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Strength training and aerobic exercise training for muscle disease

  1. Nicoline BM Voet1,*,
  2. Elly L van der Kooi2,
  3. Ingrid I Riphagen3,
  4. Eline Lindeman4,†,
  5. Baziel GM van Engelen5,
  6. Alexander CH Geurts1

Editorial Group: Cochrane Neuromuscular Group

Published Online: 9 JUL 2013

Assessed as up-to-date: 2 JUL 2012

DOI: 10.1002/14651858.CD003907.pub4


How to Cite

Voet NBM, van der Kooi EL, Riphagen II, Lindeman E, van Engelen BGM, Geurts ACH. Strength training and aerobic exercise training for muscle disease. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD003907. DOI: 10.1002/14651858.CD003907.pub4.

Author Information

  1. 1

    Radboud University Medical Centre, Department of Rehabilitation, Nijmegen Centre for Evidence Based Practice, Nijmegen, Netherlands

  2. 2

    Medical Centre Leeuwarden, Department of Neurology, Leeuwarden, Netherlands

  3. 3

    Norwegian University of Science and Technology, Unit for Applied Clinical Research, Faculty of Medicine, Trondheim, Norway

  4. 4

    University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Center of Excellence for Rehabilitation Medicine, Utrecht, Netherlands

  5. 5

    Radboud University Medical Centre, Department of Neurology, Nijmegen, Netherlands

