Intervention Review

You have free access to this content

Antibiotics for preventing infection in open limb fractures

  1. Richard A Gosselin1,*,
  2. Ian Roberts2,
  3. William J Gillespie3

Editorial Group: Cochrane Bone, Joint and Muscle Trauma Group

Published Online: 26 JAN 2004

Assessed as up-to-date: 27 JUL 2009

DOI: 10.1002/14651858.CD003764.pub2


How to Cite

Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD003764. DOI: 10.1002/14651858.CD003764.pub2.

Author Information

  1. 1

    University of Manchester, c/o Cochrane Bone, Joint and Muscle Trauma Group, Manchester, UK

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    University of Hull, Hull York Medical School, Hull, UK

*Richard A Gosselin, c/o Cochrane Bone, Joint and Muscle Trauma Group, University of Manchester, School of Translational Medicine, 2nd Floor Stopford Building, Oxford Road, Manchester, M13 9PT, UK. froggydoc@comcast.net.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 26 JAN 2004

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bergman 1982 {published data only}
Braun 1987 {published data only}
  • Braun R, Enzler MA, Rittmann WW. A double-blind clinical trial of prophylactic cloxacillin in open fractures. Journal of Orthopaedic Trauma 1987;1(1):12-7.
Dickey 1989 {published data only}
  • Dickey RL, Barnes BC, Kearns RJ, Tullos HS. Efficacy of antibiotics in low-velocity gunshot fractures. Journal of Orthopaedic Trauma 1989;3(1):6-10.
Patzakis 1974 {published data only}
Rojczyk 1983 {published data only}
  • Rojczyk M. Antibiotic doses in open fractures. Hefte zur Unfallheilkunde 1980;148:861-2.
  • Rojczyk M. Treatment results in open fractures, aspects of antibiotic therapy [Behandlungsergebnisse bei offenen frakturen, aspekte der antibiotikatherapie]. Hefte zur Unfallheilkunde 1983;162:33-8.
  • Rojczyk M, Malottke R. The effect of antibiotic prophylaxis in the treatment of open fractures [Untersuchungen uber den Einfluss einer Antibiotica-prophylaxe bei der Behandlung offener Frakturen]. Hefte zur Unfallheilkunde 1979;138:355-7.
Sloan 1987 {published data only}
Stevenson 2003 {published data only}
  • Stevenson J, McNaughton G, Riley J. The use of prophylactic flucloxacillin in treatment of open fractures of the distal phalanx within an accident and emergency department: a double-blind randomised placebo-controlled trial. Journal of Hand Surgery - British Volume 2003;28(5):388-94.
Suprock 1990 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Almanza 1999 {published data only}
  • Almanza AJ, Reyes AG, Diaz RR. Antibiotic treatment in open fractures [Tratamiento antimicrobiano en las fracturas expuestas]. Revisa Mexicana Ortopedica Traumatologia 1999;13(5):470-1.
Altergott 2008 {published data only}
  • Altergott C, Garcia FJ, Nager AL. Pediatric fingertip injuries: do prophylactic antibiotics alter infection rates?. Pediatric Emergency Care 2008;24(3):148-52. [MEDLINE: 18347491]
Cutler 1944 {published data only}
  • Cutler EC, Morton PC, Sandusky WR. Observations on the prophylactic use of penicillin in the wounds of aerial warfare. British Journal of Surgery 1944;32:207-11.
Miller 1986 {published data only}
  • Miller SD, Bray RC, Hughes GNF. Antibiotics in open fractures: a prospective randomised, double-blind study of wound infection [abstract]. Journal of Bone and Joint Surgery - British Volume 1986;68(5):850.
Peacock 1988 {published data only}
  • Peacock KC, Hanna DP, Kirkpatrick K, Breidenbach WC, Lister GD, Firrell J. Efficacy of perioperative cefamandole with postoperative cephalexin in the primary outpatient treatment of open wounds of the hand. Journal of Hand Surgery - American Volume 1988;13(6):960-4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cranny 2008
  • Cranny G, Elliott R, Weatherly H, Chambers D, Hawkins N, Myers L, et al. A systematic review and economic model of switching from non-glycopeptide to glycopeptide antibiotic prophylaxis for surgery. Health Technology Assessment 2008;12(1):i-168.
Dellinger 1991
EAST 2000
  • Luchette FA, Bone LB, Born CT, DeLong WG, Hoff WS, Mullins D, et al. EAST practice management guidelines work group: Practice management guidelines for prophylactic antibiotic use in open fractures. Eastern Association for the Surgery of Trauma www.east.org/tgp/openfrac.pdf (accessed 01 March 2002).
Gillespie 2001
Hauser 2006
  • Hauser CJ, Adams CA Jr, Eachempati SR. Prophylactic antibiotic use in open fractures: An evidence-based guideline. Surgical Infections 2006;7(4):379-405.
Lefebvre 2008
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies, Box 6.4.c. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 (updated September 2008). The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
SIGN 2008
  • Scottish Intercollegiate Guidelines Network (SIGN). Antibiotic prophylaxis in surgery. Edinburgh: SIGN, 2008. www.sign.ac.uk/pdf/sign104.pdf (accessed 26 July 2009). [: ISBN 978 1 905813 34 6]

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gosselin 2004