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Exercise for treating fibromyalgia syndrome

  1. Angela J Busch1,*,
  2. Karen A.R. Barber2,
  3. Tom J Overend3,
  4. Paul Michael J Peloso4,
  5. Candice L Schachter5

Editorial Group: Cochrane Musculoskeletal Group

Published Online: 8 OCT 2008

Assessed as up-to-date: 16 AUG 2007

DOI: 10.1002/14651858.CD003786.pub2

How to Cite

Busch AJ, Barber KA, Overend TJ, Peloso PMJ, Schachter CL. Exercise for treating fibromyalgia syndrome. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD003786. DOI: 10.1002/14651858.CD003786.pub2.

Author Information

  1. 1

    University of Saskatchewan, School of Physical Therapy, Saskatoon, Saskatchewan, Canada

  2. 2

    University of Saskatchewan, Continuing Physical Therapy Education, Saskatoon, Saskatchewan, Canada

  3. 3

    University of Western Ontario, School of Physical Therapy, London, Ontario, Canada

  4. 4

    Basking Ridge, NJ, USA

  5. 5

    Windsor, Ontario, Canada

*Angela J Busch, School of Physical Therapy, University of Saskatchewan, 1121 College Drive, Saskatoon, Saskatchewan, S7N 0W3, Canada. angela.busch@usask.ca.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 OCT 2008

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Characteristics of included studies [ordered by study ID]
Altan 2004

Methods2 groups. LENGTH: Phase 1 (active tx) 12wks, Follow-up (controlled) 12 wks.


ParticipantsFEMALE:MALE= 46:0, AGE: 31-56(43.9). INCLUSION: Dx: FMS (ACR1990), women. EXCLUSION:
Rheumatoid disease, unstable hypertension, severe cardiopulmonary problems, heat intolerance, psychiatric disorder affecting compliance, abnormal blood count and chemistry, ESR, urinalysis.


InterventionsPool exercise in heated pool (37°C) (n=24), balneotherapy without exercise (n=22).


OutcomesPain, tender points, fatigue, sleep, stiffness, muscle endurance, patient-rated disability (status), HP-rated disability (status), FIQ, depression.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Buckelew 1998

Methods4 groups. LENGTH: Phase 1 (active tx) 6 wks, Phase 2 (maintenance) 2 yrs.


ParticipantsFEMALE:MALE= 108:9, AGE: 41.9(8.1) to 45.6(9.4). INCLUSION: Dx: FMS (Yunus 1981, 1982, 1984). EXCLUSION: Organic brain syndrome, psychotic disorder, unstable or uncontrolled medical conditions, major communicative disorder, RA, widespread OA, subjective pain < 4 of 10, current participation in regular aerobic exercise, biofeedback in past year.


InterventionsBiofeedback (n=25), Exercise (n=26), Biofeedback + Exercise (n=23), Education + attention control (n=27).


OutcomesPain, tender points, physical function (self-report), global, self-efficacy, fatigue and sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Burckhardt 1994

Methods3 groups. LENGTH: 12wks.


ParticipantsFEMALE:MALE= 99:0, AGE: 46.5(8.3). INCLUSION: Dx: FMS (ACR 1990), understands Swedish. EXCLUSION: Abnormal lab tests (Hb, free thyroxine, ESR, ANA, RF, CK), other rheumatic disease.


InterventionsWait List Control (n=30),Education (n=28),Education + Exercise (n=28).


OutcomesPain, tender points, physical function (cardio-respiratory fitness, self-report, muscle-skeletal tests), global, self-efficacy, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Cedraschi 2004

Methods2 groups. LENGTH: Phase 1 (active tx) 6 wks,
Follow-up (controlled) 6 months.


ParticipantsFEMALE:MALE= 152:12, AGE: 48.9(9.7) to 49.8 (9.8). INCLUSION: Dx: FMS (ACR 1990), fluency in French. EXCLUSION: Specific medical disorders requiring immediate treatment (fractures, infectious diseases), medical disorders that prevented physical activity (cardiovascular problems), medical disorders that precluded participation in swimming pool sessions (skin diseases, allergy to chlorine).


InterventionsMultidisciplinary program (n=84), Wait List Control (n=80).


OutcomesPain, tender points, HP-rated disability (status), SF-36, FIQ, quality of life.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





DaCosta 2005

Methods2 groups. LENGTH: Phase 1 (active tx) 12 wks,
Follow-up (controlled) 9 months.


ParticipantsFEMALE:MALE= 79:0, AGE: 49.2(8.7) to 52.3(10.8). INCLUSION: Confirmed diagnosis of primary FMS, female. EXCLUSION: Concomitant diseases precluding participants in exercise, contraindications to exercise identified by examining physician, regular participation in moderate intensity exercise, recent change in medications. in previous 2/52.


InterventionsHome-Based Exercise (n=39), Treatment as Usual Control (n=40).


OutcomesPain, CR (Max), FIQ.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Genc 2002

Methods2 groups. LENGTH: 3 wks.


ParticipantsFEMALE:MALE= 32:0, AGE: 27.9(5.4) to 27.5(5.6). INCLUSION: Dx: FMS (ACR 1990), female. EXCLUSION: unknown.


InterventionsStretch + Strength (stretching, posture, strengthening group) (n=16), Remedial Exercise (n=16).


OutcomesFlexibility, FIQ.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Gowans 1999

Methods2 groups. LENGTH: 6 wks.


ParticipantsFEMALE:MALE= 32:9, AGE: 44.3(10.7) to 46.6(12.2). INCLUSION: Dx: FMS (ACR 1990), physician referral, willing to attend in daytime hours. EXCLUSION: <50% attendance.


InterventionsExercise + Education (n=20), Wait List Control (n=21).


OutcomesPain, physical function (cardio-respiratory fitness, self-report), global, self-efficacy, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?NoC - Inadequate





Gowans 2001

Methods2 groups. LENGTH: 23 wks.


ParticipantsFEMALE:MALE= 44:6, AGE: 44.6(8.7) to 49.8(7.3). INCLUSION: Dx: FMS (ACR 1990), willing to comply with experimental protocol. EXCLUSION: Diagnosis of hypertension or symptomatic cardiac disease, other serious systemic diseases (SLE, cancer, diabetes), intended to change medications or seeking professional help for anxiety or depression during the study period, were enrolled in or intended to begin an aerobic exercise program.


InterventionsExercise (n=27), Untreated Control (n=23).


OutcomesTender points, CR (functional performance), muscle strength, FIQ, self-efficacy, depression, anxiety.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Hakkinen 2001

Methods3 groups. LENGTH: 4 wks control for all groups, 21 wks intervention phase.


ParticipantsFEMALE:MALE= 33:0, AGE: 37(6) to 39(6). INCLUSION: Dx: FMS (ACR 1990), pre-menopausal women. EXCLUSION: Unspecified.


InterventionsFMS Control (n=10), Strength Training A (FMS: n=11), Strength Training B (healthy subjects: n=12).


OutcomesPain, muscle strength, global, fatigue, sleep, depression.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Hakkinen 2002

Methods3 groups. LENGTH: 21 wks.


ParticipantsFEMALE:MALE= 33:0, AGE: 37(5) to 39(6). INCLUSION: Dx: FMS (ACR 1990), pre-menopausal. EXCLUSION: None.


InterventionsFMS Training (n=11), FMS Control(n=10), Healthy Training Control (n=12).


OutcomesMusculoskeletal (strength), anthropometric measures, hormonal responses (testosterone, free test, DHEAS, IGF-I, GH).


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Isomeri 1993

Methods3 groups. LENGTH: 15 wks.


ParticipantsFEMALE:MALE= 39:6, AGE: 43.7 (range=24-55). INCLUSION: Dx: FMS (Yunus 1981, Wolfe 1985). EXCLUSION: Unable to participate in strenuous physical training due to medical conditions or medication, other disease causing pain.


InterventionsFlexibility + Amitriptyline (n=16), Aerobic Exercise (n=15), Aerobic Exercise + Amitriptyline (n=14).


