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Selenium supplementation for critically ill adults

  1. Alison Avenell1,*,
  2. David W Noble2,
  3. John Barr3,
  4. Thomas Engelhardt3

Editorial Group: Cochrane Anaesthesia Group

Published Online: 18 OCT 2004

Assessed as up-to-date: 16 AUG 2007

DOI: 10.1002/14651858.CD003703.pub2


How to Cite

Avenell A, Noble DW, Barr J, Engelhardt T. Selenium supplementation for critically ill adults. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD003703. DOI: 10.1002/14651858.CD003703.pub2.

Author Information

  1. 1

    University of Aberdeen, Health Services Research Unit, Aberdeen, UK

  2. 2

    Aberdeen Royal Infirmary, Intensive Care Unit and Department of Anaesthesia, Aberdeen, Scotland, UK

  3. 3

    Aberdeen Royal Infirmary, Department of Anaesthesia and Intensive Care, Aberdeen, Scotland, UK

*Alison Avenell, Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. a.avenell@abdn.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 18 OCT 2004

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This is not the most recent version of the article. View current version (27 JUL 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Angstwurm 1999 {published data only}
  • Angstwurm MWA, Schopohl J, Gaertner R. Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients. European Journal of Endocrinology 2004;151:47-54. [MEDLINE: PMID: 15248821]
  • Angstwurm MWA, Schottdorf J, Schopohl J, Gaertner R. Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Critical Care Medicine 1999;27:1807-13. [MEDLINE: PMID: 10507602]
  • Gärtner R, Angstwurm MWA, Schopohl J. Selenium replacement in patients with SIRS improves clinical outcome. Clinical Nutrition 2002;21(Suppl 1):66.
  • Gärtner R, Angstwurm MWA, Schottdorf J. Selenium substitution in critical ill patients [Selensubstitution bei sepsispatienten]. Medizinische Klinik 1997;92(Suppl III):12-4.
Angstwurm 2007 {published data only}
  • Angsturm MWA, Gaertner R. Selenium substitution in severe sepsis as useful additive? Preliminary results of the SIC study. Intensive Care Medicine 2005;31(Suppl 1):S84.
  • Angstwurm M, Gärtner R. Selenium in Intensive Care (SIC) study: the XX files are still unresolved. Critical Care Medicine 2007;35(3):995-6.
  • Angstwurm MW, Englemann L, Zimmermann T, Lehmann C, Spes CH, Abel P, et al. Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Critical Care Medicine 2007;35(1):118-26.
  • Gaertner R. Sodium selenite as an adjunctive therapy for sepsis - clinical data from a multi-centre intervention study (SIC Study). DIVI Congress, Hamburg, Symposium 'Adjunctive therapy in spesis: what has been confirmed?'. 4th December 2004.
Berger 2001 {published data only}
  • Berger MM, Baines M, Chioléro RL, Wardle CA, Cayeux C, Shenkin A. Influence of early trace element and vitamin E supplements on antioxidant status after major trauma: a controlled trial. Nutrition Research 2001;21:41-54.
  • Berger MM, Reymond MJ, Shenkin A, Rey F, Wardle C, Cayeux C, et al. Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Medicine 2001;27:91-100. [MEDLINE: PMID: 11280679]
Kuklinski 1991 {published data only}
  • Kuklinski B, Buchner M, Schweder R, Nagel R. Acute pancreatitis - a "free radical disease". Decrease of lethality by sodium selenite (Na2SeO3) therapy [Akute pankreatitis - eine "free radical disease". Letalitatssenkung durch natriumselenit (Na2SeO3)-therapie]. Zeitschrift fur die Gesamte Innere Medizin und Ihre Grenzgebiete 1991;46:S145-9. [MEDLINE: PMID: 1648849]
Lindner 2004 {published data only}
  • Lindner D, Lindner J, Baumann G, Dawczynski H, Bauch K. Investigation of antioxidant therapy with sodium selenite in acute pancreatitis. A prospective randomized blind trial [Untersuchung zur antioxidativen therapie mit natriumselenit bei akuter pankreatitis. Eine prospektive, randomisierte blindstudie]. Medizinische Klinik 2004;99(12):708-12. [MEDLINE: PMID: 15599680]
Mishra 2007 {published data only}
  • Mishra V, Baines M, Perry S, McLaughlin J, Carson J, Wenstone R, Shenkin A, Mostafa SM. Selenium supplementation and outcome in septic ICU patients. Clinica Chimica Acta 2005;355(Suppl 1):S45.
  • Mishra V, Baines M, Perry SE, McLaughlin PJ, Carson J, Wenstone R, et al. Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clinical Nutrition 2007;26:41-50.
  • Mishra V, Perry S, Baines M, McLaughlin J, Carson J, Wenstone R, Shenkin A, Mostafa SM. Selenium replacement, HLA-DR expression and outcome in septic ICU patients. Intensive Care Medicine 2004;30(Suppl 1):110.
Ogawa 1999 {published data only}
  • Ogawa A, Yoshimoto T, Kikuchi H, Sano K, Saito I, Yamaguchi T et al for the Ebselen Study Group. Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial. Cerebrovascular Diseases 1999;9:112-8. [MEDLINE: PMID: 9973655]
