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Intervention Review

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Interventions for protecting renal function in the perioperative period

  1. Mathew Zacharias1,*,
  2. Niamh P Conlon2,
  3. G Peter Herbison3,
  4. Pal Sivalingam4,
  5. Robert J Walker5,
  6. Karen Hovhannisyan6

Editorial Group: Cochrane Anaesthesia Group

Published Online: 8 OCT 2008

Assessed as up-to-date: 24 JUN 2007

DOI: 10.1002/14651858.CD003590.pub3

How to Cite

Zacharias M, Conlon NP, Herbison GP, Sivalingam P, Walker RJ, Hovhannisyan K. Interventions for protecting renal function in the perioperative period. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD003590. DOI: 10.1002/14651858.CD003590.pub3.

Author Information

  1. 1

    Dunedin Hospital, Department of Anaesthesia & Intensive Care, Dunedin, Otago, New Zealand

  2. 2

    Duke University Medical Center, Department of Cardiothoracic Anesthesiology , Durham, North Carolina, USA

  3. 3

    Dunedin School of Medicine, University of Otago, Department of Preventive & Social Medicine, Dunedin, New Zealand

  4. 4

    Princess Alexandria Hospital, Department of Anaesthesia & Intensive Care, Brisbane, Australia

  5. 5

    University of Otago, Department of Medical & Surgical Sciences, Dunedin, New Zealand

  6. 6

    Rigshospitalet, The Cochrane Anaesthesia Review Group, København , Denmark

*Mathew Zacharias, Department of Anaesthesia & Intensive Care, Dunedin Hospital, Great King Street, Dunedin, Otago, Private Bag 192, New Zealand.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 OCT 2008


This is not the most recent version of the article. View current version (11 SEP 2013)