OutcomesPain, tender points.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Jentoft 2001

Methods2 groups. LENGTH: Phase 1 (active tx) 20 wks,
Follow-up (controlled) 6 months. (46 wks after initiation).


ParticipantsFEMALE:MALE= 34:0, AGE: 39.4(8.8) to 42.9(8.6). INCLUSION: Women aged 20 to 60, Dx: FMS (ACR 1990). EXCLUSION: Inflammatory rheumatic disease, hypothyroidism, heart and lung disease, pregnancy.


InterventionsPool (pool based exercise) (n=18), Land (land based exercise) (n=16).


OutcomesPain, tender points, fatigue, stiffness, CR (predicted max), CR (functional performance), muscle strength, muscle endurance, patient-related disability (status), FIQ, self-efficacy, depression, anxiety.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Jones 2002

Methods2 groups. LENGTH: 12 wks.


ParticipantsFEMALE:MALE= 56:0, AGE: 46.4(8.6) to 49.2(6.3). INCLUSION: Dx: FMS (ACR 1990), female, age 20 to 60. EXCLUSION: Current or past history of CV, pulmonary, neurological, endocrine, or renal disease that would preclude exercise program, current use of medications that would affect normal physiological response to exercise, current cigarette smoking, score = 29 on Beck Depression Scale modified for FMS, current participant in a regular exercise program.


InterventionsStrength (n=28), Flexibility (n=28).


OutcomesPain, tender points, fatigue, muscle strength, flexibility, FIQ, quality of life, self-efficacy, depression, anxiety.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Keel 1998

Methods2 groups. LENGTH: Phase 1 (active tx) 15 wks, Follow-up 4 months. after post-test.


ParticipantsFEMALE: MALE= 24:3, AGE: 48 to 50. INCLUSION: Dx: FMS (Muller 1990), proficiency in German, written consent. EXCLUSION: Severe mental disorders (including drug addiction) requiring continuing psychiatric care.


InterventionsSelf-Management Training (n=14), Relaxation Training (n=13).


OutcomesPain, fatigue, sleep.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?NoC - Inadequate





King 2002

Methods4 groups. LENGTH: Phase 1 (active tx) 12 wks,
Follow-up (controlled) 3 months.


ParticipantsFEMALE:MALE= 170:0, AGE: 44.9(10) to 47.4(9). INCLUSION: Dx: FMS (ACR 1990), women, age 18-65, willing to meet 3 wks x 12 wks. EXCLUSION: Conditions precluding ability to exercise (severe cardiac arrhythmia, dizziness, severe shortness of breath), inflammatory arthritis, SLE MRA.


InterventionsExercise (n=42), Education (n=41), Exercise + Education (n=35), Control (n=34).


OutcomesTender points, CR (functional performance), FIQ, self-efficacy.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Mannerkorpi 2000

Methods2 groups. LENGTH: Exercise 24 wks. (includes 6 wks of education).


ParticipantsFEMALE:MALE= 69:0, AGE: 45(8.0) to 47(11.6). INCLUSION: Dx: FMS (ACR1990). EXCLUSION: Other rheumatic diseases, other severe somatic or psychiatric disorders, chlorine allergy, plans to start other treatments during study.


InterventionsExercise + Education (n=28), Treatment as Usual Control Group (n=29).


OutcomesPain, physical function (cardio-respiratory fitness, self-report, muscle-skeletal tests), global, self-efficacy, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?NoC - Inadequate





Martin 1996

Methods2 groups. LENGTH: 6 wks.


ParticipantsFEMALE:MALE= 37:1, AGE: 43.9(9.7) to 45.7(9.9). INCLUSION: Dx: FMS (ACR 1990). EXCLUSION: cardiovascular, pulmonary, neurological or renal disease that precluded participation in exercise, medication that changed physiological response to exercise.


InterventionsAerobic Exercise (n=18), Relaxation (n=20).


OutcomesPain, tender points, physical function (cardio-respiratory fitness, muscle-skeletal tests), global, self-efficacy.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





McCain 1988

Methods2 groups. LENGTH: 20 wks.


ParticipantsFEMALE:MALE= mixed, details unspecified, AGE: 35.8(11.1) to 45.9(8.2). INCLUSION: Dx: FMS (Smythe 1988), successful treadmill stress test. EXCLUSION: Amytriptyline within previous 3 mo., ischemic heart disease, symptomatic cardiac arrhythmias, exercise induced asthma.


InterventionsAerobic Exercise (n=18), Flexibility (n=20).


OutcomesPain, tender points, physical function (cardio-respiratory fitness), global, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Mengshoel 1992

Methods2 groups. LENGTH: 20 wks.


ParticipantsFEMALE:MALE= 25:0, AGE: 34 (range= 25-38) to 35.5 (range= 21-47). INCLUSION: Dx: FMS (ACR 1990). EXCLUSION: Abnormal lab tests (ESR, Hb, liver enzymes, serum creatinine, ANA, Waaler, latex, thyroxine).


InterventionsAerobic Exercise (n=11), Physical Activity as Usual Control Group (n=14).


OutcomesPain, physical function (cardio-respiratory fitness, muscle-skeletal tests), fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Meyer 2000

Methods3 groups. LENGTH: 24 wks.


ParticipantsFEMALE:MALE= 8:0, AGE: 49.5(6.3). INCLUSION: Dx: FMS (ACR 1990). EXCLUSION: Uncontrolled hypertension, history of heart or respiratory disease, orthopedic dysfunction that would prevent participation in walking program.


InterventionsLow Intensity Exercise (n=8 at pretest), High Intensity Exercise (n=8 at pretest), Physical Activity as Usual Control (n=5 at pretest). (Note: Began with 21 subjects but only 8 completed, original group assignment not retained).


OutcomesPain, tender points, physical function (cardio-respiratory fitness, self-report), global, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Nichols 1994

Methods2 groups. LENGTH: 8 wks.


ParticipantsFEMALE:MALE= 17:2, AGE: 47.8(11.1) to 50.8(11.8). INCLUSION: Dx: FMS (ACR 1990). EXCLUSION: Heart, lung disease, uncontrolled hypertension, orthopedic disorder, regular physical activity in previous 6 mo.


InterventionsAerobic Exercise (n=10), Sedentary Control (n=9).


OutcomesPain, physical function (self-report), psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Norregaard 1997

Methods3 groups. LENGTH: 12 wks.


ParticipantsFEMALE:MALE= unspecified, AGE: 44(8) to 55(10). INCLUSION: Dx: FMS (ACR 1990), age 20 to 70 yrs. EXCLUSION: Pregnancy, lactation, alcoholism, cardiovascular, lung, renal or rheumatic disease, anticoagulant medication.


InterventionsAerobic Exercise (n=5), Mixed Exercise (n=11), Hot Packs (n=7).


OutcomesPain, tender points, physical function (cardio-respiratory fitness, muscle-skeletal tests), global, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Ramsay 2000

Methods2 groups. LENGTH: 12 wks.


ParticipantsFEMALE:MALE= unspecified, AGE: unspecified. INCLUSION: Dx: FMS (ACR 1990), stable medication use for 1 mo. prior to entry into study (tricyclic antidepressants, analgesics, NSAIDs). EXCLUSION: Unspecified.


InterventionsSingle Exercise + Home Program (n=35), Exercise Class + Home Program (n=15).


OutcomesPain, tender points, global, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Redondo 2004

Methods2 groups. LENGTH: Phase 1 (active tx) 8 wks,
Follow-up (controlled) 6 mo., 12 mo.


ParticipantsFEMALE:MALE= 40:0, AGE: 52.5(8.8). INCLUSION: Women, Dx: FMS (ACR 1990). EXCLUSION: Serious concomitant disease, poor CV. fitness on initial test.


InterventionsPhysical exercise (n-19), Cognitive Behavioral Therapy (n=21).