Saito 1998 {published data only}
  • Asano T, Takakura K, Sano K. Comparative analysis of the clinical effects of water-soluble (AVS) and -insoluble (ebselen) antioxidants on the delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Journal of Stroke and Cerebrovascular Diseases 1996;6(Suppl 1):188-92.
  • Saito I, Abe H, Yoshimoto T, Asano T, Takakura K, Ohta T, et al. Multicentre randomised clinical trial of ebselen with aneurysmal subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism 1995;15(Suppl 1):162.
  • Saito I, Asano T, Sano K, Takakura K, Abe H, Yoshimoto T, et al. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 1998;42:269-78. [MEDLINE: PMID: 9482177]
Yamaguchi 1998 {published data only}
Zimmermann 1997 {published data only}
  • Zimmermann T, Albrecht S, Kühne H, Vogelsang U, Grützmann R, Kopprasch S. Selenium administration in patients with sepsis syndrome. A prospective randomized study [Selensubstitution bei sepsispatienten. Eine prospektiv randomisierte studie]. Medizinische Klinik 1997;92(Suppl III):3-4. [MEDLINE: PMID: 9417494]
  • Zimmermann T, Albrecht S, von Gagern G. Molecular-biological investigations of the multicenter stage-III study (SIC-study) [Molekularbiologische untersuchungen zur multizentrischen phase-III-studie (SIC-studie)]. Medizinische Klinik 1999;94(Suppl III):58-61.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Berger 1998 {published data only}
  • Berger MM, Spertini F, Shenkin A, Wardle C, Wiesner L, Schindler C, Chiolero RL. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. American Journal of Clinical Nutrition 1998;68:365-71. [MEDLINE: PMID: 9701195]
Berger 2004a {published data only}
  • Berger M, Binnert C, Baines M, Raffoul W, Cayeux M, Chiolero R, Tappy L, Shenkin A. Trace element supplements influence protein metabolism and tissue levels after major burns. Intensive Care Medicine 2004;30(Suppl 1):61.
Berger 2004b {published data only}
  • Berger M, Soguel L, Schindler C, Revelly J, Chiolero R. Antioxidant micronutrients after complex cardiac surgery and clinical evolution? Preliminary data. Intensive Care Medicine 2004;30(Suppl 1):175.
Berger 2005a {published data only}
  • Berger MM, Eggimann P, Revelly JP, Raffoul W, Shenkin A, Chiolero R. Trace element supplements are associated with fewer nosocomial pneumonia after major burns. Intensive Care Medicine 2005;31(Suppl 1):77.
  • Berger MM, Eggimann P, Revelly JP, Raffoul W, Shenkin A, Chiolero RL. Selenium supplements reduce the incidence of nosocomial pneumonia after major burns. Clinical Nutrition 2005;24:614.
Berger 2005b {published data only}
  • Berger MM, Soguel L, Pinget C, Revelly JP, Schindler C, Chiolero RL. Antioxidant supplements modulate clinical course after complex cardiac surgery, and major trauma. Intensive Care Medicine 2005;31(Suppl 1):32.
  • Berger MM, Soguel L, Pinget C, Revelly JP, Schindler C, Chiolero RL. Antioxidant supplements modulate clinical course after complex cardiac surgery, major trauma, and subarachnoid haemorrhage. Clinical Nutrition 2005;24(4):616.
Börner 1997 {published data only}
  • Börner J, Zimmermann T, Albrecht S, Roesner D. Selenium administration in severe inflammatory surgical diseases and burns in childhood [Selensubstitution bei schweren entzündlichen chirurgischen krankheitsbildern sowie verbrennungen un verbrühungen in kindesalter]. Medizinische Klinik 1997;92(Suppl III):17-9. [MEDLINE: PMID: 9417488]
Porter 1999 {published data only}
  • Porter JM, Ivatury RR, Azimuddin K, Swami R. Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: early results of a prospective randomized study. American Surgeon 1999;65:478-83 (Erratum in American Surgeon 1999; 65:902). [MEDLINE: PMID: 10231223]
Thiele 1997 {published data only}
  • Thiele R, Wagner D, Gassel M, Winnefeld K, Pleissner J, Pfeifer R. Selenium substitution in acute myocardial infarct [Selensubstitution bei akutem myokardinfarkt]. Medizinische Klinik 1997;92(Suppl III):26-8. [MEDLINE: PMID: 9417492]
Uden 1990 {published data only}
Watters 2002 {published data only}
  • Watters JM, Vallerand A, Kirkpatrick SM, Abbott HE, Norris S, Wells G, et al. Limited effects of micronutrient supplementation on strength and physical function after abdominal aortic aneursymectomy. Clinical Nutrition 2002;21:321-7. [MEDLINE: PMID: 12135593]
Wollschläger 1997 {published data only}
  • Wollschläger S, Ludwig K, Meissner D, Porst H. Effect of selenium administration on various laboratory parameters in patients with acute pancreatitis [Einfluß einer selensubstitution auf verschiedene laborparameter bei patienten mit akuter pankreatitis]. Medizinische Klinik 1997;92(Suppl III):22-4. [MEDLINE: PMID: 9417490]