  1. Deceased

*Nicoline BM Voet, Department of Rehabilitation, Nijmegen Centre for Evidence Based Practice, Radboud University Medical Centre, PO Box 9101, Nijmegen, 6500 HB, Netherlands. N.Voet@reval.umcn.nl.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 9 JUL 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Cejudo 2005 {published data only}
Kierkegaard 2011 {published data only}
  • Kierkaard M, Harms-RIngdahl K, Edstrom L, Widen Holmqvist L, Tollback A. Feasibility and effects of a physical exercise programme in adults with myotonic dystrophy type 1: a randomized controlled pilot study. Journal of Rehabilitation Medicine 2011;43:695-702. [PUBMED: 21670942]
Lindeman 1995 {published and unpublished data}
  • Lindeman E, Drukker J. Specificity of strength training in neuromuscular disorders. Journal of Rehabilitation Sciences 1994;7(3):13-5. [EMBASE: 1994291551]
  • Lindeman E, Leffers P, Spaans F, Drukker J, Reulen J, Kerckhoffs M, et al. Strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: a randomized clinical trial. Archives of Physical Medicine and Rehabilitation 1995;76(7):612-20. [PUBMED: 7605179]
  • Lindeman E, Spaans F, Reulen J, Leffers P, Drukker J. Progressive resistance training in neuromuscular patients. Effects on force and surface EMG. Journal of Electromyography and Kinesiology 1999;9(6):379-84. [PUBMED: 10597050]
van der Kooi 2004 {published and unpublished data}
  • van der Kooi EL, Kalkman JS, Lindeman E, Hendriks JC, van Engelen BG, Bleijenberg G, et al. Effects of training and albuterol on pain and fatigue in facioscapulohumeral muscular dystrophy. Journal of Neurology 2007;254(7):931-40. [PUBMED: 17361345]
  • van der Kooi EL, Vogels OJM, van Asseldonk RJGP, Lindeman E, Hendriks JCM, Padberg GW. Strength training and albuterol in facioscapulohumeral muscular dystrophy. Neurology 2001;56(8 Suppl 3):A80 (abstract).
  • van der Kooi EL, Vogels OJM, van Asseldonk RJGP, Lindeman E, Hendriks JCM, Padberg GW. The efficacy of strength training in facioscapulohumeral muscular dystrophy. Neurology 2000;54(Suppl 3):A435 (abstract).
  • van der Kooi EL, Vogels OJM, van Asseldonk RJGP, Lindeman E, Hendriks JCM, Wohlgemuth M, et al. Strength training and albuterol in facioscapulohumeral muscular dystrophy. Neurology 2004;63(4):702-8. [PUBMED: 15326246]
Wiesinger 1998a {published data only}
  • Wiesinger GF, Quittan M, Aringer M, Seeber A, Volc-Platzer B, Smolen J, et al. Improvement of physical fitness and muscle strength in polymyositis/dermatomyositis patients by a training programme. British Journal of Rheumatology 1998;37(2):196-200. [PUBMED: 9569076]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Abramson 1952 {published data only}
  • Abramson AS, Rogoff J. An approach to the rehabilitation of children with muscular dystrophy. Physical treatment in muscular dystrophy. Proceedings 1st and 2nd Medical Conferences, Muscular Dystrophy Association of America. New York, 1952:123-5.
Aitkens 1993 {published data only}
  • Aitkens SG, McCrory MA, Kilmer DD, Bernauer EM. Moderate resistance exercise program: its effect in slowly progressive neuromuscular disease. Archives of Physical Medicine and Rehabilitation 1993;74(7):711-5.
Aldehag 2005 {published data only}
  • Aldehag AS, Jonsson H, Ansved T. Effects of a hand training programme in five patients with myotonic dystrophy type 1. Occupational Therapy International 2005;12(1):14-27.
Alexanderson 1999 {published data only}
Alexanderson 2000 {published data only}
  • Alexanderson H, Stenström CH, Jenner G, Lundberg I. The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis. Scandinavian Journal of Rheumatology 2000;29(5):295-301.
Alexanderson 2007 {published data only}
Arnardottir 2003 {published data only}
  • Arnardottir S, Alexanderson H, Lundberg IE, Borg K. Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction. Journal of Rehabilitation Medicine 2003;35(1):31-5.
Chung 2007 {published data only}
  • Chung YL, Alexanderson H, Pipitone N, Morrison C, Dastmalchi M, Ståhl-Hallengren C, et al. Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial. Arthritis and Rheumatism 2007;57(4):694-702.
Dastmalchi 2007 {published data only}
  • Dastmalchi M, Alexanderson H, Loell I, Stahlberg M, Borg K, Lundberg IE, et al. Effect of physical training on the proportion of slow-twitch type I muscle fibers, a novel nonimmune-mediated mechanism for muscle impairment in polymyositis or dermatomyositis. Arthritis Care and Research 2007;57(7):1303-10.