OutcomesTender points, CR (Max), physical function, patient-rated change (improvement), SF-36, FIQ, self-efficacy, depression, anxiety, coping.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?NoC - Inadequate





Richards 2002

Methods2 groups. LENGTH: Phase 1 (active tx) 12 wks, Follow-up 1 yr from entry (evaluation at 6 & 12 mo. post-entry).


ParticipantsFEMALE:MALE= 126:10, AGE: 45(38-52) to 48(38-56). INCLUSION: Female and male, ages 18-70, Dx: FMS (ACR 1990), able to give informed consent. EXCLUSION: Individuals with alternative diagnoses that could explain current symptoms, unable to attend exercise classes (too busy, lived too far away, too incapacitated, other reasons), severe pulmonary, CV, renal, neurological disease precluding involvement in aerobic exercise, inability to co-operate.


InterventionsAerobic exercise (n=69), Relaxation (n=67).


OutcomesPain, tender points, fatigue, patient-rated change (improvement), SF-36, FIQ.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Schachter 2003

Methods3 groups. LENGTH: 16 wks.


ParticipantsFEMALE:MALE= 143:0, AGE: 41.3(8.67) to 42.5(6.69). INCLUSION: Women aged 20 to 55 yrs old from Saskatoon, Dx: FMS (ACR 1990), sedentary, family MD permission, informed consent for study, willingness to be randomly assigned. EXCLUSION: More than 2 CAD risk factors (ACSM 1995), known CV or respiratory disease, metabolic, musculoskeletal, or neurological conditions interfering with moderate intensity aerobic exercise.


InterventionsNo exercise (n=36), Short Bout Exercise (n=56), Long Bout Exercise (n=51).


OutcomesPain, tender points, sleep, stiffness, CR (max), other CR, self reported function, patient-rated disability (status), HP-rated disability (status), FIQ, self-efficacy, depression, anxiety.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Sencan 2004

Methods3 groups. LENGTH: Phase 1 (active tx) 6 wks,
Follow-up (controlled) 6 wks.


ParticipantsFEMALE:MALE= 60:0, AGE: 32.6(9.4) to 35.5 (7.9). INCLUSION: Women, Dx: FMS (ACR 1990). EXCLUSION: Tumoral, infectious, metabolic, cardiovascular, endocrine disease, drug dependency, other pharmacological treatment, co-morbid disease.


InterventionsAerobic exercise (n=20), Antidepressant (Paroxetine) (n=20), Placebo (n=20).


OutcomesPain, tender points, sleep, depression.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Valim 2003

Methods2 groups. LENGTH: 20 wks.


ParticipantsFEMALE:MALE= 76:0, AGE: 47(10) to 44(11). INCLUSION: Sedentary women, 18-60 yrs, Dx: FMS (ACR 1990), never previously treated, newly diagnosed. EXCLUSION: Cardiorespiratory disorders limiting exercise, neurological disorders, BMI >35, hyperthyroidism, other rheumatologic diseases.


InterventionsAerobic exercise (n=32), Stretching exercise (n=28).


OutcomesPain, tender points, CR (max), CR (submax), flexibility, SF-36, FIQ, depression, anxiety.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Valkeinen 2004

Methods3 groups. LENGTH: 21 wks.


ParticipantsFEMALE:MALE= 36:0, AGE: 59.1(3.5) to 60.2(2.5). INCLUSION: Dx: FMS (ACR 1990), age = 55 years, women. EXCLUSION: No other diseases, no injuries, no experience of regular strength training exercises, willingness to participate in study protocol.


InterventionsFMS Training (n=13), FMS Control (n=13), Healthy Control Training (n=10).


OutcomesPain, tender points, fatigue, sleep, other CR, muscle strength, self-reported function, depression.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





vanSanten 2002a

Methods3 groups. LENGTH: 24 wks.


ParticipantsFEMALE:MALE= 129:0, AGE: 42.8(26-59) to 46.2(26-59). INCLUSION: Female, 18-60 years, living within 30 km of either rheumatology depts., Dx: FMS (ACR1990). EXCLUSION: Known co-morbidities, female with more localized myalgia, ischemic heart disorder, arrhythmias, exercise induced asthma, unsettled disability compensation, incapacitating psych. distress, pregnancy, wait list for elective surgery, vacation during trial.


InterventionsFitness (with/without compliance strategy)(n=50), Biofeedback (with/without compliance strategy) (n=50), Treatment as Usual Control (n=29).


OutcomesPain, tender points, fatigue, cardio-respiratory fitness, CR (max), other CR, self-reported function, SIP.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





vanSanten 2002b

Methods2 groups. LENGTH: 20 wks.


ParticipantsFEMALE:MALE= 37:0, AGE: 39(20-54) to 45(25-58). INCLUSION: Dx: FMS (ACR 1990), female, 18 to 60 yrs, living within 30 km radius of Maastricht. EXCLUSION: Known cardiopulmonary or psychiatric co-morbidity, IHD, arrhythmia, EIA, unsettled disability compensation dispute, incapacitating psychological distress.


InterventionsSelf Selected Intensity Training (n=15), High Intensity Training (n=18)


OutcomesPain, tender points, CR (max), CR (submax), other CR, patient rated severity, general health status, depression, anxiety, other psychological problems.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate





Verstappen 1997

Methods2 groups. LENGTH: 6 mo.


ParticipantsFEMALE:MALE= 72:0, AGE: 42.8(8.4) to 46.6(8.3). INCLUSION: Dx: FMS (Wolfe 1988), age 18-60 yrs, female. EXCLUSION: Ischemic heart disease, cardiac arrhythmias, exercise induced bronchospasm, psychiatric disorders, current involvement in health insurance procedures.


InterventionsAerobic Exercise (n=45), Non-intervention (n=27).


OutcomesPhysical function (cardio-respiratory fitness, muscle-skeletal tests).


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Wigers 1996

Methods3 groups. LENGTH: Phase 1 (active tx) 14 wks, Follow-up 4.5 years.


ParticipantsFEMALE:MALE= 55:5, AGE: 44(10). INCLUSION: Dx: FMS (Smythe 1979 + Yunus criteria 1981) (58 of 60 met ACR 1990 criteria, evaluated retrospectively). EXCLUSION: None.


InterventionsAerobic Exercise (n=16), Stress Management Training (n=15), Treatment as Usual Control (n=17).


OutcomesPain, tender points, physical function (cardio-respiratory fitness), global, fatigue, sleep, psychological function.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?UnclearB - Unclear





Zijlstra 2005

Methods2 groups. LENGTH: Phase 1 (active tx) 2.5 wks.,
Follow-up (uncontrolled) 12 mo. from baseline.


ParticipantsFEMALE:MALE= 28:6, AGE: 47(24-64) to 48(22-64). INCLUSION: Dx: FMS (ACR 1990), 18 to 65 yrs, willingness to undergo in-patient treatment of some wks. EXCLUSION: Secondary FMS (presume of another underlying disease that causes chronic pain), co-morbidity interfering with spa, other co-morbidity, dependency on wheelchair or help from other people, current involvement in a law procedure concerning disability or employment, recent spa treatment for musculoskeletal disorders, difficulty understanding Dutch.


InterventionsSPA (n=58), Treatment as Usual Control (n=76).


OutcomesPain, tender points, fatigue, sleep, CR (submax), patient-rated general health status, FIQ, depression.


Notes


Risk of bias

ItemAuthors' judgementDescription

Allocation concealment?YesA - Adequate



 
Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Ahlgren 2001Diagnosis - trapezius myalgia

Astin 2003Did not meet exercise criteria (QiGong)

Bailey 1999One group design

Bakker 1995Between group analysis not done

Dawson 2003One group before-after design

Gandhi 2000Not randomized - 3 group design: (1)Non-exercising control(n=12), (2) hospital-based exercise group (n=10), (3) home based videotaped exercise program (n=10)

Geel 2002Not randomized

Gowans 2002Focuses on measurement issues of selected variables already reported in an included study; new variables did not include standard deviations

Guarino 2001Diagnosis - Gulf War Syndrome

Han 1998Not randomized (geographic control)

Hunt 2000Diagnosis of FMS was not clear, even when the author was contacted to clarify the diagnostic criteria that were used.

