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Oral treatments for fungal infections of the skin of the foot.

  1. Sally EM Bell-Syer1,*,
  2. Rachel Hart2,
  3. Fay Crawford3,
  4. David J Torgerson4,
  5. Wendy Tyrrell2,
  6. Ian Russell5

Editorial Group: Cochrane Skin Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 4 DEC 2001

DOI: 10.1002/14651858.CD003584

Database Title

Additional Information

How to Cite

Bell-Syer SEM, Hart R, Crawford F, Torgerson DJ, Tyrrell W, Russell I. Oral treatments for fungal infections of the skin of the foot.. Cochrane Database of Systematic Reviews 2002, Issue 2. Art. No.: CD003584. DOI: 10.1002/14651858.CD003584.

Author Information

  1. 1

    University of York, Department of Health Sciences, York, North Yorkshire, UK

  2. 2

    University of Wales Institute, Faculty of Community Health Sciences, Cardiff, Wales, UK

  3. 3

    The University of Edinburgh, Division of Community Health Sciences, Edinburgh, UK

  4. 4

    University of York, Department of Health Sciences , York, North Yorkshire, UK

  5. 5

    University of Wales Bangor, Institute of Medical and Social Care Research, Bangor, Gwynedd, Wales, UK

*Sally EM Bell-Syer, Department of Health Sciences, University of York, Area 2 Seebohm Rowntree Building, Heslington, York, North Yorkshire, YO10 5DD, UK. sembs1@york.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
DeKeyser 1994 {published data only}
  • De Keyser P, De Backer M, Massart DL, Westerlinck KJ. Two week oral treatment of tinea pedis, comparing terbinafine (250mg/day) with itraconazole (100mg/day): a double blind multicentre study. British Journal of Dermatology 1994;130(suppl 43):22-5.
    Direct Link:
Difonzo 1995 {published data only}
  • Difonzo EM, Papini M, Cilli P, Calandra P, et al. A double blind study comparison of itraconazole and fluconazole in tinea pedis and tinea manuum. Journal of the European Academy of Dermatology and Venereology 1995;4:148-52.
Fischbein 1992 {published data only}
  • Fischbein A, Haneke E, Lacner K. Comparative evaluation of oral fluconazole and oral ketoconazole in the treatment of fungal infections of the skin. International Journal of Dermatology 1992;31(suppl 2):12-6.
Hay 1995 {published data only}
  • Hay RJ, McGregor JM, Wuite J, Ryattk KS, Ziegler C, Clayton YM. A comparison of 2 weeks terbinafine 250mg/day with 4 weeks of itraconazole 100mg/day in plantar - type tinea pedis. British Journal of Dermatology 1995;132 132:604-8.
Kim 1993 {published data only}
  • Kim JH, Yoon KB. Single blind randomised study of terbinafine vs itraconazole in tinea pedis (two weeks vs four weeks). Terbinafine in the treatment of superficial fungal infections. Asia-Pacific symposium on lamisil. Papers. London: Royal Society of Medicine Services, 1993; Vol. No 205:17-20.
Nozickova 1998 {published data only}
  • Nozickova M, Kondelkova V, Kulikova Z, Malina L, et al. A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis and cutaneous candidosis. International Journal of Dermatology 1998;37:703-5.
    Direct Link:
Roberts 1987 {published data only}
Savin 1990a {published data only}
Savin 1990b {published data only}
  • Savin RC. Terbinafine (Lamisil) versus griseofulvin in moccasin type tinea pedis. Journal of Dermatological Treatment 1990;1(suppl 2):43-6.
Svejgaard 1998 {published data only}
  • Svejgaard E, Avnstorp C, Wanscher B, Nilsson J, et al. Efficacy and safety of short-term itraconazole in tinea pedis: a double-blind, randomized, placebo-controlled trial. Dermatology 1998;197:368-72.
Voravutinon 1993 {published data only}
  • Voravutinon V. Double blind comparative study of the efficacy and tolerability of terbinafine with itraconazole in patients with tinea pedis. Terbinafine in the treatment of superficial fungal infections. Asia-Pacific symposium on lamisil. Papers. London: Royal Society of Medicine Services, 1993; Vol. 205:11-6.
Widyanto 1993 {published data only}
  • Widyanto, Budimulja U, Kuswadji, Kusmarinah B. A randomised double blind comparative study of terbinafine vs griseofulvin in tinea pedis. Terbinafine in the treatment of superficial fungal infections. Asia-Pacific symposium on lamisil. Papers. Royal Society of Medicine Services, 1993; Vol. 205:21-4.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Barnetson 1998 {published data only}
  • Barnetson RStC, Marley J, Bullen M, Brookman S, Cowen P, Ellis D, Williams T. Comparison of one week of oral terbinafine (250mg/day) with four weeks of treatment with clotrimazole 1% cream in interdigital tinea pedis. British Journal of Dermatology 1998;139:675-8.
    Direct Link:
Degreef 1987 {published data only}
