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Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants

  1. Nicola Austin1,
  2. William McGuire2,*

Editorial Group: Cochrane Neonatal Group

Published Online: 30 APR 2013

Assessed as up-to-date: 28 AUG 2012

DOI: 10.1002/14651858.CD003850.pub4


How to Cite

Austin N, McGuire W. Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD003850. DOI: 10.1002/14651858.CD003850.pub4.

Author Information

  1. 1

    Christchurch Womens Hospital, NICU, Christchurch, New Zealand

  2. 2

    Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK

*William McGuire, Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK. William.McGuire@hyms.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

SEARCH

This is not the most recent version of the article. View current version (24 OCT 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Arrieta 2010 {published data only}
  • Arrieta AC, Shea K, Dhar V, Cleary JP, Kukreja S, Morris M, et al. Once-weekly liposomal amphotericin B as Candida prophylaxis in very low birth weight premature infants: a prospective, randomized, open-label, placebo-controlled pilot study. Clinical Therapeutics 2010;32(2):265-71. [PUBMED: 20206784]
Aydemir 2011a {published data only}
  • Aydemir C, Oguz SS, Dizdar EA, Akar M, Sarikabadayi YU, Saygan S, et al. Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(3):F164-8. [PUBMED: 20659937]
Aydemir 2011b {published data only}
  • Aydemir C, Oguz SS, Dizdar EA, Akar M, Sarikabadayi YU, Saygan S, et al. Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. Archives of Disease in Childhood 2011;96(3):F164-8. [PUBMED: 20659937]
Cabrera 2002 {published data only}
  • Cabrera C, Frank M, Carter D, Bhatia J. Fluconazole prophylaxis against systemic candidiasis after colonization: a randomized, double-blinded study. Journal of Perinatology 2002;22:604.
Kaufman 2001 {published data only}
  • Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Donowitz LG. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. New England Journal of Medicine 2001;345(23):1660-6.
  • Kaufman D, Boyle R, Hazen KC, Robinson M, Donowitz LG. Effectiveness of fluconazole prophylaxis in the prevention of colonization and invasive infection in preterm infants (Pediatric Academic Societies, Abstract). Pediatric Research 2001;50:309A.
  • Kaufman D, Boyle R, Robinson M, Grossman LB. Long-term safety of intravenous prophylactic fluconazole use in preterm infants less than 1000 grams (Pediatric Academic Societies, Abstract). Pediatric Research 2003;53:2735.
  • Kaufman DA, Cuff AL, Wamstad JB, Boyle R, Gurka MJ, Grossman LB, et al. Fluconazole prophylaxis in extremely low birth weight infants and neurodevelopmental outcomes and quality of life at 8 to 10 years of age. The Journal of Pediatrics 2011;158(5):759-65.e1.
Kaufman 2005 {published data only}
  • Kaufman D, Boyle R, Hazen K, Patrie J, Robinson M, Grossman LB. Twice weekly fluconazole for prophylaxis for prevention of invasive fungal infection in high-risk infants of <1000g birthweight. The Journal of Pediatrics 2005;147(2):172-9.
Kicklighter 2001 {published data only}
  • Kicklighter SD, Springer SC, Cox T, Hulsey TC, Turner RB. Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant. Pediatrics 2001;107(2):293-8.
  • Kicklighter SD, Springer SC, Phaller MA, Messer S, Cox T, Hulsey TC, et al. Fluconazole for prophylaxis against fungal rectal colonization in the very low birth weight infant (Abstract). Pediatric Research 2000;47:342A.
Manzoni 2007a {published data only}
  • Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. New England Journal of Medicine 2007;356(24):2483-95.
Manzoni 2007b {published data only}
  • Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. New England Journal of Medicine 2007;356(24):2483-95.
Parikh 2007 {published data only}
  • Parikh TB, Nanavati RN, Patankar CV, Rao S, Bisure K, Udani RH, et al. Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. Indian Pediatrics 2007;44(11):830-7.
Violaris 2010 {published data only}
  • Violaris K, Carbone T, Bateman D, Olawepo O, Doraiswamy B, LaCorte M. Comparison of fluconazole and nystatin oral suspensions for prophylaxis of systemic fungal infection in very low birthweight infants. American Journal of Perinatology 2010;27(1):73-8. [PUBMED: 19504425]