Karper 2001Not randomized (program evaluation)

Kendall 2000Did not meet exercise criteria (Body Awareness)

Kingsley 2005Diagnosis of FMS made by physician or rheumatologist but when contacted, the authors did not verify the use of published criteria (e.g., ACR 1990 classification)

Mason 1998Not randomized (subjects enrolled in a multimodal treatment compared to subjects who were unable to participate due to insurance reasons)

Meiworm 2000Not randomized (subjects self selected their group)

Mobily 2001Case study

Nielen 2000Not randomized (cross-sec. case control study of fitness)

Offenbacher 2000Non-experimental - Narrative review

Oncel 1994Insufficient description of exercise (one group received "medical therapy and exercise"; no further information about the exercise intervention given)

Peters 2002Diagnosis - Persistent unexplained symptoms

Pfeiffer 2003One group before-after design

Piso 2001Not randomized - Our translator reported: "The authors wrote only how they recruited nine of the patients. They wrote nothing about if and how the patients were allocated to the two groups." We were unsuccessful on several attempts to contact the authors for clarification.

Rooks 2002One-group design

Thieme 2003Did not meet exercise criteria (passive PT with light movement in water - the active exercise was too small a component, not described or quantified sufficiently)

Tiidus 1997One group repeated measures design

Vlaeyen1996Insufficient description of the mode of exercise. "Each session ended with a physical exercise such as swimming or bicycling, excluding systematic physical or fitness training."

Worrel 2001One-group design.



 
Comparison 1. *Aerobic Only - Moderate to High Quality by ACSM (restricted to untreated control groups)

Outcome or subgroup titleNo. of studiesNo. of participantsStatistical methodEffect size

 1 Pain4223Std. Mean Difference (IV, Random, 95% CI)0.81 [0.15, 1.47]

    1.1 Pain - Did Not Prescribe ACSM
140Std. Mean Difference (IV, Random, 95% CI)1.34 [0.65, 2.04]

    1.2 Pain - Did Prescribe ACSM
3183Std. Mean Difference (IV, Random, 95% CI)0.65 [-0.09, 1.39]

 2 Global4Std. Mean Difference (IV, Random, 95% CI)Subtotals only

    2.1 Global - Prescribed ACSM
4269Std. Mean Difference (IV, Random, 95% CI)0.49 [0.23, 0.75]

 3 Physical Function4Std. Mean Difference (IV, Random, 95% CI)Subtotals only

    3.1 Physical Function - Prescribed ACSM
4253Std. Mean Difference (IV, Random, 95% CI)0.66 [0.41, 0.92]

 4 Tender points6349Std. Mean Difference (IV, Random, 95% CI)0.76 [-0.01, 1.53]

    4.1 Tender Points - Did Not Prescribe ACSM
140Std. Mean Difference (IV, Random, 95% CI)3.90 [2.80, 4.99]

    4.2 Tender Points - Prescribed ACSM
5309Std. Mean Difference (IV, Random, 95% CI)0.23 [-0.18, 0.65]

 5 Depression5273Std. Mean Difference (IV, Random, 95% CI)0.54 [0.14, 0.94]

    5.1 Depression - Did Not Prescribe ACSM
140Std. Mean Difference (IV, Random, 95% CI)1.22 [0.54, 1.90]

    5.2 Depression - Prescribed ACSM
4233Std. Mean Difference (IV, Random, 95% CI)0.40 [0.04, 0.76]

 
Comparison 2. *Strength Training versus Control

Outcome or subgroup titleNo. of studiesNo. of participantsStatistical methodEffect size

 1 Pain1Std. Mean Difference (IV, Fixed, 95% CI)Totals not selected

 2 Global Well Being247Std. Mean Difference (IV, Fixed, 95% CI)1.43 [0.76, 2.10]

 3 Physical Function247Std. Mean Difference (IV, Fixed, 95% CI)0.52 [-0.07, 1.10]

 4 Tender Points1Std. Mean Difference (IV, Fixed, 95% CI)Totals not selected

 5 Depression1Std. Mean Difference (IV, Fixed, 95% CI)Totals not selected

 
Table 1. Search Strategy used for Busch 2002 FMS and Exercise (first edition)

ProcessParticulars

Data bases usedMEDLINE (1966-12/2000), CINAHL (1982-12/2000), HealthSTAR (1990-12/2000), Sports Discus (1975 - 12/2000), EMBASE (1974 to 12/2000), the Cochrane Controlled Trials Register (Issue 4, 2000).

Adjunctive search methodsReference lists from identified articles, meta-analyses and reviews of all types of treatment for FMS were reviewed independently by two reviewers and all promising references were scrutinized. We searched without language restriction and translated all non-English studies that were initially identified as possibly meeting the inclusion criteria.

Search Strategy used for MEDLINESearch Strategy on SilverPlatter v3.0 for Windows

1 "Fibromyalgia"/ all subheadings
2 fibromyalgia
3 fibrositis
4 fibromyalgia or fibrositis
5 #1 or #4
6 explode "Exertion"/ all subheadings
7 "Physical-Fitness"/ all subheadings
8 explode "Physical-Therapy"/ all subheadings
9 "Exercise-Test"/ all subheadings
10 "Exercise-Tolerance"/ all subheadings
11 explode "Sports"/ all subheadings
12 "Pliability"/ all subheadings
13 #6 or #7 or #8 or #9 or #10 or #11 or #12
14 exertion*
15 exercis*
16 physical 17 motion
18 fitness
19 therapy
20 therapies
21 (physical or motion) near (fitness or therapy or therapies)
22 physical
23 endurance
24 physical near endurance
25 manipulation*
26 skating
27 running
28 jogging
29 swimming
30 bicycling
31 cycling
32 walking
33 rowing
34 weight
35 training
36 muscle
37 strengthening
38 skating or running or jogging or swimming or bicycling or cycling or walking or rowing or weight training or muscle strengthening
39 #13 or #14 or #15 or #21 or #24 or #25 or #38
40 #5 and #39
41 explode "Research-Design"/ all subheadings
42 explode "Clinical-Trials"/ all subheadings
43 #41 or #42
44 #40 and #43
45 PT = "CLINICAL-TRIAL"
46 #40 and (PT = "CLINICAL-TRIAL")
47 #44 or #46

 
Table 2. Detailed Description of Exercise Protocol

StudyGroupAerobicStrengthFlexibilityOther

Altan 2004 (Information supplemented by author)Length: 12 weeks POOL BASED EXERCISE GROUP Supervised group of mixed exercisePool exercise for 35 min / day, 3 days / wk Warm-up: walking - 5 min; Activity: jumping, rhythmic ROM for upper and lower extremities, rhythmic swimming - 20 min; Cool down: stretching and relaxing - 5 min; out of pool exercise (stretching and bending) - 5 min. Target intensity was 60 to 75% age-adjust HR max progressing to 70 to 75% HRmax. Pool was heated to 37°C. No home program.Squatting - repetitions not specified.Active ROM, neck and extremity stretches in the pool, bending on land. Position of maximum muscle length was held for 5 seconds. Duration of stretching was 5 minutes without interruption. Repetitions not specified.none

Buckelew 19981. Active Phase = 6 weeks
a) EXERCISE GROUP: 1.5 hour exercise session 1/week + Home Program 2/week (unspecified duration)
b) EXERCISE & BIOFEEDBACK GROUP: Exercise component identical to Exercise group
2. Maintenance Phase = 2 years
a) EXERCISE GROUP: 1 hour exercise session 1/month + Home Program of unspecified duration and frequency
b) EXERCISE & BIOFEEDBACK GROUP: Unknown
1a. Walking @ 60-70% HRmax. Home Program @ unspecified intensity and duration
1b. Walking @ 60-70% HRmax. Home Program @ unspecified intensity and duration
2a. unspecified
2b. unspecified
1b. unspecified
2a. unspecified
2b. unspecified
1a. unspecified
1b. unspecified
2a. unspecified
2b. unspecified
1a. Active Range of Motion - details unspecified
1b.Active Range of Motion -details unspecified
2a. unspecified
2b. unspecified
1a. Posture + body mechanics instruction
1b. Posture + body mechanics instruction
2a. none
2b. none

