Intervention Review

Diuretics for Ménière's disease or syndrome

  1. Andrea Burgess1,*,
  2. Sujata Kundu2

Editorial Group: Cochrane Ear, Nose and Throat Disorders Group

Published Online: 14 APR 2010

Assessed as up-to-date: 15 APR 2009

DOI: 10.1002/14651858.CD003599.pub2

Database Title

Additional Information

How to Cite

Burgess A, Kundu S. Diuretics for Ménière's disease or syndrome. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD003599. DOI: 10.1002/14651858.CD003599.pub2.

Author Information

  1. 1

    Royal Hampshire County Hospital, Ear, Nose & Throat Department, Winchester, UK

  2. 2

    Darlington Memorial Hospital, Ear, Nose & Throat Department, Darlington, County Durham, UK

*Andrea Burgess, Ear, Nose & Throat Department, Royal Hampshire County Hospital, Romsey Road, Winchester, SO22 5DG, UK. andy_thirlwall@hotmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 14 APR 2010

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

This is an update of a review first published in The Cochrane Library Issue 3, 2006.

Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. Diuretics are used to try to reduce the severity and frequency of episodes but there is little evidence behind this treatment.

Objectives

To assess the effect of diuretic treatment in patients with Ménière's disease.

Search methods

We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; mRCT and additional sources for published and unpublished trials. The date of the most recent search was 16 April 2009.

Selection criteria

Randomised controlled trials of diuretic versus placebo in Ménière's patients.

Data collection and analysis

Search results from the original and update searches were screened independently. We retrieved full text of potentially relevant articles and applied the inclusion criteria. Ten studies were excluded from the review due to inappropriate study design or absence of randomisation.

Main results

There were no trials of high enough quality to meet the standard set for this review.

Authors' conclusions

There is insufficient good evidence of the effect of diuretics on vertigo, hearing loss, tinnitus or aural fullness in clearly defined Ménière's disease.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Diuretics for the treatment of Ménière's disease or syndrome

Diuretics (drugs which reduce fluid accumulation in the body) are commonly used in the management of the symptoms of vertigo, hearing loss, tinnitus or aural fullness in patients with Ménière's disease. 'Endolymphatic hydrops' is an increase in the pressure of the fluids in the chambers of the inner ear and is thought to be the underlying cause of Ménière's disease. Diuretics are believed to work by reducing the volume (and therefore also the pressure) of these fluids. The authors of this systematic review carried out an extensive search but could not identify any randomised controlled trials of sufficient quality to include in the review. There is no good evidence about the effect of diuretics on the symptoms of Ménière's disease and further research is needed.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

利尿劑在梅尼爾氐病或症候群(Meniere's disease or syndrome)的應用

梅尼爾氐病的典型特徵為聽力損失，耳嗚及暈眩。利尿劑被用在嘗試並減低發作的嚴重度及頻率,但其作用機轉並不明確

目標

評估利尿劑治療梅尼爾氐病的效果

搜尋策略

我們搜尋了the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1 2005), MEDLINE (1966 to 2005), EMBASE (1974 to 2005), CINAHL 及 the metaRegister of Controlled Trials (mRCT) (迄2005)

選擇標準

隨機對照試驗，比較利尿劑及安慰組治療梅尼爾氐病病人的效果

資料收集與分析

其中一位作者找到一些稍微附合納入標準的研究並把全文取出。兩位作者各自應用納入標準。當中有7個研究被排除出此回顧，原因是不適合的研究方法或沒有採用隨機方式

主要結論

被納入的研究當中沒有任何一個的品質足以完全符合此回顧所設定的標準

作者結論

利尿劑對於確診的梅尼爾氐病的症狀，如暈眩，聽力喪失或耳悶塞感的改善，並沒有足夠的有力症據顯示有效

翻譯人

本摘要由國泰綜合醫院尹丹桂翻譯

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌

總結

利尿劑在治療梅尼爾氐病或症候群主要是針對症狀改善，如暈眩，聽力損失，耳嗚或耳悶塞感。內耳淋巴水腫(Endolymphatic hydrops)是指內耳腔室的液體的壓力上升，也被認為是梅尼爾氐病的原因。利尿劑的角色主要在降低內耳液體的體積以及壓力。此回顧的作者進行了廣泛性的搜尋，但未能找到任何符合要求可被納入的randomised controlled trials 。因此利尿劑在治療梅尼爾氐病的症狀的效果仍有待進一步研究

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