on the bronchoconstrictor response to exercise in asthmatic athletes. International Journal of Sports Medicine 2007;28(6):456-62.
Millqvist 2000 {published data only}
Morandini 1982 {published data only}
  • Morandini GC. Protection of exercise-induced asthma: comparative study of drugs with a different mechanism of action. Minerva Pneumologica 1982;21(2):75-85.
Morooka 1987 {published data only}
  • Morooka T, Nishima S, Ota S. Prevention of exercise-induced bronchospasm in asthmatic children. Effect of aerosol and oral procaterol hydrochloride. Journal of Asthma 1987;24(6):335-46.
Morse 1976 {published data only}
Morton 1992 {published data only}
  • Morton AR, Papalia SM, Morton PS, Fitch KD. The efficacy of the nebuhaler method of administration of terbutaline sulphate in the prevention and amelioration of exercise induced asthma. Australian Journal of Science and Medicine in Sport 1992;24(4):103-6.
Murray 2011 {published data only}
  • Murray JJ, Waitkus-Edwards KR, Yancey SW. Evaluation of fluticasone propionate and fluticasone propionate/salmeterol combination on exercise in pediatric and adolescent patients with asthma. The Open Respiratory Medicine Journal 2011;5:11-8.
Pearlman 2009 {published data only}
Pfleger 2002 {published data only}
Pichaipat 1995 {published data only}
  • Pichaipat V, Tongpenyai Y, Nerntong T, Sriprapachiranont C. The protective effect of inhaled terbutaline, sodium cromoglycate and budesonide on exercise-induced asthma in children. Journal of the Medical Association of Thailand 1995;78(10):505-8.
Pichon 2005 {published data only}
  • Pichon A, Roulaud M, Denjean A, de Bisschop C. Airway tone during exercise in healthy subjects: effects of salbutamol and ipratropium bromide. International Journal of Sports Medicine 2005;26(5):321-6.
Poppius 1973 {published data only}
  • Poppius H, Salorinne Y. Comparative trial of salbutamol and an anticholinergic drug, SCH 1000, in prevention of exercise-induced asthma. Scandinavian Journal of Respiratory Diseases 1973;54(3):142-7.
Rabe 1993 {published data only}
Raissy 2006 {unpublished data only}
  • Raissy HH. Exercise induced bronchospasm in children. clinicaltrials.gov.
Raissy 2008 {published data only}
Revill 1998 {published data only}
  • Revill SM, Morgan MD. The cardiorespiratory response to submaximal exercise in subjects with asthma following pretreatment with controlled release oral salbutamol and high-dose inhaled salmeterol. Respiratory Medicine 1998;92(8):1053-8.
Robertson 1994 {published data only}
  • Robertson W, Simkins J, O'Hickey SP, Freeman S, Cayton RM. Does single dose salmeterol affect exercise capacity in asthmatic men?. European Respiratory Journal 1994;7(11):1978-84.
Rohr 1987 {published data only}
  • Rohr AS, Siegel SC, Katz RM, Rachelefsky GS, Spector SL, Lanier R. A comparison of inhaled albuterol and cromolyn in the prophylaxis of exercise-induced bronchospasm. Annals of Allergy 1987;59(2):107-9.
Sanguinetti 1986 {published data only}
  • Sanguinetti CM, De Luca S, Gasparini S, Massei V. Evaluation of Duovent in the prevention of exercise-induced asthma. Respiration 1986;50(2):181-5.
Schaanning 1996 {published data only}
  • Schaanning J, Vilsvik J, Henriksen AH, Bratten G. Efficacy and duration of salmeterol powder inhalation in protecting against exercise-induced bronchoconstriction. Annals of Allergy, Asthma & Immunology 1996;76(1):57-60.
Shah 1983 {published data only}
  • Shah S, Johnston D, Woodcock AA, Johnson M, Geddes DM. Breathlessness and exercise tolerance in chronic airflow obstruction: 2-hourly versus 4-hourly salbutamol by inhalation. Current Medical Research & Opinion 1983;8(5):343-9.
Shapiro 1981 {published data only}
  • Shapiro GG, McPhillips JJ, Smith K, Furukawa CT, Pierson WE, Bierman CW. Effectiveness of terbutaline and theophylline alone and in combination in exercise-induced bronchospasm. Pediatrics 1981;67(4):508-13.
