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Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

  1. Charles Shey Wiysonge1,*,
  2. Muki Shey1,
  3. Eugene J Kongnyuy2,
  4. Jonathan AC Sterne3,
  5. Peter Brocklehurst4

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 19 OCT 2005

Assessed as up-to-date: 3 FEB 2008

DOI: 10.1002/14651858.CD003648.pub2


How to Cite

Wiysonge CS, Shey M, Kongnyuy EJ, Sterne JAC, Brocklehurst P. Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003648. DOI: 10.1002/14651858.CD003648.pub2.

Author Information

  1. 1

    University of Cape Town, Institute of Infectious Disease and Molecular Medicine (IIDMM), Cape Town, South Africa

  2. 2

    Liverpool School of Tropical Medicine, Child and Reproductive Health Group, Liverpool, UK

  3. 3

    University of Bristol, Department of Social Medicine, Bristol, UK

  4. 4

    University of Oxford, National Perinatal Epidemiology Unit, Headington, Oxford, UK

*Charles Shey Wiysonge, Institute of Infectious Disease and Molecular Medicine (IIDMM), University of Cape Town, Room 2.10, Werner and Beith North Building, Anzio Road, Observatory, Cape Town, 7925, South Africa. charles.wiysonge@mrc.ac.za. wiysonge@yahoo.com.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 19 OCT 2005