References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Amano 1994 {published data only}
  • Amano J, Suzuki A, Sunamori M. Salutary effect of reduced glutathione on renal function in coronary artery bypass operation. Journal of the American College of Surgeons 1994;179:714-20. [MEDLINE: 7952483]
Amano 1995 {published data only}
Ascione 1999 {published data only}
Berendes 1997 {published data only}
  • Berendes E, Mollhoff T, van Aken H, Schmidt C, Erren M, Deng MC, et al. Effects of dopexamine on creatinine clearance, systemic inflammation, and splanchnic oxygenation in patients undergoing coronary artery bypass grafting. Anesthesia and Analgesia 1997;84:950-7. [MEDLINE: 9141914]
Bergman 2002 {published data only}
  • Bergman AS, Odar-Cederlof I, Westman L, Bjellerup P, Hoglund P, Ohqvist G. Diltiazem infusion for renal protection in cardiac surgical patients with preexisting renal dysfunction. Journal of Cardiothoracic and Vascular Anesthesia 2002;16(3):294-9. [MEDLINE: 12073199]
Burns 2005 {published data only}
Carcoana 2003 {published data only}
  • Carcoana OV, Mathew JP, Davis E, Byrne DW, Hayslett JP, Hines RL, et al. Mannitol and dopamine inn patients undergoing cardiopulmonary bypass: A randomized clinical trial. Anesthesia and Analgesia 2003;97:1222-9. [MEDLINE: 14570627]
Colson 1990 {published data only}
  • Colson P, Ribstein J, Mimran A, Grolleau D, Chaptal PA, Roquefeuil B. Effect of angiotensin converting enzyme inhibition on blood pressure and renal function during open heart surgery. Anesthesiology 1990;72:23-7. [MEDLINE: 2404429]
Colson 1992 {published data only}
Costa 1990 {published data only}
  • Costa P, Ottino GM, Matani A, Pansini S, Canavese C, Passerini G, et al. Low-dose dopamine during cardiopulmonary bypass in patients with renal dysfunction. Journal of Cardiothoracic Anesthesia 1990;4:469-73. [MEDLINE: 2132343]
Cregg 1999 {published data only}
Dawidson 1991 {published data only}
  • Dawidson IJ, Willms CD, Sandor ZF, Coorpender LL, Reisch JS, Fry WJ. Ringer's lactate with or without 3% dextran-60 as volume expanders during abdominal aortic surgery. Critical Care Medicine 1991;19:36-42. [MEDLINE: 1702696]
de Lasson 1995 {published data only}
  • de Lasson L, Hansen HE, Juhl B, Paaske WP, Pedersen EB. A randomized, clinical study of the effect of low-dose dopamine on cental and renal haemodynamics in infrarenal aortic surgery. European Journal of Endovascular Surgery 1995;10:82-90. [MEDLINE: 7633974]
de Lasson 1997 {published data only}
  • de Lasson L, Hansen HE, Juhl B, Paaske WP, Pedersen EB. Effect of felodipine on renal function and vasoactive hormones in infrarenal aortic surgery. British Journal of Anaesthesia 1997;79:719-25. [MEDLINE: 9496202]
Dehne 2001 {published data only}
Donmez 1998 {published data only}
  • Donmez A, Ergun F, Kayhan Z, Tasdelen A, Dogan S. Verapamil and nimodipine do not improve renal function during cardiopulmonary bypass. Acta Anesthesiologica Italica 1998;49:173-7.
Dural 2000 {published data only}
  • Dural O, Ozkara A, Celebioglu B, Kanbak M, Ciliv G, Aypar U. Comparative study of dopamine and mannitol effects on renal function during cardiopulmonary bypass by using N-acetyl-beta-D-glucosaminidase assay. Turkish Journal of Medical Science 2000;30:453-7.
Durmaz 2003 {published data only}
  • Durmaz I, Yagdi T, Calkavur T, Mahmudov R, Apaydin AZ, Posacioglu H, et al. Prophylactic dialysis in patients with renal dysfunction undergoing on-pump coronary artery bypass surgery. Annals of Thoracic Surgery 2003;75:859-64. [MEDLINE: 12645707]
Fischer 2005 {published data only}
Gubern 1988 {published data only}
  • Gubern JM, Sancho JJ, Simo J, Sitges-Serra A. A randomized trial on the effect of mannitol on postoperative renal function in patients with obstructive jaundice. Surgery 1988;103:39-44. [MEDLINE: 3122349]
Halpenny 2002 {published data only}
  • Halpenny M, Rushe C, Breen P, Cunningham AJ, Boucher-Hayes D, Shorten GD. The effect of fenoldopam on renal function in patients undergoing elective aortic surgery. European Journal of Anaesthesiology 2002;19(1):32-9. [MEDLINE: 11913801]
Kleinschmidt 1997 {published data only}