Shapiro 1990 {published data only}
  • Shapiro GG, Kemp JP, DeJong R, Chapko M, Bierman CW, Altman LC, et al. Effects of albuterol and procaterol on exercise-induced asthma. Annals of Allergy 1990;65(4):273-6.
Sichletidis 1993 {published data only}
  • Sichletidis L, Daskalopoulou E, Kyriazis G, Kosmidou I, Koupidou S, Pechlivanidis T, et al. Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. Journal of International Medical Research 1993;21(2):81-8.
Silverman 1973 {published data only}
Singh 1992 {published data only}
  • Singh JP, Singh R, Gupta RC, Bharadwaja B. A comparative study of bronchodilator actions of ipratropium bromide (Atrovent) and salbutamol (Ventolin) on exercise induced bronchial asthma. Journal of the Association of Physicians of India 1992;40(8):545-7.
Sly 1968 {published data only}
Sly 1975 {published data only}
Sly 1982 {published data only}
Spada 1985 {published data only}
  • Spada EL, Donner CF, Meriggi A, Vecchio C. Pharmacologic prevention of exercise-induced asthma. Minerva Pneumologica 1985;24(2):159-64.
Stark 1981 {published data only}
Steinshamn 2004 {published data only}
  • Steinshamn S, Sandsund M, Sue-Chu M, Bjermer L. Effects of montelukast and salmeterol on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction. Chest 2004;126(4):1154-60.
Svenonius 1983 {published data only}
Svenonius 1988 {published data only}
Svenonius 1994 {published data only}
Tabas 1985 {published data only}
  • Tabas A, Rodríguez A, Lobera T, Diéguez I, Oehling A. Carbuterol, salbutamol and DSCG in exercise-induced asthma. Allergologia et Immunopathologia 1985;13(6):493-500.
Tammivaara 1979 {published data only}
  • Tammivaara R. The efficacy of terbutaline and fenoterol aerosols on adult exercise-induced asthma. Scandinavian Journal of Respiratory Diseases 1979;103:212-3.
Unnithan 1994 {published data only}
Verini 1983 {published data only}
  • Verini M, Chiarelli F, Di Tullio A, Morgese G, Pallotta R. Pharmacological prevention of exercise-induced bronchospasm: review of the literature and trial of disodium cromoglycate, fenoterol and ipratropium bromide in a pediatric population. Pediatria Medica e Chirurgica 1983;5(6):501-9.
Verini 1985 {published data only}
  • Verini M, Ansaloni A, Di Vincenzo MG, Napoleone M, Morgese G. Evaluation of reproterol's effectiveness in preventing exercise-induced bronchospasm in children. Journal of International Medical Research 1985;13(1):19-23.
Verini 1999 {published data only}
  • Verini M, Verrotti A, Greco R, Chiarelli F. Functional effects of controlled physical activity in children and young adults affected by exercise-induced asthma treated with corticosteroids and beta-2 agonists. Clinical Drug Investigation 1999;17(6):467-73.
Villaran 1999 {published data only}
  • Villaran C, O'Neill SJ, Helbling A, van Noord JA, Lee TH, Chuchalin AG, et al. Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Journal of Allergy and Clinical Immunology 1999;104(3):547-53.
Vilsvik 1991 {published data only}
  • Vilsvik J, Schaanning J, Ståhl E, Holthe S. Comparison between Bricanyl Turbuhaler and Ventolin metered dose inhaler in the treatment of exercise-induced asthma in adults. Annals of Allergy 1991;67(3):315-8.
Vilsvik 2001 {published data only}
  • Vilsvik J, Ankerst J, Palmqvist M, Persson G, Schaanning J, Schwabe G, et al. Protection against cold air and exercise-induced bronchoconstriction while on regular treatment with Oxis. Respiratory Medicine 2001;95(6):484-90.
Von Berg 2002 {published data only}
  • Von Berg A, Albrecht B, Darlath W, Vo HW, Berdel D. Intraindividual, randomised, double-blind comparison between sodium cromoglycate and reproterol to assess the protective effect of the single drugs and their combination in children with exercise-induced asthma. Allergologie 2002;25(11):557-64.