  • Degreef H, Marian K, De Veyler H, Duprez K, et al. Itraconazole in the treatment of dermatophytoses: a comparison of two daily dosages. Reviews of Infectious Diseases 1987;9(suppl 1):S104-8.
Del Palacio 1993 {published data only}
  • Del Palacio A, Van Cutsem J, Lopez S, Roiz MP, et al. Double blind randomised comparative study on tinea manuum and tinea pedis treated with itraconazole and griseofulvin. Actas Dermo-Sifiligro 1993;84:45-53.
Hay 1991 {published data only}
  • Hay RJ, Logan RA, Moore MK, Midgley G, et al. A comparative study of terbinafine versus griseofulvin in 'dry - type' dermatophyte infections. Journal of American Academy of Dermatology 1991;24:243-6.
Jolly 1983 {published data only}
  • Jolly HW, Daily AD, Rex IH, et al. A multicentre double blind evaluation of ketoconazole in the treatment of dermatomycoses. Cutis 1983;31:208-18.
Legendre 1980 {published data only}
  • Legendre R, Steltz M. A multicentre double blind comparison of ketoconazole and griseofulvin in the treatment of infections due to dermatophytes. Reviews of Infectious Diseases 1980;2:586-91.
Lynfield 1974 {published data only}
  • Lynfield YL, Littman ML, Feingold LE. Treatment of tinea pedis with micronized griseofulvin and tolnaftate. Cutis 1974;13:460-2.
Russell 1960 {published data only}
Savin 1989 {published data only}
  • Savin R. Successful treatment of chronic tinea pedis (moccasin type) with terbinafine (Lamisil). Clinical Experimental Dermatology 1989;14:116-9.
    Direct Link:
Savin/b 1990 {published data only}
Schuller 1998 {published data only}
Tausch 1998 {published data only}
  • Tausch I, Decroix J, Gwiezdzinski Z, Urbanowski S, et al. Short-term itraconazole versus terbinafine in the treatment of tinea pedis or manus. International Journal of Dermatology 1998;37:128-44.
Van Hecke 1988 {published data only}
Wishart 1994 {published data only}
Won 1993 {published data only}
  • Won YH, Kim SJ, Lee HW, Chun IK. Clinical comparative study of terbinafine and itraconazole in the treatment of tinea pedis.. Shuster S & Jafary MH (Ed) Royal Society of Medicine Services Ltd Int. Congress & Symposium series 1993;205:7-10.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Auger 1993
Begg 1989
Begg 1996
  • Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schultz KF, Simel D, Stroup DF. Improving the quality of randomised controlled trials. The CONSORT Statement. JAMA 1996;276(8):637-9.
Brautigam 1995
  • Brautigam M, Nolting S, Schopf G, Weidinger G. Randomised double blind comparison of terbinafine and itraconazole for the treatment of toenail tinea infection. BMJ 1995;vol 311(7, Oct):919-21.
Brookes 1996
  • Brooks KE, Bender JF. Tinea pedis diagnosis and treatment. Clinics in Podiatric Medicine and Surgery 1996;13:31-46.
Catterall 1975
  • Catterall MD. The incidence and epidemiology of tinea pedis in the crew of a nuclear submarine. Journal Nav. Med. Serv 1975;61:92-7.
Crawford 2001
  • Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database of Systematic Reviews 2001, Issue 1. [DOI: ]
Detandt 1995
  • Detandt M, Nolard N. Fungal contamination of the floors of swimming pools, particularly subtropical swimming paradises. Mycoses 1995;38:509-13.
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Elewski 1996
English 1959
English 1961
Gardner 1989
  • Gardner MJ, Altman DG. Statistics with Confidence. London, England: BMJ Publishing Group, 1989.
Gentles 1957
  • Gentles JC, Holmes JG. Foot ringworm in coal miners. British Journal of Industrial Medicine 1957;14:22-9.
Gentles 1973
Gupta 1994a
Gupta 1994b
Hart 1999
Jadad 1996
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. Assessing the Quality of Reports of Randomised Clinical Trials: Is Blinding Necessary?. Controlled Clinical Trials 1996;17:1-12.
Jones 1982
Merlin 1999
  • Merlin K, Kilkenny M, Plunkett A, Marks R. The prevalence of common skin conditions in Australian school students: 4 Tinea Pedis. British J Dermatology 1999;140:897-901.
    Direct Link:
Moher 1995
  • Moher D, Jadad AR, Nichol G, Penman M, Tugwell P, Walsh S. Assessing the quality of Randomised Controlled Trials: An Annotated Bibliography of Scales and Checklists. Controlled Clinical Trials 1995;16:62-73.
NHS CRD 1996
  • NHS Centre for Reviews and Dissemination. Undertaking systematic reviews of research on effectiveness. Report 4. York: University of York, 1996.
Roseeuw 1999
  • Roseeuw D. Achilles foot screening project: preliminary results of patients screened by dermatologists. Journal of the European Academy of Dermatology and Venereology 1999;12(suppl 1):S6-S9.
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