  • Kleinschmidt Von S, Bauer M, Grundmann U, Schneider A, Wagmer B, Graeter T. Influence of gama-hydroxybutyrate and perntoxifylline on renal function markers in coronary artery bypass graft surgery. Anaesthesiologie Reanimation (German) 1997;22(4):102-7. [MEDLINE: 9376042]
Kramer 2002 {published data only}
  • Kramer BK, Preuner J, Ebenburger A, Kaiser M, Bergner U, Eilles C, et al. Lack of renoprotective effect of theophylline during aortocoronary bypass surgery. Nephrology, Dialysis and Transplantation 2002;17:910-5. [MEDLINE: 11981083]
Kulka 1996 {published data only}
  • Kulka PJ, Tryba M, Zenz M. Preoperative alpha2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: Results of a randomized, controlled trial. Critical Care Medicine 1996;24:947-52. [MEDLINE: 8681596]
Lassnigg 2000 {published data only}
  • Lassnigg A, Donner E, Grubhofer G, Presterl E, Drubl W, Hiesmayr M. Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. Journal of American Society of Nephrology 2000;11:97-104. [MEDLINE: 10616845]
Lau 2001 {published data only}
  • Lau LL, Halliday MI, Smye MG, Lee B, Hannon RJ, Gardiner KR, et al. Extraperitoneal approach reduces intestinal and renal dysfunction in elective abdominal aortic aneurysm repair. International Angiology 2001;20(4):282-7. [MEDLINE: 11782693]
Licker 1996 {published data only}
  • Licker M, Bednarkiewicz M, Neidhart P, Pretre R, Montessuit M, Favre H, et al. Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery. British Journal of Anaesthesia 1996;76:632-9. [MEDLINE: 12456411]
Loef 2004 {published data only}
  • Loef BG, Henning RH, Epema AH, Rietman GW, van Oeveren W, Navis GJ, et al. Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass. British Journal of Anaesthesia 2004;93(6):793-8. [MEDLINE: 15563558]
Marathias 2006 {published data only}
Morariu 2005 {published data only}
  • Morariu AM, Loaf BG, Aarts LPHJ, Rietman GW, Bakhorst G, van Oeveren W, et al. Dexamethasone: Benefits and prejudice for patients undergoing on-pump coronary artery bypass grafting. A study on myocardial, pulmonary, renal, intestinal and hepatic injury. Chest 2005;128(4):2677-86. [MEDLINE: 16236942]
Morgera 2002 {published data only}
Myles 1993 {published data only}
  • Myles PS, Buckland MR, Schenk NJ, Cannon GB, Langley M, Davis BB, et al. Effect of renal dose dopamine on renal function following cardiac surgery. Anaesthesia and Intensive Care 1993;21:56-61. [MEDLINE: 8447608]
Nicholson 1996 {published data only}
O'Hara 2002 {published data only}
Parks 1994 {published data only}
Perez 2002 {published data only}
Pull Ter Gunne 1990 {published data only}
  • Pull Ter Gunne AJ, Bruining HA, Obertop H. Haemodynamics and 'optimal' hydration in aortic cross clamping. The Netherlands Journal of Surgery 1990;42:113-7.
Ristikankare 2006 {published data only}
  • Ristikankare A, Kuitunen T, Kuitunen A, Uotila L, Vento A, Suojaranta-Ylinen R, et al. Lack of renoprotective effect of i.v. N-acetatylcysteine in patients with chronic renal failure undergoing cardiac surgery. British Journal of Anaesthesia 2006;97(5):611-6. [MEDLINE: 16914459]
Ryckwaert 2001 {published data only}
  • Ryckwaert F, Colson P, Ribstein J, Boccara G, Guillon G. Haemodynamic and renal effects of intravenous enalapril during coronary artery bypass graft surgery in patients with ischaemic heart dysfunction. British Journal of Anaesthesia 2001;86:169-75. [MEDLINE: 11573655]
Sezai 2000 {published data only}
Shackford 1983 {published data only}
  • Shackford SR, Sise MJ, Friedlund PH, Rowley WR, Peters RM, Virgilio RW, et al. Hypertonnic sodium lactate versus lactated Ringer's solution for intravenous fluid therapy in operations on the abdominal aorta. Surgery 1983;94:41-51. [MEDLINE: 6857511]
Shim 2007 {published data only}
  • Shim JK, Choi SH, Oh YJ, Kim CS, Yoo KJ, Kwak YL. The effect of mannitol on oxygenation and creatinine kinase MB release in patients unedergoing multivessel off-pump coronary arterhy bypass surgery. The Journal of Thoracic and Cardiovascular Surgery 2007;133(3):704-9. [MEDLINE: 17320568]
Tang 1999 {published data only}