Burckhardt 1994Length: 12 weeks EXERCISE & EDUCATION 1 hr, 1/wk exercise x 6 weeks followed by Home Program x 6 weeksWalking, swimming or cycling. Details unspecified. Home Program unspecifiednoneRange of Motion, stretchingCounselling on Home Program of aerobic exercise, 2 pool sessions over 6 weeks

Cedraschi 2004Length: 6 weeks MULTIDISCIPLINARY PROGRAM 10 sessions of 45 min. durationSupervised group exercise aimed at breaking inactivity patterns and learning to apply relaxation techniques
- 8 x 45 min pool sessions (34 degrees C pool)
- 2 x 45 min low impact land based sessions
Aerobic exercise information not given - participants were instructed to find their own pace.
Strengthening exercise information not specifiedFlexibility exercise information not specifiednone

DaCosta 2005Length: 12 weeks HOME-BASED AEROBIC TRAININGIndividually prescribed mode, intensity, duration, and frequency using ACSM 1998 recommendations based on baseline cardio-respiratory fitness, severity of FMS, access to equipment, time constraints and activity preferences/enjoyment. Duration was 60 to 120 min/wk. Frequency not specified. Intensity began at 60 - 70% HRmax progressing to 75 - 85% HRmax aided by use of heart rate monitor and exercise logs which were collected weekly. Participant initiation and guidance was provided by an exercise physiologist via 4 visits (at 0,1,3,9 wk).Strengthening confined to warm-up/cool down individualized to participant needs.Stretching confined to warm-up/cool down individualized to participant needs.none

Genc 2002Length: 3weeks
1. STRETCHING & STRENGTHENING
2. REMEDIAL EXERCISE
1. none
2. unknown
1. Strengthening for the cervical, thoracic and lumbar spine, 3x / wk. for 3 weeks. The structure, supervision, or details of the program (methods, equipment, reps, sets, and progression) are unknown.
2. Unknown - the term "remedial exercise" implies that an individual program was generated for each participant. Some individuals may have been prescribed strengthening exercise.
1. Stretching exercise for the cervical, thoracic and lumbar spine, 3x /wk. Reps, sets, holds, and progression are unknown.
2. Post-isometric relaxation for upper trapezius, supraspinatus, and levator scapulii. It is assumed that this was administered by a physical therapist. Frequency - 3x / wk. for 3 weeks. Reps, sets, holds, and progression are unknown
Mobilization - active/self mobilization for cervical, thoracic and lumbar regions. The structure, supervision, or details of this part of the program are unknown.
1. none
2. none

Gowans 1999Length: 6 weeks EXERCISE & EDUCATION 30 min. exercise, 2x / weekWarm-up: 10 min. Pool exercise: 20 min. walk/jog/side step/arm exercise @ 60-75% HRmax. Cool-down: 10 min.noneWarm-up, Cool-down onlynone

Gowans 2001Length: 23 weeks EXERCISE GROUP 30 min. 3/wk.Supervised group pool and land exercise (Warm-up: 5 min., Aerobic exercise: 20 min., Cool-down: 5 min.) @ 60 - 75% HRmax. Progression: Wk 1: gentle arm and leg exercise in the pool, Wk 6: running in pool, Wk 7: slow continuous walking on land with arm mvt. 2x/wk + pool 1x/wk, Wk 23: intermittent jogging in gym 2x/wk + pool 1x/wk).nonenonenone

Hakkinen 2001 and 2002Length: 21 weeks EXERCISE GROUP 2 / wkWarm-up, cool downMuscle Groups: Hip extensors, abductors, and adductors; Knee extensors and flexors; Trunk and upper extremity flexors and extensors. Training program: moderate to heavy progressive resistance using David 200 dynamometer (Wk 1-3: 15-20 reps @ 40-60% x1RM, Wk 4-7:10-12 reps @ 60-70% 1RM, Wk 8-14: 8-12 reps @ 60-80%1RM, Wk 13-20: 5-10 reps @70-80% 1RM). Emphasis of hip and knee extensors plus a selection of four or five of eight additional exercises during each session. 20% of total leg exercises were performed according to the principle of explosive strength training (low resistance, high repetitions with emphasis on speed).Warm-up, cool downnone

Isomeri, 1993Length: 15 weeks 1. STRETCHING + MEDICATION 3 weeks in hospital, 12 weeks Home Program 2. EXERCISE GROUP same 3. EXERCISE & MEDICATION same1. none
2. progressive physical fitness training, unspecified
3. progressive physical fitness training, unspecified
1. none
2. progressive physical fitness training, unspecified
3. progressive physical fitness training, unspecified
1. light muscle stretching, unspecified
2. unknown
3. unknown
1. none 2. none 3. none

Jentoft 2001Length: 20 weeks Both pool-based (PE) and land-based (LE) exercise groups were given a 'standardized' exercise program based on the Norwegian Fitness Model (reference in Norwegian language given) with aim to improve CV capacity with minimal risk of injury. This program was used in its original form for the LE group and was modified for the PE group due to restrictions imposed by the water. Pool temp was 34 degrees C. LE group was in gym with wooden floor. 60 min sessions, 2x /wk for both LE and PE groups.For both groups, in at least 40-50% of the 60-minute session, the training intensity was kept within 60-80% HRmax. for the age of each patient. HR was monitored at least twice per session.
The 1 hour session consisted of body awareness training, ergonomics, and warm-up (9 min), aerobic dance (22 min), cool down, stretching (9 min), strength training (15 min), and relaxation (5 min).
Dynamic muscle work for 15 min. included in each session - specifics not given in the article. Modeled on the Norwegian Aerobic Fitness Model which includes: strength training for thigh, back, abdominals including the deep muscle stabilizers 3-4 sets of 8-12 reps - no external loading, intensity adjusted by lever arm of the extremities (Intensity sufficient to increase strength and induce hypertrophy).Specifics not given in the article.none

Jones 2002Length: 12 weeks
1. STRENGTH SUPERVISED GROUP
2. FLEXIBILITY SUPERVISED GROUP
1 hour, 2 / week
1 and 2: Warm UpMuscle Groups: gastrocnemius, tibialis anterior, quadriceps, hamstrings, gluteus, abdominals, erector spinae, pectorals, latissimus dorsi and rhomboids, deltoids, biceps, triceps Equipment: 1 to 3 lb weights &/or surgical tubing Concentric/eccentric contractions with minimized work during eccentric phase Intensity and progression directed by participant. Single set throughout, Repetitions progressed from 4-5 to 12. Participants encouraged to decrease activity during FMS flares. 1 hour program including 5 min. warm-up, 45 min. strengthening, 10 min. cool down.1. Warm up and Cool down.
2. Muscle Groups: gastrocnemius, tibialis anterior, quadriceps, hamstrings, gluteus, abdominals, erector spinae, pectorals, latissimus dorsi, rhomboids, deltoids, biceps, triceps
Static stretch, participant controlled intensity of stretches
10 min WU, 40 min stretching, 10 min CD of guided imagery and relaxation
1. none
2. none

Keel 1998Length: 15 weeks EXERCISE: 20-30 min. 1/week + Home ProgramIntensity, duration, mode unspecifiednoneunspecifiednone

King 2002Length: 12 weeks
1. EXERCISE ONLY GROUP
2. EXERCISE AND EDUCATION GROUP
Progressed from 10-40 min. over program
3 / wk
Supervised group walking, aquacize, or low impact aerobics @ 60 - 75% HRmax monitored using Polar Accurex HRM. Progression: duration began with 10 - 15 min progressed to an average of 20 to 40 minutes.1. none
2. none
Warm-up, cool down1. none
2. none

Mannerkorpi 2000Length: 6 months EXERCISE & EDUCATION 1x / weeksee "Other" columnsee "Other" columnsee "Other" column35 min. pool exercise for endurance, flexibility, coordination, relaxation. Not intended as training. Intensity and reps self selected, below pain and fatigue threshold.