Dawes 2006 {published data only}
  • Dawes H, Korpershoek N, Freebody J, Elsworth C, van Tintelen N, Wade DT, et al. A pilot randomised controlled trial of a home-based exercise programme aimed at improving endurance and function in adults with neuromuscular disorders. Journal of Neurology, Neurosurgery and Psychiatry 2006;77(8):959-62. [PUBMED: 16614008]
De Lateur 1979 {published data only}
  • De Lateur BJ, Giaconi RM. Effect on maximal strength of submaximal exercise in Duchenne muscular dystrophy. American Journal of Physical Medicine 1979;58(1):26-36.
Escalante 1993 {published data only}
  • Escalante A, Miller L, Beardmore TD. An N-of-1 trial of resistive vs. non-resistive exercise in inflammatory muscle disease (IMD). Arthritis and Rheumatism 1991;34:S173.
  • Escalante A, Miller L, Beardmore TD. Resistive exercise in the rehabilitation of polymyositis/dermatomyositis. Journal of Rheumatology 1993;20(8):1340-4.
Florence 1984a {published data only}
Florence 1984b {published data only}
  • Florence JM, Brooke MH, Hagberg JM, Carroll JE. Endurance exercise in neuromuscular disease. In: Serratrice G editor(s). Neuromuscular Diseases. New York: Raven Press, 1984:577-81.
Fowler 1965 {published data only}
  • Fowler WM, Pearson CM, Egstrom GH, Gardner GW. Ineffective treatment of muscular dystrophy with an anabolic steroid and other measures. New England Journal of Medicine 1965;272(17):875-82.
Heikkila 2001 {published data only}
  • Heikkila S, Viitanen JV, Kautiainen H, Rajamaki T, Mantyvuo P, Harju T. Rehabilitation in myositis: preliminary study. Physiotherapy 2001;87:301-9.
Hicks 1989 {published data only}
  • Hicks J, Miller F, Plotz P, Zdrojewski M, Chen T, Gerber L. Exercise in patients with polymyositis. Arthritis and Rheumatism 1989;32:S149.
Hoberman 1955 {published data only}
  • Hoberman M. Physical medicine and rehabilitation: its value and limitations in progressive muscular dystrophy. American Journal of Physical Medicine 1955;34:109-15.
Jeppesen 2006 {published data only}
  • Jeppesen TD, Schwartz M, Olsen DB, Wibrand F, Krag T, Duno M, et al. Aerobic training is safe and improves exercise capacity in patients with mitochondrial myopathy. Brain 2006;129(12):3402-12.
Jeppesen 2009a {published data only}
Johnson 2007 {published data only}
  • Johnson LG, Hons BS, Edwards DJ, Walters S, Thickbroom GW, Mastaglia FL. The effectiveness of an individualized, home-based functional exercise program for patients with sporadic inclusion body myositis. Journal of Clinical Neuromuscular Disease 2007;8(4):187-94.
Johnson 2009 {published data only}
  • Johnson LG, Collier KE, Edwards DJ, Philippe DL, Eastwood PR, Walters SE, et al. Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis. Journal of Clinical Neuromuscular Disease 2009;10(4):178-84.
Kelm 2001 {published data only}
  • Kelm J, Ahlhelm F, Regitz T, Pape D, Schmitt E. Controlled dynamic weight training in patients with neuromuscular disorders [Kontrolliertes dynamisches Krafttraining bei Patienten mit neuromuskulären Erkrankungen]. Fortschritte der Neurologie-Psychiatrie 2001;69(8):359-66.
Kilmer 1994 {published data only}
  • Kilmer DD, McCrory MA, Wright NC, Aitkens SG, Bernauer EM. The effect of a high resistance exercise program in slowly progressive neuromuscular disease. Archives of Physical Medicine and Rehabilitation 1994;75(5):560-3.
Kilmer 2005 {published data only}
  • Kilmer DD, Wright NC, Aitkens S. Impact of a home-based activity and dietary intervention in people with slowly progressive neuromuscular diseases. Archives of Physical Medicine and Rehabilitation 2005;86(11):2150-6.
Lenman 1959 {published data only}
Mate-Munoz 2007 {published data only}
  • Mate-Munoz JL, Moran M, Perez M, Chamorro-Vina C, Gomez-Gallego F, Santiago C, et al. Favorable responses to acute and chronic exercise in McArdle patients. Clinical Journal of Sport Medicine 2007;17(4):297-303.
McCartney 1988 {published data only}
  • McCartney N, Moroz D, Garner SH, McComas AJ. The effects of strength training in patients with selected neuromuscular disorders. Medicine and Science in Sports and Exercise 1988;20(4):362-8.
Mielke 1990 {published data only}
  • Mielke U, Leipnitz, Holzer H, Schimrigk K. Dynamic muscular training in neuromuscular disease. Journal of the Neurological Sciences 1990;S98:388.
Milner-Brown 1988a {published data only}
