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Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

  1. Wiysonge CU Shey,
  2. P Brocklehurst,
  3. JAC Sterne

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 22 APR 2002

DOI: 10.1002/14651858.CD003648


How to Cite

Shey WCU, Brocklehurst P, Sterne JAC. Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection. The Cochrane Database of Systematic Reviews 2002, Issue 2. Art. No.: CD003648. DOI: 10.1002/14651858.CD003648.

Author Information

*Dr Charles Shey Wiysonge, Department of Community Health, Ministry of Public Health, BP 25125 Messa, Yaoundé, CAMEROON.

Publication History

  1. Published Online: 22 APR 2002

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This is not the most recent version of the article. View current version (19 JAN 2011)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies awaiting assessment
  3. References to ongoing studies
  4. Additional references
Coutsoudis 1999{published data only}
  • Coutsoudis A, Bobat RA, Coovadia HM, et al. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. Am J Public Health 1995;85:1076-81.
  • Coutsoudis A, Moodley D, Pillay K, et al. Effects of vitamin A supplementation on viral load in HIV-1-infected pregnant women. J Acquir Immune Defic Syndr Hum Retrovirol 1997;15:86-87.
  • Coutsoudis A, Pillay K, Spooner E, et al. Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child transmission of HIV-1 in Durban, South Africa. AIDS 1999;13:1517-1524.
  • Filteau S, Rollins NC, Coutsoudis A, et al. The effect of antenatal vitamin A and Beta-carotene supplementation on gut integrity of infants of HIV-infected South African Women. J Pediatr Gastroenterol 2001;32:464-470.
  • Kennedy CM, Coutsoudis A, Kuhn L, et al. Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women. J Acquir Immune Defic Syn 2000;24:37-44.
Fawzi 1998a{published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies awaiting assessment
  3. References to ongoing studies
  4. Additional references
Friis 1997
  • Friis H, Gomo E, Nyazema N, et al. The effect of maternal multimicronutrient supplementation. A conference on global strategies for the prevention of HIV transmission from mothers to infants. Washington, DC: 1997:87.
Semba 1997
  • Semba RD, Kumwenda N, Taha ET, et al. Plasma and breast milk vitamin A as indicators of vitamin A status in pregnant women. Int J Vitam Nutr Res 2000;7:271-277.
  • Semba RD, Kumwenda N, Taha TE, et al. Impact of vitamin A supplementation on anaemia and plasma erythropoietin concentrations in pregnant women: a controlled trial. Eur J Haematol 2001;66:389-395.
  • Semba RD, Miotti PG, Taha TE, et al. Maternal vitamin A supplementation and mother-to-child transmission of HIV. International Vitamin A Consultative Group Meeting. Cairo September 1997.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies awaiting assessment
  3. References to ongoing studies
  4. Additional references
ZVITAMBO Project
  • Zimbabwe Vitamin A for Mothers and Babies Project (ZVITAMBO).. Ongoing study November 1997.
  • Humphrey J, Ilif P, Nathoo K, et al. Rationale and design of the ZVITAMBO trial (Zimbabwe vitamin A for mothers and babies). Int Conf AIDS 2000;July 9-14:abstract no TuPeB3257.
  • Malaba L, Mbuya N, Miller M, et al. Haemoglobin distribution of HIV positive and HIV negative women during the immedate postpartum period in Harare, Zimbabwe. Int Conf AIDS 2000;July 9-14:abstract no ThPeB5042.