  • Tang AT, El-Gamel A, Keevil B, Yonan N, Deiraniya AK. The effect of renal dose dopamine on renal tubular function following cardiac surgery: assessed by measuring retinol binding protein (RBP). European Journal of Cardio-thoracic Surgery 1999;15:717-22. [MEDLINE: 10386423]
Tang 2002 {published data only}
  • Tang AT, Knott J, Nanson J, Hsu J, Haw MP, Ohri SK. A prospective randomized study to evaluate the renoprotective action of beating heart coronary surgery in low risk patients. European Journal of Cardio-thoracic Surgery 2002;22:118-23. [MEDLINE: 12103384]
Thompson 1986 {published data only}
Urzua 1992 {published data only}
  • Urzua J, Troncoso S, Bugedo G, Canessa R, Munoz H, Lema G, et al. Renal function and cardiopulmonary bypas: Effect of perfusion pressure. Journal of Cardiothoracic and Journal of Cardiothoracic and Vascular Anesthesia 1992;6(3):299-303. [MEDLINE: 1610995]
Wahbah 2000 {published data only}
  • Wahbah AM, el-Hefny MO, Wafa EM, el-Kharbotly W, el-Enin AA, Zaglol, A, et al. Perioperative renal protection in patients with obstructive jaundice using drug combinations. Hepato-gastroenterology 2000;47:1691-4. [MEDLINE: 11149033]
Welch 1995 {published data only}
Wijnen 2002 {published data only}
  • Wijnen MH, Vader HL, Van Den Wall Bake AW, Roumen RM. Can renal dysfunction after infra-renal aortic aneurysm repair be modified by multi-antioxidant supplementation?. Journal of Cardiovascular Surgery 2002;43:483-8. [MEDLINE: 12124559]
Woo 2002 {published data only}
  • Woo EB, Tang AT, el-Gamel A, Keevil B, Greenhalgh D, Patrick M, et al. Dopamine therapy for patients at risk of renal dysfunction following cardiac surgery: science or fiction?. European Journal of Cardio-thoracic Surgery 2002;22:106-11. [MEDLINE: 12103352]
Yavuz 2002A {published data only}
  • Yavuz S, Ayabaken N, Dilek K, Ozdemir A. Renal dose of dopamine in open heart surgery; does it protect renal tubular function?. Journal of Cardiovascular Surgery 2002;43:25-30. [MEDLINE: 11803323]
Yavuz 2002B {published data only}
  • Yavuz S, Ayabakan N, Goncu MT, Ozdemir A. Effect of combined dopamine and diltiazem on renal function after cardiac surgery. Medical Science Monitor 2002;8:145-50. [MEDLINE: 12011785]
Zanardo 1993 {published data only}
  • Zanardo G, Michielon P, Rosi P, Teodori T, Antonucci F, Caenaro G, et al. Effect of a continuous diltiazem infusion on renal function during cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia 1993;7(6):711-6. [MEDLINE: 8305662]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Abe 1993 {published data only}
Aho 2004 {published data only}
  • Aho PS, Niemi T, Lindgren L, Lepantalo M. Endovascular vs open AAA repair: Similar effects on renal poroximal tubular function. Scandinavian Journal of Surgery 2004;93:52-6. [MEDLINE: 15116821]
Amar 2001 {published data only}
Antonucci 1996 {published data only}
  • Antonucci F, Calo L, Rizzolo M, Cantaro S, Bertoliswsi M, Travaglini M, et al. Nifedipine can preserve renal function in patients undergoing aortic surgery with infrarenal crossclamping. Nephron 1996;74(4):668-73. [MEDLINE: 8956299]
Baldwin 1994 {published data only}
Boldt 2000 {published data only}
  • Boldt J, Lehmann A, Rompert R, Haisch G, Isgro F. Volume therapy with a new hydroxyethyl starch solution in cardiac surgical patients before cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia 2000;14:264-8. [MEDLINE: 10890478]
Boldt 2006 {published data only}
  • Boldt J, Scholhorn T, Mayer J, Piper S, Suttner S. The value of albumin-based intravascular volume replacement strategy in elderly patients undergoing major abdominal surgery. Anesthesia and Analgesia 2006;103(1):191-9. [MEDLINE: 16790652]
Boutros 1979 {published data only}
  • Boutros AR, Ruess R, Olson L, Hoyt JL, Baker WH. Comparison of hemodynamic, pulmonary, and renal effects of use of three types of fluids after major surgical procedures on the abdominal aorta. Critical Care Medicine 1979;7(1):9-13. [MEDLINE: 367709]
Bove 2005 {published data only}
  • Bove T, Lanjdoni G, Calabro MG, Aletti G, Marino G, Cerchierini E, et al. Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: A prospective, double-blind, randomized clinical trial. Circulation 2005;111(24):3230-5. [MEDLINE: 15967861]
Caglikulekci 1998 {published data only}