Martin 1996Length: 6 weeks EXERCISE GROUP 3 / week20 min. walking at 60-80% HRmax20 min. strengthening for UE, LE, trunk (reps sets, progression unspecified)20 min. flexibility unspecifiednone

McCain 1988Length: 20 weeks
1. AEROBIC: 3 / week
2. FLEXIBILITY: 3 / week
1. 50 min. 3/wk cycle ergometry at HR >150 bpm for increasing lengths of time, 10 min. Warm-up
2. none
1. none
2. none
1. none
2. 60 min., 3/wk, "flexibility maneuvers" (unspecified) @ HR<115 bpm
1. none
2. none

Mengshoel 1992Length: 20 weeks EXERCISE GROUP 2 / week60 min. aerobic dance for LE with UE exercise performed "at intervals between periods of rest", HR 120-150 bpmnonenonenone

Meyer 2000Length: 24 weeks
1. LOW INTENSITY WALKING 3 /week
2. HIGH INTENSITY WALKING 3 /week
1. Week 1=25% HRR; Week 2-6 increased by 5% /wk; Week 7-9= 50% HRR; Week 10-24 = 60% HRR
Duration: progress from 12 to 30 min by week 20.
2. Week 1=40% HRR; Week 2-4 increased by 10%/wk; Week 5= 75% HRR; Week 6-9 =80% HRR; Week 10-24= 85% HRR.
Duration: progress from 12 to 30 min by week 20.
nonenonenone

Nichols & Glenn 1994Length: 8 weeks EXERCISE GROUP 3 / week20 min. walking at 60-70% HRmax + Warm-up and Cool-downnonenonenone

Norregaard 1997Length: 12 weeks
1. AEROBIC GROUP
3 / week
2. EXERCISE GROUP
2 / week
1. 40 min. aerobic dance target 40-50% VO2max
2. none
1. none
2. none
1. none
2. stretching included in the 40 min. program, details unspecified
1. none
2. 40 min. body awareness, balance, motor control, stretching,
unspecified, 10 min. Warm-up

Ramsay 2000Length: 12 weeks
1. SINGLE SUPERVISED EXERCISE SESSION
1 session plus home program of unknown frequency
2. MULTIPLE SUPERVISED EXERCISE SESSION
1/ week plus Home Program of unknown frequency.
1. One-1 hr individual session with PT for demonstration of aerobic program + written instructions on how to progress the program. Home Program. Activity unspecified.
2. 1 hr graded circuit aerobic exercise (step-ups, sit to stand, skipping, jogging on the spot, alternate side bends, circling arms with increasing weights) plus warm-up. Program individualized for each subject by a PT. Intensity not specified.
Progression unspecified.
1. none
2. none
1. unspecified
2. unspecified
1. none
2. none

Redondo 2004 (Information supplemented by author)Length: 8 weeks EXERCISE GROUP 45 min., 5 /week as follows: Cardiovascular fitness - 2/wk Exercises in warm water pool - 1/wk Flexibility & Endurance exercises - 2/wkIncluded warm-up
Cycle ergometer. Progression: Steeply increasing difficulty of exercise. Target intensity: HRmax 50 to 80%.
Included warm up. Dynamic concentric and eccentric exercises with free weights for all major groups of the upper limbs. Specific exercise for abdominal and paraspinal muscles. Progression: graded and individualized for all subjects, beginning with 30 minutes and progressing to 45 minutes. Reps and intensity were individualized and took into account perceived fatigue and a target intensity between HRmax of 50 to 80%.Specific static exercise for upper and lower extremities and all 3 segments of the vertebral column. Duration of holds not specified.none

Richards 2002Phase 1: Active Treatment
Length: 12 weeks
a) AEROBIC EXERCISE
1 hour, 2 /wk
b) RELAXATION/FLEXIBILITY
1 hour, 2 /wk
Phase 2: Follow up
Length: 40 weeks
a) AEROBIC EXERCISE
b) RELAXATION/FLEXIBILITY
1.a) Individualized group, graded aerobic exercise, mostly treadmill walking or cycle ergometry. Usually started with two bouts of 6 min/class, progressed to two bouts of 25 min by 12 weeks at an intensity that made them perspire slightly while still being able to talk in complete sentences.
1.b) none
2. No organized exercise program of any type for either group.
1. none
2. none
1.a) none
1.b) Upper and lower limb stretches, and relaxation based on regimen of Ost.
2. none
none

Schachter 2003Length: 16 weeks
1. SHORT BOUT EXERCISE GROUP
2. LONG BOUT EXERCISE GROUP
Both groups did an unsupervised home-based program with exercise (to music), instruction video and booklet
Exercise mode was "low-impact aerobics" for lower extremities.
Intensity was modulated through changes in music tempo, participant adjustment of vigour, self-monitored target heart rate and rating of perceived exertion.
1. 2 bouts of exercise per day, progressing duration from 5 min to 15 min; frequency from 3 to 3-5 d/wk; intensity progressing from 40-50% to 65-75% HRR, all by week 9 of 16 wk program
2. One bout of exercise per day, progressing duration from 10 min to 30 min; frequency from 3 to 3-5 d/wk; intensity from 40-50% to 65-75% HRR, all by week 9 of 16 week program
noneStretching exercises as part of 5 min warm-up and cool down.none

Sencan 2004Phase 1: Active Treatment
Length: 6 weeks
EXERCISE GROUP
40 min., 3 /wk
Phase 2: Follow-up
Length: 6 months
EXERCISE GROUP
3 / wk
1. Cycle ergometry 30 min @ unspecified intensity + 5 min WU, 5 min CD
2. Unsupervised Home Program (cycle ergometry 30 min @ unspecified intensity + 5 min WU, 5 min CD)
1. none
2. none
1. none
2. none
1. none
2. none

Valim 2003Length: 20 weeks
1. AEROBIC EXERCISE GROUP
2. STRETCHING EXERCISE GROUP
1. 3x /week supervised group sessions of 45 min duration.
Walking speed was determined as the speed eliciting the HR at the anaerobic threshold detected during a maximal treadmill test.
2. none
1. none
2. none
1. none
2. 3x /week supervised group sessions of 45 min duration. 2 sets of 17 static stretches for cervical and thoracic spine, upper and lower extremities with holds of no more than 30s.
Exercises chosen to provide flexibility without increasing HR.
1. none
2. none

Valkeinin 2004Length: 21 weeks
1. FMS STRENGTH GROUP
2 /week individual supervised training sessions
2. HEALTHY STRENGTH CONTROL GROUP
2 /week individual supervised training sessions identical to above.
1. none
2. none
Muscle groups/exercises: leg extensors (2 exercises), other main muscle groups of the body (5-6 exercises). Program: Weeks 1-4: 3 sets of 15-20 reps at 40-60% of 1RM; Weeks 5-11: 4 sets of 8-12 reps at 60-70% of 1RM; Weeks 12-21: 3 to 5 sets of 5-10 reps with 70-80% of 1 RM. 20% of leg extensor training was performed as explosive strength training. 2 sets of 8-12 reps at 40-50% 1RM performed as fast as possible.1. none
2. none
1. none
2. none

vanSanten 2002aLength: 20 weeks
1. LOW INTENSITY TRAINING GROUP
2. HIGH INTENSITY TRAINING GROUP
1. 2x/wk
60 min/session
(encouraged to do a 3rd unsupervised 60 min session and to use sauna and/or swimming pool after all sessions).
"Intensive aerobic exercises" alternated with general flexibility and balance exercises for 30 min in each session, intensity left up to each subject
2. 3x/wk
60 min/session
45 min of cycle ergometer exercise to reach and maintain 70% of max HR reached on baseline GXT.
Isometric muscle strengthening (10 min) after aerobic work, before cool down1. Stretching exercises as part of warm-up and cool down, general stretches alternated with intensive aerobic exercise in main part of program
2. Lower extremity stretching as part of warm-up (total warm-up time 10-15 min)
1. none
2. none

vanSanten 2002bLength: 24 weeks
FITNESS SUPERVISED GROUP EXERCISE
60 min, 2 /wk, led by a professional fitness instructor.
Swimming/sauna encouraged after each session but not tracked.
1 independent session/wk encouraged but not performed.
60 min. class including 30 min. aerobics alternated with 5 min of general flexibility and balance, 10 min isometric exercise, WU (10 min) and CD (10 min). Intensity participant selected; (no more than moderate intensity performed) No progression achieved. WU = postural stretching CD=stretching, aerobic and relaxation exercise.10 min isometric exercise after aerobics for biceps, abdominals, hamstrings, hip abductors, adductors, quadsWU of postural stretching, General flexibility included in aerobic program. CD included stretching.none