Additional references

  1. References to studies included in this review
  2. References to studies awaiting assessment
  3. References to ongoing studies
  4. Additional references
Bell 1997
  • Bell J, Sacks HS. Cost-effectiveness analysis of vitamin A supplementation to reduce perinatal transmission of HIV in developing countries. Conf Retroviruses Opportunistic Infect 1997, Jan 22-26;abstract no 520.
Brocklehurst 2002
Burger 1997
  • Burger H, Kovacs A, Weiser B, et al. Maternal serum vitamin A levels are not associated with mother-to-child transmission of HIV-1 in the United States. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:321-6.
Burns 1999
  • Burns DN, FitzGerald G, Semba RD, et al. Vitamin A deficiency and other nutritional indices during pregnancy in human immunodeficiency virus infection: prevalence, clinical correlates, and outcome. Clin Infect Dis 1999 1999;29:328-34.
Christian 1998
Christian 1998a
  • Christian P, Schulze K, Stoltzfus RJ, et al. Hyporetinolemia, illness symptoms, and acute phase protein response in pregnant women with and without night blindness. Am J Clin Nutr 1998;67:1237-1243.
Christian 2000
  • Christian P, West KP Jr, Khatry SK. Night blindness during pregnancy and subsequent mortality among women in nepal: effects of vitamin A and beta-carotene supplementation. Am J Epidemiol 2000;152:542-547.
Clarke 2001
  • Clarke M, Oxman AD, editors. Cochrane Reviewers' Handbook 4.1.4 [Updated October 2001]. Cochrane Library Issue 4, 2001. Oxford: Update software. Updated quarterly,
De Cock 2000
  • De Cock KM, Fowler MG, Mercier E, et al. Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA 2000;283:1175-82.
Dushimimana 1992
  • Dushimimana A, Graham MN, Humphrey JH, et al. Maternal vitamin A levels and HIV-related birth outcome in Rwanda. Int Conf AIDS. Amsterdam 1992 Jul 19-24;abstract no POC 4221.
Fawzi 1993
Fawzi 1998
Fawzi 2000
Filteau 2001
  • Filteau SM, Rollins NC, Coutsoudis, et al. The effect of vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. J Pediatr Gastroenterol 2001;32:464-70.
Glasziou 1993
Green 1928
  • Green HN, Mellanby E. Vitamin A as an anti-infective agent. BMJ 1928;iii:691-6.
Greenberg 1997
IVACG 1998
  • International Vitamin A Consultative Group. IVACG Statement. Safe doses of vitamin A during pregnancy and lactation. International Vitamin A Consultative Group. Washington, IVACG 1998.
Kulier 2002
  • Kulier R, Gülmezoglu M, de Onis M, Villar J. Vitamin A supplementation during pregnancy (Protocol for a Cochrane Review). In: Cochrane Library, 1, 2002. Oxford: Update Software. 10.1002/14651858.CD001996
Landesmand 1996
  • Landesmand S. [Vitamin A relationships to mortality in HIV disease and effects on HIV infection: and late breaking studies]. Bethesda, MD: National Institutes of Health (Lawton Chiles International House) 1996.
Lefebvre 2000
  • Lefebvre C, Clarke MJ. Identifying randomised trials. In: Egger M, Davey Smith G, Altman DG, editor(s). Systematic reviews in health care: meta-analysis in context. London: BMJ Books, 2000.
McIntyre 2002
Mofenson 1994
  • Mofenson L. Epidemiology and determinants of vertical transmission of HIV. Sem Pediatr Infect Dis 1994;5:490-496].
Mofenson 2000
Newell 1998
Newell 2000
Rice 1998
  • Rice AL, Stolzfus RJ, De Francisco A, et al. Maternal vitamin A or beta-carotene supplementation in lactating Bangledashi women benefits mothers and infants but does not prevent sub clinical deficiency. J Nutr 1998;129:356-65.
Ross 1996
Semba 1995
Semba 1994
Semba 1998
Shey Wiysonge 2001
  • Shey Wiysonge C, Cunin P, Ayouba A, et al. Preventing vertical transmission of HIV-1: Cameroon's experience. Global Health Council's 28th Annual Conference. Washington DC, USA 2001, May 28 - June 04.
Shey Wiysonge 2002
UNAIDS/WHO 2001
  • UNAIDS/WHO. AIDS epidemic update. Geneva: Joint United Nations Programme on HIV/AIDS. UNAIDS/01.74-WHO/CDS/CSR/NCS/2001.2 (English original, December 2001).
West 1999
  • West KP Jr, Katz J, Khatry SJ, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ 1999;318:570-575.
West 2001
  • West K, Darnton-Hill I. Vitamin A deficiency. In: Semba R, Bloem M, editor(s). Nutrition and Health in Developing Countries. Totowa, NJ: Humana Press, Inc, 2001:267-306.
WHO 1995
  • World Health Organization. Global prevalence of vitamin A deficiency. Micronutrient deficiency information system working paper #2; Geneva: WHO 1995.
WHO 1998
  • World Health Organization. Safe vitamin A dosage during pregnancy and lactation: Recommendations and report of a consultation. WHO/NUT/98.4. Geneva: World Health Organization 1998.