  • Caglikulekciaz S, Yilmaz S, Kayaalp C, Demirbag A, Akoglu M. Postoperative renal function in obstructive jaundice and the effect of dopamine, mannitol and lactulose: A prospective clinical study. The Turkish Journal of Surgery 1998;14(4):230-6.
Cahill 1987 {published data only}
Caimmi 2003 {published data only}
  • Caimmi PP, Pagani L, Micalizzi E, Fiume C, Guani S, Bernardi M, et al. Fenoldopam for renal protection in patients undergoing cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia 2003;17(4):491-4. [MEDLINE: 12968238]
Christakis 1992 {published data only}
Christenson 1995 {published data only}
  • Christenson JT, Maurice F, Simonet V, Velebit V, Schmuziger M. Normothermic versus hypothermic perfusion during primary coronary artery bypass grafting. Cardiovascular Surgery 1995;3(5):519-24. [MEDLINE: 8574537]
Dementi'eva 1996 {published data only}
  • Dementi'eva II, Charnaia MA, Dzemeshkevich SL, Ziuliaeva TP. The preventive role of large doses of aprotinin in decreasing the degree of metabolic disorders during aortocoronary bypass operations. Anestheziologiia i Reanimatologica (Russian) 1996;1:55-8. [MEDLINE: 8686945]
Feindt 1995 {published data only}
  • Feindt PR, Walcher S, Volkmer I, Keller HE, Straub U, Hewer H, Seyfert UT, et al. Effect of high-dose aprotinin on renal function in aortocoronary bypass grafting. Annals of Thoracic Surgery 1995;60:1076-80. [MEDLINE: 7574952]
Fischer 2002 {published data only}
Fisher 1998 {published data only}
Franklin 1997 {published data only}
  • Franklin SC, Moulton M, Sicard GA, Hammerman MR, Miller SB. Insulin-like growth factor I preserves renal function postoperatively. American Journal of Physiology: Renal, Fluid and Electrolyte Physiology 1997;272(241-2):F257-9. [MEDLINE: 9124404]
Frumento 2006 {published data only}
  • Frumento RJ, Logginidou HG, Wahlqander S, Wagener G, Playford HR, Sladen RN. Dexmedetomidine infusion is associated with enhanced renal function after thoracic surgery. Journal of Clinical Anesthesia 2006;18:422-6. [MEDLINE: 16980158]
Garwood 2003 {published data only}
  • Garwood S, Swamidoss CP, Davis EA, Samson L, Hines RL. A case series of low dose fenoldopam in seventy cardiac surgical patients at increased risk of renal dysfunction. Journal of Cardiothoracic and Vascular Anesthesia 2003;17(1):17-21. [MEDLINE: 12635055]
Gatot 2004 {published data only}
Gerola 2004 {published data only}
  • Gerola LR, Buffolo E, Jasbik W, Botelho B, Bosco J, Brasil LA, et al. Off-pump versus on-pump myocardial revascularization in low-risk patients with one or two vessels disease: Perioperative results in a multicenter randomized controlled trial. Annals of Thoracic Surgery 2004;77:569-73. [MEDLINE: 14759439]
Gilbert 2001 {published data only}
  • Gilbert TB, Hasnain JU, Flinn WR, Benjamin ME. Fenoldopam infusion associated with preserving renal function after aortic cross-clamping for aneurysm repair. Journal of Cardiovascular Pharmacology and Therapeutics 2001;6:31-6. [MEDLINE: 11452334]
Goto 1992 {published data only}
Grundmann 1985 {published data only}
Halpenny 2001 {published data only}
Hayashida 1997 {published data only}
  • Hayashida M, Hanaoka K, Shimada Y, Namiki A, Amaha K. The effect of low-dose prostglandin E1 on intra- and post-operative renal function. The Japanese Journal of Anesthesiology 1997;46(4):464-70. [MEDLINE: 9128016]
Hayashida 2000 {published data only}
Izumi 2006 {published data only}
Junnarkar 2003 {published data only}
  • Junnerkar S, Lau LL, Edrees WK, Underwood D, Smye MG, Lee B, et al. Cytokine activation and intestinal mucosal and renal dysfunction are reduced in endovascular AAA repair compared to surgery. Journal of Endovascular Therapy 2003;10:195-202. [MEDLINE: 12877599]
Kulka 1993 {published data only}
  • Kulka PJ, Tryba M, Menzel C, Leurs F, Frankenberg C. Preoperative clonidine improves postoperative renal function in CABG patients. British Journal of Anaesthesia 1993;70:74.
Kumle 1999 {published data only}
Kuraoka 1995 {published data only}
  • Kuraoka S, Orita H, Watanabe T, Abe K, Abe H, Inui S, et al. Effect of combined aprotinin and prostaglandin E1 therapy on aortic arch replacement. The Japanese Journal of Thoracic Surgery 1995;48(3):198-201. [MEDLINE: 7534838]