  • Violaris K, Doraiswamy B, Olawepo O, Gulrajani-LaCorte M. Fluconazole versus nystatin prophylaxis for fungal infection in very low birth weight (VLBW) infants (Abstract). Pediatric Research 1998;44:254A.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Aghai 2006 {published data only}
  • Aghai ZH, Mudduluru M, Nakhla TA, Amendolia B, Longo D, Kemble N, et al. Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. Journal of Perinatology 2006;26(9):550-5.
Al Qurashi 2008 {published data only}
  • Al Qurashi MA, Alallah J, Salma EB, et al. Fluconazole prophylaxis is effective in reducing systemic fungal infection in VLBW infants. A single center four years retrospective study (Abstract). Pediatric Research. 2008; Vol. 63.
Aziz 2010 {published data only}
  • Aziz M, Patel AL, Losavio J, Iyengar A, Berven M, Schloemer N, et al. Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants. The Pediatric Infectious Disease Journal 2010;29(4):352-6. [PUBMED: 19934791]
Bertini 2005 {published data only}
  • Bertini B, Perugi S, Dani C, Filipp L, Pratesi S, Rubaltelli F. Fluconazole prophylaxis prevents invasive fungal infection in high-risk very low birthweight infants. The Journal of Pediatrics 2005;147(2):162-5.
Dutta 2005 {published data only}
  • Dutta S, Murki S, Varma S, Narang A, Chakrabarti A. Effects of cessation of a policy of neonatal fluconazole prophylaxis on fungal resurgence. Indian Pediatrics 2005;42(12):1226-30.
Healy 2005 {published data only}
  • Healy CM, Baker CJ, Zaccaria E, Campbell JR. Impact of fluconazole prophylaxis on incidence and outcome of invasive candidiasis in a neonatal intensive care unit. The Journal of Pediatrics 2005;147(2):166-71.
Healy 2008 {published data only}
  • Healy CM, Campbell JR, Zaccaria E, Baker CJ. Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazole-resistant Candida species. Pediatrics 2008;121(4):703-10. [PUBMED: 18381534]
Kim 2008 {published data only}
  • Kim MR, Chavda C, Jha V, et al. Prophylactic fluconazole for very low birth weight infants colonised with Candida (Abstract). Pediatric Research. 2008; Vol. 62.
Manzoni 2006 {published data only}
  • Manzoni P, Agrisio R, Mostert M, Leonessa M, Farina D, Latino M, Gomirato G. Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year retrospective cohort study. The Journal of Pediatrics 2006;117(1):e22-e32.
Manzoni 2008 {published data only}
  • Manzoni P, Leonessa M, Galletto P, Latino MA, Arisio R, Maule M, et al. Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies. The Pediatric Infectious Disease Journal 2008;27(8):731-7. [PUBMED: 18600191]
McCrossan 2007 {published data only}
  • McCrossan BA, McHenry E, O'Neill F, Ong G, Sweet DG. Selective fluconazole prophylaxis in high-risk babies to reduce invasive fungal infection. Archives of Disease in Childhood. Fetal and Neonatal Edition 2007;92(6):F454-8. [PUBMED: 17460023]
Rueda 2010 {published data only}
  • Rueda K, Moreno MT, Espinosa M, Saez-Llorens X. Impact of routine fluconazole prophylaxis for premature infants with birth weights of less than 1250 grams in a developing country. The Pediatric Infectious Disease Journal 2010;29(11):1050-2. [PUBMED: 20571460]
Uko 2006 {published data only}
  • Uko S, Soghier LM, Vega M, Marsh J, Reinersman GT, Herring L, et al. Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants. Pediatrics 2006;117(4):1243-52.
Wadhawan 2007 {published data only}
  • Wadhawan R, Dumois J, Escoto D, et al. Near elimination of Candida sepsis after fluconazole prophylaxis in ELBW infants-experience from a tertiary level NICU. Pediatric Research. 2007; Vol. 62.
Weitkamp 2008 {published data only}
  • Weitkamp JH, Ozdas A, LaFleur B, Potts AL. Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. Journal of Perinatology 2008;28(6):405-11. [PUBMED: 18185518]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Duke 2012 {published data only}
  • Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight. Ongoing study 2009.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Austin 2009
Benjamin 2003
  • Benjamin DK Jr, Poole C, Steibach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics 2003;112(3 Pt 1):634-40.
Benjamin 2006
  • Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006;117(1):84-92.
Brecht 2009
  • Brecht M, Clerihew L, McGuire W. Prevention and treatment of invasive fungal infection in very low birthweight infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2009;94(1):F65-9. [PUBMED: 18838467]