Verstappen 1997Length: 6 months AEROBIC GROUP 2 /wk + Home Program 1-2 /wk 10 min Warm-up, 30 min exercise, 10 min Cool-downTreadmill or cycle ergometry, duration unspecified, intensity subject controlled Home Program unspecifiedStrengthening (UE, LE, abdomen) unspecified Home Program unspecifiedFlexibility unspecified
Home Program unspecified
Coordination unspecified Home Program unspecified

Wigers 1996Length: 14 weeks EXERCISE GROUP 3 /wk45 min. "whole body aerobic exercise" including 18-20 min. @ 60-70% HRmaxnonenonenone

Zijlstra 2005Phase 1: Active Treatment
Length: 2.5 weeks
a) SPA GROUP
7 group supervised group exercise sessions over 15 days
b) HOME (non organized, individual) home program
Phase 2: Follow-up
1 year from baseline
1. 60 min sessions of warm-up, light stretching and low-impact aerobic activities (treadmill walking, swimming, cycling) in which subjects were encouraged to reach 70% of their predicted maximal HR.
Subjects were encouraged to do a 20-30 min swim each morning, and to do light walking or recreational swimming on mornings or afternoons with no formally scheduled treatment.
2. No organized exercise program of any type for either group.
1. none
2. none
1. Light stretching as part of the seven 1-hour exercise sessions over 15 days
2. none
1. none
2. none

 
Table 3. van Tulder Methological Analysis Item Rating and Total Scores

StudyVT Internal ValidityVT Total ScoreJadad DescriptionJadad Total Score

Items A, B, C, D, E, F, G, H, I, J, KTotal ScoreRandomization, Blinding, Drop-outTotal Score

Altan, 2004+ + + - - - - + + + -62,0, 12

Buckelew, 1998- - + - + - + + + + -61, 0, 12

Burckhardt, 1994- - + - - - - + + + -51, 0, 12

Cedraschi, 2004+ + + - + + - - + + +82, 0, 13

DaCosta, 2005+ + - - - + - + + + +72, 0, 13

Genc, 2002- - + - - - - - + + +41, 0, 12

Gowans, 1999- - + - - - - - + + -31, 0, 12

Gowans, 2001- - + - + - - + - + +51, 0, 12

Hakkinen, 2001- - + - - - - - + + +41, 0, 12

Isomeri, 1993- - + - - - - - + + -31, 0, 12

Jentoft, 2001+ - - - - + - + + + -52, 0, 13

Jones, 2002+ - + - - + - + - + -52, 0, 02

Keel, 1998- + + - + -+ N/A + + -60, 0, 11

King, 2002+ + + - + - - + - + +72, 0, 13

Mannerkorpi, 2000- - + - + + - + - + -50, 0, 11

Martin, 1996+ - + - + - - + - + +62, 0, 13

McCain, 1988- - - - + + + + + + -61, 0, 12

Mengshoel, 1992- - + - - - - + - + -31, 0, 12

Meyer, 2000- - - - - - - - - + -11, 0, 12

Nichols, 1994- - - - + - - - - + -21, 0, 12

Norregaard, 1997+ - - - + - - + - + -42, 0, 13

Ramsay, 2000- - - - - - - - + + +31, 0, 12

Redondo, 2004+ - + - - - - + - + +52, 0, 13

Richards, 2002+ + + + - - - + + + +82, 0, 02

Schachter, 2003+ + + - + + - - - + +72 ,0, 13

Sencan, 2004- - + - + - + - + + +61, 0, 12

Valim, 2003+ - + - - - - + - + -41, 0, 12

Valkeinan, 2004+ - + - - - - - + - +42, 0, 13

vanSanten, 2002a+ + + - - - - + + + +71, 0, 12

vanSanten, 2002b+ + + - - - + + + + +81, 0, 12

Verstappen, 1997- - + - - - - + + + -41, 0, 12

Wigers, 1996+ - + + + + + + + +92, 0, 13

Zijlstra, 2005+ + + - - - + - - - -42, 0, 02

Key to van Tulder (VT) internal validity items: (- = did not meet the criterion, + = met the criterion, N/A = not applicable)

A)Was the method of randomization adequate?

B)Was the treatment allocation concealed?

C)Were the groups similar at baseline regarding the most important prognostic indicators?

D)Was the patient blinded to the intervention?

E)Was the care provided blinded to the intervention?

F)Was the outcome assessor blinded to the intervention?

G)Were co-intervention avoided or similar?

H)Was the compliance acceptable in all groups?

I)Was the drop-out rate described and acceptable?

J)Was the timing of the outcome assessment in all groups similar?

K)Did the analysis include an intention-to treat analysis?

 
Table 4. Studies including Aerobic Interventions: Quality by ACSM Criteria

Low Quality (VT<5)Mod to High Quality

Met American College of Sports Medicine GuidelinesGowans 1999Altan 2004

Mengshoel 1992Buckelew 1998

Meyer 2000DaCosta 2005

Nichols 1994Gowans 2001

Valim 2003Jentoft 2001

King 2002

Martin 1996

McCain 1988

Redondo 2004

Schachter 2003

Van Santen 2002b

Wigers 1996

Did not meet American College of Sports Medicine GuidelinesBurckhardt 1998Cedraschi 2004

Genc 2002Keel 1998

Isomeri 1993Mannerkorpi 2002

Norregaard 1997Richards 2002

Ramsey 2000Sencan 2004

Verstappen 1997VanSanten 2002a

Zijlstra 2005


 
Table 5. Short-term effects (SMD, 95% CI): exercise-only interventions not meta-analyzed

Intervention 1 (n1)Intervention 2 (n2)Studyvan Tulder ScoreGlobal Well-beingPainTender PointsPhysical FunctionDepression

Aerobic (26)Biofeedback only (25)Buckelew 19986-0.26
(-0.79 0.27)
---0.06
(-0.46 0.59)
---0.03
(-0.49 0.56)

Aerobic (18)Flexibility (20)McCain 19886---0.53
(-0.12, 1.18)
0.78 (0.12, 1.90)1.12 (0.45, 1.79)---

Aerobic (18)Flexibility (20)McCain 19886---0.53 (-0.12, 1.18)0.78 (0.12, 1.90)1.12 (0.45, 1.79)---

Aerobic, supervised (35)Aerobic, unsupervised (15)Ramsay 200030.1 (-0.35, 0.56)0.15 (-0.31, 0.60)0.42 (-0.04,0.89)------

Aerobic (69)Relaxation (67)Richards 200280.31 (-0.03, 0.65)0.00 (-0.34, 0.34)0.27 (-0.07, 0.61)------

Aerobic, long bout (107)Aerobic, short bout (36)Schachter 200370.28 (-0.10, 0.66)0.42 (-0.01, 0.85)0.14 (-0.24, 0.52)0.12 (-0.26, 0.50)0.00 (-0.38, 0.38)