Lema 1995 {published data only}
  • Lema G, Meneses G, Urzua J, Jalil R, Canessa R, Moran S, et al. Effects of extracorporeal circulation on renal function in coronary surgical patients. Anesthesia and Analgesia 1995;81:446-51. [MEDLINE: 7653802]
Lema 1998 {published data only}
  • Lema G, Urzua J, Jalil R, Canessa R, Moran S, Sacco C, et al. Renal protection in patients undergoing cardiopulmonary bypass with preoperative abnormal renal function. Anesthesia and Analgesia 1998;86(1):3-8. [MEDLINE: 9428842]
Lemmer 1996 {published data only}
  • Lemmer Jr JH, Dilling EW, Morton JR, Rich JB, Robicsek F, Bricker DL, et al. Aprotinin for primary coronary artehry bypass grafting: A multicenter trial of three dose regimens. Annals of Thoracic Surgery 1996;62:1659-68. [MEDLINE: 8957369]
Levy 1995 {published data only}
  • Levy JH, Pifarre R, Schaff HV, Horrow JC, Albus R, Spiess B, et al. A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting. Circulation 1995;92(8):2236-44. [MEDLINE: 7554207]
Licker 1999 {published data only}
Lim 2002 {published data only}
Loef 2002 {published data only}
  • Loef BG, Epema AH, Navis G, Ebels T, van Oeveren W, Henning RH. Off-pump coronary revascularization attenuates transient renal damage compared with on-pump coronary revascularization. Chest 2002;121(4):1190-4. [MEDLINE: 11948052]
MacGregor 1994 {published data only}
  • MacGregor DA, Butterworth JF 4th, Zaloga CP, Prielipp RC, James R, Royster RL. Hemodynamic and renal effects of dopexamine and dobutamine in patients with reduced cardiac output following coronary artery bypass grafting. Chest 1994;106:835-41. [MEDLINE: 7915979]
Neimark 2005 {published data only}
  • Neimark MI, Merkulov IV, Flat MK. Renal protective function in surgical treatment for chronic infrarenal aortic aneurysms. Anesteziologiia i Reanimatologiia 2005;4:18-22. [MEDLINE: 16206579]
Nguyen 2001 {published data only}
Nguyen 2002 {published data only}
  • Nguyen NT, Perez RV, Fleming N, Rivers R, Wolfe BM. Effect of prolonged pneumoperitoneum on intraoperative urine output during laparoscopic gastric bypass. Journal of American College of Surgeons 2002;195:476-83. [MEDLINE: 12375752]
Niiya 2001 {published data only}
  • Niiya S, Fukusaki M, Nakamura T, Miyoshi H, Ogata K, Miyako M. Effects of dopamine and dobutamine on renal function and urinary excretion of prostglandin E2 in elderly postoperative patients [In Japanese]. Japanese Journal of Anesthesiology 2001;50:122-6. [MEDLINE: 11244764]
Nuutinen 1976 {published data only}
  • Nuutinen L, Hollmen A. The effect of prophylactic use of furosemide on renal function during open heart surgery. Annales Chirurgiae et Gynaecologiae 1976;65:258-266. [MEDLINE: 970902]
O'Hara 2002A {published data only}
  • O'Hara JF, Sprung J. The effect of dopamine on renal function in solitary partial nephrectomy patients. Anesthesia and Analgesia 2002;94 Suppl:104.
Oliver 2006 {published data only}
  • Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH. A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta. Anesthesia and Analgesia 2006;103(4):833-40. [MEDLINE: 17000789]
Ovrum 2004 {published data only}
  • Ovrum E, Tangen G, Tollofsrud S, Oystese R, Ringdal MAL, Istad R. Cold blood cardioplegia versus cold crystalloid cardioplegia: A prospective randomized study of 1440 patients undergoing coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery 2004;128(6):860-5. [MEDLINE: 15573070]
Pain 1991 {published data only}
Paul 1986 {published data only}
Pavoni 1998 {published data only}
  • Pavoni V, Verri M, Ferraro L, Volta CA, Paparella L, Capuzzo M, et al. Plasma dopamine concentration and effects of low dopamine doses on urinary output after major vascular surgery. Kidney International 1998;53 Suppl 66:S75-80. [MEDLINE: 9573579]
Petry 1992 {published data only (unpublished sought but not used)}
Piper 2003 {published data only}
Plusa 1991 {published data only}
  • Plusa SM, Clark NW. Prevention of postoperative renal dysfunction in patients with obstructive jaundice: a comparison of mannitol-induced diuresis and oral sodium taurocholate. Journal of the Royal College of Surgeons of Edinburgh 1991;36:303-5. [MEDLINE: 1757907]