Brion 2007
Burwell 2006
  • Burwell LA, Kaufman D, Blakely J, Stoll BJ, Fridkin SK. Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. Pediatrics 2006;118(4):e1019-26.
Clerihew 2006
  • Clerihew L, Lamagni TL, Brocklehurst P, McGuire W. Invasive fungal infection in very low birthweight infants: national prospective surveillance study. Archives of Disease in Childhood 2006;91(3):F188-92.
Clerihew 2008
  • Clerihew L, McGuire W. Antifungal prophylaxis for very low birthweight infants: UK national survey. Archives of Disease in Childhood. Fetal and Neonatal Edition 2008;93(3):F198-200.
Friedman 2000
  • Friedman S, Richardson SE, Jacobs SE, O'Brien K. Systemic candida infection in extremely low birth weight infants: short term morbidity and long term neurodevelopmental outcome. The Pediatric Infectious Disease Journal 2000;19(6):499-504.
Horbar 2002
  • Horbar JD, Badger GJ, Carpenter JH, Fanaroff AA, Kilpatrick S, LaCorte M, et al. Members of the Vermont Oxford Network. Trends in mortality and morbidity for very low birth weight infants, 1991–1999. Pediatrics 2002;110(1 Pt 1):143-51.
Huang 1998
Huttova 1998
  • Huttova M, Hartmanova I, Kralinsky K, Filka J, Uher J, Kurak J, et al. Candida fungemia in neonates treated with fluconazole: report of forty cases, including eight with meningitis. The Pediatric Infectious Disease Journal 1998;17(11):1012-5.
Kaguelidou 2012
  • Kaguelidou F, Pandolfini C, Manzoni P, Choonara I, Bonati M, Jacqz-Aigrain E. European survey on the use of prophylactic fluconazole in neonatal intensive care units. European Journal of Pediatrics 2012;171(3):439-45. [PUBMED: 21912893]
Karlowicz 2002
  • Karlowicz MG, Rowen JL, Barnes-Eley ML, Burke BL, Lawson ML, Bendel CM, et al. The role of birth weight and gestational age in distinguishing extremely low birth weight infants at high risk of developing candidemia from infants at low risk: a multicenter study. Pediatric Research 2002;51:301A.
Kaufman 2010
Kossoff 1998
  • Kossoff EH, Buescher ES, Karlowicz MG. Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases. The Pediatric Infectious Disease Journal 1998;17(6):504-8.
Makhoul 2002
  • Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics 2002;109(1):34-9.
Neely 2001
O'Grady 2008
Pappu-Katikaneni 1990
  • Pappu-Katikaneni LD, Rao KP, Banister E. Gastrointestinal colonization with yeast species and Candida septicemia in very low birth weight infants. Mycoses 1990;33(1):20-3.
Robinson 2009
  • Robinson JL, Davies HD, Barton M, O'Brien K, Simpson K, Asztalos E, et al. Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study. BMC Infectious Diseases 2009;9:183. [PUBMED: 19930662]
Saiman 2000
  • Saiman L, Ludington E, Pfaller M, Rangel-Frausto S, Wiblin RT, Dawson J, et al. Risk factors for candidemia in neonatal intensive care unit patients. The National Epidemiology of Mycosis Survey Study Group. The Pediatric Infectious Disease Journal 2000;19(4):319-24.
Sarvikivi 2008
  • Sarvikivi E, Lyytikäinen O, Soll DR, Pujol C, Pfaller MA, Richardson M, et al. Emergence of fluconazole resistance in a Candida parapsilosis strain that caused infections in a neonatal intensive care unit. Journal of Clinical Microbiology 2005;43(6):2729-35.
Schelonka 2003
Stoll 1996
  • Stoll BJ, Gordon T, Korones SB, Shankaran S, Tyson JE, Bauer CR, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. The Journal of Pediatrics 1996;129(1):63-71.
Stoll 2002
  • Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91.
Vergnano 2011
  • Vergnano S, Menson E, Kennea N, Embleton N, Russell AB, Watts T, et al. Neonatal infections in England: the NeonIN surveillance network. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(1):F9-14. [PUBMED: 20876594]
Wynn 2012
  • Wynn JL, Tan S, Gantz MG, Das A, Goldberg RN, Adams-Chapman I, et al. Outcomes following candiduria in extremely low birth weight infants. Clinical Infectious Diseases 2012;54(3):331-9. [PUBMED: 22144537]

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Clerihew 2007
  • Clerihew L, Austin N, McGuire W. Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database of Systematic Reviews 4, Issue 2007 10.1002/14651858.CD003850.pub3. [DOI: 10.1002/14651858.CD003850.pub3]
McGuire 2004
  • McGuire W, Clerihew L, Austin N. Prophylactic intravenous antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database of Systematic Reviews 2004, Issue 1. [DOI: 10.1002/14651858.CD003850.pub2]