Strength (28)Flexibility (28)Jones 200250.55 (0.02, 1.09)0.66 (0.12, 1.20)0.25 (-0.28, 0.76)-0.34c (-0.87, 0.18)0.41 (-0.21, 0.94)

Strength (28)Flexibility (28)Jones 20025----------0.53d (-1.06,0.00)---

Mixed exercise (24)Balneotherapy (22)Altan 200460.16 (-0.42, 0.74)0.56 (-0.03, 1.15)0.20 (-0.38, 0.78)-0.72 (-1.32, -0.12)0.88 (0.27, 1.49)

Mixed Exercise (Home-based) (39)Untreated Control (40)DaCosta
2005
80.39
(-0.05, 0.84)
---------0.25
(-0.20, 0.69)

Mixed exercise, water (18)Mixed exercise, land (16)Jentoft 200150.93 (0.22, 1.64)0.41 (-0.27, 1.09)---0.4 (-0.28, 1.09)0.54 (-0.15, 1.23)

Mixed exercise (18)Relaxation (20)Martin 199660.53 (-0.12, 1.18)---1.01 (0.33, 1.69)5.79 (4.28, 7.31)---

Mixed exercise (19)Cognitive behaviour training (21)Redondo 200450.4 (-0.22, 1.03)-0.06 (-0.68, 0.56)0.46 (-0.17, 1.09)0.42 (-0.20, 1.05-0.49 (-1.12, 0.14)

Mixed exercise (50)Untreated control (79)Van Santen 2002a7-0.20 (-0.64, 0.23)0.36 (-0.08, 0.80)-0.06 (-0.49, 0.38)0.15 (-0.29, 0.58)---

Mixed exercise, high intensity (58)Mixed exercise, self-selected intensity (85)Van Santen 2002b8-0.70 (-1.45, 0.05)0.45 (-0.28, 1.19)-0.18 (-0.90, 0.55)0.39 (-0.34, 1.12)-0.22 (-0.95, 0.50)

Note: a. All positive values denote greater improvement in Intervention 1 versus Intervention 2. Therefore, a positive value for pain intensity would mean pain intensity has decreased with intervention 1.
b. Van Tulder Score is based on the 11 internal validity items described in van Tulder et al. 2003.

c. Values provided were measured for strength.

d. Values provided were measured for flexibility.

Key: SMD = Standardized Mean Difference (small change = .2, moderate change = .5, large change = .8). Data for comparison at 12 weeks or as close to 12 weeks as possible was used to calculate SMD.

Formula: SMD= (Mean change in Intervention 1 - Mean changed in Intervention 2)/(Pooled SD of change)

 
Table 6. Short-term effects (SMD, 95%CI): composite interventions, not meta-analyzed

Intervention 1 (n1)Intervention 2 (n2)Studyvan Tulder ScoreGlobal Well-beingPainTender PointsPhysical FunctionDepression

Aerobic + Biofeedback (23)Control (27)Buckelew 199860.58 (0.25, 0.90)0.14 (-0.35, 0.63)0.64 (0.30, 0.98)---0.32 (0.00, 0.63)

Aerobic + Biofeedback (23)Aerobic-only (27)Buckelew 199860 (-0.53, 0.53)-0.5 (-1.05, 0.04)0.2 (-0.33, 0.74)----0.14 (-0.67, 0.40)

Aerobic + Biofeedback (23)Biofeedback- only (27)Buckelew 19986-0.25 (-0.80, 0.29)-0.64 (-1.19, -0.09)-0.1 (-0.64, 0.44)----0.1 (-0.64, 0.44)

Aerobic + Education (28)Education-only (28)Burckhardt 19944-0.23 (-0.75, 0.28)0.06 (-0.46, 0.57)---0.09 (-0.44, 0.61)0.05 (-0.48, 0.57)

Aerobic + Education (28)Untreated control (30)Burckhardt 199440.54 (0.01, 1.06)0 (-0.42, 0.42)---0.29 (0.18, 1.47)---

Aerobic + Education (27)Untreated control (23)Gowans 199930.97 (0.32, 1.62)0.25 (-0.36, 0.87)---0.83 (-0.23, 0.81)0.78 (0.15, 1.42)

Exercise + Education + Self Help (84)Untreated control (80)Cedraschi 200480.41 (0.11, 0.72)0.38 (0.07, 0.69)0.19 (-0.12, 0.49)---0.20 (-0.11, 0.50)

Exercise + Self-Management (14)Relaxation (13)Keel 199860.31 (-0.45, 1.07)0.55 (-0.23, 1.32)---------

Exercise + Education (28)Untreated control (29)Mannerkorpi 200050.66 (0.12, 1.19)0.45 (-0.08, 0.97)---1.21 (0.45, 1.79)0.17 (-0.35,0.69)

Exercise + Spa (58)Untreated control (76)Zijlstra 20054-0.05 (-0.39, 0.29)0.1 (-0.24, 0.44)0.50 (0.15, 0.85)0.13 (-0.21, 0.47)0.04 (-0.30, 0.39)

Note: a. All positive values denote greater improvement in Intervention 1 versus Intervention 2. Therefore, a positive value for pain intensity would mean pain intensity has decreased with intervention 1.
b. Van Tulder Score is based on the 11 internal validity items described in van Tulder et al. 2003.

Key: SMD = Standardized Mean Difference (small change = .2, moderate change = .5, large change = .8). Data for comparison at 12 weeks or as close to 12 weeks as possible was used to calculate SMD.

Formula: SMD= (Mean change in Intervention 1 - Mean changed in Intervention 2)/(Pooled SD of change)

 
Table 7. Clinical Relevance - Aerobic Training

Outcome (scale)# patients(# trials)Ctl baseline m(SD)Wt Absolute ChangeRelative % changeNNT (Benefit)Statistical sigQuality of evidence

Pain (10 cm VAS)183 (3)6.1 cm (1.97)13% (1.3 cms less on 10 cm scale)21%NANon-sig.Gold

Global Outcome Measure (0-10 scale)269 (4)5.5 (1.33)7% (0.7 points less on a scale of 0 to 10)12%5Sig.Gold

Physical Function/Fitness (peak VO2)253 (4)23.5 ml/km/min (4.27)2.8 more ml/kg/min oxygen uptake on a max treadmill test12%NASig.Gold

Tender Point (dolorimetry: pain pressure threshold)309 (5)3.7 (1.01)0.23 more kg/cm^2 per tender point6%NANon-sig.Gold

LEGEND - representative study used for estimates related to control group values: Schachter 2003; ctl=control group; m=mean; SD=standard deviation; wt=weighted; NNT=number needed to treat, refers to a 30% improvement; sig=significance; NA=not applicable

 
Table 8. Clinical Relevance - Strength Training

Outcome (scale)# patients (#trials)Ctl baseline m(SD)Wt Absolute ChangeRelative % ChangeNNT (Benefit)Statistical Sig.Quality of Evidence

Pain (0-100 scale, 0 = no pain, 100 worst possible)21 (1)35 (19)49%
(49 fewer points on scale of 0 to 100)
140%2Non-sigSilver

Global health (disease severity scale: 0-100 scale, 0 = health, 10 = severe disease)47 (2)34 (29)41%
(41 fewer points on scale of 0 to 100)
122%3sig.Silver

Physical Function (Max Isometric Force - Knee Extensors, Newtons)47 (2)415.9 Newtons (90.84)47 Newtons (4.7 more kilograms of force generated by quadriceps)11%NAnon.sig.Silver

Number of tender points (0-18 points)26 (1)15.6 tender points (1.9)2.1 fewer active tender points13%2sig.Silver

LEGEND: Hakkinen 2001 used for control group data for Pain and Global Health; Valkeinen 2004 control group data used for Physical Function and Number of Tender Points. Ctl=control group; m=mean; SD=standard deviation; wt=weighted; sig=significance; NNT=number needed to treat, refers to a 30% improvement; NA=not applicable