  • Milner-Brown HS, Miller RG. Muscle strengthening through high-resistance weight training in patients with neuromuscular disorders. Archives of Physical Medicine and Rehabilitation 1988;69(1):14-9.
Milner-Brown 1988b {published data only}
  • Milner-Brown HS, Miller RG. Muscle strengthening through electric stimulation combined with low-resistance weights in patients with neuromuscular disorders. Archives of Physical Medicine Rehabilitation 1988;69(1):20-4.
Milner-Brown 1990 {published data only}
  • Milner-Brown HS, Miller RG. Myotonic dystrophy: quantification of muscle weakness and myotonia and the effect of amitriptyline and exercise. Archives of Physical Medicine and Rehabilitation 1990;71(12):983-7.
Murphy 2008 {published data only}
  • Murphy JL, Blakely EL, Schaefer AM, He L, Wyrick P, Haller RG, et al. Resistance training in patients with single, large-scale deletions of mitochondrial DNA. Brain 2008;131(Pt 11):2832-40.
Na 1996 {published data only}
  • Na YM, Kang SW, Lee HS, Moon JH. The effect of home exercise program for patients with myotonic dystrophy. Journal of the Korean Academy of Rehabilitation Medicine 1996;20(1):33-8.
Nader 2010 {published data only}
  • Nader GA, Dastmalchi M, Alexanderson H, Grundtman C, Gernapudi R, Esbjörnsson M, et al. A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis. Molecular Medicine 2010;16(11-12):455-64.
Olsen 2005 {published data only}
Omori 2010 {published data only}
Orngreen 2005 {published data only}
Scott 1981 {published data only}
  • Dubowitz V, Hyde SA, Scott OM, Goddard C. Controlled trial of exercise in Duchenne muscular dystrophy. In: Serratrice G, Cross D, Desnuelle, C, Gastaut J-L, Pellissier J-F, Pouget J, et al. editor(s). Neuromuscular Diseases. New York: Raven Press, 1984:571-5. [0-89004-070-X]
  • Scott OM, Hyde SA, Goddard C, Jones R, Dubowitz V. Effect of exercise in Duchenne muscular dystrophy. Physiotherapy 1981;67(6):174-6. [PUBMED: 7029578]
Siciliano 2000 {published data only}
  • Siciliano G, Manca ML, Renna M, Prontera C, Mercuri A, Murri L. Effects of aerobic training on lactate and catecholaminergic exercise responses in mitochondrial myopathies. Neuromuscular Disorders 2000;10(1):40-5.
Spector 1997 {published data only}
Sunnerhagen 2004 {published data only}
Sveen 2007 {published data only}
Sveen 2008 {published data only}
  • Sveen ML, Jeppesen TD, Hauerslev S, Kober L, Krag TO, Vissing J. Endurance training improves fitness and strength in patients with Becker muscular dystrophy. Brain 2008;131(Pt 11):2824-31.
Taivassalo 1998 {published data only}
Taivassalo 1999 {published data only}
Taivassalo 2001 {published data only}
Taivassalo 2006 {published data only}
  • Taivassalo T, Gardner JL, Taylor RW, Schaefer AM, Newman J, Barron MJ, et al. Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions. Brain 2006;129(12):3391-401.
Tollbäck 1999 {published data only}
  • Tollbäck A, Eriksson S, Wredenberg A, Jenner G, Vargas R, Borg K, et al. Effects of high resistance training in patients with myotonic dystrophy. Scandinavian Journal of Rehabilitation Medicine 1999;31(1):9-16.
Trenell 2006 {published data only}
Varju 2003 {published data only}
  • Varju C, Petho E, Kutas R, Czirjak L. The effect of physical exercise following acute disease exacerbation in patients with dermatomyositis/polymyositis. Clinical Rehabilitation 2003;17(1):83-7.
Vignos 1966 {published data only}
Wiesinger 1998b {published data only}
  • Wiesinger GF, Quittan M, Graninger M, Seeber A, Ebenbichler G, Sturm B, et al. Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. British Journal of Rheumatology 1998;37(12):1338-42.
Wright 1996 {published data only}
  • Wright NC, Kilmer DD, McCrory MA, Aitkens SG, Holcomb BJ, Bernauer EM. Aerobic walking in slowly progressive neuromuscular disease: effect of a 12-week program. Archives of Physical Medicine and Rehabilitation 1996;77(1):64-9.
Yildirim 2007 {published data only}
  • Yildirim S, Erden Z, Kilinc M. Comparison of the effects of proprioceptive neuromuscular facilitation techniques and weight training in patients with neuromuscular diseases. Fizyoterapi Rehabilitasyon 2007;18(2):65-71.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Alexanderson 2009 {published data only}
  • Alexanderson H, Noren A, Munters LA, Opava CH, Lundberg IE. Early employed exercise in recent onset polymyositis or dermatomyositis a randomized, controlled 2-year follow up study. Arthritis and Rheumatism 2009;60 Suppl 10:822.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Jansen 2010 {published data only}
