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Blood pressure lowering efficacy of calcium channel blockers for primary hypertension

  • Protocol
  • Intervention

Authors

  • Michelle MY Wong,

    Corresponding author
    1. University of Alberta, Department of Medicine, Edmonton, Alberta, Canada
    • Michelle MY Wong, Department of Medicine, University of Alberta, 2F1.19 Walter C Mackenzie Health Sciences Centre, 8440 - 112 Street, Edmonton, Alberta, T6G 2R7, Canada. email_mwong@yahoo.com.

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  • Balraj S Heran,

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, British Columbia, Canada
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  • James M Wright

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, British Columbia, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective:
To quantify the dose-related effects of various doses and types of calcium channel blockers on systolic and diastolic blood pressure versus placebo in patients with primary hypertension.

Secondary objectives:
1. To determine the effects of calcium channel blockers on variability of blood pressure.
2. To determine the effects of calcium channel blockers on pulse pressure.
3. To quantify the dose-related effects of calcium channel blockers on heart rate.
4. To quantify the effects of calcium channel blockers in different doses on withdrawals due to adverse events.