Weiler 2005 {published data only}
  • Weiler JM, Nathan RA, Rupp NT, Kalberg CJ, Emmett A, Dorinsky PM. Effect of fluticasone/salmeterol administered via a single device on exercise-induced bronchospasm in patients with persistent asthma. Annals of Allergy, Asthma & Immunology 2005;94(1):65-72.
Weinberg 1982 {published data only}
Yeung 1980 {published data only}
  • Yeung R, Nolan GM, Levison H. Comparison of the effects of inhaled SCH 1000 and fenoterol on exercise-induced bronchospasm in children. Pediatrics 1980;66(1):109-14.
Zanconato 1990 {published data only}
Zimmermann 2003 {published data only}
  • Zimmermann T, Gulyas A, Bauer CP, Steinkamp G, Trautmann M. Salmeterol versus sodium cromoglycate for the protection of exercise induced asthma in children-a randomised cross-over study. European Journal of Medical Research 2003;8(9):428-34.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Kupper 2012 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Anderson 1997
  • Anderson SD. Exercise-induced asthma. In: Kay AB editor(s). Allergy and Allergic Disease. Oxford: Blackwell Scientific Publications, 1997:692-711.
Anderson 2003
  • Anderson SD, Brannan JD. Methods for "indirect" challenge tests including exercise, eucapnic voluntary hyperpnea, and hypertonic aerosols. Clinical Reviews in Allergy & Immunology 2003;24(1):27-54.
Anderson 2006
Bateman 2008
  • Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. European Respiratory Journal 2008;31(1):143-78.
Brozek 2010
  • Brozek JL,  Bousquet J,  Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. Journal of Allergy and Clinical Immunology 2010;126(3):466-76.
Carlsen 2008
  • Carlsen KH, Anderson SD, Bjermer L, Bonini S, Brusasco V, Canonica W, et al. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy 2008;63(4):387-403.
Higgins 2011
  • Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. www.cochranehandbook.org, 2011.
Kelly 2000
  • Kelly KD, Spooner CH, Rowe BH. Nedocromil sodium versus sodium cromoglycate for preventing exercise-induced bronchoconstriction. Cochrane Database of Systematic Reviews 2000, Issue 3. [DOI: 10.1002/14651858.CD002731]
Koh 2007
  • Koh MS, Tee A, Lasserson TJ, Irving LB. Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD002739.pub3]
Martinez 2005
Nelson 2006
  • Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM, for the SMART Study Group. The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006;129:15-26.
Peroni 2011
  • Peroni DG,  Pescollderungg L,  Sandri M, Chinellato I, Boner AL, Piacentini GL. Time-effect of montelukast on protection against exercise-induced bronchoconstriction. Respiratory Medicine 2011;105(12):1790-7.
Randolph 2008
RevMan 5.2 [Computer program]
  • The Cochrane Collaboration. Review Manager (RevMan) Version 5.2. The Cochrane Collaboration, 2012.
Rundell 2000
  • Rundell KW, Wilber RL, Szmedra L, Jenkinson DM, Mayers LB, Im J. Exercise-induced asthma screening of elite athletes: field versus laboratory exercise challenge. Medicine & Science in Sports & Exercise 2000;32(2):309-16.
Salpeter 2010
  • Salpeter SR,  Wall AJ,  Buckley NS. Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events. American Journal of Medicine 2010;123(4):322-8.
Shapiro 2002
  • Shapiro GS, Yegen U, Xiang J, Kottakis J, Della Cioppa G. A randomized, double-blind, single-dose, crossover clinical trial of the onset and duration of protection from exercise-induced bronchoconstriction by formoterol and albuterol. Clinical Therapeutics 2002;24(12):2077-87.
Spooner 2003
  • Spooner CH,  Spooner GR,  Rowe BH. Mast-cell stabilising agents to prevent exercise-induced bronchoconstriction. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD002307]
Sterk 1993
  • Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O'Byrne PM, Anderson SD, et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. European Respiratory Journal 1993;16(Suppl):53-83.
Weiler 2010
  • Weiler JM,  Anderson SD,  Randolph C, Bonini S, Craig TJ, Pearlman DS, et al. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Annals of Allergy, Asthma & Immunology 2010;105(6 suppl):1-47.