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Forceville 2006 {published data only}
  • Forceville X, Bellissant E. Selenium, as sodium selenite, in the treatment of septic shock. http://clinicaltrials.gov/show/NCT00207844. Accessed 8th August 2006.
  • Forceville X, Lavoille B, Annane D, Vitoux D, Bleichner G, Korach JM, et al. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Critical Care 2007;11:R73.
Kiessling 2006 {published data only}
  • Kiessling AH, Isgro F, Skuras JA, Kammerer I, Lehmann A, Saggau W. Selenium application in intensive care medicine. Intensive Care Medicine 2006;32(Suppl 1):89.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Andrews 2004 {published data only}
  • The SIGNET Trial. https://www.charttrials.abdn.ac.uk/signet/ Accessed 9th August 2006.
Yamaguchi 2003 {published data only}
  • Yamaguchi T, for Ebselen Study Group. Phase III trial of Ebselen (abstract). The American Stroke Association 28th International Stroke Conference, February 13th-15th 2003, Phoenix, Arizona. 2003.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Angstwurm 2006a
Berger 1998a
  • Berger MM, Spertini F, Shenkin A, Wardle C, Wiesner L, Schindler C, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. American Journal of Clinical Nutrition 1998;68:365-71. [MEDLINE: PMID: 9701195]
Bulger 2001
Geoghegan 2006
Heyland 1998
Heyland 2005
Higgins 2003
Higgins 2005
  • Higgins JPT, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]; Appendix 5b. In: The Cochrane Library, Issue 4, 2005. Chichester, UK: John Wiley & Sons, Ltd.
Jennett 1975
Moher 2001
Parnham 2000
Porter 1999a
  • Porter JM, Ivatury RR, Azimuddin K, Swami R. Antioxidant therapy in the prevention of organ dysfunction syndrome after trauma: early results of a prospective randomized trial. American Surgeon 1999;65:478-83. Erratum in: American Surgeon 1999 Sep;65:902. [MEDLINE: PMID: 10231223]
Rayman 2000
Sattar 1997
Shah 1989