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Coutsoudis 1999 {published data only}
  • Coutsoudis A, Bobat RA, Coovadia HM, et al. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. Am J Public Health 1995;85:1076-81.
  • Coutsoudis A, Moodley D, Pillay K, et al. Effects of vitamin A supplementation on viral load in HIV-1-infected pregnant women. J Acquir Immune Defic Syndr Hum Retrovirol 1997;15:86-87.
  • Coutsoudis A, Pillay K, Spooner E, et al. Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child transmission of HIV-1 in Durban, South Africa. AIDS 1999;13:1517-1524.
  • Filteau S, Rollins NC, Coutsoudis A, et al. The effect of antenatal vitamin A and Beta-carotene supplementation on gut integrity of infants of HIV-infected South African Women. J Pediatr Gastroenterol 2001;32:464-470.
  • Kennedy CM, Coutsoudis A, Kuhn L, et al. Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women. J Acquir Immune Defic Syn 2000;24:37-44.
Fawzi 2002 {published data only}
Friis 2004 {published and unpublished data}
  • Friis H, Gomo E, Nyasema N, et al. Effect of multinutrient supplementation on gestational length and birth size: a randomized, placebo-controlled, double-blind effectiveness trial in Zimbabwe. Am J Clin Nutr 2004;80:178-84.
  • Friis H, Gomo E, Nyazema N, et al. The effect of maternal multimicronutrient supplementation. Global strategies for the prevention of HIV transmission from mothers to infants. Washington DC, 1997:87.
Semba 2002 {published data only}
  • Kumwenda N, Miotti PG, Taha TE, et al. Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Clinical Infectious Diseases 2002;35:618-624.
  • Semba RD, Kumwenda N, Taha ET, et al. Plasma and breast milk vitamin A as indicators of vitamin A status in pregnant women. Int J Vitam Nutr Res 2000;7:271-277.
  • Semba RD, Kumwenda N, Taha TE, et al. Impact of vitamin A supplementation on anaemia and plasma erythropoietin concentrations in pregnant women: a controlled trial. Eur J Haematol 2001;66:389-395.
  • Semba RD, Miotti PG, Taha TE, et al. Maternal vitamin A supplementation and mother-to-child transmission of HIV. International Vitamin A Consultative Group Meeting. Cairo, September 1997.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Humphrey 2006 {published and unpublished data}
  • Humphrey J, Iliff P, Nathoo K, et al. Rationale and design of the ZVITAMBO trial (Zimbabwe vitamin A for mothers and babies). Int Conf AIDS 2000;July 9-14:abstract no TuPeB3257.
  • Humphrey JH, Iliff PJ, Marinda ET, Mutasa K, Moulton LH, Chidawanyika H, Ward BJ, Nathoo KJ, Malaba LC, Zijenah LS, Zvandasara P, Ntozini R, Mzengeza F, Mahomva AI, Ruff AJ, Mbizvo MT, Zunguza CD, ZVITAMBO Study Group. Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. J Infect Dis 2006;193:860-71.
  • Malaba L, Mbuya N, Miller M, et al. Haemoglobin distribution of HIV positive and HIV negative women during the immedate postpartum period in Harare, Zimbabwe. Int Conf AIDS 2000;July 9-14:abstract no ThPeB5042.
  • Malaba LC, Iliff PJ, Nathoo KJ, et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr 2005;81:454-60.
  • Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, Piwoz EG, Moulton LH, Salama P, Ward BJ, ZVITAMBO Study. Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 2007;26:519-26.
  • Miller MF, Soltzfus RJ, Mbuya NV, et al. Total body iron in HIV-positive and HIV-negative Zimbabwean newborns strogly predicts anemia throughout infancy and is predicted by maternal hemoglobin concentration. J Nutr 2003;133:3461-3468.
  • Zijenah LS, Moulton LH, Iliff P, et al. Timing of mother-to-child transmission of HIV-1 and infant mortality in the first 6 months of life in Harare, Zimbabwe. AIDS 2004;18:273-280.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Chikobvu 2000 {published data only (unpublished sought but not used)}
  • Chikobvu P, Steinberg WJ, Joubert G, Viljoen JI, Coetzee M, Kriel J, van der Ryst E. Lessons learned in establishing a randomised controlled trial to investigate the effect of vitamin A on vertical transmission of HIV. S Afr J Epidemiol Infect 2000;15:19–22.
  • Joubert G, Steinberg H, van der Ryst E, Chikobvu P. Consent for participation in the Bloemfontein vitamin A trial: how informed and voluntary?. Am J Public Health 2003;93:582-84.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Bell 1997
  • Bell J, Sacks HS. Cost-effectiveness analysis of vitamin A supplementation to reduce perinatal transmission of HIV in developing countries. Conf Retroviruses Opportunistic Infect 1997, Jan 22-26;abstract no 520.
Burger 1997
  • Burger H, Kovacs A, Weiser B, et al. Maternal serum vitamin A levels are not associated with mother-to-child transmission of HIV-1 in the United States. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:321-6.
Burns 1999
  • Burns DN, FitzGerald G, Semba RD, et al. Vitamin A deficiency and other nutritional indices during pregnancy in human immunodeficiency virus infection: prevalence, clinical correlates, and outcome. Clin Infect Dis 1999 1999;29:328-34.
Christian 1998a
  • Christian P, Schulze K, Stoltzfus RJ, et al. Hyporetinolemia, illness symptoms, and acute phase protein response in pregnant women with and without night blindness. Am J Clin Nutr 1998;67:1237-1243.
Christian 2000
  • Christian P, West KP Jr, Khatry SK. Night blindness during pregnancy and subsequent mortality among women in nepal: effects of vitamin A and beta-carotene supplementation. Am J Epidemiol 2000;152:542-547.
Dushimimana 1992
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Fawzi 1993
Fawzi 1998
Fawzi 2000
Filteau 2001
  • Filteau SM, Rollins NC, Coutsoudis, et al. The effect of vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. J Pediatr Gastroenterol 2001;32:464-70.
Glasziou 1993
Green 1928
  • Green HN, Mellanby E. Vitamin A as an anti-infective agent. BMJ 1928;iii:691-6.
Greenberg 1997
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
IVACG 1998
  • International Vitamin A Consultative Group. IVACG Statement. Safe doses of vitamin A during pregnancy and lactation. International Vitamin A Consultative Group. Washington, IVACG; 1998.
Landesmand 1996
  • Landesmand S. [Vitamin A relationships to mortality in HIV disease and effects on HIV infection: and late breaking studies]. Bethesda, MD: National Institutes of Health (Lawton Chiles International House), 1996.
McIntyre 2002
Mofenson 2000
Navér 2006
  • Navér L, Lindgren S, Belfrage E, Gyllensten K, Lidman K, Gisslén M, Ehrnst A, Arneborn M, Bohlin AB. Children born to HIV-1-infected women in Sweden in 1982-2003: trends in epidemiology and vertical transmission. J Acquir Immune Defic Syndr 2006;42:484-89.
Newell 2000
Read 2005
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Rice 1998
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Ross 1996
Semba 1995
Semba 1994
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UNAIDS 2007
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Volmink 2007
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Warszawski 2008
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West 1999
  • West Jr KP, Katz J, Khatry SJ, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ 1999;318:570-575.
West 2001
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West 2002
WHO 1995
  • World Health Organization. Global prevalence of vitamin A deficiency. Micronutrient deficiency information system working paper #2; Geneva: WHO 1995.
WHO 1998
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Wiysonge 2001
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Wiysonge 2005