Priano 1993 {published data only}
Prifti 2001 {published data only}
  • Prifti E, Boinacchi M, Frati G, Giunti G, Proietti P, Leacche M, Massetti M, Babatasi G, Sani G. Beating heart myocardial revascularization on extracorporeal circulation in patients with end-stage coronary artery disease. Cardiovascular Surgery 2001;9(6):608-13. [MEDLINE: 11604346]
Regragui 1995 {published data only}
Riess 2000 {published data only}
  • Riess FC, Moshar S, Bader R, Schofer J, Lower C, Kremer P, et al. Clinical outcome of patients with and without renal impairment undergoing a minimally invasive LIMA-to-LAD bypass operation. Heart Surgery Forum 2000;3(4):313-8. [MEDLINE: 11178293]
Ryckwaert 1995 {published data only}
  • Ryckwaert F, Calvert B, Peckstaing M, Wintrebert P, Ribstein J, Colson P. Effects of enalaprilate on haemodynamics and renal function during cardiac surgery in patients with preoperative heart failure. British Journal of Anaesthesia. 1995; Vol. 74:A103.
Sanders 2001 {published data only}
Sezai 2006 {published data only}
  • Sezai A, Shiono M, Hata M, Iida M, Wakui S, Soeda M, et al. Efficacy of continuous low-dose human atrial natriuretic peptide given from the begining of cardiopulmonary bypass for thoracic aortic surgery. Surgery Today 2006;36:508-14. [MEDLINE: 16715419]
Sherry 1997 {published data only}
  • Sherry E, Tooley MA, Bolsin SN, Monk CR, Wilcox J. Effect of dopexamine hydrochloride on renal vascular resistance index and haemodynamic responses following coronary artery bypass graft surgery. European Journal of Anaesthesiology 1997;14:184-9. [MEDLINE: 9088818]
Skillman 1975 {published data only}
Stanitsh 2002 {published data only}
  • Stanitsh MB, Sindjelitsh RB, Neshkovitsh V, Davidovitsh LB, Lotina SL. Renal protection during the operation of infra-renal aorta [(In Serbian)]. Srpski Archv Za Celokupno Lekarstvo (Serbian) 2002;130(5-6):168-72.
Straka 2004 {published data only}
  • Straka Z, Widimsky P, Jirasek K, Stros P, Votava J, Vanek T, et al. Off-pump versus on-pump coronary surgery: Final results from a prospective randomized study PRAGUE-4. Annals of Thoracic Surgery 2004;77:789-93. [MEDLINE: 14992872]
Tataranni 1994 {published data only}
Torsello 1993 {published data only}
  • Torsello G, Kutkuhn B, Kniemeyer H, Sandmann W. Prevention of acute renal failure after suprarenal aortic surgery: Results of a pilot study. Zentralblatt fur Chirurgie 1993;118:390-4. [MEDLINE: 8372519]
Tripathy 1996 {published data only}
  • Tripathy U, Dhiman RK, Attari A, Katariya RN, Ganguly NK, Chawla YK, et al. Preoperative bile salt administration versus bile salt refeeding in obstructive jaundice. The National Medical Journal of India 1996;9(2):66-9. [MEDLINE: 8857040]
Ueki 1995 {published data only}
  • Ueki M, Yokono S, Nogaya J, Taei S, Komatsu H, Ogli K. Effect of ulinastatin on renal function after subrenal aortic cross-clamping. The Japanese Journal of Anesthesiology 1995;44(3):357-61. [MEDLINE: 7609298]
Vogt 1996 {published data only}
  • Vogt NH, Bothner U, Lerch G, Lindner KH, Georgieff M. Large-dose administration of 6% hydroxyethyl starch 200/0.5 for total hip arthroplasty: Plasma homeostasis, hemostasis, and renal function compared to use of 5% human albumin. Anesthesia and Analgesia 1996;83:262-8. [MEDLINE: 8694303]
Vogt 1999 {published data only}
Welch 1993 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Brazel 1996
Deeks 2008
  • Deeks JJ, Higgins JPT, Altman DG, (editors) on behalf of the Cochrane Statistical Methods Group. Chapter 9:  Analysing data and undertaking meta-analyses: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from
Gerlach 2000
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from
Kellen 1994
Kovacs 1992
Lieh-Lai 1999
  • Leih-Lai MW, Stanitski DF, Sarnaik AP, Uy HG, Rossi NF, Simpson PM, et al. Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion. Critical Care Medicine 1999;27(3):622-7. [MEDLINE: 10199545]
Morcos 2004
Renton 2005
Solomon 1994
  • Solomon R, Werner C, Mann D, D'Elia J, Silva P. Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents. New England Journal of Medicine 1994;331(21):1416-20. [MEDLINE: 7969280]
Wang 2003
Wijeysundera 2006
Zacay 2002