  • Jansen M, de Groot IJ, van Alfen N, Geurts ACH. Physical training in boys with Duchenne Muscular Dystrophy: the protocol of the No Use is Disuse study. BMC Pediatrics 2010;10:55. [PUBMED: 20691042]
Voet 2010 {published data only}
  • Voet NBM, Bleijenberg G, Padberg GW, van Engelen BGM, Geurts ACH. Effect of aerobic exercise training and cognitive behavioural therapy on reduction of chronic fatigue in patients with facioscapulohumeral dystrophy: protocol of the FACTS-2-FSHD trial. BMC Neurology 2010;10:56. [PUBMED: 20591139]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Ansved 2008
Bohan 1975a
Bohan 1975b
Brouwer 1992
  • Brouwer OF, Padberg GW, van der Ploeg RJ, Ruys CJ, Brand R. The influence of handedness on the distribution of muscular weakness of the arm in facioscapulohumeral muscular dystrophy. Brain 1992;115(Pt 5):1587-98.
Cup 2007
  • Cup EH, Pieterse AJ, Ten Broek-Pastoor JM, Munneke M, van Engelen BG, Hendricks HT, et al. Exercise therapy and other types of physical therapy for patients with neuromuscular diseases: a systematic review. Archives of Physical Medicine and Rehabilitation 2007;88(11):1452-64.
Deidda 1996
  • Deidda G, Cacurri S, Piazzo N, Felicetti L. Direct detection of 4q35 rearrangements implicated in facioscapulohumeral muscular dystrophy (FSHD). Journal of Medical Genetics 1996;33(5):361-5.
Florence 2008
  • Florence JM, van der Ploeg A, Clemens PR, Escolar DM, Laforet P, Rosenbloom B, et al. Use of the 6min walk test as an endpoint in clinical trials for neuromuscular diseases. Neuromuscular Disorders 2008;18(9):738-9.
Fowler 1982
  • Fowler WM Jr, Taylor M. Rehabilitation management of muscular dystrophy and related disorders: I. The role of exercise. Archives of Physical Medicine and Rehabilitation 1982;63(7):319-21.
Fowler 1984
Garber 2011
  • Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Medicine & Science in Sports & Exercise 2011;43(7):1334-59.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration 2008. Available from www.cochrane-handbook.org, 20011. Version 5.1.0 [updated March 2011].
Johnson 1971
  • Johnson EW, Braddom R. Over-work weakness in facioscapulohumeral muscular dystrophy. Archives of Physical Medicine and Rehabilitation 1971;52(7):333-6. [MEDLINE: 71277095]
Kahl 2005
  • Kahl C, Cleland JA. Visual analogue scale, numeric pain rating scale and the McGill pain questionnaire: an overview of psychometric properties. Physical Therapy Reviews 2005;10(2):123–8.
Kilmer 1998
  • Kilmer DD. The role of exercise in neuromuscular disease. Physical Medicine and Rehabilitation Clinics of North America 1998;9(1):115-25.
Kilmer 2002
  • Kilmer DD. Response to aerobic exercise training in humans with neuromuscular disease. American Journal of Physical Medicine and Rehabilitation 2002;81(Suppl 11):148-50.
Kraemer 2002
  • Kraemer WJ, Adams K, Cafarellil E, Dudley GA, Dooly C, Feigenbaum MS, et al. American College of Sports position stand. Progression models in resistance training for healthy adults. Medicine and Science in Sports and Exercise 2002;34(2):364-80.
Lee 2007
McDonald 2002
Medical Research Council 1981
  • Medical Research Council. Aids to investigation of peripheral nerve injuries. London: Her Majesty's Stationary Office, 1981.
Millard 1989
  • Millard RW. The functional assessment screening questionnaire: application for evaluating pain-related disability. Archives of Physical Medicine and Rehabilitation 1989;70(4):303-7.
Munn 2004
Munn 2005
Parsons 1974
Personius 1994
  • Personius KE, Pandya S, King WM, Tawil R, McDermott MP. Facioscapulohumeral dystrophy natural history study: standardization of testing procedures and reliability of measurements. The FSH DY Group. Physical Therapy 1994;74(3):253-63.
Quinlivan 2011
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre. The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre. The Cochrane Collaboration, 2012.
Sale 1988
Shima 2002
  • Shima N, Ishida K, Katayama K, Morotome Y, Sato Y, Miyamura M. Cross education of muscular strength during unilateral resistance training and detraining. European Journal of Applied Physiology 2002;86(4):287-94.
Vercoulen 1999
  • Vercoulen JH, Alberts M, Bleijenberg G. The Checklist Individual Strength [De checklist Individual Strength (CIS)]. Gedragstherapie 1999;32:131–6.
Vignos 1983
Ware 2000